The efficacy and safety of Shenzhu Guanxin Recipe Granules for the treatment of patients with coronary artery disease: protocol for a double-blind, randomized controlled trial.

abstract：BACKGROUND:Central sensitization is modulated by the endogenous opioid system and plays a major role in the development and maintenance of pain. Recent animal studies performed following resolution of inflammatory pain showed reinstatement of tactile hypersensitivity induced by administration of a mu-opioid-antagonist,...

journal_title：Trials

authors： Pereira MP,Werner MU,Dahl JB

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clinical use. The use of a low-dos...

journal_title：Trials

authors： Cosgrave D,Galligan M,Soukhin E,McMullan V,McGuinness S,Puttappa A,Conlon N,Boylan J,Hussain R,Doran P,Nichol A

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:Tracheal intubation with the patient in the lateral position is difficult because the laryngeal view is compromised during direct laryngoscopy. Flexible video endoscopes may facilitate intubation even when laryngeal views are poor on direct laryngoscopy because the patients are positioned laterally. Thus, th...

journal_title：Trials

authors： Gao Y,Lin B,Huang J,Lin X,Lin C

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Adolescence is a high-risk time for the development of mental health and substance use problems. However, fewer than one in four 16-24 year-olds with a current disorder access health services, with those experiencing a substance use disorder being the least likely to seek professional help. Research indicate...

journal_title：Trials

authors： Lubman DI,Berridge BJ,Blee F,Jorm AF,Wilson CJ,Allen NB,McKay-Brown L,Proimos J,Cheetham A,Wolfe R

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Care management interventions in the German health-care system have been evaluated with promising results, but further research is necessary to explore their full potential in the context of multi-morbidity. Our aim in this trial is to assess the efficacy of a primary care practice network-based care managem...

journal_title：Trials

authors： Bozorgmehr K,Szecsenyi J,Ose D,Besier W,Mayer M,Krisam J,Jacke CO,Salize HJ,Brandner R,Schmitt S,Kiel M,Kamradt M,Freund T

更新日期：2014-06-21 00:00:00

abstract：BACKGROUND:There is currently a lack of randomized, sham-controlled trials that are adequately powered, using validated outcomes, to allow for firm recommendations on the use of magnetic stimulation for stress urinary incontinence. We report a protocol of a multicenter, randomized, double-blind, sham-controlled paralle...

journal_title：Trials

authors： Lim R,Liong ML,Leong WS,Khan NA,Yuen KH

更新日期：2015-06-21 00:00:00

abstract：BACKGROUND:Ascites is one of the most common complications of cirrhosis. Umbilical therapy with traditional Chinese medicines has been increasingly prescribed to treat cirrhotic ascites. However, high-quality evidence from clinical trials supporting such application of traditional Chinese medicines remains limited. The...

journal_title：Trials

authors： Yang X,Ru S,Luo L,Lv X,Bai W,Zhang F,Jiang F

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:A wide range of prophylactic antibiotic regimens are used for patients undergoing open-heart cardiac surgery. This reflects clinical equipoise in choice and duration of antibiotic agents. Although individual-level randomized control trials (RCT) are considered the gold standard when evaluating the efficacy o...

journal_title：Trials

authors： van Oostveen RB,Romero-Palacios A,Whitlock R,Lee SF,Connolly S,Carignan A,Mazer CD,Loeb M,Mertz D

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:The most important action in the resuscitation of a newborn in the delivery room is to establish effective assisted ventilation. The face mask and endotracheal tube are the devices used to achieve this goal. Laryngeal mask airways that fit over the laryngeal inlet have been shown to be effective for ventilat...

journal_title：Trials

authors： Trevisanuto D,Cavallin F,Mardegan V,Loi NN,Tien NV,Linh TD,Chien TD,Doglioni N,Chiandetti L,Moccia L

更新日期：2014-07-15 00:00:00

abstract：BACKGROUND:Recently, clinical observations reported the potential benefit of vagus nerve stimulation (VNS) for pediatric epilepsy. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is a newer non-invasive VNS, making it more accessible for treating pediatric epilepsy, yet there is limited clinical evidence for ...

