Development of an internationally agreed minimal dataset for juvenile dermatomyositis (JDM) for clinical and research use.

abstract：BACKGROUND:Neck pain is a common symptom in most patients suffering from cervical radiculopathy. However, some conservative treatments are limited by their modest effectiveness. On the other hand, surgical intervention for cervical disc disorders is indicated when symptoms are refractory to conservative treatments and ...

journal_title：Trials

authors： Cui XJ,Sun YL,You SF,Mo W,Lu S,Shi Q,Wang YJ

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:There has been a recent steep growth in platelet-rich plasma (PRP) use for musculoskeletal conditions, but findings from high quality clinical trial data are lacking in the literature. Here, we describe the statistical analysis plan (SAP) for the Platelet-rich plasma in Achilles Tendon Healing 2 (PATH-2) tri...

journal_title：Trials

authors： Schlüssel MM,Keene DJ,Wagland S,Alsousou J,Lamb SE,Willett K,Dutton SJ,PATH-2 Trial Study Group.

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Children in low and middle-income countries (LMICs) are at risk for problems in their cognitive, social and behavioural development. Factors such as a lack of cognitive stimulation, harsh parenting practices, and severe and persistent aggression in early childhood are central to the genesis of these problems...

journal_title：Trials

authors： Dowdall N,Cooper PJ,Tomlinson M,Skeen S,Gardner F,Murray L

更新日期：2017-03-09 00:00:00

abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mortality. The limitations of vancomycin, the current standard therapy for MRSA, make treatment difficult. The only other approved drug for treatment of MRSA bacteraemia, daptomycin, has not been...

journal_title：Trials

authors： Tong SY,Nelson J,Paterson DL,Fowler VG Jr,Howden BP,Cheng AC,Chatfield M,Lipman J,Van Hal S,O'Sullivan M,Robinson JO,Yahav D,Lye D,Davis JS,CAMERA2 study group and the Australasian Society for Infectious Diseases Clinical Res

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Randomised clinical trials are the 'gold standard' for evaluating the effectiveness of healthcare interventions. However, successful recruitment of participants remains a key challenge for many trialists. In this paper, we present a conceptual framework for creating a digital, population-based database for t...

journal_title：Trials

authors： Nwaru BI,Soyiri IN,Simpson CR,Griffiths C,Sheikh A

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:The current randomized controlled trial seeks to evaluate whether providing access to an Internet intervention for problem drinking in addition to an Internet intervention for problem gambling is beneficial for participants with gambling problems who do or do not have co-occurring problem drinking. METHODS:...

journal_title：Trials

authors： Cunningham JA,Hodgins DC,Keough M,Hendershot CS,Bennett K,Bennett A,Godinho A

更新日期：2018-05-25 00:00:00

abstract：BACKGROUND:Computed tomography is widely used to diagnose acute appendicitis. Many adolescents and young adults are exposed to the associated radiation. A recent single-institution trial has reported promising results for low-dose computed tomography; however, this technique has not yet been widely adopted. LOCAT (low-...

journal_title：Trials

authors： Ahn S,LOCAT group.

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality worldwide. In Denmark 2% of parturients receive blood transfusion. During the course of bleeding fibrinogen (coagulation factor I) may be depleted and fall to critically low levels, impairing haemostasis and thus worsening the ongoing...

journal_title：Trials

authors： Wikkelsoe AJ,Afshari A,Stensballe J,Langhoff-Roos J,Albrechtsen C,Ekelund K,Hanke G,Sharif HF,Mitchell AU,Svare J,Troelstrup A,Pedersen LM,Lauenborg J,Madsen MG,Bødker B,Møller AM

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:Radical lymph node dissection (LND) along the left recurrent laryngeal nerve (RLN) is surgically demanding and can be associated with substantial postoperative morbidity. The question of whether robot-assisted esophagectomy (RE) might be superior to video-assisted thoracoscopic esophagectomy (VATE) for perfo...

journal_title：Trials

authors： Chao YK,Li ZG,Wen YW,Kim DJ,Park SY,Chang YL,van der Sluis PC,Ruurda JP,van Hillegersberg R

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Video-laryngoscopes are marketed for intubation in difficult airway management. They provide a better view of the larynx and may facilitate tracheal intubation, but there is no adequately powered study comparing different types of video-laryngoscopes in a difficult airway scenario or in a simulated difficult...

journal_title：Trials

authors： Theiler L,Hermann K,Schoettker P,Savoldelli G,Urwyler N,Kleine-Brueggeney M,Arheart KL,Greif R

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people died from coronary heart disease than from any other cause. CVD is regularly treated with minimally or non-minimally invasive off- or on-pump cardiothor...

