Effect of YH0618 soup on chemotherapy-induced toxicity in patients with cancer who have completed chemotherapy: study protocol for a randomized controlled trial.

abstract：BACKGROUND:Recruiting and retaining participants in randomised controlled trials (RCTs) is challenging. Digital tools, such as social media, data mining, email or text-messaging, could improve recruitment or retention, but an overview of this research area is lacking. We aimed to systematically map the characteristics ...

journal_title：Trials

authors： Frampton GK,Shepherd J,Pickett K,Griffiths G,Wyatt JC

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:The cross-sectional area of the subclavian vein (csSCV) is an important factor determining the success rate of SCV catheterization. The head-down position increases the csSCV. However, the effects of lateral tilting on subclavian venous cross-sectional area have not yet been explored. In this trial, we test ...

journal_title：Trials

authors： Jung DE,Lee HC,Yoon HK,Park HP

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:Patients with chronic kidney disease (CKD) exhibit increased morbidity and mortality which is associated with an increased systemic inflammatory burden. Identifying and managing comorbid diseases that contribute to this load may inform novel care pathways that could have a beneficial impact on the morbidity/...

journal_title：Trials

authors： Sharma P,Cockwell P,Dietrich T,Ferro C,Ives N,Chapple ILC

更新日期：2017-11-13 00:00:00

abstract：BACKGROUND:The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effe...

journal_title：Trials

authors： Swanson SA,Holme Ø,Løberg M,Kalager M,Bretthauer M,Hoff G,Aas E,Hernán MA

更新日期：2015-11-30 00:00:00

abstract：BACKGROUND:The prevalence of depression in young people is increasing. The predominant co-morbidities of juvenile depression include sleep disturbances and persistent problems with the sleep-wake rhythm, which have shown to influence treatment outcomes negatively. Severe mood dysregulation is another condition that inc...

journal_title：Trials

authors： Bogen S,Legenbauer T,Bogen T,Gest S,Jensch T,Schneider S,Holtmann M

更新日期：2013-06-17 00:00:00

abstract：BACKGROUND:Hypnotic drugs tend to be the dominant form of treatment of insomnia, but these come with a number of reported side effects. Acupuncture has been studied as an alternative, resulting in a rising need for methodological research towards verifying its efficacy as insomnia treatment. METHODS/DESIGN:We describe...

journal_title：Trials

authors： Han KH,Kim SY,Chung SY

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:Post-dural puncture headache (PDPH) is one of the most common complications of neuraxial anaesthesia. It limits patients' general activity and increases the length of hospital stays and the use of care. It is particularly disabling during the postpartum period, when mothers have to take care of their child. ...

journal_title：Trials

authors： Depaulis C,Steer N,Garessus L,Chassard D,Aubrun F

更新日期：2020-01-08 00:00:00

abstract：BACKGROUND:Neck pain is a common symptom in most patients suffering from cervical radiculopathy. However, some conservative treatments are limited by their modest effectiveness. On the other hand, surgical intervention for cervical disc disorders is indicated when symptoms are refractory to conservative treatments and ...

journal_title：Trials

authors： Cui XJ,Sun YL,You SF,Mo W,Lu S,Shi Q,Wang YJ

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a common disease, associated with cardiovascular disease. Many patients use (long-acting) bronchodilators, whilst they continue smoking alongside. We hypothesised an interaction between bronchodilators and smoking that enhances smoke exposure, and hence cardiov...

journal_title：Trials

authors： van Dijk WD,Scheepers PT,Cremers R,Lenders JW,Klerx W,van Weel C,Schermer TR,Heijdra Y

更新日期：2011-02-10 00:00:00

abstract：BACKGROUND:In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which...

journal_title：Trials

authors： Gee Kee E,Kimble RM,Cuttle L,Stockton K

更新日期：2013-11-25 00:00:00

abstract：BACKGROUND:Metabolic acidosis is more common with advancing chronic kidney disease, and has been associated with impaired physical function, impaired bone health, accelerated decline in kidney function and increased vascular risk. Although oral sodium bicarbonate is widely used to correct metabolic acidosis, there exis...

journal_title：Trials

authors： Witham MD,Band MM,Littleford RC,Avenell A,Soiza RL,McMurdo ME,Sumukadas D,Ogston SA,Lamb EJ,Hampson G,McNamee P,BiCARB Study Group.

