Why we need easy access to all data from all clinical trials and how to accomplish it.

abstract：BACKGROUND:Irritable bowel syndrome (IBS) is reported by one in ten of the population accounting for up to 40% of new referrals to gastroenterology outpatients. Patients characteristically have abdominal discomfort and disturbed bowel habit. Diarrhoea-predominant IBS is characterised by frequent loose stools with assoc...

journal_title：Trials

authors： Leighton MP,Lam C,Mehta S,Spiller RC

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) is found in approximately 1% of the population and includes core symptoms that affect general and social development. Beside these core symptoms, it is suggested that up to 60% of children with ASD suffer from comorbid anxiety disorders which may further affect educational, soc...

journal_title：Trials

authors： Kilburn TR,Sørensen MJ,Thastum M,Rapee RM,Rask CU,Arendt KB,Thomsen PH

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:Nursing home residents are frequently affected by joint contractures, which impacts their participation and daily activities. A complex intervention, the Participation Enabling Care in Nursing (PECAN), was previously developed and pilot tested to address their needs. Its effectiveness and safety will be eval...

journal_title：Trials

authors： Nguyen N,Thalhammer R,Beutner K,Saal S,Servaty R,Klingshirn H,Icks A,Freyberg K,Vomhof M,Mansmann U,Le L,Müller M,Meyer G

更新日期：2019-05-29 00:00:00

abstract：BACKGROUND:Tackling neonatal mortality is essential for the achievement of the child survival millennium development goal. There are just under 4 million neonatal deaths, accounting for 38% of the 10.8 million deaths among children younger than 5 years of age taking place each year; 99% of these occur in low- and middl...

journal_title：Trials

authors： Kirkwood BR,Manu A,Tawiah-Agyemang C,ten Asbroek G,Gyan T,Weobong B,Lewandowski RE,Soremekun S,Danso S,Pitt C,Hanson K,Owusu-Agyei S,Hill Z

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:Trials of complex interventions are associated with high costs and burdens in terms of paperwork, management, data collection, validation, and intervention fidelity assessment occurring across multiple sites. Traditional data collection methods rely on paper-based forms, where processing can be time-consumin...

journal_title：Trials

authors： Drew CJ,Poile V,Trubey R,Watson G,Kelson M,Townson J,Rosser A,Hood K,Quinn L,Busse M

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:Research shows that more than half of the people taking medication for a chronic condition are non-adherent. Nonadherence hinders disease control with a burden on patient quality of life and healthcare systems. We developed a tool that provides insight into nonadherence risks and barriers for medication-adhe...

journal_title：Trials

authors： Hilbink M,Lacroix J,Bremer-van der Heiden L,van Halteren A,Teichert M,van Lieshout J

更新日期：2016-06-03 00:00:00

abstract：BACKGROUND:Despite the promise and popularity of advance care planning, there is insufficient evidence that advance care planning helps patients to meet their end-of-life care preferences, especially in Asian settings. Thus, the proposed study aims to assess whether patients with advanced heart failure who are receivin...

journal_title：Trials

authors： Malhotra C,Sim DK,Jaufeerally F,Vikas NN,Sim GW,Tan BC,Ng CS,Tho PL,Lim J,Chuang CY,Fong FH,Liu J,Finkelstein EA

更新日期：2016-06-10 00:00:00

abstract：BACKGROUND:Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is noninferior to ventilation with high PEEP with regard to the number of ventilator-free days and bei...

journal_title：Trials

authors： Algera AG,Pisani L,Bergmans DCJ,den Boer S,de Borgie CAJ,Bosch FH,Bruin K,Cherpanath TG,Determann RM,Dondorp AM,Dongelmans DA,Endeman H,Haringman JJ,Horn J,Juffermans NP,van Meenen DM,van der Meer NJ,Merkus MP,Moenira

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:Medically unexplained symptoms (MUS) are highly prevalent and pose a burden both on patients and on health care. In a pilot study psychosomatic therapy delivered by specialised therapists for patients with MUS showed promising results with regard to patient's acceptability, feasibility and effects on symptom...

journal_title：Trials

authors： Wortman MSH,van der Wouden JC,Grutters JPC,Visser B,Assendelft WJJ,van der Horst HE,Olde Hartman TC

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chin...

journal_title：Trials

authors： Zhao AM,Qiu WR,Mao LJ,Ren JG,Xu L,Yao MJ,Bilinksi K,Chang D,Liu JX

更新日期：2018-05-10 00:00:00

abstract：BACKGROUND:Bone microarchitecture is a significant determinant of bone strength. So far, the assessment of bone microarchitecture has required bone biopsies, limiting its utilization in clinical practice to one single skeletal site. With the advance of high-resolution imaging techniques, non-invasive in vivo measuremen...

