The prevention of anxiety in children through school-based interventions: study protocol for a 24-month follow-up of the PACES project.

abstract：BACKGROUND:Surgical microvascular decompression (MVD) is the curative treatment for hemifacial spasm (HFS). Monitoring MVD by recording the lateral spread response (LSR) intraoperatively can predict a successful clinical outcome. However, the rate of the LSR varies between trials, and the reason for this variation is u...

journal_title：Trials

authors： Fang Y,Zhang H,Liu W,Li Y

更新日期：2012-09-08 00:00:00

abstract：BACKGROUND:Previous studies have shown that acupuncture and electroacupuncture (EA) are effective in the treatment of patients with low back pain. However, there is little evidence to support the use of one intervention over the other. The aim of this study is to compare the effect of acupuncture and electroacupuncture...

journal_title：Trials

authors： Comachio J,Oliveira Magalhães M,Nogueira Burke T,Vidal Ramos LA,Peixoto Leão Almeida G,Silva AP,Ferreira de Meneses SR,Costa-Frutuoso JR,Santos Miotto Amorim C,Pasqual Marques A

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Linezolid, an oxazolidinone, substantially improves treatment outcomes of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We started a trial to test whether the use of linezolid instead of ethambutol could increase the rate of sputum culture conversion as of 8 weeks of treatment...

journal_title：Trials

authors： Lee JY,Kim DK,Lee JK,Yoon HI,Jeong I,Heo E,Park YS,Lee JH,Park SS,Lee SM,Lee CH,Lee J,Choi SM,Park JS,Joh JS,Cho YJ,Lee YJ,Kim SJ,Hwang YR,Kim H,Ki J,Choi H,Han J,Ahn H,Hahn S,Yim JJ

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:The focus in recent years on physical inactivity and metabolic disturbances in individuals with schizophrenia raises the question of potential effects of physical activity. Physical activity has shown beneficial effects on cognition in healthy older individuals as well as on symptom severity in depression. H...

journal_title：Trials

authors： Engh JA,Andersen E,Holmen TL,Martinsen EW,Mordal J,Morken G,Egeland J

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Registration of clinical trials is critical for promoting transparency and integrity in medical research; however, trials must be registered in a prospective fashion to deter unaccounted protocol modifications or selection of alternate outcomes that may enhance favorability of reported findings. We assessed ...

journal_title：Trials

authors： Gopal AD,Wallach JD,Aminawung JA,Gonsalves G,Dal-Ré R,Miller JE,Ross JS

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which...

journal_title：Trials

authors： Gee Kee E,Kimble RM,Cuttle L,Stockton K

更新日期：2013-11-25 00:00:00

abstract：BACKGROUND:Delirium is a state of confusion characterized by an acute and fluctuating decline in cognitive functioning. Delirium is common and deadly in older adults with dementia, and is often referred to as delirium superimposed on dementia, or DSD. Interventions that treat DSD are not well-developed because the mech...

journal_title：Trials

authors： Kolanowski AM,Fick DM,Litaker MS,Clare L,Leslie D,Boustani M

更新日期：2011-05-11 00:00:00

abstract：BACKGROUND:Real-time functional magnetic resonance imaging (rtfMRI) is used for neurofeedback training (NFT). Preliminary results suggest that it can help patients to control their symptoms. This study uses rtfMRI NFT for relapse prevention in alcohol dependence. METHODS/DESIGN:Participants are alcohol-dependent patie...

journal_title：Trials

authors： Cox WM,Subramanian L,Linden DE,Lührs M,McNamara R,Playle R,Hood K,Watson G,Whittaker JR,Sakhuja R,Ihssen N

更新日期：2016-10-03 00:00:00

abstract：BACKGROUND:HIV-related stigma significantly impacts HIV care engagement, including in prevention of mother-to-child transmission of HIV (PMTCT) programs. Maisha is a stigma-based counseling intervention delivered during the first antenatal care (ANC) visit, complementing routine HIV counseling and testing. The goal of ...

journal_title：Trials

authors： Watt MH,Knippler ET,Minja L,Kisigo G,Knettel BA,Ngocho JS,Renju J,Osaki H,Mwamba R,Rogathi JJ,Mmbaga BT

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Depression accounts for the greatest burden of disease among all mental health problems, and is expected to become the second-highest amongst all general health problems by 2020. By the age of 75, 1 in 7 older people meet formal diagnostic criteria for depression. Efforts to ameliorate the burden of illness ...

