Clinical trial data reuse - overcoming complexities in trial design and data sharing.

abstract：BACKGROUND:Adolescence is a high-risk time for the development of mental health and substance use problems. However, fewer than one in four 16-24 year-olds with a current disorder access health services, with those experiencing a substance use disorder being the least likely to seek professional help. Research indicate...

journal_title：Trials

authors： Lubman DI,Berridge BJ,Blee F,Jorm AF,Wilson CJ,Allen NB,McKay-Brown L,Proimos J,Cheetham A,Wolfe R

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Cesarean delivery has already become a very common method of delivery around the world, especially in low-income countries. Hypertrophic scars and wound infections have affected younger mothers and frustrated obstetricians for a long time. Mesenchymal stem cells (MSCs) have strong potential for self-renewal ...

journal_title：Trials

authors： Fan D,Xia Q,Wu S,Ye S,Liu L,Wang W,Guo X,Liu Z

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults. METHO...

journal_title：Trials

authors： Arabi Y,Al-Hameed F,Burns KEA,Mehta S,Alsolamy S,Almaani M,Mandourah Y,Almekhlafi GA,Al Bshabshe A,Finfer S,Alshahrani M,Khalid I,Mehta Y,Gaur A,Hawa H,Buscher H,Arshad Z,Lababidi H,Al Aithan A,Jose J,Abdukahil SA

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:The objective of this research was to evaluate data from a randomized clinical trial that tested injectable diacetylmorphine (DAM) and oral methadone (MMT) for substitution treatment, using a multi-domain dichotomous index, with a Bayesian approach. METHODS:Sixty two long-term, socially-excluded heroin inje...

journal_title：Trials

authors： Perea-Milla E,Ayçaguer LC,Cerdà JC,Saiz FG,Rivas-Ruiz F,Danet A,Vallecillo MR,Oviedo-Joekes E

更新日期：2009-08-14 00:00:00

abstract：BACKGROUND:Despite recent advances in the medical and surgical fields, complications such as infection, pneumonia, or brain swelling may occur after a craniotomy. In some patients, perioperative antibiotic prophylaxis causes adverse effects such as itching, rash, or digestive conditions. Certain patients still develop ...

journal_title：Trials

authors： Cho SY,Yang SB,Shin HS,Lee SH,Koh JS,Kwon S,Jung WS,Moon SK,Park JM,Ko CN,Park SU

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Recent clinical observations have reported the potential benefit of vagus nerve stimulation (VNS) as an adjunctive therapy for pediatric epilepsy. Preliminary evidence suggests that VNS treatment is effective for seizure reduction and mental development in young participants between 3 and 6 years of age who ...

journal_title：Trials

authors： Ji T,Yang Z,Liu Q,Liao J,Yin F,Chen Y,Zou L,Li B,Gao Y,Shu X,Huang S,Gao F,Liang J,Lin SF,Peng J,Song S,Wang J,Che C,Sun W,Tian M,Yang L,Hua Y,Hao Y,Cai L,Li L,Jiang Y

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Current guidelines recommend treatment of significant coronary artery disease by concomitant coronary artery bypass grafting (CABG) in patients undergoing surgical aortic valve replacement. However there is no consensus as to how best to treat coronary disease in high-risk patients requiring transcatheter ao...

journal_title：Trials

authors： Khawaja MZ,Wang D,Pocock S,Redwood SR,Thomas MR

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:Impairments of memory are commonly reported by people with traumatic brain injuries (TBI). Such deficits are persistent, debilitating, and can severely impact quality of life. Currently, many do not routinely receive follow-up appointments for residual memory problems following discharge. METHODS/DESIGN:Thi...

journal_title：Trials

authors： das Nair R,Lincoln NB,Ftizsimmons D,Brain N,Montgomery A,Bradshaw L,Drummond A,Sackley C,Newby G,Thornton J,Stapleton S,Pink A

更新日期：2015-01-06 00:00:00

abstract：BACKGROUND:Individual patient data (IPD) meta-analysis is considered the "gold standard" for exploring the effectiveness of interventions in different subgroups of patients. However, obtaining IPD is time-consuming and contact with the researchers responsible for the original trials is usually required. To date, there ...

