'We knew it was a totally at random thing': parents' experiences of being part of a neonatal trial.

abstract：BACKGROUND:Depression and bipolar disorder are associated with reduced neural plasticity and deficits in memory, attention and executive function. Drug treatments for these affective disorders have insufficient clinical effects in a large group and fail to reverse cognitive deficits. There is thus a need for more effec...

journal_title：Trials

authors： Miskowiak KW,Vinberg M,Harmer CJ,Ehrenreich H,Knudsen GM,Macoveanu J,Hansen AR,Paulson OB,Siebner HR,Kessing LV

更新日期：2010-10-13 00:00:00

abstract：UNLABELLED:Screening physical activity levels is common in trials to increase physical activity in inactive populations. Commonly applied single-item screening tools might not always be effective in identifying those who are inactive. We applied the more extensive Active Australia Survey to identify inactive people amo...

journal_title：Trials

authors： Vandelanotte C,Stanton R,Rebar AL,Van Itallie AK,Caperchione CM,Duncan MJ,Savage TN,Rosenkranz RR,Kolt GS

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:In recent years there has been an increasing interest in MRI as a non-invasive diagnostic modality for the work-up of suspicious breast lesions. The additional value of Breast MRI lies mainly in its capacity to detect multicentric and multifocal disease, to detect invasive components in ductal carcinoma in s...

journal_title：Trials

authors： Peters NH,Borel Rinkes IH,Mali WP,van den Bosch MA,Storm RK,Plaisier PW,de Boer E,van Overbeeke AJ,Peeters PH

更新日期：2007-11-28 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with increasing prevalence. It can manifest with many different clinical phenotypes; however, in its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi...

journal_title：Trials

authors： Yun Y,Ko Y,Ahn JH,Jang BH,Kim K,Ko SG,Choi I

更新日期：2017-04-12 00:00:00

abstract：OBJECTIVES:To investigate the potential efficacy of Acacia Senegal extract Gum Arabic (GA) supplementation as immunomodulatory and anti-inflammatory dietary intervention among newly diagnosed COVID 19 Sudanese patients. To study the effect of GA on the level of cytokines, TNFα, IL8, IL6 IL10, CRP and the viral load. Se...

journal_title：Trials

authors： Kaddam L,Babiker R,Ali S,Satti S,Ali N,Elamin M,Mukhtar M,Elnimeiri M,Saeed A

更新日期：2020-09-05 00:00:00

abstract：BACKGROUND:Multi-centre randomised controlled trials (RCTs) in surgery are challenging. It is particularly difficult to establish standards of surgery and ensure that interventions are delivered as intended. This study developed and tested methods for identifying the key components of surgical interventions and standar...

journal_title：Trials

authors： Blencowe NS,Blazeby JM,Donovan JL,Mills N

更新日期：2015-12-28 00:00:00

abstract：BACKGROUND:Despite efforts to improve the accuracy and transparency of the design, conduct, and reporting of randomised controlled trials (RCTs), deficiencies remain. Such deficiencies contribute to significant, avoidable waste of health research investment and impede reproducibility. This study aimed to synthesise and...

journal_title：Trials

authors： Clyne B,Boland F,Murphy N,Murphy E,Moriarty F,Barry A,Wallace E,Devine T,Smith SM,Devane D,Murphy A,Fahey T

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Tracheal intubation with the patient in the lateral position is difficult because the laryngeal view is compromised during direct laryngoscopy. Flexible video endoscopes may facilitate intubation even when laryngeal views are poor on direct laryngoscopy because the patients are positioned laterally. Thus, th...

journal_title：Trials

authors： Gao Y,Lin B,Huang J,Lin X,Lin C

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Recurrent stroke is a major contributor to stroke-related disability and costs. Improving health-risk behaviours and mental health has the potential to significantly improve recovery, enhance health-related quality of life (HRQoL), independent living, and lower the risk of recurrent stroke. The primary aim w...

journal_title：Trials

authors： Guillaumier A,McCrabb S,Spratt NJ,Pollack M,Baker AL,Magin P,Turner A,Oldmeadow C,Collins C,Callister R,Levi C,Searles A,Deeming S,Wynne O,Denham AMJ,Clancy B,Bonevski B

