Healthy lifestyle consultation based on traditional Chinese medicine versus routine patient education in the treatment of idiopathic sudden sensorineural hearing loss after failure of systemic therapy: study protocol for a clinical randomised trial.

abstract：BACKGROUND:Surgical interventions are complex, which complicates their rigorous assessment through randomised clinical trials. An important component of complexity relates to surgeon experience and the rate at which the required level of skill is achieved, known as the learning curve. There is considerable evidence tha...

journal_title：Trials

authors： Papachristofi O,Jenkins D,Sharples LD

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Quality of residential care for people with severe dementia is in urgent need of improvement. One reason for this may be the assumption that people with severe dementia are unaware of what is happening to them. However, there is converging evidence to suggest that global assumptions of unawareness are inappr...

journal_title：Trials

authors： Clare L,Woods RT,Whitaker R,Wilson BA,Downs M

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:Youth depression is highly prevalent and is related to impairments in academic, social and behavioural functioning. Evidence-based treatments are available, but many young people do not respond or sufficiently recover with first-line options, and a significant proportion experience relapse. Consequently, the...

journal_title：Trials

authors： Hallford DJ,Carmichael AM,Austin DW,Takano K,Raes F,Fuller-Tyszkiewicz M

更新日期：2020-01-14 00:00:00

abstract：BACKGROUND:HIV-related stigma significantly impacts HIV care engagement, including in prevention of mother-to-child transmission of HIV (PMTCT) programs. Maisha is a stigma-based counseling intervention delivered during the first antenatal care (ANC) visit, complementing routine HIV counseling and testing. The goal of ...

journal_title：Trials

authors： Watt MH,Knippler ET,Minja L,Kisigo G,Knettel BA,Ngocho JS,Renju J,Osaki H,Mwamba R,Rogathi JJ,Mmbaga BT

更新日期：2019-12-30 00:00:00

abstract：:Following the South African case, Treatment Action Campaign and Others v Minister of Health and Others, the use of 'pilot' studies to investigate interventions already proven efficacious, offered free of charge to government, but confined by the government to a small part of the population, may violate children's righ...

journal_title：Trials

authors： Oduwo E,Edwards SJ

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dementia symptoms are needed because current treatment options (antidepressants and antipsychotics) can...

journal_title：Trials

authors： Timler A,Bulsara C,Bulsara M,Vickery A,Smith J,Codde J

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals' foot health and quality of life. Based on the current trends of self-monitoring and self-care, provid...

journal_title：Trials

authors： Silva EQ,Suda EY,Santos DP,Veríssimo JL,Ferreira JSSP,Cruvinel Júnior RH,Monteiro RL,Sartor CD,Sacco ICN

更新日期：2020-02-13 00:00:00

abstract：BACKGROUND:The objective of this research was to evaluate data from a randomized clinical trial that tested injectable diacetylmorphine (DAM) and oral methadone (MMT) for substitution treatment, using a multi-domain dichotomous index, with a Bayesian approach. METHODS:Sixty two long-term, socially-excluded heroin inje...

journal_title：Trials

authors： Perea-Milla E,Ayçaguer LC,Cerdà JC,Saiz FG,Rivas-Ruiz F,Danet A,Vallecillo MR,Oviedo-Joekes E

更新日期：2009-08-14 00:00:00

abstract：BACKGROUND:Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated with high rates of morbidity and mortality due to uncontrolled disease and treatment...

journal_title：Trials

authors： Walsh M,Merkel PA,Peh CA,Szpirt W,Guillevin L,Pusey CD,De Zoysa J,Ives N,Clark WF,Quillen K,Winters JL,Wheatley K,Jayne D,PEXIVAS Investigators.

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Transurethral resection of the prostate (TURP) has been the standard operation for benign prostatic obstruction (BPO) for 40 years, with approximately 25,000 procedures performed annually, and has remained largely unchanged. It is generally a successful operation, but has well-documented risks for the patien...

journal_title：Trials

authors： Worthington J,Taylor H,Abrams P,Brookes ST,Cotterill N,Noble SM,Page T,Swami KS,Lane JA,Hashim H

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Unhealthy alcohol use is a leading cause of morbidity and mortality among young people, including university students. Delivering secondary prevention interventions against unhealthy alcohol use is challenging. Information technology has the potential to reach large parts of the general population. The prese...

