Tailoring and evaluating an intervention to improve shared decision-making among seniors with dementia, their caregivers, and healthcare providers: study protocol for a randomized controlled trial.

abstract：BACKGROUND:Haemorrhage remains a leading cause of morbidity and mortality in trauma patients. Fibrinogen is an essential endogenous component of haemostasis and the plasma level is associated with bleeding, transfusion and outcome. Fibrinogen concentrate is widely used to correct acquired hypofibrinogenaemia, recommend...

journal_title：Trials

authors： Steinmetz J,Sørensen AM,Henriksen HH,Lange T,Larsen CF,Johansson PI,Stensballe J

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Equine-assisted therapy is more often practiced with children and adolescents than with the elderly, although individuals in the second half of life could also profit from it. This group, from the age of 50, is characterised by increasing emotional, social, health-related and cognitive changes; a critical li...

journal_title：Trials

authors： Schmidt J,Wartenberg-Demand A,Forstmeier S

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Non-retention of participants seriously affects the credibility of clinical trial results and significantly reduces the potential of a trial to influence clinical practice. Non-retention can be defined as instances where participants leave the study prematurely. Examples include withdrawal of consent and los...

journal_title：Trials

authors： Gillies K,Bower P,Elliott J,MacLennan G,Newlands RSN,Ogden M,Treweek SP,Wells M,Witham MD,Young B,Francis JJ

更新日期：2018-03-27 00:00:00

abstract：BACKGROUND:There is a need for improvement of information provision and post-treatment care for cancer survivors. A Survivorship Care Plan (SCP) is recommended by the American Institute of Medicine and the Dutch Health Council, which is a summary of patients' course of treatment as a formal document, and includes recom...

journal_title：Trials

authors： van de Poll-Franse LV,Nicolaije KA,Vos MC,Pijnenborg JM,Boll D,Husson O,Ezendam NP,Boss EA,Hermans RH,Engelhart KC,Haartsen JE,Pijlman BM,Feijen HW,Mertens HJ,Nolting WE,van Beek JJ,Roukema JA,Kruitwagen RF

更新日期：2011-12-05 00:00:00

abstract：BACKGROUND AND AIMS:The standard whole-colon tests used to investigate patients with symptoms of colorectal cancer are barium enema and colonoscopy. Colonoscopy is the reference test but is technically difficult, resource intensive, and associated with adverse events, especially in the elderly. Barium enema is safer bu...

journal_title：Trials

authors： Halligan S,Lilford RJ,Wardle J,Morton D,Rogers P,Wooldrage K,Edwards R,Kanani R,Shah U,Atkin W

更新日期：2007-10-27 00:00:00

abstract：BACKGROUND:Approximately 50% of heart failure patients are readmitted to hospital within 6 months, owing to deterioration of their condition. Thus, symptomatic treatment of heart failure requires significant improvement. The aim of this study is to compare the effects of torasemide and furosemide on biochemical paramet...

journal_title：Trials

authors： Balsam P,Ozierański K,Tymińska A,Główczyńska R,Peller M,Fojt A,Cacko A,Sieradzki B,Bakuła E,Markulis M,Kowalik R,Huczek Z,Filipiak KJ,Opolski G,Grabowski M

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:The traditional Chinese theory of acupuncture emphasizes that the intensity of acupuncture must reach a threshold to generate de qi (a specific and compound sensation during the acupuncture), which is necessary to achieve the best therapeutic effect. However, the notion that de qi must be achieved for maximu...

journal_title：Trials

authors： Chen Q,Zhang Q,Jiang L,Li X,Liu Y,Xie Y,Mu S,Liu Y,Wang X,Yu Y,Li M

更新日期：2014-07-24 00:00:00

abstract：OBJECTIVES:Colchicine is a well-known drug, which has been used for years to treat a wide range of rheumatic and inflammatory disorders. It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress p...

journal_title：Trials

authors： Dalili N,Kashefizadeh A,Nafar M,Poorrezagholi F,Firouzan A,Samadian F,Samavat S,Ziaie S,Fatemizadeh S

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:Cardiovascular diseases (CVDs) remain the leading causes of morbidity and mortality in the world. Hypertension is an important and prevalent cardiovascular risk factor. The present study will be conducted to investigate the effect of barberry as a cardio-protective fruit on the blood pressure in patients wit...

