The INCA trial (Impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver Cirrhosis and Ascites): study protocol for a randomized controlled trial.

abstract：BACKGROUND:Systematic use of observational pain tools has been advocated as a means to improve pain management for care home residents with dementia. Pain experts suggest that any observational tool should be used as part of a comprehensive pain management protocol, which should include score interpretation and verific...

journal_title：Trials

authors： Liu JY,Lai C

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:Enrollment in interventional therapeutic clinical trials is a small fraction of all patients who might participate given reasonable access. METHODS:A hierarchical approach is utilized in measuring staged participation from trial availability to patient enrollment. Our framework suggests that concern for jus...

journal_title：Trials

authors： Kanarek NF,Kanarek MS,Olatoye D,Carducci MA

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:A wound that does not heal in the orderly stages of the healing process or does not heal within 3 months is considered a chronic wound. Wound healing is impaired when the wound remains in the inflammatory stage for too long. A range of factors can delay the healing process: imbalance between proteases and pr...

journal_title：Trials

authors： Comino-Sanz IM,López-Franco MD,Castro B,Pancorbo-Hidalgo PL

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:The application of artificial intelligence (AI) in healthcare is an area of immense interest. The high profile of 'AI in health' means that there are unusually strong drivers to accelerate the introduction and implementation of innovative AI interventions, which may not be supported by the available evidence...

journal_title：Trials

authors： Ibrahim H,Liu X,Rivera SC,Moher D,Chan AW,Sydes MR,Calvert MJ,Denniston AK

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:The risk of falling is significantly higher in people with chronic stroke and it is, therefore, important to design interventions to improve mobility and decrease falls risk. Minimum toe clearance (MTC) is the key gait cycle event for predicting tripping-falls because it occurs mid-swing during the walking c...

journal_title：Trials

authors： Begg R,Galea MP,James L,Sparrow WAT,Levinger P,Khan F,Said CM

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:Microvascular obstruction (MVO) secondary to ischaemic-reperfusion injury is an important but underappreciated determinant of short- and longer-term outcome following percutaneous coronary intervention (PCI) treatment of ST-elevation myocardial infarction (STEMI). Several small studies have demonstrated a re...

journal_title：Trials

authors： Nazir SA,Khan JN,Mahmoud IZ,Greenwood JP,Blackman DJ,Kunadian V,Been M,Abrams KR,Wilcox R,Adgey AA,McCann GP,Gershlick AH

更新日期：2014-09-25 00:00:00

abstract：BACKGROUND:In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to cease their drug use. The most commonly used detoxification agents in UK prisons are buprenorphine, ...

journal_title：Trials

authors： Sheard L,Adams CE,Wright NM,El-Sayeh H,Dalton R,Tompkins CN

更新日期：2007-01-08 00:00:00

abstract：BACKGROUND:The prevalence of central obesity is constantly increasing, and visceral fat is associated with increased production of inflammatory factors and metabolic risk factors. Lutein might retard the development of metabolic disease through its antioxidant and anti-inflammatory properties. Furthermore, epidemiologi...

journal_title：Trials

authors： Zhou J,Zhao D,Wang N,Zeng Z,Wang C,Hao L,Peng X

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Currently, there still is no treatment that eliminates tinnitus in all patients. Recent studies have shown that Tinnitus Retraining Therapy (TRT) significantly improves quality of life for tinnitus patients. Also, several studies have reported that transcranial Direct Current Stimulation (tDCS) has a positiv...

journal_title：Trials

authors： Rabau S,Van Rompaey V,Van de Heyning P

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Acute kidney allograft rejection is a major cause for declining graft function and has a negative impact on the long-term graft survival. The majority (90%) of acute rejections are T-cell mediated and, therefore, the anti-rejection therapy targets T-cell-mediated mechanisms of the rejection process. However,...

journal_title：Trials

authors： Schiffer L,Schiffer M,Merkel S,Schwarz A,Mengel M,Jürgens C,Schroeder C,Zoerner AA,Püllmann K,Bröcker V,Becker JU,Dämmrich ME,Träder J,Grosshennig A,Biertz F,Haller H,Koch A,Gwinner W

更新日期：2012-10-26 00:00:00

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a major cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and is pop...

journal_title：Trials

authors： Fei YP,Zheng Y,Lai D,Zhong P,Lu JZ,Li G,Liu P

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Muscle glycogen has been well established as the primary metabolic energy substrate during physical exercise of moderate- to high-intensity and has accordingly been implicated as a limiting factor when such activity is sustained for a prolonged duration. However, the role of this substrate during repeated ex...