journal_title：Trials

authors： Moza A,Benstoem C,Autschbach R,Stoppe C,Goetzenich A

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:Chronic thoracic pain after cardiac surgery is prevalent (11 to 56%) and may affect patients' physical and mental health status. Despite its favorable pharmacokinetic and pharmacodynamic properties, high doses of remifentanil administered during surgery are reported to cause acute postoperative pain and incr...

journal_title：Trials

authors： de Hoogd S,Ahlers SJ,van Dongen EP,Tibboel D,Dahan A,Knibbe CA

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Assistive technology and telecare (ATT) are relatively new ways of delivering care and support to people with social care needs. It is claimed that ATT reduces the need for community care, prevents unnecessary hospital admission, and delays or prevents admission into residential or nursing care. The current ...

journal_title：Trials

authors： Leroi I,Woolham J,Gathercole R,Howard R,Dunk B,Fox C,O'Brien J,Bateman A,Poland F,Bentham P,Burns A,Davies A,Forsyth K,Gray R,Knapp M,Newman S,McShane R,Ritchie C

更新日期：2013-10-23 00:00:00

abstract：:After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. ...

journal_title：Trials

authors： Langella LG,Silva PFC,Costa-Santos L,Gonçalves MLL,Motta LJ,Deana AM,Fernandes KPS,Mesquita-Ferrari RA,Bussadori SK

更新日期：2018-12-24 00:00:00

abstract：BACKGROUND:Published evaluations of successful interventions to prevent falls in people with sight impairment (SI) are limited. The aim of this feasibility study is to optimise the design and investigation of home safety (HS) and home exercise (HE) programmes to prevent falls in older people with SI. METHODS:A communi...

journal_title：Trials

authors： Waterman H,Ballinger C,Brundle C,Chastin S,Gage H,Harper R,Henson D,Laventure B,McEvoy L,Pilling M,Olleveant N,Skelton DA,Stanford P,Todd C

更新日期：2016-09-26 00:00:00

abstract：BACKGROUND:Trigeminal neuralgia (TN) is a rare severe unilateral facial pain condition. Current guidelines in trigeminal neuralgia management recommend sodium channel blockers--carbamazepine or oxcarbazepine--as the first-line treatment. However, the currently available drugs are often associated with poor tolerability...

journal_title：Trials

authors： Zakrzewska JM,Palmer J,Ettlin DA,Obermann M,Giblin GM,Morisset V,Tate S,Gunn K

更新日期：2013-11-23 00:00:00

abstract：BACKGROUND:The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults. METHO...

journal_title：Trials

authors： Arabi Y,Al-Hameed F,Burns KEA,Mehta S,Alsolamy S,Almaani M,Mandourah Y,Almekhlafi GA,Al Bshabshe A,Finfer S,Alshahrani M,Khalid I,Mehta Y,Gaur A,Hawa H,Buscher H,Arshad Z,Lababidi H,Al Aithan A,Jose J,Abdukahil SA

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Previous interventions to increase physical activity and reduce cardiovascular risk factors have been targeted at individuals with established disease; less attention has been given to intervention among individuals with high risk for disease nor has there been determination of the influence of setting in wh...

journal_title：Trials

authors： Petrella RJ,Aizawa K,Shoemaker K,Overend T,Piche L,Marin M,Shapiro S,Atkin S

更新日期：2011-02-16 00:00:00

abstract：BACKGROUND:In the last few years, excessive internet use and computer gaming have increased dramatically. Salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse have been defined as diagnostic criteria for internet addiction (IA) and computer addiction (CA) in the scientific community. Despi...

journal_title：Trials

authors： Jäger S,Müller KW,Ruckes C,Wittig T,Batra A,Musalek M,Mann K,Wölfling K,Beutel ME

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:Adverse events (AEs) in clinical trials may be reported in multiple sources. Different methods for reporting adverse events across trials or across sources for a single trial may produce inconsistent information about the adverse events associated with interventions. METHODS:We compared the methods authors ...

journal_title：Trials

authors： Mayo-Wilson E,Fusco N,Hong H,Li T,Canner JK,Dickersin K

更新日期：2019-09-05 00:00:00

abstract：BACKGROUND:Venous thromboembolism (VTE) remains a common problem in critically ill patients. Pharmacologic prophylaxis is currently the standard of care based on high-level evidence from randomized controlled trials. However, limited evidence exists regarding the effectiveness of intermittent pneumatic compression (IPC...

journal_title：Trials

authors： Arabi YM,Alsolamy S,Al-Dawood A,Al-Omari A,Al-Hameed F,Burns KE,Almaani M,Lababidi H,Al Bshabshe A,Mehta S,Al-Aithan AM,Mandourah Y,Almekhlafi G,Finfer S,Abdukahil SA,Afesh LY,Dbsawy M,Sadat M

