Single port/incision laparoscopic surgery compared with standard three-port laparoscopic surgery for appendicectomy - a randomised controlled trial.

abstract：BACKGROUND:Incurable cancer does not only affect patients, it also affects the lives of their partners. Many partners take on caregiving responsibilities. The burden of these caregiving tasks are often associated with physical, psychological, and social difficulties and many partners have unmet supportive care needs. O...

journal_title：Trials

authors： Schuit AS,Holtmaat K,Hooghiemstra N,Jansen F,Lissenberg-Witte BI,Coupé VMH,Verdonck-de Leeuw IM

更新日期：2020-01-31 00:00:00

abstract：BACKGROUND:Intraoperative driving pressure (ΔP) is associated with development of postoperative pulmonary complications (PPC). When tidal volume (VT) is kept constant, ΔP may change according to positive end-expiratory pressure (PEEP)-induced changes in lung aeration. ΔP may decrease if PEEP leads to a recruitment of c...

journal_title：Trials

authors： DESIGNATION–investigators.

更新日期：2020-02-18 00:00:00

abstract：BACKGROUND:Depression is a debilitating and costly disease for our society, especially in the case of treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy in treatment-resistant unipolar and non-psychotic depression. It can be applied according to tw...

journal_title：Trials

authors： Bulteau S,Laurin A,Volteau C,Dert C,Lagalice L,Schirr-Bonnans S,Bukowski N,Guitteny M,Simons L,Cabelguen C,Pichot A,Tessier F,Bonnin A,Lepage A,ACOUSTIM Investigators Group.,HUGOPSY Network.,Vanelle JM,Sauvaget A,Rich

更新日期：2020-04-05 00:00:00

abstract：BACKGROUND:A variety of videolaryngoscopes with angulated blade have been recently introduced into clinical practice. They provide an indirect view of the glottic structures in normal and challenging clinical settings. Despite the very good visualization of the laryngeal structures by these devices, the insertion and a...

journal_title：Trials

authors： Al-Qasmi A,Al-Alawi W,Malik AM,Khan RM,Kaul N

更新日期：2013-09-16 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Trials

authors： Sheridan R,Martin-Kerry J,Hudson J,Parker A,Bower P,Knapp P

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:An individualized treatment algorithm (Copenhagen Achilles Rupture Treatment Algorithm (CARTA)) based on the ultrasonographic appearance of an acute Achilles tendon rupture has been developed aiming to select the correct patients for operative and non-operative treatment. The objective of this study is to in...

journal_title：Trials

authors： Hansen MS,Vestermark MT,Hölmich P,Kristensen MT,Barfod KW

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:Halitosis is an unpleasant breath odour that can interfere with the professional life, social life and quality of life of people who suffer from it. A modality of treatment that has been increasing in dentistry is antimicrobial photodynamic therapy (aPDT). Bixa orellana, popularly known as "urucum" is a plan...

journal_title：Trials

authors： Gonçalves MLL,da Mota ACC,Deana AM,Guedes GH,Cavalcante LAS,Prates RA,Horliana ACRT,Pavani C,Motta LJ,Bitencourt GB,Fernandes KPS,Salgueiro MDCC,Mesquita-Ferrari RA,da Silva DFT,França CM,Bussadori SK

更新日期：2018-10-29 00:00:00

abstract：BACKGROUND:Psychosis is a serious mental illness that typically emerges during early adulthood. The disorder is characterized by inactivity, cognitive deficits and the need for ongoing support. Regular exercise has mood enhancing and anxiolytic effects that could benefit this patient group. To date, few studies have ex...

journal_title：Trials

authors： Forsell Y,Hallgren M,Mattson M,Ekblom O,Lavebratt C

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:Carpal tunnel syndrome (CTS) is the most common form of peripheral nerve injury, affecting approximately 3 % of the population. While surgery is effective in mild and moderate cases, nerve and functional recovery are often not complete in severe cases. Therefore, there is a need for adjuvant methods to impro...

journal_title：Trials

authors： Curran MW,Olson J,Morhart M,Sample D,Chan KM

更新日期：2016-04-14 00:00:00

abstract：BACKGROUND:Hospitalized older persons with Alzheimer's disease and related dementias are at greater risk for functional decline and increased care dependency after discharge due to a combination of intrinsic factors, environmental, policy, and care practices that restrict physical and cognitive activity, lack of family...

