Rationale and design for cognitive behavioral therapy for anxiety disorders in children with autism spectrum disorder: a study protocol of a randomized controlled trial.

abstract：BACKGROUND:Coronary heart disease (CHD) has become a common cardiovascular disease that seriously threatens the health of people. As reperfusion in the early phase and drug therapy, especially percutaneous coronary intervention (PCI), have become widely used in the clinic, the mortality of acute myocardial infarction i...

journal_title：Trials

authors： Wang Y,Wang X,Wang J,Li B,Yu R,Hu Y,Li X,Peng G,Zhang M,Zhu M

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:Patient-reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing-remitting conditions, such as eczema, repeated measurements may allow a more accurate reflection of disease burden and treatment effect than less frequ...

journal_title：Trials

authors： Stuart B,Rumsby K,Santer M,Ridd MJ,Francis NA,Chorozoglou M,Spreadbury C,Steele M,Nollett C,Liddiard L,Prude M,Hooper J,Thomas-Jones E,Roberts A,Thomas KS,Williams HC,Little P

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:State of the art sedation concepts on intensive care units (ICU) favor propofol for a time period of up to 72 h and midazolam for long-term sedation. However, intravenous sedation is associated with complications such as development of tolerance, insufficient sedation quality, gastrointestinal paralysis, and...

journal_title：Trials

authors： Soukup J,Selle A,Wienke A,Steighardt J,Wagner NM,Kellner P

更新日期：2012-08-10 00:00:00

abstract：BACKGROUND:Premature ejaculation (PE) is the most common sexual dysfunction among men. According to patients, the general practitioner (GP) is the appropriate professional with whom to discuss this issue. However, few patients receive the medical help needed because GPs find it difficult to talk to their patients about...

journal_title：Trials

authors： Barais M,Vaillant Roussel H,Costa D,Derriennic J,Pereira B,Cadier S

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Postoperative upper gastrointestinal fistula (PUGIF) is a devastating complication, leading to high mortality (reaching up to 80%), increased length of hospital stay, reduced health-related quality of life and increased health costs. Nutritional support is a key component of therapy in such cases, which is r...

journal_title：Trials

authors： Gronnier C,Chambrier C,Duhamel A,Dervaux B,Collet D,Vaudoyer D,Régimbeau JM,Jougon J,Théréaux J,Lebreton G,Veziant J,Valverde A,Ortega-Deballon P,Pattou F,Mathonnet M,Perinel J,Beyer-Berjot L,Fuks D,Rouanet P,Lefevr

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:Many people living with HIV suffer from depressive symptoms. In a previous pilot study, self-help cognitive behavioral therapy (in booklet format) was found to be effective in treating depressive symptoms in people with HIV. We developed an online self-help program in Dutch and English (based on the booklet)...

journal_title：Trials

authors： van Luenen S,Kraaij V,Spinhoven P,Garnefski N

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation. However, preliminary randomised clinical trials indicate that it is beneficial to reduce the sedation level. No randomised trial has been conducted comparing sedation with no se...

journal_title：Trials

authors： Toft P,Olsen HT,Jørgensen HK,Strøm T,Nibro HL,Oxlund J,Wian KA,Ytrebø LM,Kroken BA,Chew M

更新日期：2014-12-20 00:00:00

abstract：OBJECTIVES:Primary Objective • To assess the efficacy of herbal extracts in boosting innate immunity of patients with COVID-19 infection. Secondary Objectives • To assess the efficacy of herbal extracts in restoring respiratory health • To assess the efficacy of Cap. IP in early recovery of patients and decline in vira...

journal_title：Trials

authors： Rangnekar H,Patankar S,Suryawanshi K,Soni P

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:In people with chronic obstructive pulmonary disease (COPD), limb-muscle dysfunction is one of the most troublesome systemic manifestations of the disease, which at the functional level is evidenced by reduced strength and endurance of limb muscles. Improving limb-muscle function is an important therapeutic ...

journal_title：Trials

authors： Frykholm E,Klijn P,Saey D,van Hees HWH,Stål P,Sandström T,Sörlin A,Maltais F,Nyberg A

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Exercise-based cardiac rehabilitation is a beneficial therapy for patients with chronic heart failure. The delivery of exercise-based cardiac rehabilitation should adopt an evidence-based approach, as well as be culturally appropriate and sensitive to individual needs and preferences. The Baduanjin Eight-Sil...