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m2. The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutralizes the acid net produ...

journal_title：Trials

authors： Gaggl M,Cejka D,Plischke M,Heinze G,Fraunschiel M,Schmidt A,Hörl WH,Sunder-Plassmann G

更新日期：2013-07-04 00:00:00

abstract：BACKGROUND:The most important action in the resuscitation of a newborn in the delivery room is to establish effective assisted ventilation. The face mask and endotracheal tube are the devices used to achieve this goal. Laryngeal mask airways that fit over the laryngeal inlet have been shown to be effective for ventilat...

journal_title：Trials

authors： Trevisanuto D,Cavallin F,Mardegan V,Loi NN,Tien NV,Linh TD,Chien TD,Doglioni N,Chiandetti L,Moccia L

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation. However, preliminary randomised clinical trials indicate that it is beneficial to reduce the sedation level. No randomised trial has been conducted comparing sedation with no se...

journal_title：Trials

authors： Toft P,Olsen HT,Jørgensen HK,Strøm T,Nibro HL,Oxlund J,Wian KA,Ytrebø LM,Kroken BA,Chew M

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:The role of antibiotics in surgical procedures where the risk of surgical site infection (SSI) is low remains uncertain. There is, to date, no evidence to justify the routine use of antibiotics in postoperative reduction mammaplasty. The aim of this study is to evaluate the effect of postoperative antibiotic...

journal_title：Trials

authors： Garcia ES,Veiga DF,Veiga-Filho J,Cabral IV,Pinto NL,Novo NF,Sabino Neto M,Ferreira LM

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mortality. The limitations of vancomycin, the current standard therapy for MRSA, make treatment difficult. The only other approved drug for treatment of MRSA bacteraemia, daptomycin, has not been...

journal_title：Trials

authors： Tong SY,Nelson J,Paterson DL,Fowler VG Jr,Howden BP,Cheng AC,Chatfield M,Lipman J,Van Hal S,O'Sullivan M,Robinson JO,Yahav D,Lye D,Davis JS,CAMERA2 study group and the Australasian Society for Infectious Diseases Clinical Res

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Glenohumeral osteoarthritis can, in the most severe cases, require surgery with insertion of a shoulder arthroplasty. A design with a stem in the humeral bone canal is currently regarded as the standard treatment option in patients who have an intact rotator cuff function, but complications related to the st...

journal_title：Trials

authors： Nyring MRK,Olsen BS,Yilmaz M,Petersen MM,Flivik G,Rasmussen JV

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:Severe thrombocytopenia should be corrected by prophylactic platelet transfusion prior to central venous catheter (CVC) insertion, according to national and international guidelines. Even though correction is thought to prevent bleeding complications, evidence supporting the routine administration of prophyl...

journal_title：Trials

authors： van de Weerdt EK,Biemond BJ,Zeerleder SS,van Lienden KP,Binnekade JM,Vlaar APJ,Study collaborative.

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Spin in the reporting of randomized controlled trials, where authors report research in a way that potentially misrepresents results and mislead readers, has been demonstrated in the broader medical literature. We investigated spin in wound care trials with (a) no statistically significant result for the pri...

journal_title：Trials

authors： Lockyer S,Hodgson R,Dumville JC,Cullum N

更新日期：2013-11-06 00:00:00

abstract：BACKGROUND:To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils-Listerine Zero (LZ)-and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo ...

journal_title：Trials

authors： Marchetti E,Tecco S,Caterini E,Casalena F,Quinzi V,Mattei A,Marzo G

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:Individuals with spinal cord injuries (SCI) are prone to pressure ulcers (PUs) because of the loss of sensorimotor function involved as well as increased skin moisture. Treatment of PU after SCI is complicated, involving different specialties and with need for long-lasting follow-up. This study should identi...

journal_title：Trials

authors： Irgens I,Hoff JM,Sørli H,Haugland H,Stanghelle JK,Rekand T

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:Depression is a common affliction for young adults, and is associated with a range of adverse outcomes. Cognitive-reminiscence therapy is a brief, structured intervention that has been shown to be highly effective for reducing depressive symptoms, yet to date has not been evaluated in young adult populations...

