A novel mindful-compassion art therapy (MCAT) for reducing burnout and promoting resilience for end-of-life care professionals: a waitlist RCT protocol.

abstract：BACKGROUND:It was reported that prolonging the injection time or diluting administration can reduce the incidence of opioid-induced cough. However, the incidence of sufentanil-induced cough (SIC) via a standardized infusion rate is unclear. A mechanical dropper is an infusion filtering device commonly used for intraven...

journal_title：Trials

authors： Liu M,Li Z,Wang S,Liu Y,Zhong X,He R,Li F

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy (CIN) is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal insufficiency. Although some agents including hydration with saline are being prescribed to prevent renal deterioration in these high risk patients, ...

journal_title：Trials

authors： Park K,Chung WY,Seo JB,Kim SH,Zo JH,Kim MA,Park YB

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:With a prevalence of 3 to 8% among women of reproductive age, severe premenstrual symptoms are very common. Symptoms range from emotional and cognitive to physical changes. Severe symptoms (that is, premenstrual syndrome) can have a strong impact on everyday functioning and quality of life. Impairment can be...

journal_title：Trials

authors： Kues JN,Janda C,Kleinstäuber M,Weise C

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:Small incision lenticule extraction or SMILE is a novel form of 'flapless' corneal refractive surgery that was adapted from refractive lenticule extraction (ReLEx). SMILE uses only one femtosecond laser to complete the refractive surgery, potentially reducing surgical time, side effects, and cost. If success...

journal_title：Trials

authors： Ang M,Tan D,Mehta JS

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mortality. The limitations of vancomycin, the current standard therapy for MRSA, make treatment difficult. The only other approved drug for treatment of MRSA bacteraemia, daptomycin, has not been...

journal_title：Trials

authors： Tong SY,Nelson J,Paterson DL,Fowler VG Jr,Howden BP,Cheng AC,Chatfield M,Lipman J,Van Hal S,O'Sullivan M,Robinson JO,Yahav D,Lye D,Davis JS,CAMERA2 study group and the Australasian Society for Infectious Diseases Clinical Res

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Beneficial effects of placebos are high in double-blind hot flush trials. Studies in various conditions suggest that honestly prescribed placebos may elicit symptom improvement. OBJECTIVE:To determine whether open label placebo (OLP) treatment is efficacious in alleviating hot flushes among peri- and postme...

journal_title：Trials

authors： Pan Y,Meister R,Löwe B,Winkelmann A,Kaptchuk TJ,Buhling KJ,Nestoriuc Y

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:This study is a part of a series of two clinical trials. We consider diabetic polyneuropathy (DPN), a common chronic and progressive complication of diabetes mellitus that has several impacts on individuals' foot health and quality of life. Based on the current trends of self-monitoring and self-care, provid...

journal_title：Trials

authors： Silva EQ,Suda EY,Santos DP,Veríssimo JL,Ferreira JSSP,Cruvinel Júnior RH,Monteiro RL,Sartor CD,Sacco ICN

更新日期：2020-02-13 00:00:00

abstract：BACKGROUND:The logrank test is routinely applied to design and analyse randomized controlled trials (RCTs) with time-to-event outcomes. Sample size and power calculations assume the treatment effect follows proportional hazards (PH). If the PH assumption is false, power is reduced and interpretation of the hazard ratio...

journal_title：Trials

authors： Royston P,B Parmar MK

更新日期：2020-04-06 00:00:00

abstract：BACKGROUND:Graves' hyperthyroidism is an autoimmune disease causing hyperfunction of the thyroid gland. The concentration of selenium is high in the thyroid gland and two important groups of enzymes within the thyroid are selenoproteins, that is, they depend on selenium. Selenium may have beneficial effects on autoimmu...

journal_title：Trials

authors： Watt T,Cramon P,Bjorner JB,Bonnema SJ,Feldt-Rasmussen U,Gluud C,Gram J,Hansen JL,Hegedüs L,Knudsen N,Bach-Mortensen P,Nolsøe R,Nygaard B,Pociot F,Skoog M,Winkel P,Rasmussen AK