更新日期：2019-08-09 00:00:00

abstract：BACKGROUND:The management of patients with angiographically intermediate coronary lesions is a major clinical issue. Fractional flow reserve provides validated functional insights while optical coherence tomography provides high resolution anatomic imaging. Both techniques may be applied to guide management in case of ...

journal_title：Trials

authors： Burzotta F,Leone AM,De Maria GL,Niccoli G,Coluccia V,Pirozzolo G,Saffioti S,Aurigemma C,Trani C,Crea F

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:Renal transplantation represents the treatment of choice of end-stage kidney disease. Delayed graft function (DGF) remains the most frequent complication after this procedure, reaching more than 30%. Its prevention is essential as it impedes early- and long-term prognosis of transplantation. Numerous pharmac...

journal_title：Trials

authors： Orban JC,Fontaine E,Cassuto E,Baumstarck K,Leone M,Constantin JM,Ichai C,AzuRéa network.

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people died from coronary heart disease than from any other cause. CVD is regularly treated with minimally or non-minimally invasive off- or on-pump cardiothor...

journal_title：Trials

authors： Moza A,Benstoem C,Autschbach R,Stoppe C,Goetzenich A

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:Multiple pregnancies are one of the major safety concerns of in vitro fertilization (IVF) due to the increased risk of maternal and neonatal complications. Single embryo transfer is the most effective way to reduce the risk of multiple pregnancies. Selection of the embryo and optimization of the implantation...

journal_title：Trials

authors： Wei D,Sun Y,Liu J,Liang X,Zhu Y,Shi Y,Chen ZJ

更新日期：2017-06-05 00:00:00

abstract：BACKGROUND:Intellectual disability (ID) is characterized by limitations in intellectual functioning and adaptive behavior. Adults with ID exhibit higher rates of obesity and poorer health status compared to the general population. Continuity of care and barriers to health-related activities may contribute to the poorer...

journal_title：Trials

authors： Neumeier WH,Guerra N,Thirumalai M,Geer B,Ervin D,Rimmer JH

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals' foot health and quality of life. Based on the current trends of self-monitoring and self-care, provid...

journal_title：Trials

authors： Silva EQ,Suda EY,Santos DP,Veríssimo JL,Ferreira JSSP,Cruvinel Júnior RH,Monteiro RL,Sartor CD,Sacco ICN

更新日期：2020-02-13 00:00:00

abstract：BACKGROUND:Burst stimulation is a novel form of neurostimulation for the treatment of chronic pain which has demonstrated promise in small uncontrolled studies, but has not yet gained approval for use in the U.S. We report the study methods for an ongoing multicenter, randomized, controlled, cross-over study designed t...

journal_title：Trials

authors： Slavin KV,North RB,Deer TR,Staats P,Davis K,Diaz R

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Depression is a debilitating and costly disease for our society, especially in the case of treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy in treatment-resistant unipolar and non-psychotic depression. It can be applied according to tw...

journal_title：Trials

authors： Bulteau S,Laurin A,Volteau C,Dert C,Lagalice L,Schirr-Bonnans S,Bukowski N,Guitteny M,Simons L,Cabelguen C,Pichot A,Tessier F,Bonnin A,Lepage A,ACOUSTIM Investigators Group.,HUGOPSY Network.,Vanelle JM,Sauvaget A,Rich

更新日期：2020-04-05 00:00:00

abstract：BACKGROUND:Depression Care for People with Lung Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depression, which patients receive from their general practitioner and cancer service. The third Sympt...

journal_title：Trials

authors： Walker J,Cassidy J,Sharpe M,SMaRT Oncology-3 Trialists.

更新日期：2009-09-30 00:00:00

abstract：BACKGROUND:A wide range of prophylactic antibiotic regimens are used for patients undergoing open-heart cardiac surgery. This reflects clinical equipoise in choice and duration of antibiotic agents. Although individual-level randomized control trials (RCT) are considered the gold standard when evaluating the efficacy o...

journal_title：Trials

authors： van Oostveen RB,Romero-Palacios A,Whitlock R,Lee SF,Connolly S,Carignan A,Mazer CD,Loeb M,Mertz D

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Trials of complex interventions are associated with high costs and burdens in terms of paperwork, management, data collection, validation, and intervention fidelity assessment occurring across multiple sites. Traditional data collection methods rely on paper-based forms, where processing can be time-consumin...

