Hospital based care at home; study protocol for a mixed epidemiological and randomized controlled trial.

abstract：BACKGROUND:Impairments of memory are commonly reported by people with traumatic brain injuries (TBI). Such deficits are persistent, debilitating, and can severely impact quality of life. Currently, many do not routinely receive follow-up appointments for residual memory problems following discharge. METHODS/DESIGN:Thi...

journal_title：Trials

authors： das Nair R,Lincoln NB,Ftizsimmons D,Brain N,Montgomery A,Bradshaw L,Drummond A,Sackley C,Newby G,Thornton J,Stapleton S,Pink A

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Exercise has a beta cell preserving effect in patients with type 2 diabetes. This benefit of exercise has not been examined in type 1 diabetes. Significant beta cell function is present at the time of diagnosis of type 1 diabetes and therefore studies of beta cell preservation are ideally conducted immediate...

journal_title：Trials

authors： Lascar N,Kennedy A,Jackson N,Daley A,Dowswell G,Thompson D,Stokes K,Greenfield S,Holder R,Andrews R,Narendran P

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:There is a strong evidence base for the benefits of parenting interventions for parents without severe mental illness (SMI). As the impact of maternal SMI can be significant on child development, mothers need support to maximise outcomes for themselves and their children. Some mothers with SMI require admiss...

journal_title：Trials

authors： Wittkowski A,Cartwright K,Emsley R,Bee P,Calam R,Cross C,Abel KM,Reid H

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Children in low and middle-income countries (LMICs) are at risk for problems in their cognitive, social and behavioural development. Factors such as a lack of cognitive stimulation, harsh parenting practices, and severe and persistent aggression in early childhood are central to the genesis of these problems...

journal_title：Trials

authors： Dowdall N,Cooper PJ,Tomlinson M,Skeen S,Gardner F,Murray L

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:Pragmatic randomised controlled trials (RCTs) are considered essential to determine effective interventions for routine clinical practice, but many fail to recruit participants efficiently, and some really important RCTs are not undertaken because recruitment is thought to be too difficult. The 'QuinteT Recr...

journal_title：Trials

authors： Donovan JL,Rooshenas L,Jepson M,Elliott D,Wade J,Avery K,Mills N,Wilson C,Paramasivan S,Blazeby JM

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:Emergency department attendances with chest pain requiring assessment for acute coronary syndrome (ACS) are a major global health issue. Standard assessment includes history, examination, electrocardiogram (ECG) and serial troponin testing. Computerised tomography coronary angiography (CTCA) enables addition...

journal_title：Trials

authors： Gray AJ,Roobottom C,Smith JE,Goodacre S,Oatey K,O'Brien R,Storey RF,Na L,Lewis SC,Thokala P,Newby DE

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:The role of antibiotics in surgical procedures where the risk of surgical site infection (SSI) is low remains uncertain. There is, to date, no evidence to justify the routine use of antibiotics in postoperative reduction mammaplasty. The aim of this study is to evaluate the effect of postoperative antibiotic...

journal_title：Trials

authors： Garcia ES,Veiga DF,Veiga-Filho J,Cabral IV,Pinto NL,Novo NF,Sabino Neto M,Ferreira LM

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on...

journal_title：Trials

authors： Bluth T,Teichmann R,Kiss T,Bobek I,Canet J,Cinnella G,De Baerdemaeker L,Gregoretti C,Hedenstierna G,Hemmes SN,Hiesmayr M,Hollmann MW,Jaber S,Laffey JG,Licker MJ,Markstaller K,Matot I,Müller G,Mills GH,Mulier JP,Pu

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which...

journal_title：Trials

authors： Gee Kee E,Kimble RM,Cuttle L,Stockton K

更新日期：2013-11-25 00:00:00

abstract：BACKGROUND:Equipoise and role conflict have been previously identified as important factors in professionals' engagement with trials, inducing behaviours which can impact on recruitment. We explored these phenomena as potential explanations for the low levels of involvement of teenagers and young adults (TYA) with canc...

journal_title：Trials

authors： Hart RI,Hallowell N,Harden J,Jesudason AB,Lawton J

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is often associated with life-long medical, cognitive, emotional, and behavioral changes. Although long-lasting disabilities are expected, research on effective treatment options in the chronic phase of TBI is scarce. METHODS/DESIGN:This study protocol describes a randomized con...

