Exercise to preserve beta cell function in recent-onset type 1 diabetes mellitus (EXTOD)--a study protocol for a pilot randomized controlled trial.

abstract：BACKGROUND:Previous studies have shown that acupuncture and electroacupuncture (EA) are effective in the treatment of patients with low back pain. However, there is little evidence to support the use of one intervention over the other. The aim of this study is to compare the effect of acupuncture and electroacupuncture...

journal_title：Trials

authors： Comachio J,Oliveira Magalhães M,Nogueira Burke T,Vidal Ramos LA,Peixoto Leão Almeida G,Silva AP,Ferreira de Meneses SR,Costa-Frutuoso JR,Santos Miotto Amorim C,Pasqual Marques A

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:In recent years there has been an increasing interest in MRI as a non-invasive diagnostic modality for the work-up of suspicious breast lesions. The additional value of Breast MRI lies mainly in its capacity to detect multicentric and multifocal disease, to detect invasive components in ductal carcinoma in s...

journal_title：Trials

authors： Peters NH,Borel Rinkes IH,Mali WP,van den Bosch MA,Storm RK,Plaisier PW,de Boer E,van Overbeeke AJ,Peeters PH

更新日期：2007-11-28 00:00:00

abstract：BACKGROUND:The preliminary results of a randomised controlled trial are presented. The aim of the trial is to determine the efficacy, feasibility and acceptability of email-delivered psychological interventions with telephone support, for adults injured in a motor vehicle crash engaged in seeking compensation. The prim...

journal_title：Trials

authors： Guest R,Tran Y,Gopinath B,Cameron ID,Craig A

更新日期：2018-06-27 00:00:00

abstract：BACKGROUND:Current management for men with lower urinary tract symptoms (LUTS) is a pathway that results in prostate surgery in a significant proportion. While helpful in relieving benign prostatic obstruction (BPO), surgery may be ineffective for men suffering from difficulties not relating to BPO. The UPSTREAM trial ...

journal_title：Trials

authors： Young GJ,Lewis AL,Lane JA,Winton HL,Drake MJ,Blair PS

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease lowers the quality of life and increases medical costs. Electroacupuncture has been used to ease symptoms and improve gastrointestinal motility in patients with gastroesophageal reflux disease. The main purposes of this study are to evaluate the efficacy and safety of this pro...

journal_title：Trials

authors： Han G,Leem J,Lee H,Lee J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:There is a high prevalence of pain and post-traumatic symptoms among refugees and feasible interventions to manage these are needed. However, knowledge about the effect of physiotherapy and psychological group interventions among refugees is scarce. Our aim is to determine whether two different interventions...

journal_title：Trials

authors： Hasha W,Fadnes LT,Igland J,Vårdal R,Giusti LM,Strømme EM,Haj-Younes J,Heltne U,Kumar BN,Diaz E

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Studies exploring parents' trial experiences generally relate to their understanding of the consent process and the development of researcher strategies to facilitate recruitment and retention. The aim was to better understand parents' experience of being part of a trial at the time and their perceptions of ...

journal_title：Trials

authors： Harvey M,Nongena P,Edwards D,Redshaw M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Endovenous thermal techniques, such as endovenous laser ablation (EVLA), are the recommended treatment for truncal varicose veins. However, a disadvantage of thermal techniques is that it requires the administration of tumescent anaesthesia, which can be uncomfortable. Non-thermal, non-tumescent techniques, ...

journal_title：Trials

authors： Leung CC,Carradice D,Wallace T,Chetter IC

更新日期：2016-08-24 00:00:00

abstract：BACKGROUND:This study will evaluate hypoxia, as a novel concept in the pathogenesis of diabetic macular oedema (DMO). As the oxygen demand of the eye is maximum during dark-adaptation, we hypothesize that wearing light-masks during sleep will cause regression and prevent the development and progression of DMO. The stud...

journal_title：Trials

authors： Sivaprasad S,Arden G,Prevost AT,Crosby-Nwaobi R,Holmes H,Kelly J,Murphy C,Rubin G,Vasconcelos J,Hykin P

