Correction to: Prevention of Infections in Cardiac Surgery study (PICS): study protocol for a pragmatic cluster-randomized factorial crossover pilot trial.

abstract：BACKGROUND:The choice of antiepileptic drug for an individual should be based upon the highest quality evidence regarding potential benefits and harms of the available treatments. Systematic reviews and meta-analysis of randomised controlled trials should be a major source of evidence supporting this decision making pr...

journal_title：Trials

authors： Tudur Smith C,Marson AG,Chadwick DW,Williamson PR

更新日期：2007-11-05 00:00:00

abstract：:Reviews have repeatedly noted important methodological issues in the conduct and reporting of cluster randomized controlled trials (C-RCTs). These reviews usually focus on whether the intracluster correlation was explicitly considered in the design and analysis of the C-RCT. However, another important aspect requiring...

journal_title：Trials

authors： Ivers NM,Halperin IJ,Barnsley J,Grimshaw JM,Shah BR,Tu K,Upshur R,Zwarenstein M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Computed tomography is widely used to diagnose acute appendicitis. Many adolescents and young adults are exposed to the associated radiation. A recent single-institution trial has reported promising results for low-dose computed tomography; however, this technique has not yet been widely adopted. LOCAT (low-...

journal_title：Trials

authors： Ahn S,LOCAT group.

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Given the complex nature of opioid addiction treatment and the rising number of available opioid substitution and antagonist therapies (OSAT), there is no 'gold standard' measure of treatment effectiveness, and each successive trial measures a different set of outcomes which reflect success in arbitrary or o...

journal_title：Trials

authors： Dennis BB,Sanger N,Bawor M,Naji L,Plater C,Worster A,Woo J,Bhalerao A,Baptist-Mohseni N,Hillmer A,Rice D,Corace K,Hutton B,Tugwell P,Thabane L,Samaan Z

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:People with decompensated cirrhosis require complex medical care and are often prescribed an intricate and frequently changing medication and lifestyle regimen. However, many patients mismanage their medications or have poor comprehension of their disease and self-management tasks. This can lead to harm, hos...

journal_title：Trials

authors： Hayward KL,Martin JH,Cottrell WN,Karmakar A,Horsfall LU,Patel PJ,Smith DD,Irvine KM,Powell EE,Valery PC

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is a chronic, degenerative disease of the central nervous system. Because of the long-term and unpredictable nature of the disease, the burden of MS is significant from both a patient and societal perspective. Despite a recent influx of disease-modifying therapies to treat MS, many in...

journal_title：Trials

authors： Goulding FL,Evans CD,Knox KB,Lim HJ,Levin MC,Donkers SJ

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Malaria transmission is highly heterogeneous in most settings, resulting in the formation of recognizable malaria hotspots. Targeting these hotspots might represent a highly efficacious way of controlling or eliminating malaria if the hotspots fuel malaria transmission to the wider community. METHODS/DESIGN...

journal_title：Trials

authors： Bousema T,Stevenson J,Baidjoe A,Stresman G,Griffin JT,Kleinschmidt I,Remarque EJ,Vulule J,Bayoh N,Laserson K,Desai M,Sauerwein R,Drakeley C,Cox J

更新日期：2013-02-02 00:00:00

abstract：BACKGROUND:Callus is one of the most common foot skin complaints experienced by people of all ages. These painful and unsightly lesions often result in disability. The 'gold standard' of treatment is scalpel debridement by a trained specialist; however, people also seek over-the-counter remedies. There is a lack of cli...

journal_title：Trials

authors： Hashmi F,Nester CJ,Wright CR,Lam S

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:Socially disadvantaged men are at a substantially higher risk of developing alcohol-related problems. The frequency of heavy drinking in a single session is high among disadvantaged men. Brief alcohol interventions were developed for, and are usually delivered in, healthcare settings. The group who binge dri...

journal_title：Trials

authors： Crombie IK,Irvine L,Williams B,Sniehotta FF,Petrie D,Evans JM,Emslie C,Jones C,Ricketts IW,Humphris G,Norrie J,Rice P,Slane PW

更新日期：2014-12-19 00:00:00

abstract：BACKGROUND:In people with chronic obstructive pulmonary disease (COPD), limb-muscle dysfunction is one of the most troublesome systemic manifestations of the disease, which at the functional level is evidenced by reduced strength and endurance of limb muscles. Improving limb-muscle function is an important therapeutic ...

journal_title：Trials

authors： Frykholm E,Klijn P,Saey D,van Hees HWH,Stål P,Sandström T,Sörlin A,Maltais F,Nyberg A

