Physical activity screening to recruit inactive randomized controlled trial participants: how much is too much?

abstract：BACKGROUND:Delirium prevalence in the intensive care unit (ICU) is high. Numerous psychotropic agents are used to manage delirium in the ICU with limited data regarding their efficacy or harms. METHODS/DESIGN:This is a randomized controlled trial of 428 patients aged 18 and older suffering from delirium and admitted t...

journal_title：Trials

authors： Campbell NL,Khan BA,Farber M,Campbell T,Perkins AJ,Hui SL,Abernathy G,Buckley J,Sing R,Tricker J,Zawahiri M,Boustani MA

更新日期：2011-06-06 00:00:00

abstract：BACKGROUND:Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C) goals. This study compared the efficacy and safety of low doses of rosuvastatin (10 mg) and atorvastatin (20 mg) in high-risk patients with hypercholesterolemia. METHODS:A total of 996...

journal_title：Trials

authors： Clearfield MB,Amerena J,Bassand JP,Hernández García HR,Miller SS,Sosef FF,Palmer MK,Bryzinski BS

更新日期：2006-12-21 00:00:00

abstract：BACKGROUND:The serious mental illness Health Improvement Profile [HIP] is a brief pragmatic tool, which enables mental health nurses to work together with patients to screen physical health and take evidence-based action when variables are identified to be at risk. Piloting has demonstrated clinical utility and accepta...

journal_title：Trials

authors： White J,Gray RJ,Swift L,Barton GR,Jones M

更新日期：2011-07-04 00:00:00

abstract：BACKGROUND:Linezolid, an oxazolidinone, substantially improves treatment outcomes of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We started a trial to test whether the use of linezolid instead of ethambutol could increase the rate of sputum culture conversion as of 8 weeks of treatment...

journal_title：Trials

authors： Lee JY,Kim DK,Lee JK,Yoon HI,Jeong I,Heo E,Park YS,Lee JH,Park SS,Lee SM,Lee CH,Lee J,Choi SM,Park JS,Joh JS,Cho YJ,Lee YJ,Kim SJ,Hwang YR,Kim H,Ki J,Choi H,Han J,Ahn H,Hahn S,Yim JJ

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) is a major cause of maternal morbidity. Bleeding is caused by a combination of physical causes, such as failure of the uterus to contract or operations, and is made worse by impairment of the blood clotting system. A number of studies have shown that low levels of the blood clott...

journal_title：Trials

authors： Aawar N,Alikhan R,Bruynseels D,Cannings-John R,Collis R,Dick J,Elton C,Fernando R,Hall J,Hood K,Lack N,Mallaiah S,Maybury H,Nuttall J,Paranjothy S,Rayment R,Rees A,Sanders J,Townson J,Weeks A,Collins P

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not without side effects. It impedes early mobilization, could pose an infection risk, and may encourage the...

journal_title：Trials

authors： Roffe C,Nevatte T,Crome P,Gray R,Sim J,Pountain S,Handy L,Handy P

更新日期：2014-03-31 00:00:00

abstract：BACKGROUND:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about preventive COVID-19 behaviors that can be ...

journal_title：Trials

authors： Vandormael A,Adam M,Greuel M,Bärnighausen T

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Randomised clinical trials are the 'gold standard' for evaluating the effectiveness of healthcare interventions. However, successful recruitment of participants remains a key challenge for many trialists. In this paper, we present a conceptual framework for creating a digital, population-based database for t...

journal_title：Trials

authors： Nwaru BI,Soyiri IN,Simpson CR,Griffiths C,Sheikh A

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...

journal_title：Trials

authors： Smit-Fun VM,de Korte-de Boer D,Posthuma LM,Stolze A,Dirksen CD,Hollmann MW,Buhre WF,Boer C

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:Randomized controlled trials (RCTs) often have more than one primary outcome and frequently have secondary and harm outcomes. Comparison of outcomes between study arms is the primary focus of RCTs, but there are times when the relation between outcomes is important, such as determining whether an intermediat...

journal_title：Trials

authors： Schriger DL,Cooper RJ,Lopez-O'Sullivan A,Wystrach C,Altman DG

更新日期：2015-02-22 00:00:00

abstract：BACKGROUND:There has been a recent steep growth in platelet-rich plasma (PRP) use for musculoskeletal conditions, but findings from high quality clinical trial data are lacking in the literature. Here, we describe the statistical analysis plan (SAP) for the Platelet-rich plasma in Achilles Tendon Healing 2 (PATH-2) tri...

journal_title：Trials

authors： Schlüssel MM,Keene DJ,Wagland S,Alsousou J,Lamb SE,Willett K,Dutton SJ,PATH-2 Trial Study Group.

