Electroacupuncture to treat gastroesophageal reflux disease: study protocol for a randomized controlled trial.

abstract：BACKGROUND:Multiple sclerosis (MS) is a chronic, degenerative disease of the central nervous system. Because of the long-term and unpredictable nature of the disease, the burden of MS is significant from both a patient and societal perspective. Despite a recent influx of disease-modifying therapies to treat MS, many in...

journal_title：Trials

authors： Goulding FL,Evans CD,Knox KB,Lim HJ,Levin MC,Donkers SJ

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:The management of patients with angiographically intermediate coronary lesions is a major clinical issue. Fractional flow reserve provides validated functional insights while optical coherence tomography provides high resolution anatomic imaging. Both techniques may be applied to guide management in case of ...

journal_title：Trials

authors： Burzotta F,Leone AM,De Maria GL,Niccoli G,Coluccia V,Pirozzolo G,Saffioti S,Aurigemma C,Trani C,Crea F

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is one of the leading chronic inflammatory rheumatism. First-line therapy with synthetic disease-modifying antirheumatic drugs (sDMARD) is insufficiently effective in 40% of cases and these patients are treated with biotherapies. The increased use of these drugs each year is becomin...

journal_title：Trials

authors： Freites-Núñez D,Baillet A,Rodriguez-Rodriguez L,Nguyen MVC,Gonzalez I,Pablos JL,Balsa A,Vazquez M,Gaudin P,Fernandez-Gutierrez B

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...

journal_title：Trials

authors： Leyenaar JK,McDaniel CE,Acquilano SC,Schaefer AP,Bruce ML,O'Malley AJ

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:State of the art sedation concepts on intensive care units (ICU) favor propofol for a time period of up to 72 h and midazolam for long-term sedation. However, intravenous sedation is associated with complications such as development of tolerance, insufficient sedation quality, gastrointestinal paralysis, and...

journal_title：Trials

authors： Soukup J,Selle A,Wienke A,Steighardt J,Wagner NM,Kellner P

更新日期：2012-08-10 00:00:00

abstract：:Following the South African case, Treatment Action Campaign and Others v Minister of Health and Others, the use of 'pilot' studies to investigate interventions already proven efficacious, offered free of charge to government, but confined by the government to a small part of the population, may violate children's righ...

journal_title：Trials

authors： Oduwo E,Edwards SJ

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:The German welfare system follows the principle "rehabilitation rather than pension," but more than the half of all disability pensioners did not utilize medical rehabilitation before their early retirement. A major barrier is the application procedure. Lack of information about the opportunity to utilize re...

journal_title：Trials

authors： Spanier K,Streibelt M,Ünalan F,Bethge M

更新日期：2015-09-29 00:00:00

abstract：BACKGROUND:Depression is not a normal side effect of aging, however it is one of the most prevalent mental health issues in later life, imposing a tremendous burden on patients, their families, and the healthcare system. We describe the experimental implementation of a collaborative, stepped-care model for the treatmen...

journal_title：Trials

authors： Wernher I,Bjerregaard F,Tinsel I,Bleich C,Boczor S,Kloppe T,Scherer M,Härter M,Niebling W,König HH,Hüll M

更新日期：2014-09-06 00:00:00

abstract：BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...

journal_title：Trials

authors： Oliveira CLP,Boulé NG,Sharma AM,Elliott S,Siervo M,Ghosh S,Berg A,Prado CM

更新日期：2019-12-27 00:00:00

abstract：:After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. ...

journal_title：Trials

authors： Langella LG,Silva PFC,Costa-Santos L,Gonçalves MLL,Motta LJ,Deana AM,Fernandes KPS,Mesquita-Ferrari RA,Bussadori SK

更新日期：2018-12-24 00:00:00

abstract：BACKGROUND:Randomised clinical trials are the 'gold standard' for evaluating the effectiveness of healthcare interventions. However, successful recruitment of participants remains a key challenge for many trialists. In this paper, we present a conceptual framework for creating a digital, population-based database for t...

journal_title：Trials

authors： Nwaru BI,Soyiri IN,Simpson CR,Griffiths C,Sheikh A

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:Patients affected by hepatic cirrhosis show reductions in muscle mass and function, with poor quality of life and functional performance. As such, resistance training with blood flow restriction (BFR-RT) could be a useful therapeutic tool for health promotion. Thus, we aim to verify the effects of this inter...

journal_title：Trials

authors： Nóbrega SR,Chachá SGF,Libardi CA

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Depression Care for People with Lung Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depression, which patients receive from their general practitioner and cancer service. The third Sympt...

journal_title：Trials

authors： Walker J,Cassidy J,Sharpe M,SMaRT Oncology-3 Trialists.