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Orthodontic treatment is commonly undertaken in young people, with over 40% of children in the UK needing treatment and currently one third having treatment, at a cost to the National Health Service in England and Wales of £273 million each year. Most current research about orthodontic care does not consider...

journal_title：Trials

authors： Tsichlaki A,O'Brien K,Johal A,Marshman Z,Benson P,Colonio Salazar FB,Fleming PS

更新日期：2017-08-04 00:00:00

abstract：:Following the South African case, Treatment Action Campaign and Others v Minister of Health and Others, the use of 'pilot' studies to investigate interventions already proven efficacious, offered free of charge to government, but confined by the government to a small part of the population, may violate children's righ...

journal_title：Trials

authors： Oduwo E,Edwards SJ

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:Many babies in the UK are born to drug-dependent parents, and dependence on psychoactive drugs during the postnatal period is associated with high rates of child maltreatment, with around a quarter of these children being subject to a child protection plan. Parents who are dependent on psychoactive drugs are...

journal_title：Trials

authors： Barlow J,Sembi S,Gardner F,Macdonald G,Petrou S,Parsons H,Harnett P,Dawe S

更新日期：2013-07-11 00:00:00

abstract：BACKGROUND:Neck pain is a common symptom in most patients suffering from cervical radiculopathy. However, some conservative treatments are limited by their modest effectiveness. On the other hand, surgical intervention for cervical disc disorders is indicated when symptoms are refractory to conservative treatments and ...

journal_title：Trials

authors： Cui XJ,Sun YL,You SF,Mo W,Lu S,Shi Q,Wang YJ

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:Research has shown that recruitment to trials is a process that stretches from identifying potentially eligible patients, through eligibility assessment, to obtaining informed consent. The length and complexity of this pathway means that many patients do not have the opportunity to consider participation. Th...

journal_title：Trials

authors： Wilson C,Rooshenas L,Paramasivan S,Elliott D,Jepson M,Strong S,Birtle A,Beard DJ,Halliday A,Hamdy FC,Lewis R,Metcalfe C,Rogers CA,Stein RC,Blazeby JM,Donovan JL

更新日期：2018-01-19 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and disabling condition with considerable personal and economic impact. Cognitive behavioural therapy (CBT) is a recommended psychological therapy for GAD; however, there are substantial barriers to accessing treatment. Digital CBT, in particular smartphone-del...

journal_title：Trials

authors： Gu J,Miller CB,Henry AL,Espie CA,Davis ML,Stott R,Emsley R,Smits JAJ,Craske M,Saunders KEA,Goodwin G,Carl JR

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:Hypnotic drugs tend to be the dominant form of treatment of insomnia, but these come with a number of reported side effects. Acupuncture has been studied as an alternative, resulting in a rising need for methodological research towards verifying its efficacy as insomnia treatment. METHODS/DESIGN:We describe...

journal_title：Trials

authors： Han KH,Kim SY,Chung SY

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS:Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, a...

journal_title：Trials

authors： Hind D,Reeves BC,Bathers S,Bray C,Corkhill A,Hayward C,Harper L,Napp V,Norrie J,Speed C,Tremain L,Keat N,Bradburn M

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:Previous interventions to increase physical activity and reduce cardiovascular risk factors have been targeted at individuals with established disease; less attention has been given to intervention among individuals with high risk for disease nor has there been determination of the influence of setting in wh...

journal_title：Trials

authors： Petrella RJ,Aizawa K,Shoemaker K,Overend T,Piche L,Marin M,Shapiro S,Atkin S

更新日期：2011-02-16 00:00:00

abstract：OBJECTIVES:The GETAFIX trial will test the hypothesis that favipiravir is a more effective treatment for COVID-19 infection in patients who have early stage disease, compared to current standard of care. This study will also provide an important opportunity to investigate the safety and tolerability of favipiravir, the...

journal_title：Trials

authors： Hanna CR,Blyth KG,Burley G,Carmichael S,Evans C,Hinsley S,Khadra I,Khoo S,Lewsley LA,Jones RR,Sharma R,Taladriz-Sender A,Thomson EC,Scott JT

