Efficacy of a family practice-based lifestyle intervention program to increase physical activity and reduce clinical and physiological markers of vascular health in patients with high normal blood pressure and/or high normal blood glucose (SNAC): study pr

abstract：BACKGROUND:For the last decade continuous efforts have been made to translate regenerative cell therapy protocols in the cardiovascular field from 'bench to bedside'. Successful clinical introduction, supporting safety, and feasibility of this new therapeutic approach, led to the initiation of the German, Phase III, mu...

journal_title：Trials

authors： Donndorf P,Kaminski A,Tiedemann G,Kundt G,Steinhoff G

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a major cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and is pop...

journal_title：Trials

authors： Fei YP,Zheng Y,Lai D,Zhong P,Lu JZ,Li G,Liu P

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' understandings are inevitably influenced by the recruiting clinician's understanding of the trial, yet rel...

journal_title：Trials

authors： Ziebland S,Featherstone K,Snowdon C,Barker K,Frost H,Fairbank J

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Among patients with hepatocellular carcinoma (HCC), 85% of patients have an advanced disease stage at diagnosis and curative therapies cannot be performed. Prognosis has been quite poor as until recently there was no proven effective chemotherapy. Our group found that all-trans-retinoic acid (ATRA) could imp...

journal_title：Trials

authors： Shi J,Sun J,Liu C,Chai Z,Wang N,Zhang H,Cheng S

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:Patients admitted to intensive care units (ICU) with acute respiratory failure (ARF) face chronic complications that can impede return to normal daily function. A mobile, collaborative critical care model may enhance the recovery of ARF survivors. METHODS:The Mobile Critical Care Recovery Program (m-CCRP) s...

journal_title：Trials

authors： Khan S,Biju A,Wang S,Gao S,Irfan O,Harrawood A,Martinez S,Brewer E,Perkins A,Unverzagt FW,Lasiter S,Zarzaur B,Rahman O,Boustani M,Khan B

更新日期：2018-02-07 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is one of the leading chronic inflammatory rheumatism. First-line therapy with synthetic disease-modifying antirheumatic drugs (sDMARD) is insufficiently effective in 40% of cases and these patients are treated with biotherapies. The increased use of these drugs each year is becomin...

journal_title：Trials

authors： Freites-Núñez D,Baillet A,Rodriguez-Rodriguez L,Nguyen MVC,Gonzalez I,Pablos JL,Balsa A,Vazquez M,Gaudin P,Fernandez-Gutierrez B

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Depression and bipolar disorder are associated with reduced neural plasticity and deficits in memory, attention and executive function. Drug treatments for these affective disorders have insufficient clinical effects in a large group and fail to reverse cognitive deficits. There is thus a need for more effec...

journal_title：Trials

authors： Miskowiak KW,Vinberg M,Harmer CJ,Ehrenreich H,Knudsen GM,Macoveanu J,Hansen AR,Paulson OB,Siebner HR,Kessing LV

更新日期：2010-10-13 00:00:00

abstract：BACKGROUND:Sharing interim results by the Data Safety Monitoring Board (DSMB) with non-DSMB members is an issue that can affect trial integrity. It is unclear what should be shared. This study assesses the views of professionals to understand what interim information should be shared at interim, with whom and why. MET...

journal_title：Trials

authors： Borg Debono V,Mbuagbaw L,Paul J,Buckley N,Thabane L

更新日期：2018-05-21 00:00:00

abstract：BACKGROUND:At least 40% of people with psychosis have persistent distressing symptoms despite optimal medication treatment. Cognitive behaviour therapy for psychosis (CBTp) is the only NICE-recommended individual therapy for psychosis, with effects on symptoms, distress and quality of life. Yet <10% of service-users re...

journal_title：Trials

authors： Greenwood K,Alford K,O'Leary I,Peters E,Hardy A,Cavanagh K,Field AP,de Visser R,Fowler D,Davies M,Papamichail A,Garety P

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Meta-analyses of randomized controlled trials (RCTs) have shown that exercise has beneficial effects on quality of life (QoL) in patients with breast cancer. However, these effects were often small. Blinding in an exercise trial is not possible, which has the possible disadvantage of difficult accrual, drop-...

journal_title：Trials

authors： Gal R,Monninkhof EM,Groenwold RHH,van Gils CH,van den Bongard DHJG,Peeters PHM,Verkooijen HM,May AM

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Individual patient data (IPD) meta-analysis is considered the "gold standard" for exploring the effectiveness of interventions in different subgroups of patients. However, obtaining IPD is time-consuming and contact with the researchers responsible for the original trials is usually required. To date, there ...