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Standard coronary artery bypass graft surgery uses a single internal mammary artery and supplemental vein or radial artery grafts. Several observational studies have suggested a survival benefit with two internal mammary artery grafts compared to a single internal mammary artery graft, but this has not been ...

journal_title：Trials

authors： Taggart DP,Lees B,Gray A,Altman DG,Flather M,Channon K,ART Investigators.

更新日期：2006-03-30 00:00:00

abstract：BACKGROUND:An increasing number of clinical trials of traditional Chinese medicine are being conducted in the treatment of non-valvular atrial fibrillation (NVAF) in China. However, the heterogeneity of outcomes and outcome measurement instruments has produced little evidence for traditional Chinese medicine in treatin...

journal_title：Trials

authors： Qiu R,Li M,Zhang X,Chen S,Li C,Shang H

更新日期：2018-10-05 00:00:00

abstract：BACKGROUND:Muscle glycogen has been well established as the primary metabolic energy substrate during physical exercise of moderate- to high-intensity and has accordingly been implicated as a limiting factor when such activity is sustained for a prolonged duration. However, the role of this substrate during repeated ex...

journal_title：Trials

authors： Alghannam AF,Tsintzas K,Thompson D,Bilzon J,Betts JA

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:At least 40% of people with psychosis have persistent distressing symptoms despite optimal medication treatment. Cognitive behaviour therapy for psychosis (CBTp) is the only NICE-recommended individual therapy for psychosis, with effects on symptoms, distress and quality of life. Yet <10% of service-users re...

journal_title：Trials

authors： Greenwood K,Alford K,O'Leary I,Peters E,Hardy A,Cavanagh K,Field AP,de Visser R,Fowler D,Davies M,Papamichail A,Garety P

更新日期：2018-11-20 00:00:00

abstract：:The period toward the end of patients' participation in late stage blinded clinical trials is highly resource intensive for the sponsor. Consider first a Phase 3 trial. If the trial is a success, the sponsor has to implement the next steps, which might be filing for approval of the drug with the US Food and Drug Admin...

journal_title：Trials

authors： Ganju J

更新日期：2016-07-20 00:00:00

abstract：BACKGROUND:Trials of complex interventions are associated with high costs and burdens in terms of paperwork, management, data collection, validation, and intervention fidelity assessment occurring across multiple sites. Traditional data collection methods rely on paper-based forms, where processing can be time-consumin...

journal_title：Trials

authors： Drew CJ,Poile V,Trubey R,Watson G,Kelson M,Townson J,Rosser A,Hood K,Quinn L,Busse M

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:Home parenteral nutrition (HPN) is a life-preserving therapy for patients with chronic intestinal failure (CIF) indicated for patients who cannot achieve their nutritional requirements by enteral intake. Intravenously administered lipid emulsions (ILEs) are an essential component of HPN, providing energy and...

journal_title：Trials

authors： Klek S,Chambrier C,Cooper SC,Gabe S,Kunecki M,Pironi L,Rahman F,Sobocki J,Szczepanek K,Wanten G,Lincke N,Glotzbach B,Forbes A

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:Among patients with hepatocellular carcinoma (HCC), 85% of patients have an advanced disease stage at diagnosis and curative therapies cannot be performed. Prognosis has been quite poor as until recently there was no proven effective chemotherapy. Our group found that all-trans-retinoic acid (ATRA) could imp...

journal_title：Trials

authors： Shi J,Sun J,Liu C,Chai Z,Wang N,Zhang H,Cheng S

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:Osteoporosis-related fractures are a significant public health concern. Interventions that increase detection and treatment of osteoporosis, as well as prevention of fractures and falls, are substantially underutilized. This paper outlines the protocol for a pragmatic randomised trial of a multifaceted commu...

journal_title：Trials

authors： Ciaschini PM,Straus SE,Dolovich LR,Goeree RA,Leung KM,Woods CR,Zimmerman GM,Majumdar SR,Spadafora S,Fera LA,Lee HN

更新日期：2008-11-04 00:00:00

abstract：OBJECTIVES:Assessing the effect of surfactant on clinical outcome in patients with COVID-19 under mechanical ventilation TRIAL DESIGN: Single centre, two arm, parallel group (1:1 allocation ratio), randomised superiority trial with blinded care and outcome assessment. PARTICIPANTS:Inclusion criteria: Adult COVID-19 pa...

