Adjunctive intraocular and peri-ocular steroid (triamcinolone acetonide) versus standard treatment in eyes undergoing vitreoretinal surgery for open globe trauma (ASCOT): study protocol for a phase III, multi-centre, double-masked randomised controlled tr

abstract：BACKGROUND:The gap between the level of care recommended by evidence-based clinical practice guidelines and the actual care delivered to patients in practice has been well established. The Canadian Diabetes Association (CDA) created an implementation strategy to improve the implementation of its 2008 guidelines. This s...

journal_title：Trials

authors： Shah BR,Bhattacharyya O,Yu C,Mamdani M,Parsons JA,Straus SE,Zwarenstein M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Glenohumeral osteoarthritis can, in the most severe cases, require surgery with insertion of a shoulder arthroplasty. A design with a stem in the humeral bone canal is currently regarded as the standard treatment option in patients who have an intact rotator cuff function, but complications related to the st...

journal_title：Trials

authors： Nyring MRK,Olsen BS,Yilmaz M,Petersen MM,Flivik G,Rasmussen JV

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND AND AIMS:The standard whole-colon tests used to investigate patients with symptoms of colorectal cancer are barium enema and colonoscopy. Colonoscopy is the reference test but is technically difficult, resource intensive, and associated with adverse events, especially in the elderly. Barium enema is safer bu...

journal_title：Trials

authors： Halligan S,Lilford RJ,Wardle J,Morton D,Rogers P,Wooldrage K,Edwards R,Kanani R,Shah U,Atkin W

更新日期：2007-10-27 00:00:00

abstract：BACKGROUND:The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the ef...

journal_title：Trials

authors： Demant MN,Jensen RG,Jakobsen JC,Gluud C,Homøe P

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:Patients with testicular germ cell cancer (GCC) have a high cure rate; however, cancer-related fatigue is the most common complication among patients with GCC undergoing treatment with chemotherapy. Although exercise is widely recommended, information about the physio-pathological effects of cancer therapy o...

journal_title：Trials

authors： Cuesta-Vargas AI,Carabantes F,Caracuel Z,Conejo I,Alba E

更新日期：2016-01-05 00:00:00

abstract：BACKGROUND:The key aim of the study is to establish an agreed standardised core outcome set (COS) for use when evaluating non-pharmacological health and social care interventions for people living at home with dementia. METHODS/DESIGN:Drawing on the guidance and approaches of the Core Outcome Measures in Effectiveness...

journal_title：Trials

authors： Harding AJE,Morbey H,Ahmed F,Opdebeeck C,Wang YY,Williamson P,Swarbrick C,Leroi I,Challis D,Davies L,Reeves D,Holland F,Hann M,Hellström I,Hydén LC,Burns A,Keady J,Reilly S

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:Spontaneous recovery from articular cartilage injury is difficult, and the ongoing progression of disease can eventually lead to osteoarthritis. Currently, there is no effective non-surgical treatment for articular cartilage injury. Arthroscopic debridement and microfracture surgery are performed for fibroca...

journal_title：Trials

authors： Ma N,Wang H,Xu X,Wan Y,Liu Y,Wang M,Yu W,Dai Y,Peng J,Guo Q,Yu C,Lu S

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:In cardiac surgery with cardiopulmonary bypass (CPB), large amounts of fluids are administered. CPB priming with crystalloid solution causes marked hemodilution and fluid extravasation. Colloid solutions may reduce fluid overload because they have a better volume expansion effect than crystalloids. The Europ...

journal_title：Trials

authors： Vlasov H,Juvonen T,Hiippala S,Suojaranta R,Peltonen M,Schramko A,Arvonen K,Salminen US,Kleine Budde I,Eränen T,Mazanikov M,Meinberg M,Vähäsilta T,Wilkman E,Pettilä V,Pesonen E

更新日期：2020-02-28 00:00:00

abstract：BACKGROUND:The incidence of cancer has been staying at a high level worldwide in recent years. With advances in cancer diagnosis and therapy strategy, the survival rate of patients with cancer has been increasing, but the side effects of these treatments, especially chemotherapy, are obvious even when the chemotherapy ...

journal_title：Trials

authors： You JS,Chen JP,Chan JS,Lee HF,Wong MK,Yeung WF,Lao LX

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:The German welfare system follows the principle "rehabilitation rather than pension," but more than the half of all disability pensioners did not utilize medical rehabilitation before their early retirement. A major barrier is the application procedure. Lack of information about the opportunity to utilize re...