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:In the last few years, excessive internet use and computer gaming have increased dramatically. Salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse have been defined as diagnostic criteria for internet addiction (IA) and computer addiction (CA) in the scientific community. Despi...

journal_title：Trials

authors： Jäger S,Müller KW,Ruckes C,Wittig T,Batra A,Musalek M,Mann K,Wölfling K,Beutel ME

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:This study aims to evaluate the feasibility and efficacy of a complex health intervention, based on the combination of conventional Western medicine and traditional Chinese medicine (TCM), in an outpatient department of a university hospital for patients with frequent episodic or chronic tension-type headach...

journal_title：Trials

authors： Schiller J,Kellner T,Briest J,Hoepner K,Woyciechowski A,Ostermann A,Korallus C,Sturm C,Weiberlenn T,Jiang L,Egen C,Beissner F,Stiesch M,Karst M,Gutenbrunner C,Fink MG

更新日期：2019-11-08 00:00:00

abstract：BACKGROUND:An increasing number of clinical trials of traditional Chinese medicine are being conducted in the treatment of non-valvular atrial fibrillation (NVAF) in China. However, the heterogeneity of outcomes and outcome measurement instruments has produced little evidence for traditional Chinese medicine in treatin...

journal_title：Trials

authors： Qiu R,Li M,Zhang X,Chen S,Li C,Shang H

更新日期：2018-10-05 00:00:00

abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that causes paralysis of limb, swallowing, and breathing muscles. Riluzole, the Food and Drug Administration-approved drug for ALS, provides minimal benefit, prolonging patient life by only 2-3 months. Previous studies have found a neur...

journal_title：Trials

authors： Kim S,Kim JK,Son MJ,Kim D,Song B,Son I,Kang HW,Lee J,Kim S

更新日期：2018-04-13 00:00:00

abstract：BACKGROUND:Delirium prevalence in the intensive care unit (ICU) is high. Numerous psychotropic agents are used to manage delirium in the ICU with limited data regarding their efficacy or harms. METHODS/DESIGN:This is a randomized controlled trial of 428 patients aged 18 and older suffering from delirium and admitted t...

journal_title：Trials

authors： Campbell NL,Khan BA,Farber M,Campbell T,Perkins AJ,Hui SL,Abernathy G,Buckley J,Sing R,Tricker J,Zawahiri M,Boustani MA

更新日期：2011-06-06 00:00:00

abstract：BACKGROUND:Disinvestment from inefficient or ineffective health services is a growing priority for health care systems. Provision of allied health services over the weekend is now commonplace despite a relative paucity of evidence supporting their provision. The relatively high cost of providing this service combined w...

journal_title：Trials

authors： Haines TP,O'Brien L,Mitchell D,Bowles KA,Haas R,Markham D,Plumb S,Chiu T,May K,Philip K,Lescai D,McDermott F,Sarkies M,Ghaly M,Shaw L,Juj G,Skinner EH

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at < 30 weeks' gestation. The incidence of NEC is reduced when infants are fed human milk. However, in many neonatal intensive care units (NICUs), it is standard practice to freeze and/or pasteurize human milk, which dea...

journal_title：Trials

authors： Sun H,Cao Y,Han S,Cheng R,Liu L,Liu J,Xia S,Zhang J,Li Z,Cheng X,Yang C,Pan X,Li L,Ding X,Wang R,Wu M,Li X,Shi L,Xu F,Yu F,Pan J,Zhang X,Li L,Yang J,Li M,Yan C,Zhou Q,Lu J,Wei M,Wang L,Yang L,

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:The lack of approved treatments for the majority of rare diseases is reflective of the unique challenges of orphan drug development. Novel methodologies, including new functionally relevant endpoints, are needed to render the development process more feasible and appropriate for these rare populations and th...

journal_title：Trials

authors： Fields T,Patterson M,Bremova-Ertl T,Belcher G,Billington I,Churchill GC,Davis W,Evans W,Flint S,Galione A,Granzer U,Greenfield J,Karl R,Kay R,Lewi D,Mathieson T,Meyer T,Pangonis D,Platt FM,Tsang L,Verburg C,Fact

更新日期：2021-01-22 00:00:00

abstract：BACKGROUND:With a survival rate of 6 to 11%, out-of-hospital cardiac arrest (OHCA) remains a healthcare challenge with room for improvement in morbidity and mortality. The guidelines emphasize the highest possible quality of cardiopulmonary resuscitation (CPR) and chest compressions (CC). It is essential to minimize CC...