journal_title：Trials

authors： Chen X,Jiang W,Lin X,Lundborg CS,Wen Z,Lu W,Marrone G

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Alcohol use disorder (AUD) is a chronic and relapsing condition for which current pharmacological treatments are only modestly effective. The development of efficacious medications for AUD remains a high research priority with recent emphasis on identifying novel molecular targets for AUD treatment and to ef...

journal_title：Trials

authors： Burnette EM,Baskerville WA,Grodin EN,Ray LA

更新日期：2020-09-11 00:00:00

abstract：BACKGROUND:Effective programs to help children manage their weight are required. Families for Health focuses on a parenting approach, designed to help parents develop their parenting skills to support lifestyle change within the family. Families for Health V1 showed sustained reductions in overweight after 2 years in a...

journal_title：Trials

authors： Robertson W,Stewart-Brown S,Stallard N,Petrou S,Griffiths F,Thorogood M,Simkiss D,Lang R,Reddington K,Poole F,Rye G,Khan KA,Hamborg T,Kirby J

更新日期：2013-03-20 00:00:00

abstract：BACKGROUND:Spontaneous recovery from articular cartilage injury is difficult, and the ongoing progression of disease can eventually lead to osteoarthritis. Currently, there is no effective non-surgical treatment for articular cartilage injury. Arthroscopic debridement and microfracture surgery are performed for fibroca...

journal_title：Trials

authors： Ma N,Wang H,Xu X,Wan Y,Liu Y,Wang M,Yu W,Dai Y,Peng J,Guo Q,Yu C,Lu S

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:There is no existing report on the quality of randomized controlled trials (RCTs) of melasma treatment currently conducted in China. This study aims to assess the quality of RCT- reporting in the treatment of melasma conducted in China. METHODS:Several databases were searched from their inception through to...

journal_title：Trials

authors： Chen Z,Chen Y,Zeng J,Wang Y,Ye T,Zhou Q,Du X,Su W,Ding Z

更新日期：2015-04-12 00:00:00

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have side effects and poor adherence. Qigong has been studied as an alternative therapy for hypertension; however, the types of qigong used in those stu...

journal_title：Trials

authors： Park JE,Liu Y,Park T,Hong S,Kim JE,Kim TH,Kim AR,Jung SY,Park H,Choi SM

更新日期：2011-11-21 00:00:00

abstract：BACKGROUND:Eyes sustaining open globe trauma are at high risk of severe visual impairment. Ocular injuries which result in visual loss invariably affect the posterior segment of the eye, and prevention of visual loss involves posterior segment (vitreoretinal) surgery. Despite improvements in vitreoretinal surgical tech...

journal_title：Trials

authors： Banerjee PJ,Cornelius VR,Phillips R,Lo JW,Bunce C,Kelly J,Murphy C,Edwards RT,Robertson EL,Charteris DG

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:National obesity rates have dramatically risen over the last decade. Being obese significantly reduces life expectancy, increases the risk of a range of diseases, and compromises quality of life. Costs to both the National Health Service and society are high. An increased prevalence of obesity in people with...

journal_title：Trials

authors： Beeken RJ,Spanos D,Fovargue S,Hunter R,Omar R,Hassiotis A,King M,Wardle J,Croker H

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Among patients with hepatocellular carcinoma (HCC), 85% of patients have an advanced disease stage at diagnosis and curative therapies cannot be performed. Prognosis has been quite poor as until recently there was no proven effective chemotherapy. Our group found that all-trans-retinoic acid (ATRA) could imp...

journal_title：Trials

authors： Shi J,Sun J,Liu C,Chai Z,Wang N,Zhang H,Cheng S

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:Delirium is a highly prevalent and morbid syndrome in intensive care units (ICUs). Changing the stressful environment within the ICU via music may be an effective and a scalable way to reduce the burden of delirium. METHODS/DESIGN:The Decreasing Delirium through Music (DDM) study is a three-arm, single-blin...

journal_title：Trials

authors： Khan SH,Wang S,Harrawood A,Martinez S,Heiderscheit A,Chlan L,Perkins AJ,Tu W,Boustani M,Khan B

更新日期：2017-11-29 00:00:00

abstract：BACKGROUND:Effective recruitment is an essential element of successful research but notoriously difficult to achieve. This article examines health care professionals' views on the factors influencing decision-making regarding referral to a stroke rehabilitation trial. METHODS:Semi-structured interviews and a card-sort...