更新日期：2016-08-03 00:00:00

abstract：BACKGROUND:Incisional hernia is a frequent complication in abdominal surgery. This article describes the development of a prospective randomized clinical trial designed to determine whether watchful waiting is an acceptable alternative to surgical repair for patients with oligosymptomatic incisional hernia. METHODS/DE...

journal_title：Trials

authors： Lauscher JC,Martus P,Stroux A,Neudecker J,Behrens U,Hammerich R,Buhr HJ,Ritz JP

更新日期：2012-02-07 00:00:00

abstract：BACKGROUND:Active surveillance (AS) is the disease management option of choice for low-risk prostate cancer. Despite this, men with low-risk prostate cancer (LRPC) find management decisions distressing and confusing. We developed Navigate, an online decision aid to help men and their partners make management decisions ...

journal_title：Trials

authors： Schofield P,Gough K,Hyatt A,White A,Frydenberg M,Chambers S,Gordon LG,Gardiner R,Murphy DG,Cavedon L,Richards N,Murphy B,Quinn S,Juraskova I

更新日期：2021-01-11 00:00:00

abstract：RATIONALE:In critically ill patients receiving invasive mechanical ventilation (MV), research supports the use of daily screening to identify patients who are ready to undergo a spontaneous breathing trial (SBT) followed by conduct of an SBT. However, once daily (OD) screening is poorly aligned with the continuous care...

journal_title：Trials

authors： Burns KEA,Rizvi L,Cook DJ,Seely AJE,Rochwerg B,Lamontagne F,Devlin JW,Dodek P,Mayette M,Tanios M,Gouskos A,Kay P,Mitchell S,Kiedrowski KC,Hill NS,Canadian Critical Care Trials Group.

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:Impulsivity and compulsivity are related to emotional and social maladjustment and often underlie psychiatric disorders. Recently, alterations in microbiota composition have been shown to have implications for brain development and social behavior via the microbiota-gut-brain axis. However, the exact mechani...

journal_title：Trials

authors： Arteaga-Henríquez G,Rosales-Ortiz SK,Arias-Vásquez A,Bitter I,Ginsberg Y,Ibañez-Jimenez P,Kilencz T,Lavebratt C,Matura S,Reif A,Rethelyi J,Richarte V,Rommelse N,Siegl A,Ramos-Quiroga JA

更新日期：2020-02-11 00:00:00

abstract：:After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled. ...

journal_title：Trials

authors： Tegtmeier F,Schinzel R,Beer R,Bulters D,LeFrant JY,Sahuquillo J,Unterberg A,Andrews P,Belli A,Ibanez J,Lagares A,Mokry M,Willschke H,Flüh C,Schmutzhard E,NOSTRA Investigators.

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:A commonly reported problem with the conduct of multicentre randomised controlled trials (RCTs) is that recruitment is often slower or more difficult than expected, with many trials failing to reach their planned sample size within the timescale and funding originally envisaged. The aim of this study was to ...

journal_title：Trials

authors： McDonald AM,Knight RC,Campbell MK,Entwistle VA,Grant AM,Cook JA,Elbourne DR,Francis D,Garcia J,Roberts I,Snowdon C

更新日期：2006-04-07 00:00:00

abstract：BACKGROUND:With a survival rate of 6 to 11%, out-of-hospital cardiac arrest (OHCA) remains a healthcare challenge with room for improvement in morbidity and mortality. The guidelines emphasize the highest possible quality of cardiopulmonary resuscitation (CPR) and chest compressions (CC). It is essential to minimize CC...

journal_title：Trials

authors： Buléon C,Parienti JJ,Morilland-Lecoq E,Halbout L,Cesaréo E,Dubien PY,Jardel B,Boyer C,Husson K,Andriamirado F,Benet X,Morel-Marechal E,Aubrion A,Muntean C,Dupire E,Roupie E,Hubert H,Vilhelm C,Gueugniaud PY,CILICA-HS

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Cancer is one of the major health issues worldwide. An increasing number of cancer patients are offered treatment with surgery, chemotherapy and radiotherapy. Traditional Chinese medicine (TCM) is one of the most common complementary therapies offered to cancer patients in Taiwan. We designed a randomized, d...

journal_title：Trials

authors： Lo LC,Chen CY,Chen ST,Chen HC,Lee TC,Chang CS

更新日期：2012-12-03 00:00:00

abstract：BACKGROUND:Modern clinical-research practice favors placebo controls over usual-care controls whenever a credible placebo exists. An unrecognized consequence of this preference is that clinicians are more limited in their ability to provide the benefits of the non-specific healing effects of placebos in clinical practi...

journal_title：Trials

authors： Avins AL,Cherkin DC,Sherman KJ,Goldberg H,Pressman A

更新日期：2012-04-27 00:00:00