Abstract:
BACKGROUND:Depression accounts for the greatest burden of disease among all mental health problems, and is expected to become the second-highest amongst all general health problems by 2020. By the age of 75, 1 in 7 older people meet formal diagnostic criteria for depression. Efforts to ameliorate the burden of illness and personal suffering associated with depression in older people have focussed on those with more severe depressive syndromes. Less attention has been paid to those with mild disorders/sub-threshold depressive syndromes but these patients also suffer impairments in their quality of life and level of functioning. METHODS/DESIGN:The CASPER study has been designed to assemble an epidemiological cohort of people over 75 years of age (the CASPER cohort), from which we will identify those eligible to participate in a trial of collaborative care for sub-threshold depression (the CASPER trial).We aim to undertake a pragmatic randomised controlled multi-centre trial evaluating the effectiveness and cost-effectiveness of collaborative care; a low intensity psychological intervention in addition to usual general practitioner care versus usual general practitioner care alone. General practitioners from practices based in the North of England will be asked to identify potentially eligible patients over the age of 75 years. Patients will be sent a letter inviting them to participate in the study.We aim to recruit approximately 540 participants for the CASPER trial. A diagnostic interview will be carried out to ascertain trial eligibility with the major depressive episode module of the Mini International Neuropsychiatric Interview (M.I.N.I.), eligible participants randomised to either the intervention or usual care. The primary outcome will be measured with the Patient Health Questionnaire-9 (PHQ-9) and additional quality of life measures will be collected. Data will be collected at baseline, 4 and 12 months for both trial and cohort participants. TRIAL REGISTRATION:ISRCTN: ISRCTN02202951.
journal_name
Trialsjournal_title
Trialsauthors
Mitchell N,Hewitt C,Adamson J,Parrott S,Torgerson D,Ekers D,Holmes J,Lester H,McMillan D,Richards D,Spilsbury K,Godfrey C,Gilbody Sdoi
10.1186/1745-6215-12-225subject
Has Abstractpub_date
2011-10-11 00:00:00pages
225issn
1745-6215pii
1745-6215-12-225journal_volume
12pub_type
杂志文章,多中心研究,随机对照试验相关文献
Trials文献大全abstract:BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04889-9
更新日期:2020-11-30 00:00:00
abstract:BACKGROUND:Suffering linked to previous interpersonal trauma is common among patients in mental health care. Diagnostic labels may vary, but the clinical picture is often characterized by long-lasting and complex psychological and somatic symptoms, subjective distress and reduced quality of health and life. A substanti...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04297-z
更新日期:2020-05-27 00:00:00
abstract:BACKGROUND:Sleep disturbance in older people is an important health issue that is associated with many other health problems. Effective interventions are required to address sleep problems in this group. Acupressure has been suggested as a potential therapeutic technique to improve sleep. The aim of this study is to ev...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04286-2
更新日期:2020-04-25 00:00:00
abstract:BACKGROUND:Although conventional laparoscopic and hand-assisted laparoscopic surgery for colorectal cancer is widely used today, there remain many technical challenges especially for right colon cancer in obese patients. Herein, we develop a novel hand-assisted laparoscopic surgery (HALS) with complete mesocolic excisi...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2084-3
更新日期:2017-07-26 00:00:00
abstract:BACKGROUND:There is a strong evidence base for the benefits of parenting interventions for parents without severe mental illness (SMI). As the impact of maternal SMI can be significant on child development, mothers need support to maximise outcomes for themselves and their children. Some mothers with SMI require admiss...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2869-z
更新日期:2018-09-10 00:00:00
abstract:BACKGROUND:Suicide risk among individuals with schizophrenia (SZ) is intractably high, with over 40% of individuals attempting to take their own lives during their lifetime and an estimated 5-10% completing suicide. At present, available pharmacological and psychotherapeutic treatments offer limited risk reduction bene...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04788-z
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND:Surgical site infections (SSI) remain one of the most common complications in conventional abdominal surgery with an incidence between 4% and 19% (Sandini et al., Medicine (Baltimore) 95:e4057, 2016) in the literature. It is unclear whether the use of coated suture material for skin closure reduces the risk ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3492-3
更新日期:2019-07-02 00:00:00
abstract:OBJECTIVE:The objective of the Dutch Sildenafil therapy in dismal prognosis early onset fetal growth restriction (STRIDER) randomised clinical trial is to assess the beneficial and harmful effects of sildenafil versus placebo on fetal and neonatal mortality in pregnant women with severe early-onset fetal growth restric...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-018-3136-z
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs results in an increase in the...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2542-6
更新日期:2018-03-05 00:00:00
abstract::Reviews have repeatedly noted important methodological issues in the conduct and reporting of cluster randomized controlled trials (C-RCTs). These reviews usually focus on whether the intracluster correlation was explicitly considered in the design and analysis of the C-RCT. However, another important aspect requiring...