更新日期：2014-11-22 00:00:00

abstract：BACKGROUND:Spinal manipulative therapy is commonly used in the treatment of adolescent idiopathic scoliosis. Some therapists also rely on physiotherapeutic scoliosis-specific exercise (PSSE). Combining these two modalities seems reasonable, but the effectiveness of this combination has never been rigorously tested. Her...

journal_title：Trials

authors： Wang L,Wang C,Youssef ASA,Xu J,Huang X,Xia N

更新日期：2021-01-14 00:00:00

abstract：OBJECTIVES:Colchicine is a well-known drug, which has been used for years to treat a wide range of rheumatic and inflammatory disorders. It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress p...

journal_title：Trials

authors： Dalili N,Kashefizadeh A,Nafar M,Poorrezagholi F,Firouzan A,Samadian F,Samavat S,Ziaie S,Fatemizadeh S

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:Premature ejaculation (PE) is the most common sexual dysfunction among men. According to patients, the general practitioner (GP) is the appropriate professional with whom to discuss this issue. However, few patients receive the medical help needed because GPs find it difficult to talk to their patients about...

journal_title：Trials

authors： Barais M,Vaillant Roussel H,Costa D,Derriennic J,Pereira B,Cadier S

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Compulsory submission of a checklist from the relevant reporting guideline is one of the most widespread journal requirements aiming to improve completeness of reporting. However, the current suboptimal levels of adherence to reporting guidelines observed in the literature may indicate that this journal poli...

journal_title：Trials

authors： Blanco D,Biggane AM,Cobo E,MiRoR network.

更新日期：2018-01-29 00:00:00

abstract：BACKGROUND:Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' understandings are inevitably influenced by the recruiting clinician's understanding of the trial, yet rel...

journal_title：Trials

authors： Ziebland S,Featherstone K,Snowdon C,Barker K,Frost H,Fairbank J

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Chronic central serous chorioretinopathy (cCSC) is an eye disease characterized by an accumulation of serous fluid under the retina. It is postulated that this fluid accumulation results from hyperpermeability and swelling of the choroid, the underlying vascular tissue of the eye, causing a dysfunction of th...

journal_title：Trials

authors： Breukink MB,Downes SM,Querques G,van Dijk EHC,den Hollander AI,Blanco-Garavito R,Keunen JEE,Souied EH,MacLaren RE,Hoyng CB,Fauser S,Boon CJF

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:Three decades of research suggests that prevention of iron deficiency anemia (IDA) in the primary care setting may be an unrealized and unique opportunity to prevent poor developmental outcomes in children. A longitudinal study of infants with IDA showed that the developmental disadvantage persists long term...

journal_title：Trials

authors： Abdullah K,Thorpe KE,Mamak E,Maguire JL,Birken CS,Fehlings D,Hanley AJ,Macarthur C,Zlotkin SH,Parkin PC

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Perineal pain due to episiotomy is commonly reported and can be severe enough to disturb the mother-infant dyad during the postpartum period. Its incidence at day 7 postpartum varies from 63% to 74%. Recent studies have investigated the analgesic efficacy of perineal infiltration of ropivacaine after episiot...

journal_title：Trials

authors： Cardaillac C,Ploteau S,Le Thuaut A,Dochez V,Winer N,Ducarme G

更新日期：2020-06-12 00:00:00

abstract：BACKGROUND:Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and instrumental variables (I...

journal_title：Trials

authors： Merrill PD,McClure LA

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Bone graft substitutes are widely used for reconstruction of posttraumatic bone defects. However, their clinical significance in comparison to autologous bone grafting, the gold-standard in reconstruction of larger bone defects, still remains under debate. This prospective, randomized, controlled clinical st...

journal_title：Trials

authors： Nusselt T,Hofmann A,Wachtlin D,Gorbulev S,Rommens PM

更新日期：2014-03-08 00:00:00

abstract：:There are many acknowledged benefits for the reuse of clinical trial data; from independent verification of published results to the evaluation of new hypotheses. However, the reuse of shared clinical trial data is not without obstacles. Here we present some of the issues and lessons learned from our own experiences i...

journal_title：Trials

authors： Wilkinson T,Sinha S,Peek N,Geifman N

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Increasing numbers of patients are surviving critical illness, but survival may be associated with a constellation of physical and psychological sequelae that can cause ongoing disability and reduced health-related quality of life. Limited evidence currently exists to guide the optimum structure, timing, and...

journal_title：Trials

authors： Ramsay P,Salisbury LG,Merriweather JL,Huby G,Rattray JE,Hull AM,Brett SJ,Mackenzie SJ,Murray GD,Forbes JF,Walsh TS,RECOVER trial collaboration.

