Abstract:
BACKGROUND:The clinical benefits of bioimpedance spectroscopy (BIS)-guided fluid management in patients on hemodialysis have been widely demonstrated. However, no previous reports have evaluated the effect of regular and serial BIS-guided fluid management on the residual renal function (RRF) in patients on peritoneal dialysis (PD). Therefore, we will evaluate the clinical efficacy of BIS-guided fluid management for preserving RRF and protecting cardiovascular events in patients on PD. METHODS/DESIGN:This is a multicenter, prospective, randomized controlled trial. A total of 138 participants on PD will be enrolled and randomly assigned to receive either BIS-guided fluid management or fluid management based only on the clinical information for 1 year. The primary outcome is the change in the glomerular filtration rate (GFR) between months 0 and 12 after starting treatment. The secondary outcomes will include GFR at month 12, time to the anuric state (urine volume <100 ml/day), and fatal and nonfatal cardiovascular events during treatment. DISCUSSION:This is the first clinical trial to investigate the effect of BIS-guided fluid management on RRF and for protecting against cardiovascular events in patients on PD. TRIAL REGISTRATION:Clinical Trials.gov number NCT01887262, June 24, 2013.
journal_name
Trialsjournal_title
Trialsauthors
Baek SH,Oh KH,Kim S,Kim DK,Joo KW,Oh YK,Han BG,Chang JH,Chung W,Kim YS,Na KYdoi
10.1186/1745-6215-15-432subject
Has Abstractpub_date
2014-11-06 00:00:00pages
432issn
1745-6215pii
1745-6215-15-432journal_volume
15pub_type
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