The EVERT (effective verruca treatments) trial protocol: a randomised controlled trial to evaluate cryotherapy versus salicylic acid for the treatment of verrucae.

abstract：BACKGROUND:To prevent clinical relapse in teenagers with inflammatory bowel disease (IBD) there is a need to monitor disease activity continuously. Timely optimisation of medical treatment may nip a preclinical relapse in the bud and change the natural course of IBD. Traditionally, disease monitoring is done during sch...

journal_title：Trials

authors： Heida A,Dijkstra A,Groen H,Muller Kobold A,Verkade H,van Rheenen P

更新日期：2015-06-16 00:00:00

abstract：INTRODUCTION:End-of-life (EoL) care professionals are prone to burnout given the intense emotional nature of their work. Previous research supports the efficacy of art therapy in reducing work-related stress and enhancing emotional health among professional EoL caregivers. Integrating mindfulness meditation with art th...

journal_title：Trials

authors： Ho AHY,Tan-Ho G,Ngo TA,Ong G,Chong PH,Dignadice D,Potash J

更新日期：2019-07-08 00:00:00

abstract：BACKGROUND:Motivational interviewing (MI) has great potential in changing health-related behaviors. In addition to delivery in face-to-face individual counseling, MI can be delivered through online groups, a method that is particularly appealing to adolescents and may offer several benefits. This randomized controlled ...

journal_title：Trials

authors： Gao X,Lo EC,McGrath C,Ho SM

更新日期：2015-09-18 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and disabling condition with considerable personal and economic impact. Cognitive behavioural therapy (CBT) is a recommended psychological therapy for GAD; however, there are substantial barriers to accessing treatment. Digital CBT, in particular smartphone-del...

journal_title：Trials

authors： Gu J,Miller CB,Henry AL,Espie CA,Davis ML,Stott R,Emsley R,Smits JAJ,Craske M,Saunders KEA,Goodwin G,Carl JR

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:In a sham-controlled double-blind trial, we aim to establish the efficacy and safety of the local application of laser therapy in patients with diabetes, onychomycosis and risk factors for diabetes-related foot complications. Onychomycosis leads to thickened and distorted nails, which in turn lead to increas...

journal_title：Trials

authors： Nijenhuis-Rosien L,Kleefstra N,Wolfhagen MJ,Groenier KH,Bilo HJ,Landman GW

更新日期：2015-03-22 00:00:00

abstract：BACKGROUND:Anxiety and affective disorders can be disabling and have a major impact on the ability to work. In Denmark, people with a mental disorder, and mainly non-psychotic disorders, represent a substantial and increasing part of those receiving disability pensions. Previous studies have indicated that Individual P...

journal_title：Trials

authors： Hellström L,Bech P,Nordentoft M,Lindschou J,Eplov LF

更新日期：2013-12-24 00:00:00

abstract：BACKGROUND:The incidence of cancer has been staying at a high level worldwide in recent years. With advances in cancer diagnosis and therapy strategy, the survival rate of patients with cancer has been increasing, but the side effects of these treatments, especially chemotherapy, are obvious even when the chemotherapy ...

journal_title：Trials

authors： You JS,Chen JP,Chan JS,Lee HF,Wong MK,Yeung WF,Lao LX

更新日期：2016-07-26 00:00:00

abstract：BACKGROUND:Diabetes mellitus is associated with risk of sudden sensorineural hearing loss (SSNHL). Systemic and intratympanic corticosteroids are the two primary treatments for SSNHL in patients with diabetes mellitus. The benefit of intratympanic compared to systemic treatment is the reduced systemic steroid exposure ...

journal_title：Trials

authors： Yang W,Li X,Zhong J,Mei X,Liu H,Yang L,Lu L,Hu H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Burst stimulation is a novel form of neurostimulation for the treatment of chronic pain which has demonstrated promise in small uncontrolled studies, but has not yet gained approval for use in the U.S. We report the study methods for an ongoing multicenter, randomized, controlled, cross-over study designed t...

journal_title：Trials

authors： Slavin KV,North RB,Deer TR,Staats P,Davis K,Diaz R

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:The physical and mental health of college students tends to continuously decline around the world. Since they are in a significant transition period which presents opportunities and challenges in health promotion, it is important to improve their health in this period. As a traditional Chinese exercise form ...