更新日期：2009-09-30 00:00:00

abstract：BACKGROUND:Loss of upper limb function affects up to 85 % of acute stroke patients. Recovery of upper limb function requires regular intensive practise of specific upper limb tasks. To enhance intensity of practice interventions are being developed to encourage patients to undertake self-directed exercise practice. Mos...

journal_title：Trials

authors： Moore SA,Da Silva R,Balaam M,Brkic L,Jackson D,Jamieson D,Ploetz T,Rodgers H,Shaw L,van Wijck F,Price C

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Obesity affects 25% of the UK adult population but modest weight loss can reduce the incidence of obesity-related chronic disease. Some effective weight loss treatments exist but there is no nationally available National Health Service (NHS) treatment service, and general practitioners (GPs) rarely discuss w...

journal_title：Trials

authors： Lewis A,Jolly K,Adab P,Daley A,Farley A,Jebb S,Lycett D,Clarke S,Christian A,Jin J,Thompson B,Aveyard P

更新日期：2013-11-19 00:00:00

abstract：BACKGROUND:Parkinson's Disease is a degenerative neurological condition that causes movement problems and other distressing symptoms. People with Parkinson's disease gradually lose their independence and strain is placed on family members. A multidisciplinary approach to rehabilitation for people with Parkinson's is re...

journal_title：Trials

authors： Gage H,Ting S,Williams P,Bryan K,Kaye J,Castleton B,Trend P,Wade D

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) remains a leading cause of maternal mortality worldwide. In Denmark 2% of parturients receive blood transfusion. During the course of bleeding fibrinogen (coagulation factor I) may be depleted and fall to critically low levels, impairing haemostasis and thus worsening the ongoing...

journal_title：Trials

authors： Wikkelsoe AJ,Afshari A,Stensballe J,Langhoff-Roos J,Albrechtsen C,Ekelund K,Hanke G,Sharif HF,Mitchell AU,Svare J,Troelstrup A,Pedersen LM,Lauenborg J,Madsen MG,Bødker B,Møller AM

更新日期：2012-07-17 00:00:00

abstract：BACKGROUND:It is reported that nursing is one of the most vulnerable jobs for developing depression. While they may not be clinically diagnosed as depressed, nurses often suffer from depression and anxiety symptoms, which can lead to a low level of patient care. However, there is no rigorous evidence base for determini...

journal_title：Trials

authors： Watanabe N,Furukawa TA,Horikoshi M,Katsuki F,Narisawa T,Kumachi M,Oe Y,Shinmei I,Noguchi H,Hamazaki K,Matsuoka Y

更新日期：2015-01-31 00:00:00

abstract：BACKGROUND:Delirium is a highly prevalent and morbid syndrome in intensive care units (ICUs). Changing the stressful environment within the ICU via music may be an effective and a scalable way to reduce the burden of delirium. METHODS/DESIGN:The Decreasing Delirium through Music (DDM) study is a three-arm, single-blin...

journal_title：Trials

authors： Khan SH,Wang S,Harrawood A,Martinez S,Heiderscheit A,Chlan L,Perkins AJ,Tu W,Boustani M,Khan B

更新日期：2017-11-29 00:00:00

abstract：BACKGROUND:The gap between the level of care recommended by evidence-based clinical practice guidelines and the actual care delivered to patients in practice has been well established. The Canadian Diabetes Association (CDA) created an implementation strategy to improve the implementation of its 2008 guidelines. This s...