journal_title：Trials

authors： Mitchell N,Hewitt C,Adamson J,Parrott S,Torgerson D,Ekers D,Holmes J,Lester H,McMillan D,Richards D,Spilsbury K,Godfrey C,Gilbody S

更新日期：2011-10-11 00:00:00

abstract：BACKGROUND:Recovery after a major stroke is usually limited, but cell therapy for patients with fixed neurologic deficits is emerging. Several recent clinical trials have investigated mesenchymal stem cell (MSC) therapy for patients with ischemic stroke. We previously reported the results of a controlled trial on the a...

journal_title：Trials

authors： Kim SJ,Moon GJ,Chang WH,Kim YH,Bang OY,STARTING-2 (STem cell Application Researches and Trials In NeuroloGy-2) collaborators.

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:In 2007, the Chinese Science Division of the State Administration of Traditional Chinese Medicine(TCM) convened a special conference to discuss quality control for TCM clinical research. Control and assurance standards were established to guarantee the quality of clinical research. This paper provides practi...

journal_title：Trials

authors： Zhao L,Liang FR,Li Y,Zhang FW,Zheng H,Wu X

更新日期：2009-12-27 00:00:00

abstract：BACKGROUND:Central sensitization is modulated by the endogenous opioid system and plays a major role in the development and maintenance of pain. Recent animal studies performed following resolution of inflammatory pain showed reinstatement of tactile hypersensitivity induced by administration of a mu-opioid-antagonist,...

journal_title：Trials

authors： Pereira MP,Werner MU,Dahl JB

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Diabetic distal symmetric polyneuropathy (DSPN) is one of the most common microvascular complications of diabetes mellitus, and it has become a major public health problem worldwide because of its high and increasing prevalence, morbidity, and disability rate. The current medications for DSPN are not entirel...

journal_title：Trials

authors： Jin,Huang WJ,Meng X,Yang F,Zheng YJ,Bao Q,Zhang MZ,Yang YN,Ni Q,Lian FM,Tong XL

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:Knee osteoarthritis (KOA) is one of the most common bone and joint diseases. As one of the main non-drug therapies, acupuncture is widely used to treat KOA, although the evidence for its efficacy is inconclusive. The objective of this pilot trial is to clarify the clinical efficacy and safety of fire acupunc...

journal_title：Trials

authors： Fu YB,Li B,Sun SF,Liu HL,Wang X,Wang SS,Zhang F,Du X,Ge DJ,Shang L,Liang RL,Wang LN,Yuan F,Sun JQ,Chen JW

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA)-associated uveitis is a chronic paediatric ocular inflammatory condition that can result in visual impairment. Adalimumab, a tumour necrosis factor (TNF)-alpha inhibitor, effectively controls joint and eye inflammation; however, its long-term use may increase the risk of a...

journal_title：Trials

authors： Acharya NR,Ebert CD,Kelly NK,Porco TC,Ramanan AV,Arnold BF,ADJUST Research Group.

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:In the last few years, excessive internet use and computer gaming have increased dramatically. Salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse have been defined as diagnostic criteria for internet addiction (IA) and computer addiction (CA) in the scientific community. Despi...

journal_title：Trials

authors： Jäger S,Müller KW,Ruckes C,Wittig T,Batra A,Musalek M,Mann K,Wölfling K,Beutel ME

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:With a survival rate of 6 to 11%, out-of-hospital cardiac arrest (OHCA) remains a healthcare challenge with room for improvement in morbidity and mortality. The guidelines emphasize the highest possible quality of cardiopulmonary resuscitation (CPR) and chest compressions (CC). It is essential to minimize CC...

journal_title：Trials

authors： Buléon C,Parienti JJ,Morilland-Lecoq E,Halbout L,Cesaréo E,Dubien PY,Jardel B,Boyer C,Husson K,Andriamirado F,Benet X,Morel-Marechal E,Aubrion A,Muntean C,Dupire E,Roupie E,Hubert H,Vilhelm C,Gueugniaud PY,CILICA-HS

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Patients can struggle to make sense of trials in emergency situations. This study examines patient experience of participating in the United Kingdom, Wound management of Open Lower Limb Fractures (UK WOLLF) study, a trial of standard wound management versus Negative Pressure Wound Therapy (NPWT). METHODS:Th...

journal_title：Trials

authors： Tutton E,Achten J,Lamb SE,Willett K,Costa ML,UK WOLLF Research Collaborators.

