MEsenchymal StEm cells for Multiple Sclerosis (MESEMS): a randomized, double blind, cross-over phase I/II clinical trial with autologous mesenchymal stem cells for the therapy of multiple sclerosis.

abstract：BACKGROUND:Computed tomography is widely used to diagnose acute appendicitis. Many adolescents and young adults are exposed to the associated radiation. A recent single-institution trial has reported promising results for low-dose computed tomography; however, this technique has not yet been widely adopted. LOCAT (low-...

journal_title：Trials

authors： Ahn S,LOCAT group.

更新日期：2014-01-17 00:00:00

abstract：BACKGROUND:Linezolid, an oxazolidinone, substantially improves treatment outcomes of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We started a trial to test whether the use of linezolid instead of ethambutol could increase the rate of sputum culture conversion as of 8 weeks of treatment...

journal_title：Trials

authors： Lee JY,Kim DK,Lee JK,Yoon HI,Jeong I,Heo E,Park YS,Lee JH,Park SS,Lee SM,Lee CH,Lee J,Choi SM,Park JS,Joh JS,Cho YJ,Lee YJ,Kim SJ,Hwang YR,Kim H,Ki J,Choi H,Han J,Ahn H,Hahn S,Yim JJ

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Burst stimulation is a novel form of neurostimulation for the treatment of chronic pain which has demonstrated promise in small uncontrolled studies, but has not yet gained approval for use in the U.S. We report the study methods for an ongoing multicenter, randomized, controlled, cross-over study designed t...

journal_title：Trials

authors： Slavin KV,North RB,Deer TR,Staats P,Davis K,Diaz R

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Necrotizing enterocolitis (NEC) is the leading cause of death among preterm infants born at < 30 weeks' gestation. The incidence of NEC is reduced when infants are fed human milk. However, in many neonatal intensive care units (NICUs), it is standard practice to freeze and/or pasteurize human milk, which dea...

journal_title：Trials

authors： Sun H,Cao Y,Han S,Cheng R,Liu L,Liu J,Xia S,Zhang J,Li Z,Cheng X,Yang C,Pan X,Li L,Ding X,Wang R,Wu M,Li X,Shi L,Xu F,Yu F,Pan J,Zhang X,Li L,Yang J,Li M,Yan C,Zhou Q,Lu J,Wei M,Wang L,Yang L,

更新日期：2020-02-11 00:00:00

abstract：BACKGROUND:Cognitive behaviour therapy (CBT) is an effective treatment for depression. However, CBT is a complex therapy that requires highly trained and qualified practitioners, and its scalability is therefore limited by the costs of training and employing sufficient therapists to meet demand. Behavioural activation ...

journal_title：Trials

authors： Rhodes S,Richards DA,Ekers D,McMillan D,Byford S,Farrand PA,Gilbody S,Hollon SD,Kuyken W,Martell C,O'Mahen HA,O'Neill E,Reed N,Taylor RS,Watkins ER,Wright KA

更新日期：2014-01-21 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease lowers the quality of life and increases medical costs. Electroacupuncture has been used to ease symptoms and improve gastrointestinal motility in patients with gastroesophageal reflux disease. The main purposes of this study are to evaluate the efficacy and safety of this pro...

journal_title：Trials

authors： Han G,Leem J,Lee H,Lee J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:The perimenopausal period refers to the interval when women's menstrual cycles become irregular and is characterized by an increased risk of depressive symptoms. Use of homeopathy to treat depression is widespread but there is a lack of clinical trials about its efficacy in depression in peri- and postmenopa...

journal_title：Trials

authors： Macías-Cortés Edel C,Aguilar-Faisal L,Asbun-Bojalil J

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:As intensive care mortality is high, end of life is a subject of major concern for intensivists. In this context, relatives are particularly vulnerable and prone to post-ICU syndrome, in the form of high levels of anxiety, depression, post-traumatic stress, and complicated grief. Grieving families suffer fro...

journal_title：Trials

authors： Kentish-Barnes N,Chevret S,Azoulay E

更新日期：2016-02-20 00:00:00

abstract：BACKGROUND:The oversight and conduct of a randomised controlled trial involves several stakeholders, including a Trial Steering Committee (TSC), Trial Management Group (TMG), Data Monitoring Committee (DMC), funder and sponsor. We aimed to examine how the relationships between these stakeholders affect the trial oversi...

journal_title：Trials

authors： Daykin A,Selman LE,Cramer H,McCann S,Shorter GW,Sydes MR,Gamble C,Macefield R,Lane JA,Shaw A

