Exploring mechanisms of fatigue during repeated exercise and the dose dependent effects of carbohydrate and protein ingestion: study protocol for a randomised controlled trial.

abstract：BACKGROUND:A variety of videolaryngoscopes with angulated blade have been recently introduced into clinical practice. They provide an indirect view of the glottic structures in normal and challenging clinical settings. Despite the very good visualization of the laryngeal structures by these devices, the insertion and a...

journal_title：Trials

authors： Al-Qasmi A,Al-Alawi W,Malik AM,Khan RM,Kaul N

更新日期：2013-09-16 00:00:00

abstract：BACKGROUND:Adolescent idiopathic scoliosis (AIS) is one of the most prevalent spinal deformities that may progress sharply during growth. The aim of this study will be to evaluate the efficacy of three-dimensionally integrated exercise on the Cobb angle, angle of trunk rotation, sagittal profile, and quality of life in...

journal_title：Trials

authors： Liang J,Zhou X,Chen N,Li X,Yu H,Yang Y,Song Y,Du Q

更新日期：2018-09-10 00:00:00

abstract：UNLABELLED:Screening physical activity levels is common in trials to increase physical activity in inactive populations. Commonly applied single-item screening tools might not always be effective in identifying those who are inactive. We applied the more extensive Active Australia Survey to identify inactive people amo...

journal_title：Trials

authors： Vandelanotte C,Stanton R,Rebar AL,Van Itallie AK,Caperchione CM,Duncan MJ,Savage TN,Rosenkranz RR,Kolt GS

更新日期：2015-10-08 00:00:00

abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mortality. The limitations of vancomycin, the current standard therapy for MRSA, make treatment difficult. The only other approved drug for treatment of MRSA bacteraemia, daptomycin, has not been...

journal_title：Trials

authors： Tong SY,Nelson J,Paterson DL,Fowler VG Jr,Howden BP,Cheng AC,Chatfield M,Lipman J,Van Hal S,O'Sullivan M,Robinson JO,Yahav D,Lye D,Davis JS,CAMERA2 study group and the Australasian Society for Infectious Diseases Clinical Res

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Active surveillance (AS) is the disease management option of choice for low-risk prostate cancer. Despite this, men with low-risk prostate cancer (LRPC) find management decisions distressing and confusing. We developed Navigate, an online decision aid to help men and their partners make management decisions ...

journal_title：Trials

authors： Schofield P,Gough K,Hyatt A,White A,Frydenberg M,Chambers S,Gordon LG,Gardiner R,Murphy DG,Cavedon L,Richards N,Murphy B,Quinn S,Juraskova I

更新日期：2021-01-11 00:00:00

abstract：OBJECTIVES:Primary Objective • To assess the efficacy of herbal extracts in boosting innate immunity of patients with COVID-19 infection. Secondary Objectives • To assess the efficacy of herbal extracts in restoring respiratory health • To assess the efficacy of Cap. IP in early recovery of patients and decline in vira...

journal_title：Trials

authors： Rangnekar H,Patankar S,Suryawanshi K,Soni P

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:This study protocol evaluates the effectiveness of adjuvant electroacupuncture (EA) for urinary retention in poststroke patients undergoing conventional treatments, in comparison with that of a sham control. METHODS/DESIGN:A multicenter, blinded, randomized controlled trial will be conducted in three hospit...

journal_title：Trials

authors： Shin S,Lee J,Yoo J,Lim SM,Lee E

更新日期：2016-04-12 00:00:00

abstract：BACKGROUND:The logrank test is routinely applied to design and analyse randomized controlled trials (RCTs) with time-to-event outcomes. Sample size and power calculations assume the treatment effect follows proportional hazards (PH). If the PH assumption is false, power is reduced and interpretation of the hazard ratio...

journal_title：Trials

authors： Royston P,B Parmar MK

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Current management for men with lower urinary tract symptoms (LUTS) is a pathway that results in prostate surgery in a significant proportion. While helpful in relieving benign prostatic obstruction (BPO), surgery may be ineffective for men suffering from difficulties not relating to BPO. The UPSTREAM trial ...

journal_title：Trials

authors： Young GJ,Lewis AL,Lane JA,Winton HL,Drake MJ,Blair PS

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Tackling neonatal mortality is essential for the achievement of the child survival millennium development goal. There are just under 4 million neonatal deaths, accounting for 38% of the 10.8 million deaths among children younger than 5 years of age taking place each year; 99% of these occur in low- and middl...

journal_title：Trials

authors： Kirkwood BR,Manu A,Tawiah-Agyemang C,ten Asbroek G,Gyan T,Weobong B,Lewandowski RE,Soremekun S,Danso S,Pitt C,Hanson K,Owusu-Agyei S,Hill Z

更新日期：2010-05-17 00:00:00

abstract：BACKGROUND:Research has shown that recruitment to trials is a process that stretches from identifying potentially eligible patients, through eligibility assessment, to obtaining informed consent. The length and complexity of this pathway means that many patients do not have the opportunity to consider participation. Th...