journal_title：Trials

authors： Borgen IMH,Løvstad M,Andelic N,Hauger S,Sigurdardottir S,Søberg HL,Sveen U,Forslund MV,Kleffelgård I,Lindstad MØ,Winter L,Røe C

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:AirSeal is a novel class of valve-free insufflation system that enables a stable pneumoperitoneum with continuous smoke evacuation and carbon dioxide (CO₂) recirculation during laparoscopic surgery. Comparison data to standard CO₂ pressure pneumoperitoneum insufflators is scarce. The aim of this study is to ...

journal_title：Trials

authors： Luketina RR,Knauer M,Köhler G,Koch OO,Strasser K,Egger M,Emmanuel K

更新日期：2014-06-20 00:00:00

abstract：BACKGROUND:Hypnotic drugs tend to be the dominant form of treatment of insomnia, but these come with a number of reported side effects. Acupuncture has been studied as an alternative, resulting in a rising need for methodological research towards verifying its efficacy as insomnia treatment. METHODS/DESIGN:We describe...

journal_title：Trials

authors： Han KH,Kim SY,Chung SY

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:Indigenous Australian youth (aged 15 to 34) have up to four times the risk of suicide compared with their non-Indigenous counterparts. Barriers to help-seeking include shame, feared loss of autonomy and negative attitudes towards healthcare providers. The use of mobile devices and apps continues to rise amon...

journal_title：Trials

authors： Shand FL,Ridani R,Tighe J,Christensen H

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Despite a burgeoning interest in using interprofessional approaches to promote effective collaboration in health care, systematic reviews find scant evidence of benefit. This protocol describes the first cluster randomized controlled trial (RCT) to design and evaluate an intervention intended to improve inte...

journal_title：Trials

authors： Zwarenstein M,Reeves S,Russell A,Kenaszchuk C,Conn LG,Miller KL,Lingard L,Thorpe KE

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Approximately 40% of the newly diagnosed patients with advanced ovarian cancer are aged 70 years or older. Standard treatment for advanced disease consists of cytoreductive surgery and combination chemotherapy. In older patients, standard treatment is often withheld or prematurely stopped due to suspected fr...

journal_title：Trials

authors： van Soolingen NJ,Smorenburg CH,Hamaker ME,Groen WG,Retèl VP,Lok CAR,van de Poll-Franse LV,Trum JW

更新日期：2020-02-22 00:00:00

abstract：BACKGROUND:Post-stroke cognitive impairment (PSCI) is a series of syndromes that meet the diagnostic criteria for cognitive impairment that appear after a stroke. The treatment of PSCI with oral drugs alone is not ideal and has obvious side effects. Therefore, complementary and alternative treatments are needed for pat...

journal_title：Trials

authors： Liu R,Yu X,Wang J,Liu Y,Liu B,Li X,Wang Y,Cao T,Yuan H

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:Obesity is an increasingly prevalent chronic condition that is associated with serious morbidity and mortality. Excess body weight is a risk factor contributing to diseases such as hypertension, heart disease, hypercholesterolaemia, diabetes mellitus, cerebrovascular disease, gall bladder disease, and some t...

journal_title：Trials

authors： Zhong LL,Kun W,Lam TF,Zhang SP,Yang JJ,Ziea TC,Ng B,Bian ZX

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Bone microarchitecture is a significant determinant of bone strength. So far, the assessment of bone microarchitecture has required bone biopsies, limiting its utilization in clinical practice to one single skeletal site. With the advance of high-resolution imaging techniques, non-invasive in vivo measuremen...

journal_title：Trials

authors： Richert L,Uebelhart B,Engelhardt M,Azria M,Rizzoli R

更新日期：2008-04-13 00:00:00

abstract：BACKGROUND:Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of professionals to understand what interim information should be shared at interim, with whom and why. MET...

journal_title：Trials

authors： Borg Debono V,Mbuagbaw L,Paul J,Buckley N,Thabane L

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:Diabetic foot ulcers (DFUs) represent a significant source of morbidity and an enormous financial burden. Standard care for DFUs involves systemic glucose control, ensuring adequate perfusion, debridement of nonviable tissue, off-loading, control of infection, local wound care and patient education, all admi...