journal_title：Trials

authors： Emamat H,Zahedmehr A,Asadian S,Tangestani H,Nasrollahzadeh J

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:Trials in rare diseases have many challenges, among which are the need to set up multiple sites in different countries to achieve recruitment targets and the divergent landscape of clinical trial regulations in those countries. Over the past years, there have been initiatives to facilitate the process of int...

journal_title：Trials

authors： Crow RA,Hart KA,McDermott MP,Tawil R,Martens WB,Herr BE,McColl E,Wilkinson J,Kirschner J,King WM,Eagle M,Brown MW,Hirtz D,Lochmuller H,Straub V,Ciafaloni E,Shieh PB,Spinty S,Childs AM,Manzur AY,Morandi L,Butterf

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Hearing and vision impairments are highly prevalent in people with dementia and may have a negative impact on quality of life and other dementia-related outcomes. Intervening to optimise sensory impairment and support sensory function may be a means of improving dementia-related outcomes. The SENSE-Cog trial...

journal_title：Trials

authors： Regan J,Frison E,Collin F,Dawes P,Hann M,Himmelsbach I,Hooper E,Reeves D,Simkin Z,Thodi C,Yang F,Leroi I,SENSE-Cog Trial Development Team.

更新日期：2019-01-25 00:00:00

abstract：BACKGROUND:Video-laryngoscopes are marketed for intubation in difficult airway management. They provide a better view of the larynx and may facilitate tracheal intubation, but there is no adequately powered study comparing different types of video-laryngoscopes in a difficult airway scenario or in a simulated difficult...

journal_title：Trials

authors： Theiler L,Hermann K,Schoettker P,Savoldelli G,Urwyler N,Kleine-Brueggeney M,Arheart KL,Greif R

更新日期：2013-04-04 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) is a major cause of maternal morbidity. Bleeding is caused by a combination of physical causes, such as failure of the uterus to contract or operations, and is made worse by impairment of the blood clotting system. A number of studies have shown that low levels of the blood clott...

journal_title：Trials

authors： Aawar N,Alikhan R,Bruynseels D,Cannings-John R,Collis R,Dick J,Elton C,Fernando R,Hall J,Hood K,Lack N,Mallaiah S,Maybury H,Nuttall J,Paranjothy S,Rayment R,Rees A,Sanders J,Townson J,Weeks A,Collins P

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:HIV-related stigma significantly impacts HIV care engagement, including in prevention of mother-to-child transmission of HIV (PMTCT) programs. Maisha is a stigma-based counseling intervention delivered during the first antenatal care (ANC) visit, complementing routine HIV counseling and testing. The goal of ...

journal_title：Trials

authors： Watt MH,Knippler ET,Minja L,Kisigo G,Knettel BA,Ngocho JS,Renju J,Osaki H,Mwamba R,Rogathi JJ,Mmbaga BT

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Generalized anxiety disorder (GAD) is a psychiatric disorder characterized by a constant and unspecific anxiety that interferes with daily-life activities. Its high prevalence in general population and the severe limitations it causes, point out the necessity to find new efficient strategies to treat it. Tog...

journal_title：Trials

authors： Gorini A,Riva G

更新日期：2008-05-05 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Glaucoma is a chronic eye disease associated with irreversible visual loss. In Africa, glaucoma patients often present late, with very advanced disease. One-off procedures, such as laser or surgery, are recommended in Africa because of lack of or poor adherence to medical treatment. However, acceptance of su...

journal_title：Trials

authors： Abdull MM,Gilbert C,McCambridge J,Evans J

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:In the presence of heterogeneous treatment effects, it is desirable to divide patients into subgroups based on their expected response to treatment. This is formalised via a personalised treatment recommendation: an algorithm that uses biomarker measurements to select treatments. It could be that multiple, r...

journal_title：Trials

authors： Pierce M,Emsley R

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:The perimenopausal period refers to the interval when women's menstrual cycles become irregular and is characterized by an increased risk of depressive symptoms. Use of homeopathy to treat depression is widespread but there is a lack of clinical trials about its efficacy in depression in peri- and postmenopa...