更新日期：2017-12-22 00:00:00

abstract：BACKGROUND:Tobacco smoking remains the leading preventable cause of death in the US. A hospital admission provides smokers with a unique opportunity to stop smoking because it requires temporary tobacco abstinence while illness may enhance motivation to quit. Hospital interventions must continue post-discharge to incre...

journal_title：Trials

authors： Rigotti NA,Schnitzer K,Davis EM,Regan S,Chang Y,Kelley JHK,Notier AE,Gilliam K,Douaihy A,Levy DE,Singer DE,Tindle HA

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) has become a common cardiovascular disease that seriously threatens the health of people. As reperfusion in the early phase and drug therapy, especially percutaneous coronary intervention (PCI), have become widely used in the clinic, the mortality of acute myocardial infarction i...

journal_title：Trials

authors： Wang Y,Wang X,Wang J,Li B,Yu R,Hu Y,Li X,Peng G,Zhang M,Zhu M

更新日期：2020-03-20 00:00:00

abstract：BACKGROUND:Tetramethylpyrazine (TMP), an active ingredient in the traditional Chinese herbal medicine Rhizoma Chuanxiong, has been used clinically for the prevention and treatment of cardiovascular disease. The benefits of TMP are largely attributed to its anti-oxidative and vasodilative properties. However, the effica...

journal_title：Trials

authors： Chen Y,He W,Ouyang H,Liu C,Hong C,Wang T,Yang K,Lu W,Wang J

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:The effect of pregabalin on acute herpes zoster pain has not been previously evaluated. METHODS:In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster. RESULT...

journal_title：Trials

authors： Jensen-Dahm C,Rowbotham MC,Reda H,Petersen KL

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:The ACTION study (Attention deficit hyperactivity disorder Controlled Trial Investigation Of a Non-stimulant) is a multi-center, double-blind, randomized cross-over trial of the non-stimulant medication, Atomoxetine, in children and adolescents with attention deficit hyperactivity disorder (ADHD). The primar...

journal_title：Trials

authors： Tsang TW,Kohn MR,Hermens DF,Clarke SD,Clark CR,Efron D,Cranswick N,Lamb C,Williams LM

更新日期：2011-03-13 00:00:00

abstract：:International calls for registering all trials involving humans and for sharing the results, and sometimes also the raw data and the trial protocols, have increased in recent years. Such calls have come, for example, from the Organization for Economic Cooperation and Development (OECD), the World Health Organization (...

journal_title：Trials

authors： Gøtzsche PC

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Practicing activities improves recovery after stroke, but many people in hospital do little activity. Feedback on activity using an accelerometer is a potential method to increase activity in hospital inpatients. This study's goal is to investigate the effect of feedback, enabled by a Smart watch, on daily p...

journal_title：Trials

authors： Dong Y,Steins D,Sun S,Li F,Amor JD,James CJ,Xia Z,Dawes H,Izadi H,Cao Y,Wade DT,Smart watch activity feedback trial committee (SWAFT).

更新日期：2018-03-09 00:00:00

abstract：BACKGROUND:This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals' foot health and quality of life. Based on the current trends of self-monitoring and self-care, provid...

journal_title：Trials

authors： Silva EQ,Suda EY,Santos DP,Veríssimo JL,Ferreira JSSP,Cruvinel Júnior RH,Monteiro RL,Sartor CD,Sacco ICN

更新日期：2020-02-13 00:00:00

abstract：:Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for individual patients, we propose a new RCT adaptation termed the nested-pr...

journal_title：Trials

authors： Kappelmann N,Müller-Myhsok B,Kopf-Beck J

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) are frequent after on-pump cardiac surgery. Cardiac surgery results in a complex pulmonary insult leading to high susceptibility to perioperative pulmonary atelectasis. For technical reasons, ventilator settings interact with the surgical procedure and traditional...

journal_title：Trials

authors： Lagier D,Fischer F,Fornier W,Fellahi JL,Colson P,Cholley B,Jaber S,Baumstarck K,Guidon C,PROVECS investigators and the ARCOTHOVA group.