journal_title：Trials

authors： Alghannam AF,Tsintzas K,Thompson D,Bilzon J,Betts JA

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:Mobile health (mHealth) presents one of the potential solutions to maximize health worker impact and efficiency in an effort to reach the Sustainable Development Goals 3.1 and 3.2, particularly in sub-Saharan African countries. Poor-quality clinical decision-making is known to be associated with poor pregnan...

journal_title：Trials

authors： Amoakoh HB,Klipstein-Grobusch K,Amoakoh-Coleman M,Agyepong IA,Kayode GA,Sarpong C,Grobbee DE,Ansah EK

更新日期：2017-04-04 00:00:00

abstract：BACKGROUND:Depression and bipolar disorder are associated with reduced neural plasticity and deficits in memory, attention and executive function. Drug treatments for these affective disorders have insufficient clinical effects in a large group and fail to reverse cognitive deficits. There is thus a need for more effec...

journal_title：Trials

authors： Miskowiak KW,Vinberg M,Harmer CJ,Ehrenreich H,Knudsen GM,Macoveanu J,Hansen AR,Paulson OB,Siebner HR,Kessing LV

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS:Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, a...

journal_title：Trials

authors： Hind D,Reeves BC,Bathers S,Bray C,Corkhill A,Hayward C,Harper L,Napp V,Norrie J,Speed C,Tremain L,Keat N,Bradburn M

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Real-time functional magnetic resonance imaging (rtfMRI) is used for neurofeedback training (NFT). Preliminary results suggest that it can help patients to control their symptoms. This study uses rtfMRI NFT for relapse prevention in alcohol dependence. METHODS/DESIGN:Participants are alcohol-dependent patie...

journal_title：Trials

authors： Cox WM,Subramanian L,Linden DE,Lührs M,McNamara R,Playle R,Hood K,Watson G,Whittaker JR,Sakhuja R,Ihssen N

更新日期：2016-10-03 00:00:00

abstract：BACKGROUND:Juvenile dermatomyositis (JDM) is a rare autoimmune inflammatory disorder associated with significant morbidity and mortality. International collaboration is necessary to better understand the pathogenesis of the disease, response to treatment and long-term outcome. To aid international collaboration, it is ...

journal_title：Trials

authors： McCann LJ,Kirkham JJ,Wedderburn LR,Pilkington C,Huber AM,Ravelli A,Appelbe D,Williamson PR,Beresford MW

更新日期：2015-06-12 00:00:00

abstract：BACKGROUND:Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dementia symptoms are needed because current treatment options (antidepressants and antipsychotics) can...

journal_title：Trials

authors： Timler A,Bulsara C,Bulsara M,Vickery A,Smith J,Codde J

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:In bipolar spectrum disorder, some individuals experience ongoing, frequent fluctuations in mood outside of affective episodes. There are currently no evidence-based psychological interventions designed to address this. This feasibility study is a phase II evaluation of a dialectical behavioural therapy-info...

journal_title：Trials

authors： Wright K,Dodd A,Warren FC,Medina-Lara A,Taylor R,Jones S,Owens C,Javaid M,Dunn B,Harvey JE,Newbold A,Lynch T

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:The management of patients with angiographically intermediate coronary lesions is a major clinical issue. Fractional flow reserve provides validated functional insights while optical coherence tomography provides high resolution anatomic imaging. Both techniques may be applied to guide management in case of ...

journal_title：Trials

authors： Burzotta F,Leone AM,De Maria GL,Niccoli G,Coluccia V,Pirozzolo G,Saffioti S,Aurigemma C,Trani C,Crea F

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:Halitosis is an unpleasant breath odour that can interfere with the professional life, social life and quality of life of people who suffer from it. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orellana, popularly known as "urucum" is a plan...

journal_title：Trials

authors： Gonçalves MLL,da Mota ACC,Deana AM,Guedes GH,Cavalcante LAS,Prates RA,Horliana ACRT,Pavani C,Motta LJ,Bitencourt GB,Fernandes KPS,Salgueiro MDCC,Mesquita-Ferrari RA,da Silva DFT,França CM,Bussadori SK