journal_title：Trials

authors： Lev-Tov H,Li CS,Dahle S,Isseroff RR

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:A growing body of evidence shows the short-term benefits of breastfeeding, which include protection against infections, allergies, and lung diseases. However, evidence on the long-term benefits of breastfeeding is scarce and often conflicting. The BReastfeeding Attitude and Volume Optimization (BRAVO) trial ...

journal_title：Trials

authors： Savitri AI,Idris NS,Indawati W,Saldi SR,Amelia D,Baharuddin M,Sastroasmoro S,Grobbee DE,Uiterwaal CS

更新日期：2016-06-02 00:00:00

abstract：BACKGROUND:Heart valve diseases are common with an estimated prevalence of 2.5% in the Western world. The number is rising due to an ageing population. Once symptomatic, heart valve diseases are potentially lethal, and heavily influence daily living and quality of life. Surgical treatment, either valve replacement or r...

journal_title：Trials

authors： Sibilitz KL,Berg SK,Hansen TB,Risom SS,Rasmussen TB,Hassager C,Køber L,Steinbrüchel D,Gluud C,Winkel P,Thygesen LC,Hansen JL,Schmid JP,Conraads V,Brocki BC,Zwisler AD

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:Compulsory submission of a checklist from the relevant reporting guideline is one of the most widespread journal requirements aiming to improve completeness of reporting. However, the current suboptimal levels of adherence to reporting guidelines observed in the literature may indicate that this journal poli...

journal_title：Trials

authors： Blanco D,Biggane AM,Cobo E,MiRoR network.

更新日期：2018-01-29 00:00:00

abstract：BACKGROUND:Non-cystic fibrosis bronchiectasis is characterized by the irreversible dilatation of the medium-sized bronchi as a result of airway injury from recurrent or chronic inflammation and lower respiratory tract infections. Bronchiectasis airways are commonly colonized with bacterial species. Infections of the ai...

journal_title：Trials

authors： Gao J,Gao X,Kong L

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Parkinson's Disease is a degenerative neurological condition that causes movement problems and other distressing symptoms. People with Parkinson's disease gradually lose their independence and strain is placed on family members. A multidisciplinary approach to rehabilitation for people with Parkinson's is re...

journal_title：Trials

authors： Gage H,Ting S,Williams P,Bryan K,Kaye J,Castleton B,Trend P,Wade D

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Adaptive servo-ventilation (ASV) therapy, which is a form of noninvasive positive pressure ventilation therapy and uses an innovative ventilator that has simple operability and provides good patient adherence, potentially has therapeutic benefits-suppression of the deterioration and progression of chronic he...

journal_title：Trials

authors： Seino Y,Momomura S,Kihara Y,Adachi H,Yasumura Y,Yokoyama H,SAVIOR-C investigators.

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:Although conventional laparoscopic and hand-assisted laparoscopic surgery for colorectal cancer is widely used today, there remain many technical challenges especially for right colon cancer in obese patients. Herein, we develop a novel hand-assisted laparoscopic surgery (HALS) with complete mesocolic excisi...

journal_title：Trials

authors： Yang X,Wu Q,Jin C,He W,Wang M,Yang T,Wei M,Deng X,Meng W,Wang Z

更新日期：2017-07-26 00:00:00

abstract：BACKGROUND:In 2007, the Chinese Science Division of the State Administration of Traditional Chinese Medicine(TCM) convened a special conference to discuss quality control for TCM clinical research. Control and assurance standards were established to guarantee the quality of clinical research. This paper provides practi...

journal_title：Trials

authors： Zhao L,Liang FR,Li Y,Zhang FW,Zheng H,Wu X

更新日期：2009-12-27 00:00:00

abstract：BACKGROUND:Untreated advanced hepatocellular carcinoma (HCC) is linked to poor prognosis. While sorafenib is the current recommended treatment for advanced HCC, radioembolisation (RE; also called selective internal radiation therapy or SIRT) with yttrium-90 microspheres has shown efficacy in cohort studies. However, th...

journal_title：Trials

authors： Vilgrain V,Abdel-Rehim M,Sibert A,Ronot M,Lebtahi R,Castéra L,Chatellier G,SARAH Trial Group.

更新日期：2014-12-03 00:00:00