journal_title：Trials

authors： Macías-Cortés Edel C,Aguilar-Faisal L,Asbun-Bojalil J

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:Preterm birth accounts for 75% of perinatal deaths and more than 50% of long-term neurological disabilities. For a singleton pregnancy, progesterone treatment is effective in prevention of preterm birth in women with an asymptomatic short cervix or a history of preterm birth. However, a large proportion of p...

journal_title：Trials

authors： Cheung KW,Seto MTY,Ng EHY

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:The ability to retrieve specific memories is a cognitive and emotional protective factor. Among the most effective techniques to generate autobiographical memories is the use of audio-visual stimuli, particularly images. Developing and improving techniques that facilitate the generation of such memories coul...

journal_title：Trials

authors： Fernández D,Ros L,Sánchez-Reolid R,Ricarte JJ,Latorre JM

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with increasing prevalence. It can manifest with many different clinical phenotypes; however, in its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi...

journal_title：Trials

authors： Yun Y,Ko Y,Ahn JH,Jang BH,Kim K,Ko SG,Choi I

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:Depression and bipolar disorder are associated with reduced neural plasticity and deficits in memory, attention and executive function. Drug treatments for these affective disorders have insufficient clinical effects in a large group and fail to reverse cognitive deficits. There is thus a need for more effec...

journal_title：Trials

authors： Miskowiak KW,Vinberg M,Harmer CJ,Ehrenreich H,Knudsen GM,Macoveanu J,Hansen AR,Paulson OB,Siebner HR,Kessing LV

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:Oxygen is a life-saving, essential medicine that is important for the treatment of many common childhood conditions. Improved oxygen systems can reduce childhood pneumonia mortality substantially. However, providing oxygen to children is challenging, especially in small hospitals with weak infrastructure and...

journal_title：Trials

authors： Graham HR,Ayede AI,Bakare AA,Oyewole OB,Peel D,Gray A,McPake B,Neal E,Qazi S,Izadnegahdar R,Falade AG,Duke T

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Despite long-standing problems in decisions to stop clinical trials, stopping guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assist the data monitoring committees for effectiveness trials. MAIN TEXT:To specify better stopping gui...

journal_title：Trials

authors： Tyson JE,Pedroza C,Wallace D,D'Angio C,Bell EF,Das A

更新日期：2016-05-10 00:00:00

abstract：:After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled. ...

journal_title：Trials

authors： Tegtmeier F,Schinzel R,Beer R,Bulters D,LeFrant JY,Sahuquillo J,Unterberg A,Andrews P,Belli A,Ibanez J,Lagares A,Mokry M,Willschke H,Flüh C,Schmutzhard E,NOSTRA Investigators.

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:With high morbidity, mortality and disability rate, brain infarction brings a huge economic and health burden to the whole society in China. Although some previous studies suggested that telerehabilitation may facilitate rehabilitation for stroke survivors at home, the evidence is insufficient for clinical a...

journal_title：Trials

authors： Jin W,Chen J,Shi F,Yang W,Zhang Y,Liu Y,Dong W,Jin Y,Ma W,Ma Z,Min X,Jin Y,Gu Y,Ren C

更新日期：2015-02-25 00:00:00

abstract：:Following the South African case, Treatment Action Campaign and Others v Minister of Health and Others, the use of 'pilot' studies to investigate interventions already proven efficacious, offered free of charge to government, but confined by the government to a small part of the population, may violate children's righ...

journal_title：Trials

authors： Oduwo E,Edwards SJ

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:The role of antibiotics in surgical procedures where the risk of surgical site infection (SSI) is low remains uncertain. There is, to date, no evidence to justify the routine use of antibiotics in postoperative reduction mammaplasty. The aim of this study is to evaluate the effect of postoperative antibiotic...

journal_title：Trials

authors： Garcia ES,Veiga DF,Veiga-Filho J,Cabral IV,Pinto NL,Novo NF,Sabino Neto M,Ferreira LM

更新日期：2016-11-30 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have side effects and poor adherence. Qigong has been studied as an alternative therapy for hypertension; however, the types of qigong used in those stu...

journal_title：Trials

authors： Park JE,Liu Y,Park T,Hong S,Kim JE,Kim TH,Kim AR,Jung SY,Park H,Choi SM

更新日期：2011-11-21 00:00:00