journal_title：Trials

authors： Veroniki AA,Straus SE,Ashoor H,Stewart LA,Clarke M,Tricco AC

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND AND AIMS:The standard whole-colon tests used to investigate patients with symptoms of colorectal cancer are barium enema and colonoscopy. Colonoscopy is the reference test but is technically difficult, resource intensive, and associated with adverse events, especially in the elderly. Barium enema is safer bu...

journal_title：Trials

authors： Halligan S,Lilford RJ,Wardle J,Morton D,Rogers P,Wooldrage K,Edwards R,Kanani R,Shah U,Atkin W

更新日期：2007-10-27 00:00:00

abstract：BACKGROUND:The physical and mental health of college students tends to continuously decline around the world. Since they are in a significant transition period which presents opportunities and challenges in health promotion, it is important to improve their health in this period. As a traditional Chinese exercise form ...

journal_title：Trials

authors： Zheng G,Li M,Lan X,Yan X,Lin Q,Chen L,Tao J,Zheng X,Li J,Chen B,Fang Q

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Fibroblast growth factor 23 (FGF23) is associated with left ventricular hypertrophy (LVH) in patients with chronic kidney disease, and calcimimetic therapy reduces plasma concentrations of FGF23. It remains unknown whether treatment with the calcimimetic etelcalcetide (ETL) reduces LVH in patients on hemodia...

journal_title：Trials

authors： Dörr K,Kammer M,Reindl-Schwaighofer R,Lorenz M,Loewe C,Marculescu R,Erben R,Oberbauer R

更新日期：2019-10-24 00:00:00

abstract：BACKGROUND:Automatic tendencies to approach drug-related cues have been linked to the development and maintainance of harmful drug-taking behavior. Recent studies have demonstrated that these automatic approach tendencies can be targeted directly by means of cognitive bias modification (CBM). Moreover, changing those a...

journal_title：Trials

authors： Machulska A,Kleinke K,Eiler TJ,Grünewald A,Brück R,Jahn K,Niehaves B,Gethmann CF,Klucken T

更新日期：2019-12-12 00:00:00

abstract：BACKGROUND:Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C) goals. This study compared the efficacy and safety of low doses of rosuvastatin (10 mg) and atorvastatin (20 mg) in high-risk patients with hypercholesterolemia. METHODS:A total of 996...

journal_title：Trials

authors： Clearfield MB,Amerena J,Bassand JP,Hernández García HR,Miller SS,Sosef FF,Palmer MK,Bryzinski BS

更新日期：2006-12-21 00:00:00

abstract：BACKGROUND:A wound that does not heal in the orderly stages of the healing process or does not heal within 3 months is considered a chronic wound. Wound healing is impaired when the wound remains in the inflammatory stage for too long. A range of factors can delay the healing process: imbalance between proteases and pr...

journal_title：Trials

authors： Comino-Sanz IM,López-Franco MD,Castro B,Pancorbo-Hidalgo PL

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Optimising the use of antibiotic agents is a pressing challenge to overcoming the rapid emergence and spread of multidrug-resistant pathogens in intensive care units (ICUs). Although Gram staining may possibly provide immediate information for predicting pathogenic bacteria, Gram stain-guided initial antibio...

journal_title：Trials

authors： Yoshimura J,Yamakawa K,Kinoshita T,Ohta Y,Morimoto T

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy (CIN) is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal insufficiency. Although some agents including hydration with saline are being prescribed to prevent renal deterioration in these high risk patients, ...

journal_title：Trials

authors： Park K,Chung WY,Seo JB,Kim SH,Zo JH,Kim MA,Park YB

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:The ACTION study (Attention deficit hyperactivity disorder Controlled Trial Investigation Of a Non-stimulant) is a multi-center, double-blind, randomized cross-over trial of the non-stimulant medication, Atomoxetine, in children and adolescents with attention deficit hyperactivity disorder (ADHD). The primar...

journal_title：Trials

authors： Tsang TW,Kohn MR,Hermens DF,Clarke SD,Clark CR,Efron D,Cranswick N,Lamb C,Williams LM

更新日期：2011-03-13 00:00:00

abstract：:Periconceptional supplementation could extend the period over which maternal and fetal nutrition is improved, but there are many challenges facing early-life intervention studies. Periconceptional trials differ from pregnancy supplementation trials, not only because of the very early or pre-gestational timing of nutri...