journal_title：Trials

authors： Wilson C,Rooshenas L,Paramasivan S,Elliott D,Jepson M,Strong S,Birtle A,Beard DJ,Halliday A,Hamdy FC,Lewis R,Metcalfe C,Rogers CA,Stein RC,Blazeby JM,Donovan JL

更新日期：2018-01-19 00:00:00

abstract：BACKGROUND:Attrition is problematic in trials, and may be exacerbated in longer studies, telehealth trials and participants with depression - three features of The Healthlines Study. Advance notification, including a photograph and using action-oriented email subject lines might increase response rates, but require fur...

journal_title：Trials

authors： Edwards L,Salisbury C,Horspool K,Foster A,Garner K,Montgomery AA

更新日期：2016-02-24 00:00:00

abstract：BACKGROUND:Knee osteoarthritis (KOA) is one of the most common bone and joint diseases. As one of the main non-drug therapies, acupuncture is widely used to treat KOA, although the evidence for its efficacy is inconclusive. The objective of this pilot trial is to clarify the clinical efficacy and safety of fire acupunc...

journal_title：Trials

authors： Fu YB,Li B,Sun SF,Liu HL,Wang X,Wang SS,Zhang F,Du X,Ge DJ,Shang L,Liang RL,Wang LN,Yuan F,Sun JQ,Chen JW

更新日期：2019-12-04 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease lowers the quality of life and increases medical costs. Electroacupuncture has been used to ease symptoms and improve gastrointestinal motility in patients with gastroesophageal reflux disease. The main purposes of this study are to evaluate the efficacy and safety of this pro...

journal_title：Trials

authors： Han G,Leem J,Lee H,Lee J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:Young men in South Africa face concurrent epidemics of HIV, drug and alcohol abuse, and unemployment. Standard HIV prevention programs, located in healthcare settings and/or using counseling models, fail to engage men. Soccer and vocational training are examined as contexts to deliver male-specific, HIV prev...

journal_title：Trials

authors： Rotheram-Borus MJ,Tomlinson M,Mayekiso A,Bantjes J,Harris DM,Stewart J,Weiss RE

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:Basal cell carcinoma is the most common skin cancer worldwide. Treatment options include both surgical and topical modalities. Although risk of metastasis is low, basal cell carcinoma can be invasive and infiltrate important underlying structures such as bone or cartilage. While many clinical trials examinin...

journal_title：Trials

authors： Schlessinger DI,Iyengar S,Yanes AF,Lazaroff JM,Godinez-Puig V,Chen BR,Kurta AO,Henley JK,Chiren SG,Furlan KC,Schmitt J,Deckert S,Poon E,Sobanko JF,Cartee TV,Alam M,Maher IA

更新日期：2017-10-23 00:00:00

abstract：OBJECTIVES:To assess the effect of prone positioning therapy on intubation rate in awake patients with COVID-19 and acute respiratory failure. TRIAL DESIGN:This is a two-center parallel group, superiority, randomized (1:1 allocation ratio) controlled trial. PARTICIPANTS:All patients admitted to the Hospital Civil de ...

journal_title：Trials

authors： Ibarra-Estrada MÁ,Marín-Rosales M,García-Salcido R,Aguirre-Díaz SA,Vargas-Obieta A,Chávez-Peña Q,López-Pulgarín JA,Mijangos-Méndez JC,Aguirre-Avalos G

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on...

journal_title：Trials

authors： Bluth T,Teichmann R,Kiss T,Bobek I,Canet J,Cinnella G,De Baerdemaeker L,Gregoretti C,Hedenstierna G,Hemmes SN,Hiesmayr M,Hollmann MW,Jaber S,Laffey JG,Licker MJ,Markstaller K,Matot I,Müller G,Mills GH,Mulier JP,Pu

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual...

journal_title：Trials

authors： Hvenegaard M,Watkins ER,Poulsen S,Rosenberg NK,Gondan M,Grafton B,Austin SF,Howard H,Moeller SB

更新日期：2015-08-11 00:00:00

abstract：BACKGROUND:Periprosthetic joint infection (PJI) affects approximately 1% of patients following total hip replacement (THR) and often results in severe physical and emotional suffering. Current surgical treatment options are debridement, antibiotics and implant retention; revision THR; excision of the joint and amputati...

journal_title：Trials

authors： Strange S,Whitehouse MR,Beswick AD,Board T,Burston A,Burston B,Carroll FE,Dieppe P,Garfield K,Gooberman-Hill R,Jones S,Kunutsor S,Lane A,Lenguerrand E,MacGowan A,Moore A,Noble S,Simon J,Stockley I,Taylor AH,Toms A

更新日期：2016-02-17 00:00:00

abstract：BACKGROUND:In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to cease their drug use. The most commonly used detoxification agents in UK prisons are buprenorphine, ...

