Effects of controlled hypotension with restrictive transfusion on intraoperative blood loss and systemic oxygen metabolism in elderly patients who underwent lumbar fusion.

abstract：OBJECTIVES:Colchicine is a well-known drug, which has been used for years to treat a wide range of rheumatic and inflammatory disorders. It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress p...

journal_title：Trials

authors： Dalili N,Kashefizadeh A,Nafar M,Poorrezagholi F,Firouzan A,Samadian F,Samavat S,Ziaie S,Fatemizadeh S

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dementia symptoms are needed because current treatment options (antidepressants and antipsychotics) can...

journal_title：Trials

authors： Timler A,Bulsara C,Bulsara M,Vickery A,Smith J,Codde J

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease lowers the quality of life and increases medical costs. Electroacupuncture has been used to ease symptoms and improve gastrointestinal motility in patients with gastroesophageal reflux disease. The main purposes of this study are to evaluate the efficacy and safety of this pro...

journal_title：Trials

authors： Han G,Leem J,Lee H,Lee J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:Trials of complex interventions are associated with high costs and burdens in terms of paperwork, management, data collection, validation, and intervention fidelity assessment occurring across multiple sites. Traditional data collection methods rely on paper-based forms, where processing can be time-consumin...

journal_title：Trials

authors： Drew CJ,Poile V,Trubey R,Watson G,Kelson M,Townson J,Rosser A,Hood K,Quinn L,Busse M

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:Obesity is an increasingly prevalent chronic condition that is associated with serious morbidity and mortality. Excess body weight is a risk factor contributing to diseases such as hypertension, heart disease, hypercholesterolaemia, diabetes mellitus, cerebrovascular disease, gall bladder disease, and some t...

journal_title：Trials

authors： Zhong LL,Kun W,Lam TF,Zhang SP,Yang JJ,Ziea TC,Ng B,Bian ZX

更新日期：2016-07-25 00:00:00

abstract：:There are many acknowledged benefits for the reuse of clinical trial data; from independent verification of published results to the evaluation of new hypotheses. However, the reuse of shared clinical trial data is not without obstacles. Here we present some of the issues and lessons learned from our own experiences i...

journal_title：Trials

authors： Wilkinson T,Sinha S,Peek N,Geifman N

更新日期：2019-08-19 00:00:00

abstract：RATIONALE:In critically ill patients receiving invasive mechanical ventilation (MV), research supports the use of daily screening to identify patients who are ready to undergo a spontaneous breathing trial (SBT) followed by conduct of an SBT. However, once daily (OD) screening is poorly aligned with the continuous care...

journal_title：Trials

authors： Burns KEA,Rizvi L,Cook DJ,Seely AJE,Rochwerg B,Lamontagne F,Devlin JW,Dodek P,Mayette M,Tanios M,Gouskos A,Kay P,Mitchell S,Kiedrowski KC,Hill NS,Canadian Critical Care Trials Group.

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD). METHODS:We systematically reviewed n...

journal_title：Trials

authors： Jawad S,Modi N,Prevost AT,Gale C

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS:Based on a comprehe...

journal_title：Trials

authors： Hummers-Pradier E,Bleidorn J,Schmiemann G,Joos S,Becker A,Altiner A,Chenot JF,Scherer M,German ‘Clinical Trials in German General Practice Network’.

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Effective programs to help children manage their weight are required. Families for Health focuses on a parenting approach, designed to help parents develop their parenting skills to support lifestyle change within the family. Families for Health V1 showed sustained reductions in overweight after 2 years in a...

journal_title：Trials

authors： Robertson W,Stewart-Brown S,Stallard N,Petrou S,Griffiths F,Thorogood M,Simkiss D,Lang R,Reddington K,Poole F,Rye G,Khan KA,Hamborg T,Kirby J

更新日期：2013-03-20 00:00:00

abstract：BACKGROUND:A variety of videolaryngoscopes with angulated blade have been recently introduced into clinical practice. They provide an indirect view of the glottic structures in normal and challenging clinical settings. Despite the very good visualization of the laryngeal structures by these devices, the insertion and a...