更新日期：2018-11-13 00:00:00

abstract：BACKGROUND:Anxiety in children is common and incapacitating and increases the risk of mental health disorders in adulthood. Although effective interventions are available, few children are identified and referred for specialist treatment. Alternative approaches in which prevention programmes are delivered in school app...

journal_title：Trials

authors： Stallard P,Taylor G,Anderson R,Daniels H,Simpson N,Phillips R,Skryabina E

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:Attrition is problematic in trials, and may be exacerbated in longer studies, telehealth trials and participants with depression - three features of The Healthlines Study. Advance notification, including a photograph and using action-oriented email subject lines might increase response rates, but require fur...

journal_title：Trials

authors： Edwards L,Salisbury C,Horspool K,Foster A,Garner K,Montgomery AA

更新日期：2016-02-24 00:00:00

abstract：BACKGROUND:In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS:Based on a comprehe...

journal_title：Trials

authors： Hummers-Pradier E,Bleidorn J,Schmiemann G,Joos S,Becker A,Altiner A,Chenot JF,Scherer M,German ‘Clinical Trials in German General Practice Network’.

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Chronic subdural hematoma (cSDH) is one of the most common conditions encountered in neurosurgical practice. Recurrence, observed in 5-30% of patients, is a major clinical problem. The temperature of the irrigation fluid used during evacuation of the hematoma might theoretically influence recurrence rates si...

journal_title：Trials

authors： Bartley A,Jakola AS,Bartek J Jr,Sundblom J,Förander P,Marklund N,Tisell M

更新日期：2017-10-11 00:00:00

abstract：:Reviews have repeatedly noted important methodological issues in the conduct and reporting of cluster randomized controlled trials (C-RCTs). These reviews usually focus on whether the intracluster correlation was explicitly considered in the design and analysis of the C-RCT. However, another important aspect requiring...

journal_title：Trials

authors： Ivers NM,Halperin IJ,Barnsley J,Grimshaw JM,Shah BR,Tu K,Upshur R,Zwarenstein M

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on...

journal_title：Trials

authors： Bluth T,Teichmann R,Kiss T,Bobek I,Canet J,Cinnella G,De Baerdemaeker L,Gregoretti C,Hedenstierna G,Hemmes SN,Hiesmayr M,Hollmann MW,Jaber S,Laffey JG,Licker MJ,Markstaller K,Matot I,Müller G,Mills GH,Mulier JP,Pu

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the elders. It is also associated with several extra-articular symptoms (fatigue, sleep disorders, anxiety and depression) and a reduction of life quality. Studies...

journal_title：Trials

authors： Huang Z,Pan X,Deng W,Huang Z,Huang Y,Huang X,Zhu Z,Han W,Zheng S,Guo X,Ding C,Li T

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Cardiac surgery has been shown to result in a significant decrease of the antioxidant selenium, which is associated with the development of multiorgan dysfunction and increased mortality. Thus, a large-scale study is needed to investigate the effect of perioperative selenium supplementation on the occurrence...

journal_title：Trials

authors： Stoppe C,McDonald B,Rex S,Manzanares W,Whitlock R,Fremes S,Fowler R,Lamarche Y,Meybohm P,Haberthür C,Rossaint R,Goetzenich A,Elke G,Day A,Heyland DK

更新日期：2014-08-28 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a common disease, associated with cardiovascular disease. Many patients use (long-acting) bronchodilators, whilst they continue smoking alongside. We hypothesised an interaction between bronchodilators and smoking that enhances smoke exposure, and hence cardiov...

journal_title：Trials

authors： van Dijk WD,Scheepers PT,Cremers R,Lenders JW,Klerx W,van Weel C,Schermer TR,Heijdra Y

更新日期：2011-02-10 00:00:00

abstract：BACKGROUND:Quadriplegia is a severe, catastrophic injury that predominantly affects people early in life, resulting in lifelong physical disability. Obstructive sleep apnoea is a direct consequence of quadriplegia and is associated with neurocognitive deficits, sleepiness and reduced quality of life. The usual treatmen...

journal_title：Trials

authors： Berlowitz DJ,Ayas N,Barnes M,Brown DJ,Cistulli PA,Geraghty T,Graham A,Lee BB,Morris M,O'Donoghue F,Rochford PD,Ross J,Singhal B,Spong J,Wadsworth B,Pierce RJ

更新日期：2013-06-19 00:00:00

abstract：BACKGROUND:People with severe mental illness (SMI) are two to three times more likely to be overweight and obese than the general population and this is associated with significant morbidity and premature mortality. Although lifestyle interventions can support people with SMI to lose weight, some are unable to make the...

journal_title：Trials

authors： Whicher CA,Price HC,Phiri P,Rathod S,Barnard-Kelly K,Reidy C,Thorne K,Asher C,Peveler R,McCarthy J,Holt RIG

更新日期：2019-11-20 00:00:00