journal_title：Trials

authors： Richert L,Uebelhart B,Engelhardt M,Azria M,Rizzoli R

更新日期：2008-04-13 00:00:00

abstract：BACKGROUND:Individuals with spinal cord injuries (SCI) are prone to pressure ulcers (PUs) because of the loss of sensorimotor function involved as well as increased skin moisture. Treatment of PU after SCI is complicated, involving different specialties and with need for long-lasting follow-up. This study should identi...

journal_title：Trials

authors： Irgens I,Hoff JM,Sørli H,Haugland H,Stanghelle JK,Rekand T

更新日期：2019-01-24 00:00:00

abstract：BACKGROUND:Maternal and perinatal mortality are major problems for which progress in sub-Saharan Africa has been inadequate, even though childbirth services are available, even in the poorest countries. Reducing them is the aim of two of the main Millennium Development Goals. Many initiatives have been undertaken to re...

journal_title：Trials

authors： Dumont A,Fournier P,Fraser W,Haddad S,Traore M,Diop I,Gueye M,Gaye A,Couturier F,Pasquier JC,Beaudoin F,Lalonde A,Hatem M,Abrahamowicz M

更新日期：2009-09-18 00:00:00

abstract：BACKGROUND:Glaucoma is a chronic eye disease associated with irreversible visual loss. In Africa, glaucoma patients often present late, with very advanced disease. One-off procedures, such as laser or surgery, are recommended in Africa because of lack of or poor adherence to medical treatment. However, acceptance of su...

journal_title：Trials

authors： Abdull MM,Gilbert C,McCambridge J,Evans J

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Depression Care for People with Lung Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depression, which patients receive from their general practitioner and cancer service. The third Sympt...

journal_title：Trials

authors： Walker J,Cassidy J,Sharpe M,SMaRT Oncology-3 Trialists.

更新日期：2009-09-30 00:00:00

abstract：BACKGROUND:Delirium prevalence in the intensive care unit (ICU) is high. Numerous psychotropic agents are used to manage delirium in the ICU with limited data regarding their efficacy or harms. METHODS/DESIGN:This is a randomized controlled trial of 428 patients aged 18 and older suffering from delirium and admitted t...

journal_title：Trials

authors： Campbell NL,Khan BA,Farber M,Campbell T,Perkins AJ,Hui SL,Abernathy G,Buckley J,Sing R,Tricker J,Zawahiri M,Boustani MA

更新日期：2011-06-06 00:00:00

abstract：BACKGROUND:The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effe...

journal_title：Trials

authors： Swanson SA,Holme Ø,Løberg M,Kalager M,Bretthauer M,Hoff G,Aas E,Hernán MA

更新日期：2015-11-30 00:00:00

abstract：BACKGROUND:A commonly reported problem with the conduct of multicentre randomised controlled trials (RCTs) is that recruitment is often slower or more difficult than expected, with many trials failing to reach their planned sample size within the timescale and funding originally envisaged. The aim of this study was to ...

journal_title：Trials

authors： McDonald AM,Knight RC,Campbell MK,Entwistle VA,Grant AM,Cook JA,Elbourne DR,Francis D,Garcia J,Roberts I,Snowdon C

更新日期：2006-04-07 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) is a major cause of maternal morbidity. Bleeding is caused by a combination of physical causes, such as failure of the uterus to contract or operations, and is made worse by impairment of the blood clotting system. A number of studies have shown that low levels of the blood clott...

journal_title：Trials

authors： Aawar N,Alikhan R,Bruynseels D,Cannings-John R,Collis R,Dick J,Elton C,Fernando R,Hall J,Hood K,Lack N,Mallaiah S,Maybury H,Nuttall J,Paranjothy S,Rayment R,Rees A,Sanders J,Townson J,Weeks A,Collins P

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:There are more than a quarter of a million individuals aged ≥ 65 years who are resident in care homes in England and Wales. Care home residents have high levels of cognitive impairment, physical disability, multimorbidity and polypharmacy. Research is needed to ensure there are robust, evidence-based interve...

journal_title：Trials

authors： Ellwood A,Airlie J,Cicero R,Cundill B,Ellard DR,Farrin A,Godfrey M,Graham L,Green J,McLellan V,Siddiqi N,Forster A,REACH Programme Team.