journal_title：Trials

authors： Bertholet N,Schmutz E,Grazioli VS,Faouzi M,McNeely J,Gmel G,Daeppen JB,Cunningham JA

更新日期：2020-02-17 00:00:00

abstract：BACKGROUND:The purpose of clinical trials of acupuncture is to help clinicians and patients make decisions about treatment. Yet this is not straightforward: some trials report acupuncture to be superior to sham (placebo) acupuncture while others show evidence that acupuncture is superior to usual care but not sham, and...

journal_title：Trials

authors： Vickers AJ,Cronin AM,Maschino AC,Lewith G,Macpherson H,Victor N,Sherman KJ,Witt C,Linde K,Acupuncture Trialists' Collaboration.

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea (OSA) and hypertension are well-known cardiovascular risk factors. Their control could reduce the burden of heart disease across populations. Several drugs are used to control hypertension, but the only consistently effective treatment of OSA is continuous positive airway pressure. Th...

journal_title：Trials

authors： Cichelero FT,Martinez D,Fuchs SC,Gus M,Moreira LB,Fuchs FD

更新日期：2014-01-02 00:00:00

abstract：BACKGROUND:Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and advantages. Although a combination of TCM and WM therapies, adjusted to the clinical situation, is ...

journal_title：Trials

authors： Sun X,Zhou X,Wei Y,Yang W,Huang N,Ding Y,Hu R,Guo S,Yang C,Weng H,Zhang Y,Chen X,Ding X,Liu L,Yin Q,Wang R,Li X,Li B

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:In the presence of heterogeneous treatment effects, it is desirable to divide patients into subgroups based on their expected response to treatment. This is formalised via a personalised treatment recommendation: an algorithm that uses biomarker measurements to select treatments. It could be that multiple, r...

journal_title：Trials

authors： Pierce M,Emsley R

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Haemostasis in liver surgery remains a challenge despite improved resection techniques. Oozing from blood vessels too small to be ligated necessitate a treatment with haemostats in order to prevent complications attributed to bleeding. There is good evidence from randomised trials for the efficacy of fibrin ...

journal_title：Trials

authors： Moench C,Bechstein WO,Hermanutz V,Hoexter G,Knaebel HP

更新日期：2010-11-19 00:00:00

abstract：BACKGROUND:The choice of antiepileptic drug for an individual should be based upon the highest quality evidence regarding potential benefits and harms of the available treatments. Systematic reviews and meta-analysis of randomised controlled trials should be a major source of evidence supporting this decision making pr...

journal_title：Trials

authors： Tudur Smith C,Marson AG,Chadwick DW,Williamson PR

更新日期：2007-11-05 00:00:00

abstract：BACKGROUND:Trauma contributes to psychosis and in psychotic disorders post-traumatic stress disorder (PTSD) is often a comorbid disorder. A problem is that PTSD is underdiagnosed and undertreated in people with psychotic disorders. This study's primary goal is to examine the efficacy and safety of prolonged exposure an...

journal_title：Trials

authors： de Bont PA,van den Berg DP,van der Vleugel BM,de Roos C,Mulder CL,Becker ES,de Jongh A,van der Gaag M,van Minnen A

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:Incurable cancer does not only affect patients, it also affects the lives of their partners. Many partners take on caregiving responsibilities. The burden of these caregiving tasks are often associated with physical, psychological, and social difficulties and many partners have unmet supportive care needs. O...

journal_title：Trials

authors： Schuit AS,Holtmaat K,Hooghiemstra N,Jansen F,Lissenberg-Witte BI,Coupé VMH,Verdonck-de Leeuw IM

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:A high intake of salt is a major risk factor for cardiovascular diseases. Despite decades of effort to reduce salt consumption, the salt intake in China is still considerably above the recommended level. Thus, this study aims to design and implement an intelligent household added salt monitoring system (SALT...

journal_title：Trials

authors： Xian J,Zeng M,Zhu R,Cai Z,Shi Z,Abdullah AS,Zhao Y

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Allergic rhinitis is a chronic illness, affecting 10 to 40% of the worldwide population. Chinese herbal medicines, the treatment of allergic rhinitis, adopted thousands of years in ancient China, has recently raised much attention among researchers globally. This study evaluates the effects of two Chinese he...

journal_title：Trials

authors： Chan RY,Chien WT

更新日期：2014-07-02 00:00:00

abstract：BACKGROUND:Recovery after a major stroke is usually limited, but cell therapy for patients with fixed neurologic deficits is emerging. Several recent clinical trials have investigated mesenchymal stem cell (MSC) therapy for patients with ischemic stroke. We previously reported the results of a controlled trial on the a...

journal_title：Trials

authors： Kim SJ,Moon GJ,Chang WH,Kim YH,Bang OY,STARTING-2 (STem cell Application Researches and Trials In NeuroloGy-2) collaborators.