journal_title：Trials

authors： Zheng G,Li M,Lan X,Yan X,Lin Q,Chen L,Tao J,Zheng X,Li J,Chen B,Fang Q

更新日期：2013-12-05 00:00:00

abstract：BACKGROUND:Currently, there still is no treatment that eliminates tinnitus in all patients. Recent studies have shown that Tinnitus Retraining Therapy (TRT) significantly improves quality of life for tinnitus patients. Also, several studies have reported that transcranial Direct Current Stimulation (tDCS) has a positiv...

journal_title：Trials

authors： Rabau S,Van Rompaey V,Van de Heyning P

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:In coronary artery bypass grafting surgery, arterial conduits are preferred because of more favourable long-term patency and outcome. Anyway the greater saphenous vein continues to be the most commonly used bypass conduit. Minimally invasive endoscopic saphenous vein harvesting is increasingly being investig...

journal_title：Trials

authors： Campanella A,Bergamasco L,Macri L,Asioli S,Devotini R,Scipioni S,Barbaro S,Rispoli P,Rinaldi M

更新日期：2011-11-18 00:00:00

abstract：BACKGROUND:Cardiovascular diseases are the major cause of death in the world. Current treatments have not been able to reverse this scenario, creating the need for the development of new therapies. Cell therapies have emerged as an alternative for cardiac diseases of distinct causes in experimental animal studies and m...

journal_title：Trials

authors： Tura BR,Martino HF,Gowdak LH,dos Santos RR,Dohmann HF,Krieger JE,Feitosa G,Vilas-Boas F,Oliveira SA,Silva SA,Bozza AZ,Borojevic R,de Carvalho AC

更新日期：2007-01-18 00:00:00

abstract：BACKGROUND:Low mood is a common mental health problem with significant health consequences. Studies have shown that cognitive behavioural therapy (CBT) is an effective treatment for low mood and anxiety when delivered one-to-one by an expert practitioner. However, access to this talking therapy is often limited and wai...

journal_title：Trials

authors： Williams C,McClay CA,Martinez R,Morrison J,Haig C,Jones R,Farrand P

更新日期：2016-04-27 00:00:00

abstract：BACKGROUND:Co-infection with malaria parasite and HIV is an emerging public health problem in tropical areas, particularly in pregnant women, and management of the concurrent effects of these two infections is challenging. Co-trimoxazole is a sulfamide preparation used to prevent opportunistic infections in HIV-infecte...

journal_title：Trials

authors： Manirakiza A,Sepou A,Serdouma E,Gondje S,Bata GG,Moussa S,Boulay A,Moyen JM,Sakanga O,Le-Fouler L,Kazanji M,Vray M

更新日期：2013-08-14 00:00:00

abstract：BACKGROUND:Intellectual disability (ID) is characterized by limitations in intellectual functioning and adaptive behavior. Adults with ID exhibit higher rates of obesity and poorer health status compared to the general population. Continuity of care and barriers to health-related activities may contribute to the poorer...

journal_title：Trials

authors： Neumeier WH,Guerra N,Thirumalai M,Geer B,Ervin D,Rimmer JH

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Immunologic derangement may be the critical pathophysiologic mechanism in sepsis, and immunotherapy might be a potential new treatment. Si-ni-tang (SNT), an ancient Chinese herbal formula documented in Shanghan Lun, has been used for treating severe sepsis for thousands of years. Research shows that it may h...

journal_title：Trials

authors： Zeng R,Zheng Y,Fan R,Zhou G,Zhang Y,Mai S,Xie D,Weng Y,Du J,Han Y,Lai F

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:Muscle glycogen has been well established as the primary metabolic energy substrate during physical exercise of moderate- to high-intensity and has accordingly been implicated as a limiting factor when such activity is sustained for a prolonged duration. However, the role of this substrate during repeated ex...

journal_title：Trials

authors： Alghannam AF,Tsintzas K,Thompson D,Bilzon J,Betts JA

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:Acupuncture has been widely applied in the clinic to treat irritable bowel syndrome (IBS), but the underlying mechanism remains unknown. Diffuse noxious inhibitory control (DNIC) is deficient in patients with IBS, which attenuates the systemic analgesic effect elicited by noxious stimulation that is remote f...

journal_title：Trials

authors： Peng Y,You H,Chen X,Chen Y,Yang Y,Huang J,Xu N,Liu J

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Chronic nonspecific low back pain (CNSLBP) troubles approximately 30% of people worldwide. Silver needle therapy (SNT) is a treatment method to relieve soft tissue pain through heating. Therefore, this study aimed to observe the effects of SNT on CNSLBP. METHODS:In this study, 100 patients were randomly div...