journal_title：Trials

authors： He W,Wang XY,Zhou L,Li ZM,Jing XH,Lv ZL,Zhao YF,Shi H,Hu L,Su YS,Zhu B

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:The prevalence of depressive disorder in adults with advanced cancer is around 20 %. Although cognitive behavioural therapy (CBT) is recommended for depression and may be beneficial in depressed people with cancer, its use for depression in those with advanced disease for whom cure is not likely has not been...

journal_title：Trials

authors： Serfaty M,King M,Nazareth I,Tookman A,Wood J,Gola A,Aspden T,Mannix K,Davis S,Moorey S,Jones L

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:It is reported that nursing is one of the most vulnerable jobs for developing depression. While they may not be clinically diagnosed as depressed, nurses often suffer from depression and anxiety symptoms, which can lead to a low level of patient care. However, there is no rigorous evidence base for determini...

journal_title：Trials

authors： Watanabe N,Furukawa TA,Horikoshi M,Katsuki F,Narisawa T,Kumachi M,Oe Y,Shinmei I,Noguchi H,Hamazaki K,Matsuoka Y

更新日期：2015-01-31 00:00:00

abstract：BACKGROUND:Intraoperative driving pressure (ΔP) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (VT) is kept constant, ΔP may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. ΔP may decrease if PEEP leads to a recruitment of c...

journal_title：Trials

authors： DESIGNATION–investigators.

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Glenohumeral osteoarthritis can, in the most severe cases, require surgery with insertion of a shoulder arthroplasty. A design with a stem in the humeral bone canal is currently regarded as the standard treatment option in patients who have an intact rotator cuff function, but complications related to the st...

journal_title：Trials

authors： Nyring MRK,Olsen BS,Yilmaz M,Petersen MM,Flivik G,Rasmussen JV

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:With high morbidity, mortality and disability rate, brain infarction brings a huge economic and health burden to the whole society in China. Although some previous studies suggested that telerehabilitation may facilitate rehabilitation for stroke survivors at home, the evidence is insufficient for clinical a...

journal_title：Trials

authors： Jin W,Chen J,Shi F,Yang W,Zhang Y,Liu Y,Dong W,Jin Y,Ma W,Ma Z,Min X,Jin Y,Gu Y,Ren C

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:Spin in the reporting of randomized controlled trials, where authors report research in a way that potentially misrepresents results and mislead readers, has been demonstrated in the broader medical literature. We investigated spin in wound care trials with (a) no statistically significant result for the pri...

journal_title：Trials

authors： Lockyer S,Hodgson R,Dumville JC,Cullum N

更新日期：2013-11-06 00:00:00

abstract：BACKGROUND:Hysterosalpingography (HSG) is an accepted radiologic diagnostic modality for initial infertility workup, and is generally considered uncomfortable and painful. However, the management of pain related to HSG remains inefficient. As an emerging nonpharmacologic and noninvasive pain control strategy, virtual r...

journal_title：Trials

authors： Wang YL,Gao HX,Wang JS,Wang JH,Bo L,Zhang TT,Dai YL,Gao LL,Liu Q,Zhang JJ,Cai JM,Yu JQ,Li YX

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Previous research has suggested an association between more liberal red blood cell (RBC) transfusion and greater risk of further bleeding and mortality following acute upper gastrointestinal bleeding (AUGIB). METHODS AND DESIGN:The Transfusion in Gastrointestinal Bleeding (TRIGGER) trial is a pragmatic clus...

journal_title：Trials

authors： Kahan BC,Jairath V,Murphy MF,Doré CJ

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:The prevalence of central obesity is constantly increasing, and visceral fat is associated with increased production of inflammatory factors and metabolic risk factors. Lutein might retard the development of metabolic disease through its antioxidant and anti-inflammatory properties. Furthermore, epidemiologi...

journal_title：Trials

authors： Zhou J,Zhao D,Wang N,Zeng Z,Wang C,Hao L,Peng X

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:People with decompensated cirrhosis require complex medical care and are often prescribed an intricate and frequently changing medication and lifestyle regimen. However, many patients mismanage their medications or have poor comprehension of their disease and self-management tasks. This can lead to harm, hos...