journal_title：Trials

authors： Al-Qasmi A,Al-Alawi W,Malik AM,Khan RM,Kaul N

更新日期：2013-09-16 00:00:00

abstract：BACKGROUND:Emerging evidence has shown that vitamin D and magnesium have anti-inflammatory and anti-depressant effects. Dietary intake of magnesium is associated with reduced body mass index, waist circumference, body fat percentage, as well as inflammatory biomarkers and depressive symptoms. Vitamin D deficiency has b...

journal_title：Trials

authors： Abiri B,Vafa M

更新日期：2020-02-26 00:00:00

abstract：BACKGROUND:Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chin...

journal_title：Trials

authors： Zhao AM,Qiu WR,Mao LJ,Ren JG,Xu L,Yao MJ,Bilinksi K,Chang D,Liu JX

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Non-cystic fibrosis bronchiectasis is characterized by the irreversible dilatation of the medium-sized bronchi as a result of airway injury from recurrent or chronic inflammation and lower respiratory tract infections. Bronchiectasis airways are commonly colonized with bacterial species. Infections of the ai...

journal_title：Trials

authors： Gao J,Gao X,Kong L

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Exercise has a beta cell preserving effect in patients with type 2 diabetes. This benefit of exercise has not been examined in type 1 diabetes. Significant beta cell function is present at the time of diagnosis of type 1 diabetes and therefore studies of beta cell preservation are ideally conducted immediate...

journal_title：Trials

authors： Lascar N,Kennedy A,Jackson N,Daley A,Dowswell G,Thompson D,Stokes K,Greenfield S,Holder R,Andrews R,Narendran P

更新日期：2013-06-18 00:00:00

abstract：BACKGROUND:Radical lymph node dissection (LND) along the left recurrent laryngeal nerve (RLN) is surgically demanding and can be associated with substantial postoperative morbidity. The question of whether robot-assisted esophagectomy (RE) might be superior to video-assisted thoracoscopic esophagectomy (VATE) for perfo...

journal_title：Trials

authors： Chao YK,Li ZG,Wen YW,Kim DJ,Park SY,Chang YL,van der Sluis PC,Ruurda JP,van Hillegersberg R

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have side effects and poor adherence. Qigong has been studied as an alternative therapy for hypertension; however, the types of qigong used in those stu...

journal_title：Trials

authors： Park JE,Liu Y,Park T,Hong S,Kim JE,Kim TH,Kim AR,Jung SY,Park H,Choi SM

更新日期：2011-11-21 00:00:00

abstract：BACKGROUND:At an early stage, prostate cancer patients are often eligible for more than one treatment option, or may choose to defer curative treatment. Without a pre-existing superior option, a patient has to weigh his personal preferences against the risks and benefits of each alternative to select the most appropria...

journal_title：Trials

authors： Cuypers M,Lamers RE,Kil PJ,van de Poll-Franse LV,de Vries M

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) are frequent after on-pump cardiac surgery. Cardiac surgery results in a complex pulmonary insult leading to high susceptibility to perioperative pulmonary atelectasis. For technical reasons, ventilator settings interact with the surgical procedure and traditional...

journal_title：Trials

authors： Lagier D,Fischer F,Fornier W,Fellahi JL,Colson P,Cholley B,Jaber S,Baumstarck K,Guidon C,PROVECS investigators and the ARCOTHOVA group.