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Increasingly, genomics is informing clinical practice, but challenges remain for medical professionals lacking genetics expertise, and in access to and clinical utility of genomic testing for minority and underrepresented populations. The latter is a particularly pernicious problem due to the historical lack...

journal_title：Trials

authors： Odgis JA,Gallagher KM,Suckiel SA,Donohue KE,Ramos MA,Kelly NR,Bertier G,Blackburn C,Brown K,Fielding L,Lopez J,Aguiniga KL,Maria E,Rodriguez JE,Sebastin M,Teitelman N,Watnick D,Yelton NM,Abhyankar A,Abul-Husn NS,B

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Ascites is one of the most common complications of cirrhosis. Umbilical therapy with traditional Chinese medicines has been increasingly prescribed to treat cirrhotic ascites. However, high-quality evidence from clinical trials supporting such application of traditional Chinese medicines remains limited. The...

journal_title：Trials

authors： Yang X,Ru S,Luo L,Lv X,Bai W,Zhang F,Jiang F

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) is a major cause of maternal morbidity. Bleeding is caused by a combination of physical causes, such as failure of the uterus to contract or operations, and is made worse by impairment of the blood clotting system. A number of studies have shown that low levels of the blood clott...

journal_title：Trials

authors： Aawar N,Alikhan R,Bruynseels D,Cannings-John R,Collis R,Dick J,Elton C,Fernando R,Hall J,Hood K,Lack N,Mallaiah S,Maybury H,Nuttall J,Paranjothy S,Rayment R,Rees A,Sanders J,Townson J,Weeks A,Collins P

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the ef...

journal_title：Trials

authors： Demant MN,Jensen RG,Jakobsen JC,Gluud C,Homøe P

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:A large number of stakeholders have accepted the need for greater transparency in clinical research and, in the context of various initiatives and systems, have developed a diverse and expanding number of repositories for storing the data and documents created by clinical studies (collectively known as data ...

journal_title：Trials

authors： Canham S,Ohmann C

更新日期：2016-11-24 00:00:00

abstract：BACKGROUND:Colorectal cancer remains a considerable challenge in healthcare nowadays. Most patients' disease develops via the adenoma-carcinoma sequence; colonoscopy with polypectomy effectively reduces both mortality and incidence by removing precancerous adenomas. Previous studies showed that polypectomy without elec...

journal_title：Trials

authors： Chen YN,Chang LC,Chang CY,Chen PJ,Chen CY,Tseng CH,Chiu HM

更新日期：2018-07-06 00:00:00

abstract：BACKGROUND:Indigenous Australian youth (aged 15 to 34) have up to four times the risk of suicide compared with their non-Indigenous counterparts. Barriers to help-seeking include shame, feared loss of autonomy and negative attitudes towards healthcare providers. The use of mobile devices and apps continues to rise amon...

journal_title：Trials

authors： Shand FL,Ridani R,Tighe J,Christensen H

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Intensive rehabilitation of patients with severe traumatic brain injury is generally applied in the subacute stages of the hospital stay. Few studies have assessed the association between early and intensive physical rehabilitation and functional outcomes. The aim of this trial is to assess the feasibility o...

journal_title：Trials

authors： Riberholt CG,Lindschou J,Gluud C,Mehlsen J,Møller K

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:There has been longstanding interesting in cognitive training for older adults with cognitive impairment. In this study, we will investigate the effects of working memory training, and explore augmentation strategies that could possibly consolidate the effects in older adults with mild neurocognitive disorde...

journal_title：Trials

authors： Cheng CP,Chan SS,Mak AD,Chan WC,Cheng ST,Shi L,Wang D,Lam LC

更新日期：2015-10-24 00:00:00

abstract：BACKGROUND:Patients taking opioids are known to develop opioid-induced constipation (OIC), which reduces their quality of life. The aim of this study is to compare magnesium oxide with naldemedine and determine which is more effective in preventing OIC. METHODS:This proof-of-concept, prospective, randomized controlled...

journal_title：Trials

authors： Ozaki A,Kessoku T,Iwaki M,Kobayashi T,Yoshihara T,Kato T,Honda Y,Ogawa Y,Imajo K,Higurashi T,Yoneda M,Taguri M,Yamanaka T,Ishiki H,Kobayashi N,Saito S,Ichikawa Y,Nakajima A

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:Primary Objective • To assess the efficacy of herbal extracts in boosting innate immunity of patients with COVID-19 infection. Secondary Objectives • To assess the efficacy of herbal extracts in restoring respiratory health • To assess the efficacy of Cap. IP in early recovery of patients and decline in vira...

journal_title：Trials

authors： Rangnekar H,Patankar S,Suryawanshi K,Soni P

更新日期：2020-11-23 00:00:00