journal_title：Trials

authors： Veroniki AA,Straus SE,Ashoor H,Stewart LA,Clarke M,Tricco AC

更新日期：2016-03-15 00:00:00

abstract：BACKGROUND:People with serious mental illness (SMI) (psychosis, bipolar disorder and major depressive disorder) experience a considerable risk of premature mortality because of cardiovascular disease. Recent research has demonstrated that this population spends almost 13 h per day being sedentary. Sedentary behaviour i...

journal_title：Trials

authors： Williams J,Stubbs B,Gaughran F,Craig T

更新日期：2016-12-12 00:00:00

abstract：BACKGROUND:Sub-threshold depression is common, impairs functioning, and increases the risk of developing major depression. Although psychological treatments have been investigated for sub-threshold depression, they are costly. A less costly alternative could be an educational health promotion campaign about effective s...

journal_title：Trials

authors： Morgan AJ,Jorm AF,Mackinnon AJ

更新日期：2011-01-13 00:00:00

abstract：BACKGROUND AND AIMS:The standard whole-colon tests used to investigate patients with symptoms of colorectal cancer are barium enema and colonoscopy. Colonoscopy is the reference test but is technically difficult, resource intensive, and associated with adverse events, especially in the elderly. Barium enema is safer bu...

journal_title：Trials

authors： Halligan S,Lilford RJ,Wardle J,Morton D,Rogers P,Wooldrage K,Edwards R,Kanani R,Shah U,Atkin W

更新日期：2007-10-27 00:00:00

abstract：BACKGROUND:There has been a recent steep growth in platelet-rich plasma (PRP) use for musculoskeletal conditions, but findings from high quality clinical trial data are lacking in the literature. Here, we describe the statistical analysis plan (SAP) for the Platelet-rich plasma in Achilles Tendon Healing 2 (PATH-2) tri...

journal_title：Trials

authors： Schlüssel MM,Keene DJ,Wagland S,Alsousou J,Lamb SE,Willett K,Dutton SJ,PATH-2 Trial Study Group.

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Cognitive behaviour therapy (CBT) is an effective treatment for depression. However, CBT is a complex therapy that requires highly trained and qualified practitioners, and its scalability is therefore limited by the costs of training and employing sufficient therapists to meet demand. Behavioural activation ...

journal_title：Trials

authors： Rhodes S,Richards DA,Ekers D,McMillan D,Byford S,Farrand PA,Gilbody S,Hollon SD,Kuyken W,Martell C,O'Mahen HA,O'Neill E,Reed N,Taylor RS,Watkins ER,Wright KA

更新日期：2014-01-21 00:00:00

abstract：BACKGROUND:Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortality. Exercise has potential to improve depression, and has been shown in existing trials to improve o...

journal_title：Trials

authors： Underwood M,Eldridge S,Lamb S,Potter R,Sheehan B,Slowther AM,Taylor S,Thorogood M,Weich S

更新日期：2011-02-02 00:00:00

abstract：OBJECTIVES:Colchicine is a well-known drug, which has been used for years to treat a wide range of rheumatic and inflammatory disorders. It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress p...

journal_title：Trials

authors： Dalili N,Kashefizadeh A,Nafar M,Poorrezagholi F,Firouzan A,Samadian F,Samavat S,Ziaie S,Fatemizadeh S

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:The prevalence of depression in young people is increasing. The predominant co-morbidities of juvenile depression include sleep disturbances and persistent problems with the sleep-wake rhythm, which have shown to influence treatment outcomes negatively. Severe mood dysregulation is another condition that inc...

journal_title：Trials

authors： Bogen S,Legenbauer T,Bogen T,Gest S,Jensch T,Schneider S,Holtmann M

更新日期：2013-06-17 00:00:00

abstract：BACKGROUND:Osteoarthritis often results in prolonged periods of reduced physical activity and is associated with adverse health outcomes, including increased risk of cardiovascular and metabolic diseases. Exercise interventions for patients on the waiting list for arthroplasty can reduce the risk of long-term adverse o...

journal_title：Trials

authors： O'Brien J,Hamilton K,Williams A,Fell J,Mulford J,Cheney M,Wu S,Bird ML

更新日期：2018-08-07 00:00:00

abstract：BACKGROUND:Effective programs to help children manage their weight are required. Families for Health focuses on a parenting approach, designed to help parents develop their parenting skills to support lifestyle change within the family. Families for Health V1 showed sustained reductions in overweight after 2 years in a...

journal_title：Trials

authors： Robertson W,Stewart-Brown S,Stallard N,Petrou S,Griffiths F,Thorogood M,Simkiss D,Lang R,Reddington K,Poole F,Rye G,Khan KA,Hamborg T,Kirby J

更新日期：2013-03-20 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a degenerative component, leading to irreversible disability. Mesenchymal stem cells (MSC) have been shown to prevent inflammation and neurodegeneration in animal models of MS, but no large phase II clinical trials have yet...

journal_title：Trials

authors： Uccelli A,Laroni A,Brundin L,Clanet M,Fernandez O,Nabavi SM,Muraro PA,Oliveri RS,Radue EW,Sellner J,Soelberg Sorensen P,Sormani MP,Wuerfel JT,Battaglia MA,Freedman MS,MESEMS study group.