journal_title:Trials
pub_type: 杂志文章,评审
doi:10.1186/1745-6215-13-120
更新日期:2012-08-01 00:00:00
abstract:BACKGROUND:Patients with liver cirrhosis have a highly elevated risk of developing bacterial infections that significantly decrease survival rates. One of the most relevant infections is spontaneous bacterial peritonitis (SBP). Recently, NOD2 germline variants were found to be potential predictors of the development of...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-015-0594-4
更新日期:2015-03-08 00:00:00
abstract:BACKGROUND:As people live longer, their risk of disability increases. Disability affects quality of life and increases health and social care costs. Preventing or delaying disability is therefore an important objective, and identifying an effective intervention could improve the lives of many older people. Observationa...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-015-0610-8
更新日期:2015-03-13 00:00:00
abstract:BACKGROUND:Addressing the increasing prevalence, and associated disease burden, of diabetes is a priority of health services internationally. Interventions to support patients to effectively self-manage their condition have the potential to reduce the risk of costly and debilitating complications. The utilisation of mo...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-016-1305-5
更新日期:2016-04-02 00:00:00
abstract:BACKGROUND:Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining repetitive active transcranial direct current stimulation (tDCS) with...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2776-3
更新日期:2018-07-16 00:00:00
abstract:BACKGROUND:Children in low and middle-income countries (LMICs) are at risk for problems in their cognitive, social and behavioural development. Factors such as a lack of cognitive stimulation, harsh parenting practices, and severe and persistent aggression in early childhood are central to the genesis of these problems...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-1790-1
更新日期:2017-03-09 00:00:00
abstract:BACKGROUND:Bipolar disorder (BD) is commonly associated with cognitive and functional impairments even during remission periods, and although a growing number of studies have demonstrated the benefits of psychotherapy as an add-on to pharmacological treatment, its effectiveness appears to be less compelling in severe p...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-1896-5
更新日期:2017-03-28 00:00:00
abstract:OBJECTIVES:To investigate the potential efficacy of Acacia Senegal extract Gum Arabic (GA) supplementation as immunomodulatory and anti-inflammatory dietary intervention among newly diagnosed COVID 19 Sudanese patients. To study the effect of GA on the level of cytokines, TNFα, IL8, IL6 IL10, CRP and the viral load. Se...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04707-2
更新日期:2020-09-05 00:00:00
abstract:BACKGROUND:The physical and mental health of college students tends to continuously decline around the world. Since they are in a significant transition period which presents opportunities and challenges in health promotion, it is important to improve their health in this period. As a traditional Chinese exercise form ...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-14-422
更新日期:2013-12-05 00:00:00
abstract:BACKGROUND:The success of a clinical trial is often dependant on whether recruitment targets can be met in the required time frame. Despite an increase in research into the benefits of exercise in people with multiple sclerosis (PwMS), no trial has reported detailed data on effective recruitment strategies for large-sc...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-015-0996-3
更新日期:2015-10-15 00:00:00
abstract:BACKGROUND:Malaria transmission is highly heterogeneous in most settings, resulting in the formation of recognizable malaria hotspots. Targeting these hotspots might represent a highly efficacious way of controlling or eliminating malaria if the hotspots fuel malaria transmission to the wider community. METHODS/DESIGN...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-14-36
更新日期:2013-02-02 00:00:00
abstract:OBJECTIVES:Primary Objective: To determine the feasibility of delivering a protocolised, remote, online, Eye Movement Desensitisation and Reprocessing (EMDR) intervention, within 12-weeks of hospital discharge, for adult survivors of Covid-19 related critical illness. Secondary objectives: To investigate whether remote...
journal_title:Trials
pub_type: 信件
doi:10.1186/s13063-020-04805-1
更新日期:2020-11-17 00:00:00
abstract:BACKGROUND:Depression is a debilitating and costly disease for our society, especially in the case of treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy in treatment-resistant unipolar and non-psychotic depression. It can be applied according to tw...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04255-9
更新日期:2020-04-05 00:00:00
abstract:BACKGROUND:The effect of pregabalin on acute herpes zoster pain has not been previously evaluated. METHODS:In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster. RESULT...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-12-55
更新日期:2011-02-28 00:00:00
abstract:BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3950-y
更新日期:2019-12-27 00:00:00
abstract:BACKGROUND:ICU stay is often associated with negative experiences for the individual patient. Many patients are disabled and their communication is restricted during the ICU stay. Specific information on procedures, sensations and coping behavior are thought to reduce anxiety on the ICU. Until now information programs ...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1745-6215-10-84
更新日期:2009-09-14 00:00:00
abstract:BACKGROUND:There is currently an absence of high-grade evidence regarding the treatment of chronic sciatica (CS). Whilst gabapentin (GBP) and pregabalin (PGB) are both currently used to treat CS, equipoise exists regarding their individual use. In particular, no head-to-head study of GBP and PGB in CS exists. Despite e...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2400-y
更新日期:2018-01-09 00:00:00
abstract::There is a critical need for objective data to guide effective health promotion and care for homeless populations. However, many investigators exclude homeless populations from clinical trials due to practical concerns about conducting research with this population. This report is based on our experience and lessons l...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2046-9
更新日期:2017-07-05 00:00:00
abstract:BACKGROUND:Intellectual disability (ID) is characterized by limitations in intellectual functioning and adaptive behavior. Adults with ID exhibit higher rates of obesity and poorer health status compared to the general population. Continuity of care and barriers to health-related activities may contribute to the poorer...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-017-2239-2
更新日期:2017-10-23 00:00:00
abstract:BACKGROUND:Multi-centre randomised controlled trials (RCTs) in surgery are challenging. It is particularly difficult to establish standards of surgery and ensure that interventions are delivered as intended. This study developed and tested methods for identifying the key components of surgical interventions and standar...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-015-1127-x
更新日期:2015-12-28 00:00:00
abstract:BACKGROUND:Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and advantages. Although a combination of TCM and WM therapies, adjusted to the clinical situation, is ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-4209-3
更新日期:2020-03-30 00:00:00