Effectiveness of a medication-adherence tool: study protocol for a randomized controlled trial.

abstract：BACKGROUND:The gap between the level of care recommended by evidence-based clinical practice guidelines and the actual care delivered to patients in practice has been well established. The Canadian Diabetes Association (CDA) created an implementation strategy to improve the implementation of its 2008 guidelines. This s...

journal_title：Trials

authors： Shah BR,Bhattacharyya O,Yu C,Mamdani M,Parsons JA,Straus SE,Zwarenstein M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Given the complex nature of opioid addiction treatment and the rising number of available opioid substitution and antagonist therapies (OSAT), there is no 'gold standard' measure of treatment effectiveness, and each successive trial measures a different set of outcomes which reflect success in arbitrary or o...

journal_title：Trials

authors： Dennis BB,Sanger N,Bawor M,Naji L,Plater C,Worster A,Woo J,Bhalerao A,Baptist-Mohseni N,Hillmer A,Rice D,Corace K,Hutton B,Tugwell P,Thabane L,Samaan Z

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Spleen qi deficiency (SQD), a syndrome based on traditional Chinese medicine (TCM) theory, is common in patients after radical gastrectomy. SQD manifests with chronic gastrointestinal disorders and systemic symptoms and is challenging to manage. Hou Gu Mi Xi (HGMX) is a dietary TCM formula for SQD. This stud...

journal_title：Trials

authors： Zhou X,Yan DM,Zhu WF,Liu WJ,Nie HY,Xu S,Jiang YP,Zhang KH,Fu Y,Wan YY,Yu XY,Li H,Sun X,Chen XF

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Through many years, the standard care has been to use continuous sedation of critically ill patients during mechanical ventilation. However, preliminary randomised clinical trials indicate that it is beneficial to reduce the sedation level. No randomised trial has been conducted comparing sedation with no se...

journal_title：Trials

authors： Toft P,Olsen HT,Jørgensen HK,Strøm T,Nibro HL,Oxlund J,Wian KA,Ytrebø LM,Kroken BA,Chew M

更新日期：2014-12-20 00:00:00

abstract：BACKGROUND:Verrucae are a common, infectious and sometimes painful problem. The optimal treatment for verrucae is unclear due to a lack of high quality randomised controlled trials. The primary objective of this study is to compare the clinical effectiveness of two common treatments for verrucae: cryotherapy using liqu...

journal_title：Trials

authors： Cockayne ES,EVERT Trial Team.

更新日期：2010-02-08 00:00:00

abstract：BACKGROUND:Visible light (400 to 700 nm) is common in our environment, comprising 44% of total solar radiation and a large component of environmental light exposure. The effects of visible light on skin remain undefined. The red light portion of the visible spectrum (600 to 700 nm) may be used to treat skin diseases as...

journal_title：Trials

authors： Wang EB,Kaur R,Nguyen J,Ho D,Austin E,Maverakis E,Li CS,Hwang ST,Isseroff RR,Jagdeo J

更新日期：2019-03-20 00:00:00

abstract：BACKGROUND:Tobacco smoking is a highly prevalent, addictive behaviour and a key public health priority. However available cessation therapies have low quit and high relapse rates, indicating an urgent need for more effective treatments. Predicated on promising preclinical and pilot clinical data, this paper presents a ...

journal_title：Trials

authors： Arancini L,Bortolasci CC,Dodd S,Dean OM,Berk M

更新日期：2019-09-10 00:00:00

abstract：BACKGROUND:Understanding why people take part in health research is critical to improve research efficiency and generalisability. The aim of this overview of systematic reviews was to identify psychosocial determinants of research participation and map them to psychological theory and empirical recruitment research, to...

journal_title：Trials

authors： Sheridan R,Martin-Kerry J,Hudson J,Parker A,Bower P,Knapp P

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:In coronary artery bypass grafting surgery, arterial conduits are preferred because of more favourable long-term patency and outcome. Anyway the greater saphenous vein continues to be the most commonly used bypass conduit. Minimally invasive endoscopic saphenous vein harvesting is increasingly being investig...

journal_title：Trials

authors： Campanella A,Bergamasco L,Macri L,Asioli S,Devotini R,Scipioni S,Barbaro S,Rispoli P,Rinaldi M