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:The clinical benefits of bioimpedance spectroscopy (BIS)-guided fluid management in patients on hemodialysis have been widely demonstrated. However, no previous reports have evaluated the effect of regular and serial BIS-guided fluid management on the residual renal function (RRF) in patients on peritoneal d...

journal_title：Trials

authors： Baek SH,Oh KH,Kim S,Kim DK,Joo KW,Oh YK,Han BG,Chang JH,Chung W,Kim YS,Na KY

更新日期：2014-11-06 00:00:00

abstract：BACKGROUND:Beneficial effects of placebos are high in double-blind hot flush trials. Studies in various conditions suggest that honestly prescribed placebos may elicit symptom improvement. OBJECTIVE:To determine whether open label placebo (OLP) treatment is efficacious in alleviating hot flushes among peri- and postme...

journal_title：Trials

authors： Pan Y,Meister R,Löwe B,Winkelmann A,Kaptchuk TJ,Buhling KJ,Nestoriuc Y

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:The most important action in the resuscitation of a newborn in the delivery room is to establish effective assisted ventilation. The face mask and endotracheal tube are the devices used to achieve this goal. Laryngeal mask airways that fit over the laryngeal inlet have been shown to be effective for ventilat...

journal_title：Trials

authors： Trevisanuto D,Cavallin F,Mardegan V,Loi NN,Tien NV,Linh TD,Chien TD,Doglioni N,Chiandetti L,Moccia L

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:The current randomized controlled trial seeks to evaluate whether providing access to an Internet intervention for problem drinking in addition to an Internet intervention for problem gambling is beneficial for participants with gambling problems who do or do not have co-occurring problem drinking. METHODS:...

journal_title：Trials

authors： Cunningham JA,Hodgins DC,Keough M,Hendershot CS,Bennett K,Bennett A,Godinho A

更新日期：2018-05-25 00:00:00

abstract：:After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. We would like to formally apologize and give credit to the authors of that article [2]: Chris Smith, Uk Vannak, Ly Sokhey, Thoai D Ngo, Judy Gold, Khemrin Khut,...

journal_title：Trials

authors： Brody C,Tuot S,Chhoun P,Swendeman D,Kaplan KC,Yi S

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:Chronic thoracic pain after cardiac surgery is prevalent (11 to 56%) and may affect patients' physical and mental health status. Despite its favorable pharmacokinetic and pharmacodynamic properties, high doses of remifentanil administered during surgery are reported to cause acute postoperative pain and incr...

journal_title：Trials

authors： de Hoogd S,Ahlers SJ,van Dongen EP,Tibboel D,Dahan A,Knibbe CA

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Obesity is an increasingly prevalent chronic condition that is associated with serious morbidity and mortality. Excess body weight is a risk factor contributing to diseases such as hypertension, heart disease, hypercholesterolaemia, diabetes mellitus, cerebrovascular disease, gall bladder disease, and some t...

journal_title：Trials

authors： Zhong LL,Kun W,Lam TF,Zhang SP,Yang JJ,Ziea TC,Ng B,Bian ZX

更新日期：2016-07-25 00:00:00

abstract：BACKGROUND:Postoperative upper gastrointestinal fistula (PUGIF) is a devastating complication, leading to high mortality (reaching up to 80%), increased length of hospital stay, reduced health-related quality of life and increased health costs. Nutritional support is a key component of therapy in such cases, which is r...

journal_title：Trials

authors： Gronnier C,Chambrier C,Duhamel A,Dervaux B,Collet D,Vaudoyer D,Régimbeau JM,Jougon J,Théréaux J,Lebreton G,Veziant J,Valverde A,Ortega-Deballon P,Pattou F,Mathonnet M,Perinel J,Beyer-Berjot L,Fuks D,Rouanet P,Lefevr

更新日期：2020-06-02 00:00:00

abstract：BACKGROUND:Biomass fuel smoke is a leading risk factor for the burden of disease worldwide. International campaigns are promoting the widespread adoption of liquefied petroleum gas (LPG) in resource-limited settings. However, it is unclear if the introduction and use of LPG stoves, in settings where biomass fuels are u...

journal_title：Trials

authors： Fandiño-Del-Rio M,Goodman D,Kephart JL,Miele CH,Williams KN,Moazzami M,Fung EC,Koehler K,Davila-Roman VG,Lee KA,Nangia S,Harvey SA,Steenland K,Gonzales GF,Checkley W,Cardiopulmonary outcomes and Household Air Pollution tria

更新日期：2017-11-03 00:00:00