journal_title：Trials

authors： Brabin BJ,Gies S,Owens S,Claeys Y,D'Alessandro U,Tinto H,Brabin L

更新日期：2016-01-30 00:00:00

abstract：BACKGROUND:This descriptive study aimed to investigate adolescents' motivations for participating in a randomised controlled trial (RCT), to explore the understanding that the young people had regarding a number of aspects of the trial design, to examine whether or not they found participation in the trial to be accept...

journal_title：Trials

authors： Midgley N,Isaacs D,Weitkamp K,Target M

更新日期：2016-07-28 00:00:00

abstract：BACKGROUND:To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils-Listerine Zero (LZ)-and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo ...

journal_title：Trials

authors： Marchetti E,Tecco S,Caterini E,Casalena F,Quinzi V,Mattei A,Marzo G

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:Laparoscopic surgery has become the preferred approach for many procedures because of reduced post-operative pain, better recovery, shorter hospital stay and improved cosmesis. Single incision laparoscopic surgery is one of the many recent variants where either standard ports or a specially designed single m...

journal_title：Trials

authors： Malik M,McCormack K,Krukowski ZH,McDonald A,McPherson G,Cook JA,Ahmed I,SCARLESS Study Group.

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:Comprehensive rehabilitation therapy based on traditional Chinese medicine (TCM) has been widely applied in various cancer treatments in China. Thus far, Chinese herbal medicine (CHM) has been shown effective in reducing the adverse effects of chemotherapy and improving the quality of life (QoL) during chemo...

journal_title：Trials

authors： Yao J,Jiao L,Yao Y,Lu Y,Shi J,Li J,Chen P,Xu L,Gong Y

更新日期：2020-04-03 00:00:00

abstract：BACKGROUND:The incidence of cancer has been staying at a high level worldwide in recent years. With advances in cancer diagnosis and therapy strategy, the survival rate of patients with cancer has been increasing, but the side effects of these treatments, especially chemotherapy, are obvious even when the chemotherapy ...

journal_title：Trials

authors： You JS,Chen JP,Chan JS,Lee HF,Wong MK,Yeung WF,Lao LX

更新日期：2016-07-26 00:00:00

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Computed tomography is widely used to diagnose acute appendicitis. Many adolescents and young adults are exposed to the associated radiation. A recent single-institution trial has reported promising results for low-dose computed tomography; however, this technique has not yet been widely adopted. LOCAT (low-...

journal_title：Trials

authors： Ahn S,LOCAT group.

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Renal transplantation represents the treatment of choice of end-stage kidney disease. Delayed graft function (DGF) remains the most frequent complication after this procedure, reaching more than 30%. Its prevention is essential as it impedes early- and long-term prognosis of transplantation. Numerous pharmac...

journal_title：Trials

authors： Orban JC,Fontaine E,Cassuto E,Baumstarck K,Leone M,Constantin JM,Ichai C,AzuRéa network.

更新日期：2018-04-17 00:00:00

abstract：:International calls for registering all trials involving humans and for sharing the results, and sometimes also the raw data and the trial protocols, have increased in recent years. Such calls have come, for example, from the Organization for Economic Cooperation and Development (OECD), the World Health Organization (...

journal_title：Trials

authors： Gøtzsche PC

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Intra-operative electrocorticography, based on interictal spikes and spike patterns, is performed to optimize delineation of the epileptogenic tissue during epilepsy surgery. High frequency oscillations (HFOs, 80-500 Hz) have been identified as more precise biomarkers for epileptogenic tissue. The aim of the...

journal_title：Trials

authors： van 't Klooster MA,Leijten FS,Huiskamp G,Ronner HE,Baayen JC,van Rijen PC,Eijkemans MJ,Braun KP,Zijlmans M,HFO study group.

更新日期：2015-09-23 00:00:00

abstract：BACKGROUND:In rural Ethiopia, 72% of women are exposed to lifetime intimate partner violence (IPV); IPV is most prevalent during pregnancy. As well as adversely affecting women's physical and mental health, IPV also increases the risk of child morbidity and mortality associated with maternal depression, thus making ant...

journal_title：Trials

authors： Keynejad RC,Bitew T,Sorsdahl K,Myers B,Honikman S,Medhin G,Deyessa N,Sevdalis N,Tol WA,Howard L,Hanlon C

更新日期：2020-06-01 00:00:00