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Using next-generation sequencing (NGS) in newborn screening (NBS) could expand the number of genetic conditions detected pre-symptomatically, simultaneously challenging current precedents, raising ethical concerns, and extending the role of parental decision-making in NBS. The NC NEXUS (Newborn Exome Sequenc...

journal_title：Trials

authors： Milko LV,Rini C,Lewis MA,Butterfield RM,Lin FC,Paquin RS,Powell BC,Roche MI,Souris KJ,Bailey DB Jr,Berg JS,Powell CM

更新日期：2018-06-28 00:00:00

abstract：BACKGROUND:Depressive and anxiety disorders are common in general practice but not always treated adequately. Introducing stepped care might improve this. In this randomized trial we examined the effectiveness of such a stepped care model. METHODS:The study population consisted of primary care attendees aged 18-65 yea...

journal_title：Trials

authors： Seekles W,van Straten A,Beekman A,van Marwijk H,Cuijpers P

更新日期：2011-07-07 00:00:00

abstract：BACKGROUND:The gap between the level of care recommended by evidence-based clinical practice guidelines and the actual care delivered to patients in practice has been well established. The Canadian Diabetes Association (CDA) created an implementation strategy to improve the implementation of its 2008 guidelines. This s...

journal_title：Trials

authors： Shah BR,Bhattacharyya O,Yu C,Mamdani M,Parsons JA,Straus SE,Zwarenstein M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Studies exploring parents' trial experiences generally relate to their understanding of the consent process and the development of researcher strategies to facilitate recruitment and retention. The aim was to better understand parents' experience of being part of a trial at the time and their perceptions of ...

journal_title：Trials

authors： Harvey M,Nongena P,Edwards D,Redshaw M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Depression is seriously affecting the physical and mental health of young people worldwide. Subthreshold depression, as an early stage of depression, is essential for early prevention and treatment of depression. Tai Chi, as a traditional Chinese mind-body therapy, may become an alternative intervention. How...

journal_title：Trials

authors： Xie X,Song J,Zhu J,Han M,He Y,Huang J,Tao J,Wu J

更新日期：2021-01-30 00:00:00

abstract：BACKGROUND:Callus is one of the most common foot skin complaints experienced by people of all ages. These painful and unsightly lesions often result in disability. The 'gold standard' of treatment is scalpel debridement by a trained specialist; however, people also seek over-the-counter remedies. There is a lack of cli...

journal_title：Trials

authors： Hashmi F,Nester CJ,Wright CR,Lam S

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...

journal_title：Trials

authors： Oliveira CLP,Boulé NG,Sharma AM,Elliott S,Siervo M,Ghosh S,Berg A,Prado CM

更新日期：2019-12-27 00:00:00

abstract：:Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise the use of data and permit the exploration of additional hypotheses. On the other hand, the quality of secondary analyses cannot always be ascertained, and it may be unfair to investigators who ...

journal_title：Trials

authors： Mbuagbaw L,Foster G,Cheng J,Thabane L

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Liver failure patients have traditionally been empirically transfused prior to invasive procedures. Blood transfusion is associated with immunologic and nonimmunologic reactions, increased risk of adverse outcomes and high costs. Scientific evidence supporting empirical transfusion is lacking, and the best a...

journal_title：Trials

authors： Rocha LL,Pessoa CM,Neto AS,do Prado RR,Silva E,de Almeida MD,Correa TD,POCKET Trial Investigators.

更新日期：2017-02-27 00:00:00

abstract：BACKGROUND:Impulsivity and compulsivity are related to emotional and social maladjustment and often underlie psychiatric disorders. Recently, alterations in microbiota composition have been shown to have implications for brain development and social behavior via the microbiota-gut-brain axis. However, the exact mechani...

journal_title：Trials

authors： Arteaga-Henríquez G,Rosales-Ortiz SK,Arias-Vásquez A,Bitter I,Ginsberg Y,Ibañez-Jimenez P,Kilencz T,Lavebratt C,Matura S,Reif A,Rethelyi J,Richarte V,Rommelse N,Siegl A,Ramos-Quiroga JA

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:This study protocol evaluates the effectiveness of adjuvant electroacupuncture (EA) for urinary retention in poststroke patients undergoing conventional treatments, in comparison with that of a sham control. METHODS/DESIGN:A multicenter, blinded, randomized controlled trial will be conducted in three hospit...

journal_title：Trials

authors： Shin S,Lee J,Yoo J,Lim SM,Lee E

更新日期：2016-04-12 00:00:00