journal_title：Trials

authors： Hallford DJ,Mellor D

更新日期：2013-10-21 00:00:00

abstract：BACKGROUND:Conventional whole brain radiotherapy (WBRT) has been established as the treatment standard in patients with cerebral metastases from small-cell lung cancer (SCLC), however, it has only modest efficacy and limited prospective data is available for WBRT as well as local treatments such as stereotactic radiosu...

journal_title：Trials

authors： Bernhardt D,Hommertgen A,Schmitt D,El Shafie R,Paul A,König L,Mair-Walther J,Krisam J,Klose C,Welzel T,Hörner-Rieber J,Kappes J,Thomas M,Heußel CP,Steins M,Kieser M,Debus J,Rieken S

更新日期：2018-07-16 00:00:00

abstract：OBJECTIVES:To assess the impact of adding statin (atorvastatin) and/or aspirin on clinical deterioration in patients infected with SARS-CoV-2 who require hospitalisation. The safety of these drugs in COVID-19 patients will also be evaluated. TRIAL DESIGN:This is a single-centre, prospective, four-arm parallel design, ...

journal_title：Trials

authors： Ghati N,Roy A,Bhatnagar S,Bhati S,Bhushan S,Mahendran M,Thakur A,Tiwari P,Dwivedi T,Mani K,Gupta R,Mohan A,Garg R,Saxena A,Guleria R,Deepti S

更新日期：2020-10-30 00:00:00

abstract：BACKGROUND:It is expected that in 2020 more than 17,000 cases of colorectal cancer will be diagnosed in The Netherlands. To date, patients are included in a surgeon-led follow-up programme whose main focus is recurrence detection. However, patients often experience multiple physical and psychosocial problems. Currently...

journal_title：Trials

authors： Duineveld LA,Wieldraaijer T,van Asselt KM,Nugteren IC,Donkervoort SC,van de Ven AW,Smits AB,van Geloven AA,Bemelman WA,Beverdam FH,van Tets WF,Govaert MJ,Bosmans JE,Verdonck-de Leeuw IM,van Uden-Kraan CF,van Weert HC,Wind

更新日期：2015-06-26 00:00:00

abstract：OBJECTIVES:Assessing the effect of surfactant on clinical outcome in patients with COVID-19 under mechanical ventilation TRIAL DESIGN: Single centre, two arm, parallel group (1:1 allocation ratio), randomised superiority trial with blinded care and outcome assessment. PARTICIPANTS:Inclusion criteria: Adult COVID-19 pa...

journal_title：Trials

authors： Dabbagh A,Rajaei S,Ghahremani M,Fathi M,Massoudi N,Tavana S,Fani K,Nooraee N,Malekpour Alamdari N,Besharat S,Najafi Abrandabadi A,Pirsalehi A,Khabiri Khatiri MA

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:There is an urgent need for clinically effective and cost-effective methods to manage antisocial and criminal behaviour in adolescents. Youth conduct disorder is increasingly prevalent in the UK and is associated with a range of negative outcomes. Quantitative systematic reviews carried out for the National ...

journal_title：Trials

authors： Fonagy P,Butler S,Goodyer I,Cottrell D,Scott S,Pilling S,Eisler I,Fuggle P,Kraam A,Byford S,Wason J,Haley R

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:Incurable cancer does not only affect patients, it also affects the lives of their partners. Many partners take on caregiving responsibilities. The burden of these caregiving tasks are often associated with physical, psychological, and social difficulties and many partners have unmet supportive care needs. O...

journal_title：Trials

authors： Schuit AS,Holtmaat K,Hooghiemstra N,Jansen F,Lissenberg-Witte BI,Coupé VMH,Verdonck-de Leeuw IM

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Youth depression is highly prevalent and is related to impairments in academic, social and behavioural functioning. Evidence-based treatments are available, but many young people do not respond or sufficiently recover with first-line options, and a significant proportion experience relapse. Consequently, the...

journal_title：Trials

authors： Hallford DJ,Carmichael AM,Austin DW,Takano K,Raes F,Fuller-Tyszkiewicz M

更新日期：2020-01-14 00:00:00

abstract：BACKGROUND:Enrollment in interventional therapeutic clinical trials is a small fraction of all patients who might participate given reasonable access. METHODS:A hierarchical approach is utilized in measuring staged participation from trial availability to patient enrollment. Our framework suggests that concern for jus...

journal_title：Trials

authors： Kanarek NF,Kanarek MS,Olatoye D,Carducci MA

更新日期：2012-12-10 00:00:00