journal_title：Trials

authors： Boltz M,Kuzmik A,Resnick B,Trotta R,Mogle J,BeLue R,Leslie D,Galvin JE

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:In a sham-controlled double-blind trial, we aim to establish the efficacy and safety of the local application of laser therapy in patients with diabetes, onychomycosis and risk factors for diabetes-related foot complications. Onychomycosis leads to thickened and distorted nails, which in turn lead to increas...

journal_title：Trials

authors： Nijenhuis-Rosien L,Kleefstra N,Wolfhagen MJ,Groenier KH,Bilo HJ,Landman GW

更新日期：2015-03-22 00:00:00

abstract：BACKGROUND:In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS:Based on a comprehe...

journal_title：Trials

authors： Hummers-Pradier E,Bleidorn J,Schmiemann G,Joos S,Becker A,Altiner A,Chenot JF,Scherer M,German ‘Clinical Trials in German General Practice Network’.

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Immunologic derangement may be the critical pathophysiologic mechanism in sepsis, and immunotherapy might be a potential new treatment. Si-ni-tang (SNT), an ancient Chinese herbal formula documented in Shanghan Lun, has been used for treating severe sepsis for thousands of years. Research shows that it may h...

journal_title：Trials

authors： Zeng R,Zheng Y,Fan R,Zhou G,Zhang Y,Mai S,Xie D,Weng Y,Du J,Han Y,Lai F

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Fimasartan is the ninth angiotensin receptor blocker to be developed. However, it has not yet been evaluated for reno-protective effects in hypertensive diabetic chronic kidney disease (CKD). The target blood pressure (BP) for hypertensive diabetic CKD is also a controversial topic. This trial was designed t...

journal_title：Trials

authors： Kim JY,Son JW,Park S,Yoo TH,Kim YJ,Ryu DR,Chin HJ

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:Obesity represents a major public health problem and is the fifth leading risk factor for mortality. Morbid obesity is associated with chronic systemic inflammation which increases the risk of comorbidities. Bariatric surgery (BS) is considered an effective intervention for obese patients. However, BS is ass...

journal_title：Trials

authors： Delgado André L,Basso-Vanelli RP,Di Thommazo-Luporini L,Angélica Ricci P,Cabiddu R,Pilon Jürgensen S,Ricardo de Oliveira C,Arena R,Borghi-Silva A

更新日期：2018-10-31 00:00:00

abstract：BACKGROUND:This is a phase II randomised, double-blind, sham-controlled trial to evaluate the effectiveness and tolerability of repetitive transcranial magnetic stimulation for preventive treatment of episodic migraine amongst migraine subjects. METHODS:Subjects age 18 to 60 years will undergo a baseline evaluation to...

journal_title：Trials

authors： Mohamad Safiai NI,Amir NA,Basri H,Inche Mat LN,Hoo FK,Yusof Khan AHK,Loh WC,Chia PK,Ramachandran V,Mat Din H,Samsudin IN,Fernandez A,Mohamed MH,Ching SM,Hashim HZ,Wan Sulaiman WA

更新日期：2020-11-11 00:00:00

abstract：:After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled. ...

journal_title：Trials

authors： Tegtmeier F,Schinzel R,Beer R,Bulters D,LeFrant JY,Sahuquillo J,Unterberg A,Andrews P,Belli A,Ibanez J,Lagares A,Mokry M,Willschke H,Flüh C,Schmutzhard E,NOSTRA Investigators.

更新日期：2020-02-12 00:00:00

abstract：BACKGROUND:We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD). METHODS:We systematically reviewed n...

journal_title：Trials

authors： Jawad S,Modi N,Prevost AT,Gale C

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs results in an increase in the...

journal_title：Trials

authors： Al-Shahi Salman R,Dennis MS,Murray GD,Innes K,Drever J,Dinsmore L,Williams C,White PM,Whiteley WN,Sandercock PAG,Sudlow CLM,Newby DE,Sprigg N,Werring DJ,RESTART collaborators.

更新日期：2018-03-05 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Acute kidney injury is a common and devastating complication of critical illness, for which renal replacement therapy is frequently needed to manage severe cases. While a recent systematic review suggested that "earlier" initiation of renal replacement therapy improves survival, completed trials are limited ...

journal_title：Trials

authors： Smith OM,Wald R,Adhikari NK,Pope K,Weir MA,Bagshaw SM,Canadian Critical Care Trials Group.