journal_title：Trials

authors： Hayward KL,Martin JH,Cottrell WN,Karmakar A,Horsfall LU,Patel PJ,Smith DD,Irvine KM,Powell EE,Valery PC

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:The focus in recent years on physical inactivity and metabolic disturbances in individuals with schizophrenia raises the question of potential effects of physical activity. Physical activity has shown beneficial effects on cognition in healthy older individuals as well as on symptom severity in depression. H...

journal_title：Trials

authors： Engh JA,Andersen E,Holmen TL,Martinsen EW,Mordal J,Morken G,Egeland J

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Neck pain is a common symptom in most patients suffering from cervical radiculopathy. However, some conservative treatments are limited by their modest effectiveness. On the other hand, surgical intervention for cervical disc disorders is indicated when symptoms are refractory to conservative treatments and ...

journal_title：Trials

authors： Cui XJ,Sun YL,You SF,Mo W,Lu S,Shi Q,Wang YJ

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:Loss of upper limb function affects up to 85 % of acute stroke patients. Recovery of upper limb function requires regular intensive practise of specific upper limb tasks. To enhance intensity of practice interventions are being developed to encourage patients to undertake self-directed exercise practice. Mos...

journal_title：Trials

authors： Moore SA,Da Silva R,Balaam M,Brkic L,Jackson D,Jamieson D,Ploetz T,Rodgers H,Shaw L,van Wijck F,Price C

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Age-related muscle wasting has been strongly implicated with falls and fractures in the elderly, but it has also been associated with cognitive decline and dementia. Progressive resistance training (PRT) and adequate dietary protein are recognised as important contributors to the maintenance of muscle health...

journal_title：Trials

authors： Daly RM,Gianoudis J,Prosser M,Kidgell D,Ellis KA,O'Connell S,Nowson CA

更新日期：2015-08-08 00:00:00

abstract：BACKGROUND:There is evidence to suggest that delivery of diabetes self-management support by diabetes educators in primary care may improve patient care processes and patient clinical outcomes; however, the evaluation of such a model in primary care is nonexistent in Canada. This article describes the design for the ev...

journal_title：Trials

authors： Gucciardi E,Fortugno M,Horodezny S,Lou W,Sidani S,Espin S,Webster F,Shah BR

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:Published evaluations of successful interventions to prevent falls in people with sight impairment (SI) are limited. The aim of this feasibility study is to optimise the design and investigation of home safety (HS) and home exercise (HE) programmes to prevent falls in older people with SI. METHODS:A communi...

journal_title：Trials

authors： Waterman H,Ballinger C,Brundle C,Chastin S,Gage H,Harper R,Henson D,Laventure B,McEvoy L,Pilling M,Olleveant N,Skelton DA,Stanford P,Todd C

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not without side effects. It impedes early mobilization, could pose an infection risk, and may encourage the...

journal_title：Trials

authors： Roffe C,Nevatte T,Crome P,Gray R,Sim J,Pountain S,Handy L,Handy P

更新日期：2014-03-31 00:00:00

abstract：BACKGROUND:Spinal manipulative therapy is commonly used in the treatment of adolescent idiopathic scoliosis. Some therapists also rely on physiotherapeutic scoliosis-specific exercise (PSSE). Combining these two modalities seems reasonable, but the effectiveness of this combination has never been rigorously tested. Her...

journal_title：Trials

authors： Wang L,Wang C,Youssef ASA,Xu J,Huang X,Xia N

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease. The benefits of TMP are largely attributed to its anti-oxidative and vasodilative properties. However, the effica...

journal_title：Trials

authors： Chen Y,He W,Ouyang H,Liu C,Hong C,Wang T,Yang K,Lu W,Wang J

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:Trauma contributes to psychosis and in psychotic disorders post-traumatic stress disorder (PTSD) is often a comorbid disorder. A problem is that PTSD is underdiagnosed and undertreated in people with psychotic disorders. This study's primary goal is to examine the efficacy and safety of prolonged exposure an...

journal_title：Trials

authors： de Bont PA,van den Berg DP,van der Vleugel BM,de Roos C,Mulder CL,Becker ES,de Jongh A,van der Gaag M,van Minnen A

更新日期：2013-05-23 00:00:00