journal_title：Trials

authors： Drew CJ,Poile V,Trubey R,Watson G,Kelson M,Townson J,Rosser A,Hood K,Quinn L,Busse M

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:Anxiety in children is common and incapacitating and increases the risk of mental health disorders in adulthood. Although effective interventions are available, few children are identified and referred for specialist treatment. Alternative approaches in which prevention programmes are delivered in school app...

journal_title：Trials

authors： Stallard P,Taylor G,Anderson R,Daniels H,Simpson N,Phillips R,Skryabina E

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:Less invasive surfactant administration (LISA) is a way of giving surfactant without endotracheal intubation and has shown to be promising in reducing the incidence of bronchopulmonary dysplasia (BPD) in preterm infants. However, the mechanism underlying its beneficial effect and variations in the technique ...

journal_title：Trials

authors： Zhu J,Bao Y,Du L,Huang H,Lv Q,Jiang Y,Dai Y,Chen Z,Shi J,Shi Y,Yang C,Mei H,Jiang H,Sun Y,Sun X

更新日期：2020-06-11 00:00:00

abstract：BACKGROUND:Low mood is a common mental health problem with significant health consequences. Studies have shown that cognitive behavioural therapy (CBT) is an effective treatment for low mood and anxiety when delivered one-to-one by an expert practitioner. However, access to this talking therapy is often limited and wai...

journal_title：Trials

authors： Williams C,McClay CA,Martinez R,Morrison J,Haig C,Jones R,Farrand P

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on...

journal_title：Trials

authors： Bluth T,Teichmann R,Kiss T,Bobek I,Canet J,Cinnella G,De Baerdemaeker L,Gregoretti C,Hedenstierna G,Hemmes SN,Hiesmayr M,Hollmann MW,Jaber S,Laffey JG,Licker MJ,Markstaller K,Matot I,Müller G,Mills GH,Mulier JP,Pu

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:In coronary artery bypass grafting surgery, arterial conduits are preferred because of more favourable long-term patency and outcome. Anyway the greater saphenous vein continues to be the most commonly used bypass conduit. Minimally invasive endoscopic saphenous vein harvesting is increasingly being investig...

journal_title：Trials

authors： Campanella A,Bergamasco L,Macri L,Asioli S,Devotini R,Scipioni S,Barbaro S,Rispoli P,Rinaldi M

更新日期：2011-11-18 00:00:00

abstract：BACKGROUND:Several drugs are being repurposed for the treatment of the coronavirus disease 2019 (COVID-19) pandemic based on in vitro or early clinical findings. As these drugs are being used in varied regimens and dosages, it is important to enable synthesis of existing safety data from clinical trials. However, avail...

journal_title：Trials

authors： Rodgers F,Pepperrell T,Keestra S,Pilkington V

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Oxygen is a life-saving, essential medicine that is important for the treatment of many common childhood conditions. Improved oxygen systems can reduce childhood pneumonia mortality substantially. However, providing oxygen to children is challenging, especially in small hospitals with weak infrastructure and...

journal_title：Trials

authors： Graham HR,Ayede AI,Bakare AA,Oyewole OB,Peel D,Gray A,McPake B,Neal E,Qazi S,Izadnegahdar R,Falade AG,Duke T

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Asthma is a prevalent and costly disease resulting in reduced quality of life for a large proportion of individuals. Effective patient self-management is critical for improving health outcomes. However, key aspects of self-management such as self-monitoring of behaviours and symptoms, coupled with regular fe...

journal_title：Trials

authors： Ahmed S,Bartlett SJ,Ernst P,Paré G,Kanter M,Perreault R,Grad R,Taylor L,Tamblyn R

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:The most important action in the resuscitation of a newborn in the delivery room is to establish effective assisted ventilation. The face mask and endotracheal tube are the devices used to achieve this goal. Laryngeal mask airways that fit over the laryngeal inlet have been shown to be effective for ventilat...

journal_title：Trials

authors： Trevisanuto D,Cavallin F,Mardegan V,Loi NN,Tien NV,Linh TD,Chien TD,Doglioni N,Chiandetti L,Moccia L

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirel...

journal_title：Trials

authors： Jin,Huang WJ,Meng X,Yang F,Zheng YJ,Bao Q,Zhang MZ,Yang YN,Ni Q,Lian FM,Tong XL

更新日期：2017-12-29 00:00:00