更新日期：2020-11-19 00:00:00

abstract：BACKGROUND:Haemorrhage remains a leading cause of morbidity and mortality in trauma patients. Fibrinogen is an essential endogenous component of haemostasis and the plasma level is associated with bleeding, transfusion and outcome. Fibrinogen concentrate is widely used to correct acquired hypofibrinogenaemia, recommend...

journal_title：Trials

authors： Steinmetz J,Sørensen AM,Henriksen HH,Lange T,Larsen CF,Johansson PI,Stensballe J

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Parkinson's Disease is a degenerative neurological condition that causes movement problems and other distressing symptoms. People with Parkinson's disease gradually lose their independence and strain is placed on family members. A multidisciplinary approach to rehabilitation for people with Parkinson's is re...

journal_title：Trials

authors： Gage H,Ting S,Williams P,Bryan K,Kaye J,Castleton B,Trend P,Wade D

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Quality of residential care for people with severe dementia is in urgent need of improvement. One reason for this may be the assumption that people with severe dementia are unaware of what is happening to them. However, there is converging evidence to suggest that global assumptions of unawareness are inappr...

journal_title：Trials

authors： Clare L,Woods RT,Whitaker R,Wilson BA,Downs M

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people died from coronary heart disease than from any other cause. CVD is regularly treated with minimally or non-minimally invasive off- or on-pump cardiothor...

journal_title：Trials

authors： Moza A,Benstoem C,Autschbach R,Stoppe C,Goetzenich A

更新日期：2015-12-02 00:00:00

abstract：BACKGROUND:In recent years there has been an increasing interest in MRI as a non-invasive diagnostic modality for the work-up of suspicious breast lesions. The additional value of Breast MRI lies mainly in its capacity to detect multicentric and multifocal disease, to detect invasive components in ductal carcinoma in s...

journal_title：Trials

authors： Peters NH,Borel Rinkes IH,Mali WP,van den Bosch MA,Storm RK,Plaisier PW,de Boer E,van Overbeeke AJ,Peeters PH

更新日期：2007-11-28 00:00:00

abstract：BACKGROUND:Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clinical use. The use of a low-dos...

journal_title：Trials

authors： Cosgrave D,Galligan M,Soukhin E,McMullan V,McGuinness S,Puttappa A,Conlon N,Boylan J,Hussain R,Doran P,Nichol A

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:Laparoscopic surgery has become the preferred approach for many procedures because of reduced post-operative pain, better recovery, shorter hospital stay and improved cosmesis. Single incision laparoscopic surgery is one of the many recent variants where either standard ports or a specially designed single m...

journal_title：Trials

authors： Malik M,McCormack K,Krukowski ZH,McDonald A,McPherson G,Cook JA,Ahmed I,SCARLESS Study Group.

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as acupuncture. Based on the ...

journal_title：Trials

authors： Shi GX,Han LL,Liu LY,Li QQ,Liu CZ,Wang LP

更新日期：2012-11-23 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Trials

authors： Sheridan R,Martin-Kerry J,Hudson J,Parker A,Bower P,Knapp P

更新日期：2020-10-08 00:00:00

abstract：BACKGROUND:The evidence base to assess the efficacy and effectiveness of alcohol brief interventions (ABI) is weakened by variation in the outcomes measured and by inconsistent reporting. The 'Outcome Reporting in Brief Intervention Trials: Alcohol' (ORBITAL) project aims to develop a core outcome set (COS) and reporti...

journal_title：Trials

authors： Shorter GW,Heather N,Bray JW,Giles EL,Holloway A,Barbosa C,Berman AH,O'Donnell AJ,Clarke M,Stockdale KJ,Newbury-Birch D

更新日期：2017-12-22 00:00:00

abstract：BACKGROUND:We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD). METHODS:We systematically reviewed n...

journal_title：Trials

authors： Jawad S,Modi N,Prevost AT,Gale C

更新日期：2019-12-16 00:00:00