journal_title：Trials

authors： Buléon C,Parienti JJ,Morilland-Lecoq E,Halbout L,Cesaréo E,Dubien PY,Jardel B,Boyer C,Husson K,Andriamirado F,Benet X,Morel-Marechal E,Aubrion A,Muntean C,Dupire E,Roupie E,Hubert H,Vilhelm C,Gueugniaud PY,CILICA-HS

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Endovenous thermal techniques, such as endovenous laser ablation (EVLA), are the recommended treatment for truncal varicose veins. However, a disadvantage of thermal techniques is that it requires the administration of tumescent anaesthesia, which can be uncomfortable. Non-thermal, non-tumescent techniques, ...

journal_title：Trials

authors： Leung CC,Carradice D,Wallace T,Chetter IC

更新日期：2016-08-24 00:00:00

abstract：BACKGROUND:School-based comprehensive sexual health education can improve adolescent health outcomes, and web-based programs are a promising approach to overcoming challenges associated with teacher-led formats by ensuring that students receive content that is consistent, unbiased, and medically accurate. However, many...

journal_title：Trials

authors： Scull TM,Malik CV,Morrison A,Keefe EM

更新日期：2020-01-08 00:00:00

abstract：BACKGROUND:Despite a burgeoning interest in using interprofessional approaches to promote effective collaboration in health care, systematic reviews find scant evidence of benefit. This protocol describes the first cluster randomized controlled trial (RCT) to design and evaluate an intervention intended to improve inte...

journal_title：Trials

authors： Zwarenstein M,Reeves S,Russell A,Kenaszchuk C,Conn LG,Miller KL,Lingard L,Thorpe KE

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a major cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and is pop...

journal_title：Trials

authors： Fei YP,Zheng Y,Lai D,Zhong P,Lu JZ,Li G,Liu P

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a health condition sensitive to patient's preferences and values regarding the benefits and risks of the different treatment options. In this sense, patient decision aids (PtDA) can play an important role in helping patients to incorporate their values, needs, and preferences into the ...

journal_title：Trials

authors： Perestelo-Pérez L,Álvarez-Pérez Y,Rivero-Santana A,Ramos-García V,Duarte-Díaz A,Torres-Castaño A,Toledo-Chávarri A,Herrera-Perez M,País-Brito JL,Del Castillo JC,Vázquez JR,Orrego C,Serrano-Aguilar P

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Burns and the associated wound care procedures can be extremely painful and anxiety-provoking for children. Burn injured children and adolescents are therefore at greater risk of experiencing a range of psychological reactions, in particular posttraumatic stress disorder, which can persist for months to year...

journal_title：Trials

authors： Chester SJ,Stockton K,De Young A,Kipping B,Tyack Z,Griffin B,Chester RL,Kimble RM

更新日期：2016-04-29 00:00:00

abstract：BACKGROUND:Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of professionals to understand what interim information should be shared at interim, with whom and why. MET...

journal_title：Trials

authors： Borg Debono V,Mbuagbaw L,Paul J,Buckley N,Thabane L

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:The Swiss health ministry launched a national quality program 'QualiCCare' in 2011 to improve health care for patients with COPD.The aim of this study is to determine whether participation in the COPD quality initiative ('QualiCCare') improves adherence to recommended clinical processes and shows impact on p...

journal_title：Trials

authors： Steurer-Stey C,Markun S,Lana KD,Frei A,Held U,Wensing M,Rosemann T

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Delirium is a state of confusion characterized by an acute and fluctuating decline in cognitive functioning. Delirium is common and deadly in older adults with dementia, and is often referred to as delirium superimposed on dementia, or DSD. Interventions that treat DSD are not well-developed because the mech...

journal_title：Trials

authors： Kolanowski AM,Fick DM,Litaker MS,Clare L,Leslie D,Boustani M

更新日期：2011-05-11 00:00:00

abstract：BACKGROUND:Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated with high rates of morbidity and mortality due to uncontrolled disease and treatment...

journal_title：Trials

authors： Walsh M,Merkel PA,Peh CA,Szpirt W,Guillevin L,Pusey CD,De Zoysa J,Ives N,Clark WF,Quillen K,Winters JL,Wheatley K,Jayne D,PEXIVAS Investigators.

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:It is widely agreed that triglyceride (TG)-lowering therapy is imperative in early hypertriglyceridemia-induced acute pancreatitis (HTG-AP). Intravenous insulin with or without heparin, and plasmapheresis are available regimens. However, there is no consensus on first-line therapy. METHODS/DESIGN:The Bi-TPA...

journal_title：Trials

authors： Song X,Shi D,Cui Q,Yu S,Yang J,Song P,Walline J,Xu J,Zhu H,Yu X

更新日期：2019-06-18 00:00:00