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:The purpose of clinical trials of acupuncture is to help clinicians and patients make decisions about treatment. Yet this is not straightforward: some trials report acupuncture to be superior to sham (placebo) acupuncture while others show evidence that acupuncture is superior to usual care but not sham, and...

journal_title：Trials

authors： Vickers AJ,Cronin AM,Maschino AC,Lewith G,Macpherson H,Victor N,Sherman KJ,Witt C,Linde K,Acupuncture Trialists' Collaboration.

更新日期：2010-09-28 00:00:00

abstract：:Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for individual patients, we propose a new RCT adaptation termed the nested-pr...

journal_title：Trials

authors： Kappelmann N,Müller-Myhsok B,Kopf-Beck J

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a health condition sensitive to patient's preferences and values regarding the benefits and risks of the different treatment options. In this sense, patient decision aids (PtDA) can play an important role in helping patients to incorporate their values, needs, and preferences into the ...

journal_title：Trials

authors： Perestelo-Pérez L,Álvarez-Pérez Y,Rivero-Santana A,Ramos-García V,Duarte-Díaz A,Torres-Castaño A,Toledo-Chávarri A,Herrera-Perez M,País-Brito JL,Del Castillo JC,Vázquez JR,Orrego C,Serrano-Aguilar P

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Many funding bodies require researchers to actively involve service users in research to improve relevance, accountability and quality. Current guidance to researchers mainly discusses general principles. Formal guidance about how to involve service users operationally in the conduct of trials is lacking. We...

journal_title：Trials

authors： Evans BA,Bedson E,Bell P,Hutchings H,Lowes L,Rea D,Seagrove A,Siebert S,Smith G,Snooks H,Thomas M,Thorne K,Russell I,West Wales Organisation for Rigorous Trials in Health (WWORTH).

更新日期：2013-07-17 00:00:00

abstract：BACKGROUND:In 2007, the Chinese Science Division of the State Administration of Traditional Chinese Medicine(TCM) convened a special conference to discuss quality control for TCM clinical research. Control and assurance standards were established to guarantee the quality of clinical research. This paper provides practi...

journal_title：Trials

authors： Zhao L,Liang FR,Li Y,Zhang FW,Zheng H,Wu X

更新日期：2009-12-27 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and debilitating condition characterised by high co-morbidity. Alongside pharmacological treatment, cognitive behavioural therapy (CBT) is an established psychological therapy for GAD. Its effectiveness is limited, however, with only an estimated 50% of clients...

journal_title：Trials

authors： Timulak L,Keogh D,Chigwedere C,Wilson C,Ward F,Hevey D,Griffin P,Jacobs L,Irwin B

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Sexual dysfunction can have a negative impact on women's quality of life and relationships. There is limited information about female sexual function and treatment, particularly during pregnancy and the postpartum period. The effect of pelvic floor muscle exercise (PFME) on sexual function (SF) has not been ...

journal_title：Trials

authors： Sobhgol SS,Priddis H,Smith CA,Dahlen HG

更新日期：2019-02-20 00:00:00

abstract：BACKGROUND:Assistive technology and telecare (ATT) are relatively new ways of delivering care and support to people with social care needs. It is claimed that ATT reduces the need for community care, prevents unnecessary hospital admission, and delays or prevents admission into residential or nursing care. The current ...

journal_title：Trials

authors： Leroi I,Woolham J,Gathercole R,Howard R,Dunk B,Fox C,O'Brien J,Bateman A,Poland F,Bentham P,Burns A,Davies A,Forsyth K,Gray R,Knapp M,Newman S,McShane R,Ritchie C

更新日期：2013-10-23 00:00:00

abstract：BACKGROUND:To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils-Listerine Zero (LZ)-and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo ...

journal_title：Trials

authors： Marchetti E,Tecco S,Caterini E,Casalena F,Quinzi V,Mattei A,Marzo G

更新日期：2017-03-31 00:00:00