journal_title：Trials

authors： Dabbagh A,Rajaei S,Ghahremani M,Fathi M,Massoudi N,Tavana S,Fani K,Nooraee N,Malekpour Alamdari N,Besharat S,Najafi Abrandabadi A,Pirsalehi A,Khabiri Khatiri MA

更新日期：2020-11-11 00:00:00

abstract：:There is a critical need for objective data to guide effective health promotion and care for homeless populations. However, many investigators exclude homeless populations from clinical trials due to practical concerns about conducting research with this population. This report is based on our experience and lessons l...

journal_title：Trials

authors： Ojo-Fati O,Joseph AM,Ig-Izevbekhai J,Thomas JL,Everson-Rose SA,Pratt R,Raymond N,Cooney NL,Luo X,Okuyemi KS

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:Heart valve diseases are common with an estimated prevalence of 2.5% in the Western world. The number is rising due to an ageing population. Once symptomatic, heart valve diseases are potentially lethal, and heavily influence daily living and quality of life. Surgical treatment, either valve replacement or r...

journal_title：Trials

authors： Sibilitz KL,Berg SK,Hansen TB,Risom SS,Rasmussen TB,Hassager C,Køber L,Steinbrüchel D,Gluud C,Winkel P,Thygesen LC,Hansen JL,Schmid JP,Conraads V,Brocki BC,Zwisler AD

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:Maintaining adequate oxygenation during rapid sequence intubation (RSI) is imperative to prevent peri-intubation adverse events that can lead to increased duration of hospital and intensive care unit stay, or a prolonged vegetative state requiring long-term institutionalisation. Despite employing current bes...

journal_title：Trials

authors： Chua MT,Khan FA,Ng WM,Lu Q,Low MJW,Yau YW,Punyadasa A,Kuan WS

更新日期：2019-04-04 00:00:00

abstract：BACKGROUND:Findings suggest approximately one in six people with intellectual disability engage in 'challenging behaviours', which include aggression towards others/property and self-injurious actions. In residential settings, actions of staff members can make challenging behaviours more likely to occur, or make these ...

journal_title：Trials

authors： Randell E,Hastings RP,McNamara R,Knight R,Gillespie D,Taylor Z

更新日期：2017-10-05 00:00:00

abstract：BACKGROUND:Care management interventions in the German health-care system have been evaluated with promising results, but further research is necessary to explore their full potential in the context of multi-morbidity. Our aim in this trial is to assess the efficacy of a primary care practice network-based care managem...

journal_title：Trials

authors： Bozorgmehr K,Szecsenyi J,Ose D,Besier W,Mayer M,Krisam J,Jacke CO,Salize HJ,Brandner R,Schmitt S,Kiel M,Kamradt M,Freund T

更新日期：2014-06-21 00:00:00

abstract：BACKGROUND:Advance care planning (ACP) is a process whereby patients prepare for medical decision-making. The traditional objective of ACP has focused on the completion of advance directives. We have developed a new paradigm of ACP focused on preparing patients and their loved ones for communication and informed medica...

journal_title：Trials

authors： Sudore R,Le GM,McMahan R,Feuz M,Katen M,Barnes DE

更新日期：2015-12-12 00:00:00

abstract：BACKGROUND:In the presence of heterogeneous treatment effects, it is desirable to divide patients into subgroups based on their expected response to treatment. This is formalised via a personalised treatment recommendation: an algorithm that uses biomarker measurements to select treatments. It could be that multiple, r...

journal_title：Trials

authors： Pierce M,Emsley R

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:At an early stage, prostate cancer patients are often eligible for more than one treatment option, or may choose to defer curative treatment. Without a pre-existing superior option, a patient has to weigh his personal preferences against the risks and benefits of each alternative to select the most appropria...

journal_title：Trials

authors： Cuypers M,Lamers RE,Kil PJ,van de Poll-Franse LV,de Vries M

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a common cause of disability among U.S. military personnel. Approximately 20% of all diagnoses resulting in disability discharges are linked to back-related conditions. Because LBP can negatively influence trunk muscle strength, balance, and endurance, the military readiness of active-...

journal_title：Trials

authors： Vining R,Minkalis A,Long CR,Corber L,Franklin C,Gudavalli MR,Xia T,Goertz CM

更新日期：2018-12-05 00:00:00