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) is found in approximately 1% of the population and includes core symptoms that affect general and social development. Beside these core symptoms, it is suggested that up to 60% of children with ASD suffer from comorbid anxiety disorders which may further affect educational, soc...

journal_title：Trials

authors： Kilburn TR,Sørensen MJ,Thastum M,Rapee RM,Rask CU,Arendt KB,Thomsen PH

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:Effective recruitment is an essential element of successful research but notoriously difficult to achieve. This article examines health care professionals' views on the factors influencing decision-making regarding referral to a stroke rehabilitation trial. METHODS:Semi-structured interviews and a card-sort...

journal_title：Trials

authors： Thomas N,Plant S,Woodward-Nutt K,Prior Y,Tyson S

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m2. The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutralizes the acid net produ...

journal_title：Trials

authors： Gaggl M,Cejka D,Plischke M,Heinze G,Fraunschiel M,Schmidt A,Hörl WH,Sunder-Plassmann G

更新日期：2013-07-04 00:00:00

abstract：BACKGROUND:A core outcome set (COS) represents the agreed minimum set of domains and measurement instruments that should be measured and reported in any clinical trial for a given condition. In BMS randomized controlled trials (RCTs), the outcomes identified in the existing literature regarding the efficacy of therapeu...

journal_title：Trials

authors： Carey B,Farag AM,Nasri-Heir C,Klasser GD,Ariyawardana A,Chmieliauskaite M,Sardella A,Carlson CR,Miller CS,Mejia L,O'Neill FE,Albuquerque R

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Neointimal hyperplasia plays a pivotal role in the pathogenesis of in-stent restenosis in patients undergoing percutaneous coronary interventions. Drug-eluting balloons are a promising tool to prevent restenosis after coronary angioplasty. Moreover, an increased knowledge of the pathophysiology of restenosis...

journal_title：Trials

authors： Burzotta F,Brancati MF,Trani C,Porto I,Tommasino A,De Maria G,Niccoli G,Leone AM,Coluccia V,Schiavoni G,Crea F

更新日期：2012-05-06 00:00:00

abstract：BACKGROUND:Inconsistent outcome reporting is one significant hurdle to combining results from trials into systematic reviews. Core outcome sets (COS) can reduce this barrier. The aim of this review was to map outcomes reported in caries prevention and management randomised controlled trials (RCT) as a first step to COS...

journal_title：Trials

authors： Levey C,Innes N,Schwendicke F,Lamont T,Göstemeyer G

更新日期：2017-11-02 00:00:00

abstract：BACKGROUND:Trials in rare diseases have many challenges, among which are the need to set up multiple sites in different countries to achieve recruitment targets and the divergent landscape of clinical trial regulations in those countries. Over the past years, there have been initiatives to facilitate the process of int...

journal_title：Trials

authors： Crow RA,Hart KA,McDermott MP,Tawil R,Martens WB,Herr BE,McColl E,Wilkinson J,Kirschner J,King WM,Eagle M,Brown MW,Hirtz D,Lochmuller H,Straub V,Ciafaloni E,Shieh PB,Spinty S,Childs AM,Manzur AY,Morandi L,Butterf

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Patient-ventilator asynchrony is a common problem in mechanically ventilated patients with acute respiratory failure. It is assumed that asynchronies worsen lung function and prolong the duration of mechanical ventilation (MV). Neurally Adjusted Ventilatory Assist (NAVA) is a novel approach to MV based on ne...

journal_title：Trials

authors： Villar J,Belda J,Blanco J,Suarez-Sipmann F,Añón JM,Pérez-Méndez L,Ferrando C,Parrilla D,Montiel R,Corpas R,González-Higueras E,Pestaña D,Martínez D,Fernández L,Soro M,García-Bello MA,Fernández RL,Kacmarek RM,NAVa In A

更新日期：2016-10-13 00:00:00