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:Most people who stop smoking successfully for a few weeks will return to smoking again in the medium term. There are few effective interventions to prevent this relapse and none used routinely in clinical practice. A previous exploratory meta-analysis suggested that self-help booklets may be effective but re...

journal_title：Trials

authors： Song F,Holland R,Barton GR,Bachmann M,Blyth A,Maskrey V,Aveyard P,Sutton S,Leonardi-Bee J,Brandon TH

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:Multiple pregnancies are one of the major safety concerns of in vitro fertilization (IVF) due to the increased risk of maternal and neonatal complications. Single embryo transfer is the most effective way to reduce the risk of multiple pregnancies. Selection of the embryo and optimization of the implantation...

journal_title：Trials

authors： Wei D,Sun Y,Liu J,Liang X,Zhu Y,Shi Y,Chen ZJ

更新日期：2017-06-05 00:00:00

abstract：BACKGROUND:The application of artificial intelligence (AI) in healthcare is an area of immense interest. The high profile of 'AI in health' means that there are unusually strong drivers to accelerate the introduction and implementation of innovative AI interventions, which may not be supported by the available evidence...

journal_title：Trials

authors： Ibrahim H,Liu X,Rivera SC,Moher D,Chan AW,Sydes MR,Calvert MJ,Denniston AK

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality worldwide. In Denmark 2% of parturients receive blood transfusion. During the course of bleeding fibrinogen (coagulation factor I) may be depleted and fall to critically low levels, impairing haemostasis and thus worsening the ongoing...

journal_title：Trials

authors： Wikkelsoe AJ,Afshari A,Stensballe J,Langhoff-Roos J,Albrechtsen C,Ekelund K,Hanke G,Sharif HF,Mitchell AU,Svare J,Troelstrup A,Pedersen LM,Lauenborg J,Madsen MG,Bødker B,Møller AM

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:Attention-deficit hyperactivity disorder (ADHD) is a mental disorder beginning in childhood, and about half of patients have symptoms lasting into adulthood. Adult ADHD causes various impairments of emotional, self-esteem, and executive function and life quality aspects. Furthermore, adverse outcomes include...

journal_title：Trials

authors： Huang F,Qian Q,Wang Y

更新日期：2015-04-14 00:00:00

abstract：BACKGROUND:Three decades of research suggests that prevention of iron deficiency anemia (IDA) in the primary care setting may be an unrealized and unique opportunity to prevent poor developmental outcomes in children. A longitudinal study of infants with IDA showed that the developmental disadvantage persists long term...

journal_title：Trials

authors： Abdullah K,Thorpe KE,Mamak E,Maguire JL,Birken CS,Fehlings D,Hanley AJ,Macarthur C,Zlotkin SH,Parkin PC

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:It is reported that nursing is one of the most vulnerable jobs for developing depression. While they may not be clinically diagnosed as depressed, nurses often suffer from depression and anxiety symptoms, which can lead to a low level of patient care. However, there is no rigorous evidence base for determini...

journal_title：Trials

authors： Watanabe N,Furukawa TA,Horikoshi M,Katsuki F,Narisawa T,Kumachi M,Oe Y,Shinmei I,Noguchi H,Hamazaki K,Matsuoka Y

更新日期：2015-01-31 00:00:00

abstract：BACKGROUND AND AIMS:The standard whole-colon tests used to investigate patients with symptoms of colorectal cancer are barium enema and colonoscopy. Colonoscopy is the reference test but is technically difficult, resource intensive, and associated with adverse events, especially in the elderly. Barium enema is safer bu...

journal_title：Trials

authors： Halligan S,Lilford RJ,Wardle J,Morton D,Rogers P,Wooldrage K,Edwards R,Kanani R,Shah U,Atkin W

更新日期：2007-10-27 00:00:00

abstract：BACKGROUND:Immunologic derangement may be the critical pathophysiologic mechanism in sepsis, and immunotherapy might be a potential new treatment. Si-ni-tang (SNT), an ancient Chinese herbal formula documented in Shanghan Lun, has been used for treating severe sepsis for thousands of years. Research shows that it may h...

journal_title：Trials

authors： Zeng R,Zheng Y,Fan R,Zhou G,Zhang Y,Mai S,Xie D,Weng Y,Du J,Han Y,Lai F

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of professionals to understand what interim information should be shared at interim, with whom and why. MET...

journal_title：Trials

authors： Borg Debono V,Mbuagbaw L,Paul J,Buckley N,Thabane L

更新日期：2018-05-21 00:00:00