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Sexual dysfunction can have a negative impact on women's quality of life and relationships. There is limited information about female sexual function and treatment, particularly during pregnancy and the postpartum period. The effect of pelvic floor muscle exercise (PFME) on sexual function (SF) has not been ...

journal_title：Trials

authors： Sobhgol SS,Priddis H,Smith CA,Dahlen HG

更新日期：2019-02-20 00:00:00

abstract：BACKGROUND:With high morbidity, mortality and disability rate, brain infarction brings a huge economic and health burden to the whole society in China. Although some previous studies suggested that telerehabilitation may facilitate rehabilitation for stroke survivors at home, the evidence is insufficient for clinical a...

journal_title：Trials

authors： Jin W,Chen J,Shi F,Yang W,Zhang Y,Liu Y,Dong W,Jin Y,Ma W,Ma Z,Min X,Jin Y,Gu Y,Ren C

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:Using next-generation sequencing (NGS) in newborn screening (NBS) could expand the number of genetic conditions detected pre-symptomatically, simultaneously challenging current precedents, raising ethical concerns, and extending the role of parental decision-making in NBS. The NC NEXUS (Newborn Exome Sequenc...

journal_title：Trials

authors： Milko LV,Rini C,Lewis MA,Butterfield RM,Lin FC,Paquin RS,Powell BC,Roche MI,Souris KJ,Bailey DB Jr,Berg JS,Powell CM

更新日期：2018-06-28 00:00:00

abstract：BACKGROUND:Obesity represents a major public health problem and is the fifth leading risk factor for mortality. Morbid obesity is associated with chronic systemic inflammation which increases the risk of comorbidities. Bariatric surgery (BS) is considered an effective intervention for obese patients. However, BS is ass...

journal_title：Trials

authors： Delgado André L,Basso-Vanelli RP,Di Thommazo-Luporini L,Angélica Ricci P,Cabiddu R,Pilon Jürgensen S,Ricardo de Oliveira C,Arena R,Borghi-Silva A

更新日期：2018-10-31 00:00:00

abstract：BACKGROUND:Oral mucositis (OM) is the most frequent and debilitating acute side effect associated with head and neck cancer (HNC) treatment. When present, severe OM negatively impacts the quality of life of patients undergoing HNC treatment. Photobiomodulation is a well-consolidated and effective therapy for the treatm...

journal_title：Trials

authors： Martins AFL,Nogueira TE,Morais MO,Oton-Leite AF,Valadares MC,Batista AC,Freitas NMA,Leles CR,Mendonça EF

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have side effects and poor adherence. Qigong has been studied as an alternative therapy for hypertension; however, the types of qigong used in those stu...

journal_title：Trials

authors： Park JE,Liu Y,Park T,Hong S,Kim JE,Kim TH,Kim AR,Jung SY,Park H,Choi SM

更新日期：2011-11-21 00:00:00

abstract：BACKGROUND:Hand-assisted laparoscopic living donor nephrectomy (HALDN) using a periumbilical or Pfannenstiel incision was developed to improve donor outcome after a kidney transplant. The aim of this study was to investigate two methods of hand assistance and kidney removal during HALDN and their effect on the time it ...

journal_title：Trials

authors： Kulu Y,Müller-Stich BP,Ghamarnejad O,Khajeh E,Polychronidis G,Golriz M,Nickel F,Benner L,Knebel P,Diener M,Morath C,Zeier M,Büchler MW,Mehrabi A

更新日期：2018-07-13 00:00:00

abstract：BACKGROUND:Oxygen is a life-saving, essential medicine that is important for the treatment of many common childhood conditions. Improved oxygen systems can reduce childhood pneumonia mortality substantially. However, providing oxygen to children is challenging, especially in small hospitals with weak infrastructure and...

journal_title：Trials

authors： Graham HR,Ayede AI,Bakare AA,Oyewole OB,Peel D,Gray A,McPake B,Neal E,Qazi S,Izadnegahdar R,Falade AG,Duke T

更新日期：2017-10-27 00:00:00