更新日期：2013-10-05 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a common chronic disease in older adults. Currently, there are no effective therapies to reduce disease severity and progression of knee OA (KOA), particularly in mid- to late-stages. This study aims to examine the effect of methotrexate (MTX) on knee effusion-synovitis and pain in sym...

journal_title：Trials

authors： Zhu Z,Yu Q,Leng X,Han W,Li Z,Huang C,Gu J,Zhao Y,Wang K,Li T,Mei Y,Xu J,Zhang Z,Hunter D,Cicuttini F,Zeng X,Ding C

更新日期：2020-09-16 00:00:00

abstract：BACKGROUND:Preterm birth accounts for 75% of perinatal deaths and more than 50% of long-term neurological disabilities. For a singleton pregnancy, progesterone treatment is effective in prevention of preterm birth in women with an asymptomatic short cervix or a history of preterm birth. However, a large proportion of p...

journal_title：Trials

authors： Cheung KW,Seto MTY,Ng EHY

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:With a survival rate of 6 to 11%, out-of-hospital cardiac arrest (OHCA) remains a healthcare challenge with room for improvement in morbidity and mortality. The guidelines emphasize the highest possible quality of cardiopulmonary resuscitation (CPR) and chest compressions (CC). It is essential to minimize CC...

journal_title：Trials

authors： Buléon C,Parienti JJ,Morilland-Lecoq E,Halbout L,Cesaréo E,Dubien PY,Jardel B,Boyer C,Husson K,Andriamirado F,Benet X,Morel-Marechal E,Aubrion A,Muntean C,Dupire E,Roupie E,Hubert H,Vilhelm C,Gueugniaud PY,CILICA-HS

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:Children in low and middle-income countries (LMICs) are at risk for problems in their cognitive, social and behavioural development. Factors such as a lack of cognitive stimulation, harsh parenting practices, and severe and persistent aggression in early childhood are central to the genesis of these problems...

journal_title：Trials

authors： Dowdall N,Cooper PJ,Tomlinson M,Skeen S,Gardner F,Murray L

更新日期：2017-03-09 00:00:00

abstract：:The period toward the end of patients' participation in late stage blinded clinical trials is highly resource intensive for the sponsor. Consider first a Phase 3 trial. If the trial is a success, the sponsor has to implement the next steps, which might be filing for approval of the drug with the US Food and Drug Admin...

journal_title：Trials

authors： Ganju J

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Radical lymph node dissection (LND) along the left recurrent laryngeal nerve (RLN) is surgically demanding and can be associated with substantial postoperative morbidity. The question of whether robot-assisted esophagectomy (RE) might be superior to video-assisted thoracoscopic esophagectomy (VATE) for perfo...

journal_title：Trials

authors： Chao YK,Li ZG,Wen YW,Kim DJ,Park SY,Chang YL,van der Sluis PC,Ruurda JP,van Hillegersberg R

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Malaria transmission is highly heterogeneous in most settings, resulting in the formation of recognizable malaria hotspots. Targeting these hotspots might represent a highly efficacious way of controlling or eliminating malaria if the hotspots fuel malaria transmission to the wider community. METHODS/DESIGN...

journal_title：Trials

authors： Bousema T,Stevenson J,Baidjoe A,Stresman G,Griffin JT,Kleinschmidt I,Remarque EJ,Vulule J,Bayoh N,Laserson K,Desai M,Sauerwein R,Drakeley C,Cox J

更新日期：2013-02-02 00:00:00

abstract：BACKGROUND:In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to cease their drug use. The most commonly used detoxification agents in UK prisons are buprenorphine, ...

journal_title：Trials

authors： Sheard L,Adams CE,Wright NM,El-Sayeh H,Dalton R,Tompkins CN

更新日期：2007-01-08 00:00:00

abstract：BACKGROUND:Endoscopic ultrasonography (EUS)-guided drainage has become the first-line therapy for late peri-pancreatic fluid collection (PFC). Double pigtail plastic stents (DPPS) and lumen-apposing metal stents (LAMS) are commonly used for PFC drainage. Recently, a multi-institutional consensus on PFC drainage has rec...

journal_title：Trials

authors： Zhu HY,Xie P,Song YX,Li ZS,Jin ZD,Du YQ

更新日期：2018-10-11 00:00:00