journal_title：Trials

authors： Thomas N,Plant S,Woodward-Nutt K,Prior Y,Tyson S

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:Hysterosalpingography (HSG) is an accepted radiologic diagnostic modality for initial infertility workup, and is generally considered uncomfortable and painful. However, the management of pain related to HSG remains inefficient. As an emerging nonpharmacologic and noninvasive pain control strategy, virtual r...

journal_title：Trials

authors： Wang YL,Gao HX,Wang JS,Wang JH,Bo L,Zhang TT,Dai YL,Gao LL,Liu Q,Zhang JJ,Cai JM,Yu JQ,Li YX

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Depression occurs in up to 50% of patients after stroke and limits rehabilitation and recovery. Mood disorders are also highly prevalent in carers; their mental health intertwined with the physical and mental wellbeing of the person they are caring for. We argue that working with families, rather than patien...

journal_title：Trials

authors： Gray RJ,Myint PK,Elender F,Barton G,Pfeil M,Price G,Wyatt N,Ravenhill G,Thomas E,Jagger J,Hursey A,Waterfield K,Hardy S

更新日期：2011-04-30 00:00:00

abstract：BACKGROUND:Osteoarthritis often results in prolonged periods of reduced physical activity and is associated with adverse health outcomes, including increased risk of cardiovascular and metabolic diseases. Exercise interventions for patients on the waiting list for arthroplasty can reduce the risk of long-term adverse o...

journal_title：Trials

authors： O'Brien J,Hamilton K,Williams A,Fell J,Mulford J,Cheney M,Wu S,Bird ML

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue currently approved for type 2 diabetes and obesity. Preclinical evidence in transgenic models of Alzheimer's disease suggests that liraglutide exerts neuroprotective effects by reducing amyloid oligomers, normalising synaptic plasticity and cerebral g...

journal_title：Trials

authors： Femminella GD,Frangou E,Love SB,Busza G,Holmes C,Ritchie C,Lawrence R,McFarlane B,Tadros G,Ridha BH,Bannister C,Walker Z,Archer H,Coulthard E,Underwood BR,Prasanna A,Koranteng P,Karim S,Junaid K,McGuinness B,Nilfo

更新日期：2019-04-03 00:00:00

abstract：BACKGROUND:This study will evaluate hypoxia, as a novel concept in the pathogenesis of diabetic macular oedema (DMO). As the oxygen demand of the eye is maximum during dark-adaptation, we hypothesize that wearing light-masks during sleep will cause regression and prevent the development and progression of DMO. The stud...

journal_title：Trials

authors： Sivaprasad S,Arden G,Prevost AT,Crosby-Nwaobi R,Holmes H,Kelly J,Murphy C,Rubin G,Vasconcelos J,Hykin P

更新日期：2014-11-22 00:00:00

abstract：BACKGROUND:There are a large number of clinical outcome measures used to assess the effectiveness of prevention and management strategies of periodontal diseases. This heterogeneity causes difficulties when trying to synthesise data for systematic reviews or clinical guidelines, reducing their impact. Core outcome sets...

journal_title：Trials

authors： Lamont TJ,Clarkson JE,Ricketts DNJ,Heasman PA,Ramsay CR

更新日期：2017-09-20 00:00:00

abstract：:Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise the use of data and permit the exploration of additional hypotheses. On the other hand, the quality of secondary analyses cannot always be ascertained, and it may be unfair to investigators who ...

journal_title：Trials

authors： Mbuagbaw L,Foster G,Cheng J,Thabane L

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Depression is one of the most common reasons for consulting in primary care. Acupuncture is a popular complementary therapy choice for depression but its evidence base is poor with more robust high quality trials being required. More than half of depressed patients experience painful symptoms, with severe pa...

journal_title：Trials

authors： Schroer S,Macpherson H

更新日期：2009-01-09 00:00:00

abstract：BACKGROUND:Chest tube insertion is a standard intervention for management of various injuries of the thorax. Quick and accurate execution facilitates efficient therapy without further complications. Here, we propose a new training concept comprised of e-learning elements as well as continuous rating using an objective ...

journal_title：Trials

authors： Friedrich M,Bergdolt C,Haubruck P,Bruckner T,Kowalewski KF,Müller-Stich BP,Tanner MC,Nickel F

更新日期：2017-02-06 00:00:00