journal_title：Trials

authors： Spanier K,Streibelt M,Ünalan F,Bethge M

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:Intra-operative electrocorticography, based on interictal spikes and spike patterns, is performed to optimize delineation of the epileptogenic tissue during epilepsy surgery. High frequency oscillations (HFOs, 80-500 Hz) have been identified as more precise biomarkers for epileptogenic tissue. The aim of the...

journal_title：Trials

authors： van 't Klooster MA,Leijten FS,Huiskamp G,Ronner HE,Baayen JC,van Rijen PC,Eijkemans MJ,Braun KP,Zijlmans M,HFO study group.

更新日期：2015-09-23 00:00:00

abstract：BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...

journal_title：Trials

authors： Oliveira CLP,Boulé NG,Sharma AM,Elliott S,Siervo M,Ghosh S,Berg A,Prado CM

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:There is evidence to suggest that delivery of diabetes self-management support by diabetes educators in primary care may improve patient care processes and patient clinical outcomes; however, the evaluation of such a model in primary care is nonexistent in Canada. This article describes the design for the ev...

journal_title：Trials

authors： Gucciardi E,Fortugno M,Horodezny S,Lou W,Sidani S,Espin S,Webster F,Shah BR

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:Chronic central serous chorioretinopathy (cCSC) is an eye disease characterized by an accumulation of serous fluid under the retina. It is postulated that this fluid accumulation results from hyperpermeability and swelling of the choroid, the underlying vascular tissue of the eye, causing a dysfunction of th...

journal_title：Trials

authors： Breukink MB,Downes SM,Querques G,van Dijk EHC,den Hollander AI,Blanco-Garavito R,Keunen JEE,Souied EH,MacLaren RE,Hoyng CB,Fauser S,Boon CJF

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD). METHODS:We systematically reviewed n...

journal_title：Trials

authors： Jawad S,Modi N,Prevost AT,Gale C

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:The insertion of central venous access devices, such as totally implantable venous access ports (TIVAPs), is routine in patients who need a safe and permanent venous access. The number of port implantations is increasing due to the development of innovative adjuvant and neo-adjuvant therapies. Currently, two...

journal_title：Trials

authors： Hüttner FJ,Bruckner T,Alldinger I,Hennes R,Ulrich A,Büchler MW,Diener MK,Knebel P

更新日期：2015-03-31 00:00:00

abstract：BACKGROUND:It is expected that in 2020 more than 17,000 cases of colorectal cancer will be diagnosed in The Netherlands. To date, patients are included in a surgeon-led follow-up programme whose main focus is recurrence detection. However, patients often experience multiple physical and psychosocial problems. Currently...

journal_title：Trials

authors： Duineveld LA,Wieldraaijer T,van Asselt KM,Nugteren IC,Donkervoort SC,van de Ven AW,Smits AB,van Geloven AA,Bemelman WA,Beverdam FH,van Tets WF,Govaert MJ,Bosmans JE,Verdonck-de Leeuw IM,van Uden-Kraan CF,van Weert HC,Wind

更新日期：2015-06-26 00:00:00

abstract：BACKGROUND:Angulated fractures of the distal forearm are very frequent lesions in childhood. Currently, there are no standard guidelines on whether these children should be treated conservatively with a cast; with reduction and a cast; or with reduction, pinning and a cast under anesthesia. Minor prospective and retros...

journal_title：Trials

authors： Adrian M,Wachtlin D,Kronfeld K,Sommerfeldt D,Wessel LM

更新日期：2015-09-30 00:00:00

abstract：BACKGROUND:After major abdominal surgery (MAS), 20% of patients endure major complications, which require invasive treatment and are associated with increased morbidity and mortality. A quality control algorithm after major abdominal surgery aimed at early identification of patients at risk of developing major complica...

journal_title：Trials

authors： Straatman J,Cuesta MA,Schreurs WH,Dwars BJ,Cense HA,Rijna H,Sonneveld DJ,den Boer FC,de Lange-de Klerk ES,van der Peet DL

更新日期：2015-08-28 00:00:00

abstract：BACKGROUND:It was reported that prolonging the injection time or diluting administration can reduce the incidence of opioid-induced cough. However, the incidence of sufentanil-induced cough (SIC) via a standardized infusion rate is unclear. A mechanical dropper is an infusion filtering device commonly used for intraven...