journal_title：Trials

authors： Shah BR,Bhattacharyya O,Yu C,Mamdani M,Parsons JA,Straus SE,Zwarenstein M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a major health problem in modern society, with 70-85% of the population experiencing LBP at some time in their lives. Each year, 5-10% of the workforce misses work due to LBP, most for less than 7 days. Almost 10% of all patients are at risk of developing chronic pain and disability. L...

journal_title：Trials

authors： Buselli P,Bosoni R,Busè G,Fasoli P,La Scala E,Mazzolari R,Zanetti F,Messina S

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:Low back pain is a common, disabling musculoskeletal disorder in both developing and developed countries. Although often recommended, the potential efficacy of massage therapy in general, and Chinese massage (tuina) in particular, for relief of chronic low back pain (CLBP) has not been fully established due ...

journal_title：Trials

authors： Yang M,Feng Y,Pei H,Deng S,Wang M,Xiao X,Zheng H,Lai Z,Chen J,Li X,He X,Liang F

更新日期：2014-10-29 00:00:00

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:There are marked disparities between pre-school children in key skills affecting school readiness, disparities that commonly persist and influence children's later academic achievements, employment, and adjustment. Much of this disparity is linked to socio-economic disadvantage and its impact on the home lea...

journal_title：Trials

authors： Murray L,Jennings S,Mortimer A,Prout A,Melhuish E,Hughes C,Duncan J,Holmes J,Dishington C,Cooper PJ

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:There is an urgent need for clinically effective and cost-effective methods to manage antisocial and criminal behaviour in adolescents. Youth conduct disorder is increasingly prevalent in the UK and is associated with a range of negative outcomes. Quantitative systematic reviews carried out for the National ...

journal_title：Trials

authors： Fonagy P,Butler S,Goodyer I,Cottrell D,Scott S,Pilling S,Eisler I,Fuggle P,Kraam A,Byford S,Wason J,Haley R

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND/AIMS:Prediabetes and diabetes disproportionately impact Latino youth, yet few diabetes prevention programs have prioritized inclusion of this underrepresented population. This report describes the recruitment process, yields, associated costs, and phenotypic characteristics of Latino youth with obesity and p...

journal_title：Trials

authors： Vander Wyst KB,Olson ML,Hooker E,Soltero EG,Konopken YP,Keller CS,Castro FG,Williams AN,Fernández ADR,Patrick DL,Ayers SL,Hu HH,Peña A,Pimentel J,Knowler WC,Shaibi GQ

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist....

journal_title：Trials

authors： Lluch-Girbés E,Dueñas L,Mena-Del Horno S,Luque-Suarez A,Navarro-Ledesma S,Louw A

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Recent clinical observations have reported the potential benefit of vagus nerve stimulation (VNS) as an adjunctive therapy for pediatric epilepsy. Preliminary evidence suggests that VNS treatment is effective for seizure reduction and mental development in young participants between 3 and 6 years of age who ...

journal_title：Trials

authors： Ji T,Yang Z,Liu Q,Liao J,Yin F,Chen Y,Zou L,Li B,Gao Y,Shu X,Huang S,Gao F,Liang J,Lin SF,Peng J,Song S,Wang J,Che C,Sun W,Tian M,Yang L,Hua Y,Hao Y,Cai L,Li L,Jiang Y

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Glenohumeral osteoarthritis can, in the most severe cases, require surgery with insertion of a shoulder arthroplasty. A design with a stem in the humeral bone canal is currently regarded as the standard treatment option in patients who have an intact rotator cuff function, but complications related to the st...

journal_title：Trials

authors： Nyring MRK,Olsen BS,Yilmaz M,Petersen MM,Flivik G,Rasmussen JV

更新日期：2020-10-07 00:00:00

abstract：BACKGROUND:The evidence base to assess the efficacy and effectiveness of alcohol brief interventions (ABI) is weakened by variation in the outcomes measured and by inconsistent reporting. The 'Outcome Reporting in Brief Intervention Trials: Alcohol' (ORBITAL) project aims to develop a core outcome set (COS) and reporti...

journal_title：Trials

authors： Shorter GW,Heather N,Bray JW,Giles EL,Holloway A,Barbosa C,Berman AH,O'Donnell AJ,Clarke M,Stockdale KJ,Newbury-Birch D

更新日期：2017-12-22 00:00:00