当前位置： SCI文献检索 > Trials期刊下所有文献 > Should we reconsider the routine use of placebo controls in clinical research?

Should we reconsider the routine use of placebo controls in clinical research?

Abstract：

BACKGROUND:Modern clinical-research practice favors placebo controls over usual-care controls whenever a credible placebo exists. An unrecognized consequence of this preference is that clinicians are more limited in their ability to provide the benefits of the non-specific healing effects of placebos in clinical practice. METHODS:We examined the issues in choosing between placebo and usual-care controls. We considered why placebo controls place constraints on clinicians and the trade-offs involved in the choice of control groups. RESULTS:We find that, for certain studies, investigators should consider usual-care controls, even if an adequate placebo is available. Employing usual-care controls would be of greatest value for pragmatic trials evaluating treatments to improve clinical care and for which threats to internal validity can be adequately managed without a placebo-control condition. CONCLUSIONS:Intentionally choosing usual-care controls, even when a satisfactory placebo exists, would allow clinicians to capture the value of non-specific therapeutic benefits that are common to all interventions. The result could be more effective, patient-centered care that makes the best use of both specific and non-specific benefits of medical interventions.

journal_name

Trials

journal_title

Trials

authors

Avins AL,Cherkin DC,Sherman KJ,Goldberg H,Pressman A

doi

10.1186/1745-6215-13-44

subject

Has Abstract

pub_date

2012-04-27 00:00:00

pages

44

issn

1745-6215

pii

1745-6215-13-44

journal_volume

13

pub_type

杂志文章

相关文献

Trials文献大全