journal_title：Trials

authors： Liu M,Li Z,Wang S,Liu Y,Zhong X,He R,Li F

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Intensive rehabilitation of patients with severe traumatic brain injury is generally applied in the subacute stages of the hospital stay. Few studies have assessed the association between early and intensive physical rehabilitation and functional outcomes. The aim of this trial is to assess the feasibility o...

journal_title：Trials

authors： Riberholt CG,Lindschou J,Gluud C,Mehlsen J,Møller K

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Tobacco smoking remains the leading preventable cause of death in the US. A hospital admission provides smokers with a unique opportunity to stop smoking because it requires temporary tobacco abstinence while illness may enhance motivation to quit. Hospital interventions must continue post-discharge to incre...

journal_title：Trials

authors： Rigotti NA,Schnitzer K,Davis EM,Regan S,Chang Y,Kelley JHK,Notier AE,Gilliam K,Douaihy A,Levy DE,Singer DE,Tindle HA

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is often associated with life-long medical, cognitive, emotional, and behavioral changes. Although long-lasting disabilities are expected, research on effective treatment options in the chronic phase of TBI is scarce. METHODS/DESIGN:This study protocol describes a randomized con...

journal_title：Trials

authors： Borgen IMH,Løvstad M,Andelic N,Hauger S,Sigurdardottir S,Søberg HL,Sveen U,Forslund MV,Kleffelgård I,Lindstad MØ,Winter L,Røe C

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:There are more than a quarter of a million individuals aged ≥ 65 years who are resident in care homes in England and Wales. Care home residents have high levels of cognitive impairment, physical disability, multimorbidity and polypharmacy. Research is needed to ensure there are robust, evidence-based interve...

journal_title：Trials

authors： Ellwood A,Airlie J,Cicero R,Cundill B,Ellard DR,Farrin A,Godfrey M,Graham L,Green J,McLellan V,Siddiqi N,Forster A,REACH Programme Team.

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:The Northwestern University Center for Education and Research on Therapeutics (CERT), funded by the Agency for Healthcare Research and Quality, is one of seven such centers in the USA. The thematic focus of the Northwestern CERT is 'Tools for Optimizing Medication Safety.' Ensuring drug safety is essential, ...

journal_title：Trials

authors： Przytula K,Bailey SC,Galanter WL,Lambert BL,Shrestha N,Dickens C,Falck S,Wolf MS

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirel...

journal_title：Trials

authors： Jin,Huang WJ,Meng X,Yang F,Zheng YJ,Bao Q,Zhang MZ,Yang YN,Ni Q,Lian FM,Tong XL

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:In recent years there has been an increasing interest in MRI as a non-invasive diagnostic modality for the work-up of suspicious breast lesions. The additional value of Breast MRI lies mainly in its capacity to detect multicentric and multifocal disease, to detect invasive components in ductal carcinoma in s...

journal_title：Trials

authors： Peters NH,Borel Rinkes IH,Mali WP,van den Bosch MA,Storm RK,Plaisier PW,de Boer E,van Overbeeke AJ,Peeters PH

更新日期：2007-11-28 00:00:00

abstract：BACKGROUND:Real-time functional magnetic resonance imaging (rtfMRI) is used for neurofeedback training (NFT). Preliminary results suggest that it can help patients to control their symptoms. This study uses rtfMRI NFT for relapse prevention in alcohol dependence. METHODS/DESIGN:Participants are alcohol-dependent patie...

journal_title：Trials

authors： Cox WM,Subramanian L,Linden DE,Lührs M,McNamara R,Playle R,Hood K,Watson G,Whittaker JR,Sakhuja R,Ihssen N

更新日期：2016-10-03 00:00:00

abstract：BACKGROUND:Small incision lenticule extraction or SMILE is a novel form of 'flapless' corneal refractive surgery that was adapted from refractive lenticule extraction (ReLEx). SMILE uses only one femtosecond laser to complete the refractive surgery, potentially reducing surgical time, side effects, and cost. If success...

journal_title：Trials

authors： Ang M,Tan D,Mehta JS

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a rapid-onset sensorineural hearing impairment with unclear etiology and unsatisfying treatment effects. Vestibular dysfunction has been considered as a poor indicator in the clinical manifestations and prognosis of ISSNHL, which occurred in approximat...

journal_title：Trials

authors： Hao W,Zhao L,Yu H,Li H

更新日期：2020-07-22 00:00:00