journal_title：Trials

authors： Hu X,Dong S,Zhang B,Wang X,Yin Y,Liu C,Yu J,Wu X,Xu F,Meng C

更新日期：2021-01-21 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a common cause of pain and disability. Currently available analgesics are often insufficiently effective or have unacceptable adverse effects. Tricyclic antidepressants may offer a useful centrally-acting analgesic. Nortriptyline is a readily-available, cheap and comparatively well-tol...

journal_title：Trials

authors： Hudson B,Williman JA,Stamp LK,Alchin JS,Hooper GJ,Mangin D,Thompson BF,Toop L

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:Patients taking opioids are known to develop opioid-induced constipation (OIC), which reduces their quality of life. The aim of this study is to compare magnesium oxide with naldemedine and determine which is more effective in preventing OIC. METHODS:This proof-of-concept, prospective, randomized controlled...

journal_title：Trials

authors： Ozaki A,Kessoku T,Iwaki M,Kobayashi T,Yoshihara T,Kato T,Honda Y,Ogawa Y,Imajo K,Higurashi T,Yoneda M,Taguri M,Yamanaka T,Ishiki H,Kobayashi N,Saito S,Ichikawa Y,Nakajima A

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) is one of the most common types of the cardiovascular disease. Previous pilot trials have suggested that Traditional Chinese Medicine (TCM) has brought clinical benefits for patients with CAD. We will conduct this trial to determine the efficacy and safety of Shenzhu Guanxin Rec...

journal_title：Trials

authors： Jin X,Pan B,Wu H,Wu B,Li Y,Wang X,Liu G,Dang X,Xu D

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy (CIN) is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal insufficiency. Although some agents including hydration with saline are being prescribed to prevent renal deterioration in these high risk patients, ...

journal_title：Trials

authors： Park K,Chung WY,Seo JB,Kim SH,Zo JH,Kim MA,Park YB

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:Lower urinary tract symptoms (LUTS) can relate to urinary storage or voiding. In men, the prevalence and severity of LUTS increases with age, with a significant impact on quality of life. The majority of men presenting with LUTS are managed by their general practitioner (GP) in the first instance, with conse...

journal_title：Trials

authors： Frost J,Lane JA,Cotterill N,Fader M,Hackshaw-McGeagh L,Hashim H,Macaulay M,MacNeill SJ,Noble S,Rees J,Ridd MJ,Robles L,Taylor G,Taylor J,Drake MJ,Worthington J

更新日期：2019-09-02 00:00:00

abstract：BACKGROUND:Despite long-standing problems in decisions to stop clinical trials, stopping guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assist the data monitoring committees for effectiveness trials. MAIN TEXT:To specify better stopping gui...

journal_title：Trials

authors： Tyson JE,Pedroza C,Wallace D,D'Angio C,Bell EF,Das A

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:Despite recent advances in the medical and surgical fields, complications such as infection, pneumonia, or brain swelling may occur after a craniotomy. In some patients, perioperative antibiotic prophylaxis causes adverse effects such as itching, rash, or digestive conditions. Certain patients still develop ...

journal_title：Trials

authors： Cho SY,Yang SB,Shin HS,Lee SH,Koh JS,Kwon S,Jung WS,Moon SK,Park JM,Ko CN,Park SU

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:The application of neuroendoscopy in intraventricular hemorrhage (IVH) has attracted more and more attention in recent years. Studies have shown that the use of neuroendoscopy for IVH evacuation has advantages over external ventricular drainage (EVD) alone. However, the cases of most current research are sma...

journal_title：Trials

authors： Zhu J,Tang C,Cong Z,Yang J,Cai X,Liu Y,Ma C

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD). METHODS:We systematically reviewed n...

journal_title：Trials

authors： Jawad S,Modi N,Prevost AT,Gale C

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:The Northwestern University Center for Education and Research on Therapeutics (CERT), funded by the Agency for Healthcare Research and Quality, is one of seven such centers in the USA. The thematic focus of the Northwestern CERT is 'Tools for Optimizing Medication Safety.' Ensuring drug safety is essential, ...

journal_title：Trials

authors： Przytula K,Bailey SC,Galanter WL,Lambert BL,Shrestha N,Dickens C,Falck S,Wolf MS

更新日期：2015-01-27 00:00:00