更新日期：2011-11-18 00:00:00

abstract：:After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. We would like to formally apologize and give credit to the authors of that article [2]: Chris Smith, Uk Vannak, Ly Sokhey, Thoai D Ngo, Judy Gold, Khemrin Khut,...

journal_title：Trials

authors： Brody C,Tuot S,Chhoun P,Swendeman D,Kaplan KC,Yi S

更新日期：2019-12-09 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) is found in approximately 1% of the population and includes core symptoms that affect general and social development. Beside these core symptoms, it is suggested that up to 60% of children with ASD suffer from comorbid anxiety disorders which may further affect educational, soc...

journal_title：Trials

authors： Kilburn TR,Sørensen MJ,Thastum M,Rapee RM,Rask CU,Arendt KB,Thomsen PH

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:National obesity rates have dramatically risen over the last decade. Being obese significantly reduces life expectancy, increases the risk of a range of diseases, and compromises quality of life. Costs to both the National Health Service and society are high. An increased prevalence of obesity in people with...

journal_title：Trials

authors： Beeken RJ,Spanos D,Fovargue S,Hunter R,Omar R,Hassiotis A,King M,Wardle J,Croker H

更新日期：2013-03-12 00:00:00

abstract：BACKGROUND:Surgical microvascular decompression (MVD) is the curative treatment for hemifacial spasm (HFS). Monitoring MVD by recording the lateral spread response (LSR) intraoperatively can predict a successful clinical outcome. However, the rate of the LSR varies between trials, and the reason for this variation is u...

journal_title：Trials

authors： Fang Y,Zhang H,Liu W,Li Y

更新日期：2012-09-08 00:00:00

abstract：:The period toward the end of patients' participation in late stage blinded clinical trials is highly resource intensive for the sponsor. Consider first a Phase 3 trial. If the trial is a success, the sponsor has to implement the next steps, which might be filing for approval of the drug with the US Food and Drug Admin...

journal_title：Trials

authors： Ganju J

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Cognitive behaviour therapy (CBT) is an effective treatment for depression. However, CBT is a complex therapy that requires highly trained and qualified practitioners, and its scalability is therefore limited by the costs of training and employing sufficient therapists to meet demand. Behavioural activation ...

journal_title：Trials

authors： Rhodes S,Richards DA,Ekers D,McMillan D,Byford S,Farrand PA,Gilbody S,Hollon SD,Kuyken W,Martell C,O'Mahen HA,O'Neill E,Reed N,Taylor RS,Watkins ER,Wright KA

更新日期：2014-01-21 00:00:00

abstract：BACKGROUND:Despite recent advances in the medical and surgical fields, complications such as infection, pneumonia, or brain swelling may occur after a craniotomy. In some patients, perioperative antibiotic prophylaxis causes adverse effects such as itching, rash, or digestive conditions. Certain patients still develop ...

journal_title：Trials

authors： Cho SY,Yang SB,Shin HS,Lee SH,Koh JS,Kwon S,Jung WS,Moon SK,Park JM,Ko CN,Park SU

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:In the last few years, excessive internet use and computer gaming have increased dramatically. Salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse have been defined as diagnostic criteria for internet addiction (IA) and computer addiction (CA) in the scientific community. Despi...

journal_title：Trials

authors： Jäger S,Müller KW,Ruckes C,Wittig T,Batra A,Musalek M,Mann K,Wölfling K,Beutel ME

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:Depression Care for People with Lung Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depression, which patients receive from their general practitioner and cancer service. The third Sympt...

journal_title：Trials

authors： Walker J,Cassidy J,Sharpe M,SMaRT Oncology-3 Trialists.

更新日期：2009-09-30 00:00:00

abstract：BACKGROUND:Sleep disturbance in older people is an important health issue that is associated with many other health problems. Effective interventions are required to address sleep problems in this group. Acupressure has been suggested as a potential therapeutic technique to improve sleep. The aim of this study is to ev...

journal_title：Trials

authors： Hmwe NTT,Browne G,Mollart L,Allanson V,Chan SW

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:Around 35-45 % of people in contact with services for a first episode of psychosis are using cannabis. Cannabis use is associated with delays in remission, poorer clinical outcomes, significant increases in the risk of relapse, and lower engagement in work or education. While there is a clear need for effect...