journal_title：Trials

authors： Sheard L,Adams CE,Wright NM,El-Sayeh H,Dalton R,Tompkins CN

更新日期：2007-01-08 00:00:00

abstract：BACKGROUND:Coronary artery disease is the leading cause of morbidity and mortality in patients with type 2 diabetes. Screening for asymptomatic coronary artery disease with treatment by means of revascularization seems to be an appealing option for prevention. The utility of such a strategy has never been challenged in...

journal_title：Trials

authors： Turrini F,Messora R,Giovanardi P,Tondi S,Magnavacchi P,Cavani R,Tosoni G,Cappelli C,Pellegrini E,Romano S,Baldini A,Zennaro RG,Bondi M

更新日期：2009-12-23 00:00:00

abstract：OBJECTIVES:To assess the impact of adding statin (atorvastatin) and/or aspirin on clinical deterioration in patients infected with SARS-CoV-2 who require hospitalisation. The safety of these drugs in COVID-19 patients will also be evaluated. TRIAL DESIGN:This is a single-centre, prospective, four-arm parallel design, ...

journal_title：Trials

authors： Ghati N,Roy A,Bhatnagar S,Bhati S,Bhushan S,Mahendran M,Thakur A,Tiwari P,Dwivedi T,Mani K,Gupta R,Mohan A,Garg R,Saxena A,Guleria R,Deepti S

更新日期：2020-10-30 00:00:00

abstract：BACKGROUND:Bone graft substitutes are widely used for reconstruction of posttraumatic bone defects. However, their clinical significance in comparison to autologous bone grafting, the gold-standard in reconstruction of larger bone defects, still remains under debate. This prospective, randomized, controlled clinical st...

journal_title：Trials

authors： Nusselt T,Hofmann A,Wachtlin D,Gorbulev S,Rommens PM

更新日期：2014-03-08 00:00:00

abstract：BACKGROUND:Disinvestment from inefficient or ineffective health services is a growing priority for health care systems. Provision of allied health services over the weekend is now commonplace despite a relative paucity of evidence supporting their provision. The relatively high cost of providing this service combined w...

journal_title：Trials

authors： Haines TP,O'Brien L,Mitchell D,Bowles KA,Haas R,Markham D,Plumb S,Chiu T,May K,Philip K,Lescai D,McDermott F,Sarkies M,Ghaly M,Shaw L,Juj G,Skinner EH

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Heart valve diseases are common with an estimated prevalence of 2.5% in the Western world. The number is rising due to an ageing population. Once symptomatic, heart valve diseases are potentially lethal, and heavily influence daily living and quality of life. Surgical treatment, either valve replacement or r...

journal_title：Trials

authors： Sibilitz KL,Berg SK,Hansen TB,Risom SS,Rasmussen TB,Hassager C,Køber L,Steinbrüchel D,Gluud C,Winkel P,Thygesen LC,Hansen JL,Schmid JP,Conraads V,Brocki BC,Zwisler AD

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:Renal transplantation represents the treatment of choice of end-stage kidney disease. Delayed graft function (DGF) remains the most frequent complication after this procedure, reaching more than 30%. Its prevention is essential as it impedes early- and long-term prognosis of transplantation. Numerous pharmac...

journal_title：Trials

authors： Orban JC,Fontaine E,Cassuto E,Baumstarck K,Leone M,Constantin JM,Ichai C,AzuRéa network.

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) are frequent after on-pump cardiac surgery. Cardiac surgery results in a complex pulmonary insult leading to high susceptibility to perioperative pulmonary atelectasis. For technical reasons, ventilator settings interact with the surgical procedure and traditional...

journal_title：Trials

authors： Lagier D,Fischer F,Fornier W,Fellahi JL,Colson P,Cholley B,Jaber S,Baumstarck K,Guidon C,PROVECS investigators and the ARCOTHOVA group.

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Hand-assisted laparoscopic living donor nephrectomy (HALDN) using a periumbilical or Pfannenstiel incision was developed to improve donor outcome after a kidney transplant. The aim of this study was to investigate two methods of hand assistance and kidney removal during HALDN and their effect on the time it ...

journal_title：Trials

authors： Kulu Y,Müller-Stich BP,Ghamarnejad O,Khajeh E,Polychronidis G,Golriz M,Nickel F,Benner L,Knebel P,Diener M,Morath C,Zeier M,Büchler MW,Mehrabi A

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a degenerative component, leading to irreversible disability. Mesenchymal stem cells (MSC) have been shown to prevent inflammation and neurodegeneration in animal models of MS, but no large phase II clinical trials have yet...

journal_title：Trials

authors： Uccelli A,Laroni A,Brundin L,Clanet M,Fernandez O,Nabavi SM,Muraro PA,Oliveri RS,Radue EW,Sellner J,Soelberg Sorensen P,Sormani MP,Wuerfel JT,Battaglia MA,Freedman MS,MESEMS study group.

更新日期：2019-05-09 00:00:00