journal_title：Trials

authors： Johnson S,Sheridan Rains L,Marwaha S,Strang J,Craig T,Weaver T,McCrone P,King M,Fowler D,Pilling S,Marston L,Omar RZ,Craig M,Hinton M

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:Despite long-standing problems in decisions to stop clinical trials, stopping guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assist the data monitoring committees for effectiveness trials. MAIN TEXT:To specify better stopping gui...

journal_title：Trials

authors： Tyson JE,Pedroza C,Wallace D,D'Angio C,Bell EF,Das A

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:There is currently a lack of randomized, sham-controlled trials that are adequately powered, using validated outcomes, to allow for firm recommendations on the use of magnetic stimulation for stress urinary incontinence. We report a protocol of a multicenter, randomized, double-blind, sham-controlled paralle...

journal_title：Trials

authors： Lim R,Liong ML,Leong WS,Khan NA,Yuen KH

更新日期：2015-06-21 00:00:00

abstract：BACKGROUND:The German welfare system follows the principle "rehabilitation rather than pension," but more than the half of all disability pensioners did not utilize medical rehabilitation before their early retirement. A major barrier is the application procedure. Lack of information about the opportunity to utilize re...

journal_title：Trials

authors： Spanier K,Streibelt M,Ünalan F,Bethge M

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with increasing prevalence. It can manifest with many different clinical phenotypes; however, in its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi...

journal_title：Trials

authors： Yun Y,Ko Y,Ahn JH,Jang BH,Kim K,Ko SG,Choi I

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) is commonly associated with cognitive and functional impairments even during remission periods, and although a growing number of studies have demonstrated the benefits of psychotherapy as an add-on to pharmacological treatment, its effectiveness appears to be less compelling in severe p...

journal_title：Trials

authors： Gomes BC,Rocca CC,Belizario GO,Lafer B

更新日期：2017-03-28 00:00:00

abstract：BACKGROUND:In rural Ethiopia, 72% of women are exposed to lifetime intimate partner violence (IPV); IPV is most prevalent during pregnancy. As well as adversely affecting women's physical and mental health, IPV also increases the risk of child morbidity and mortality associated with maternal depression, thus making ant...

journal_title：Trials

authors： Keynejad RC,Bitew T,Sorsdahl K,Myers B,Honikman S,Medhin G,Deyessa N,Sevdalis N,Tol WA,Howard L,Hanlon C

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Intellectual disability (ID) is characterized by limitations in intellectual functioning and adaptive behavior. Adults with ID exhibit higher rates of obesity and poorer health status compared to the general population. Continuity of care and barriers to health-related activities may contribute to the poorer...

journal_title：Trials

authors： Neumeier WH,Guerra N,Thirumalai M,Geer B,Ervin D,Rimmer JH

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Acute respiratory failure (ARF) remains the leading reason for intensive care unit (ICU) admission of immunocompromised patients. In the most severe cases, high-flow oxygen therapy may fail to ensure adequate gas exchange, and mechanical ventilation (MV) must be used. This scenario is associated with high mo...

journal_title：Trials

authors： Lemiale V,Resche-Rigon M,Azoulay E,Study Group for Respiratory Intensive Care in Malignancies Groupe de Recherche en Réanimation Respiratoire du patient d’Onco-Hématologie.

更新日期：2014-09-25 00:00:00

abstract：BACKGROUND:HIV-related stigma significantly impacts HIV care engagement, including in prevention of mother-to-child transmission of HIV (PMTCT) programs. Maisha is a stigma-based counseling intervention delivered during the first antenatal care (ANC) visit, complementing routine HIV counseling and testing. The goal of ...

journal_title：Trials

authors： Watt MH,Knippler ET,Minja L,Kisigo G,Knettel BA,Ngocho JS,Renju J,Osaki H,Mwamba R,Rogathi JJ,Mmbaga BT

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Atrial fibrillation is common in patients with structural heart disease who are undergoing cardiac surgery. Surgical CryoMaze has been shown to be an effective treatment in several trials, but success rates have varied considerably, between 47-95 %. The sequential hybrid approach, combining surgical CryoMaze...

journal_title：Trials

authors： Eisenberger M,Bulava A,Kautzner J,Neuzil P,Mokracek A,Hanis J,Dusek L

更新日期：2016-10-24 00:00:00