Effect of photobiomodulation on the severity of oral mucositis and molecular changes in head and neck cancer patients undergoing radiotherapy: a study protocol for a cost-effectiveness randomized clinical trial.

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Individuals with chronic lung disease are more susceptible to present reduction in exercise tolerance and muscles strength not only due to pulmonary limitations but also due systemic repercussions of the pulmonary disease. The aim of this study is to assess the physical capacity, peripheral muscle function, ...

journal_title：Trials

authors： Reimberg MM,Castro RA,Selman JP,Meneses AS,Politti F,Mallozi MC,Wandalsen GF,Solé D,De Angelis K,Dal Corso S,Lanza FC

更新日期：2015-08-13 00:00:00

abstract：BACKGROUND:Osteoporosis-related fractures are a significant public health concern. Interventions that increase detection and treatment of osteoporosis, as well as prevention of fractures and falls, are substantially underutilized. This paper outlines the protocol for a pragmatic randomised trial of a multifaceted commu...

journal_title：Trials

authors： Ciaschini PM,Straus SE,Dolovich LR,Goeree RA,Leung KM,Woods CR,Zimmerman GM,Majumdar SR,Spadafora S,Fera LA,Lee HN

更新日期：2008-11-04 00:00:00

abstract：OBJECTIVES:To assess the impact of adding statin (atorvastatin) and/or aspirin on clinical deterioration in patients infected with SARS-CoV-2 who require hospitalisation. The safety of these drugs in COVID-19 patients will also be evaluated. TRIAL DESIGN:This is a single-centre, prospective, four-arm parallel design, ...

journal_title：Trials

authors： Ghati N,Roy A,Bhatnagar S,Bhati S,Bhushan S,Mahendran M,Thakur A,Tiwari P,Dwivedi T,Mani K,Gupta R,Mohan A,Garg R,Saxena A,Guleria R,Deepti S

更新日期：2020-10-30 00:00:00

abstract：BACKGROUND:Acupuncture has been widely applied in the clinic to treat irritable bowel syndrome (IBS), but the underlying mechanism remains unknown. Diffuse noxious inhibitory control (DNIC) is deficient in patients with IBS, which attenuates the systemic analgesic effect elicited by noxious stimulation that is remote f...

journal_title：Trials

authors： Peng Y,You H,Chen X,Chen Y,Yang Y,Huang J,Xu N,Liu J

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Delirium is a state of confusion characterized by an acute and fluctuating decline in cognitive functioning. Delirium is common and deadly in older adults with dementia, and is often referred to as delirium superimposed on dementia, or DSD. Interventions that treat DSD are not well-developed because the mech...

journal_title：Trials

authors： Kolanowski AM,Fick DM,Litaker MS,Clare L,Leslie D,Boustani M

更新日期：2011-05-11 00:00:00

abstract：BACKGROUND:Randomised clinical trials are the 'gold standard' for evaluating the effectiveness of healthcare interventions. However, successful recruitment of participants remains a key challenge for many trialists. In this paper, we present a conceptual framework for creating a digital, population-based database for t...

journal_title：Trials

authors： Nwaru BI,Soyiri IN,Simpson CR,Griffiths C,Sheikh A

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:Many people living with HIV suffer from depressive symptoms. In a previous pilot study, self-help cognitive behavioral therapy (in booklet format) was found to be effective in treating depressive symptoms in people with HIV. We developed an online self-help program in Dutch and English (based on the booklet)...

journal_title：Trials

authors： van Luenen S,Kraaij V,Spinhoven P,Garnefski N

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Chronic back pain is a major public health problem and the primary reason patients seek massage treatment. Despite the growing use of massage for chronic low back pain, there have been few studies of its effectiveness. This trial will be the first evaluation of the effectiveness of relaxation massage for chr...

journal_title：Trials

authors： Cherkin DC,Sherman KJ,Kahn J,Erro JH,Deyo RA,Haneuse SJ,Cook AJ

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:Evidence increases that a high or a standard dose of tranexamic acid (TA) reduces postpartum bleeding. The TRACES pharmacobiological substudy aims to establish a therapeutic strategy in hemorrhagic (H) Cesarean section (CS) with respect to the intensity of fibrinolysis by using innovative assays. METHOD/DES...

journal_title：Trials

authors： Ducloy-Bouthors AS,Jeanpierre E,Saidi I,Baptiste AS,Simon E,Lannoy D,Duhamel A,Allorge D,Susen S,Hennart B

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Youth depression is highly prevalent and is related to impairments in academic, social and behavioural functioning. Evidence-based treatments are available, but many young people do not respond or sufficiently recover with first-line options, and a significant proportion experience relapse. Consequently, the...

journal_title：Trials

authors： Hallford DJ,Carmichael AM,Austin DW,Takano K,Raes F,Fuller-Tyszkiewicz M

更新日期：2020-01-14 00:00:00

abstract：BACKGROUND:Dizziness is one of the most challenging symptoms in medicine. No medication for dizziness in current use has well-established curative or prophylactic value or is suitable for long-term palliative use. Unconventional remedies, such as acupuncture, should be considered and scientifically evaluated. However, ...

journal_title：Trials

authors： Xue Z,Liu CZ,Shi GX,Liu Y,Li ZX,Zhang ZH,Wang LP

更新日期：2013-12-13 00:00:00

abstract：BACKGROUND:Neck pain caused by cervical spondylosis (CS) has become one of the most common health problems around the world. Electroacupuncture (EA) has been employed to relieve CS neck pain, but there is limited clinical evidence for its effectiveness. METHODS/DESIGN:This study consists of a randomized controlled tri...

journal_title：Trials

authors： Sun ZR,Yue JH,Zhang QH

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:At an early stage, prostate cancer patients are often eligible for more than one treatment option, or may choose to defer curative treatment. Without a pre-existing superior option, a patient has to weigh his personal preferences against the risks and benefits of each alternative to select the most appropria...

journal_title：Trials

authors： Cuypers M,Lamers RE,Kil PJ,van de Poll-Franse LV,de Vries M

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:HIV-related stigma significantly impacts HIV care engagement, including in prevention of mother-to-child transmission of HIV (PMTCT) programs. Maisha is a stigma-based counseling intervention delivered during the first antenatal care (ANC) visit, complementing routine HIV counseling and testing. The goal of ...

journal_title：Trials

authors： Watt MH,Knippler ET,Minja L,Kisigo G,Knettel BA,Ngocho JS,Renju J,Osaki H,Mwamba R,Rogathi JJ,Mmbaga BT

更新日期：2019-12-30 00:00:00

abstract：BACKGROUND:The ACTION study (Attention deficit hyperactivity disorder Controlled Trial Investigation Of a Non-stimulant) is a multi-center, double-blind, randomized cross-over trial of the non-stimulant medication, Atomoxetine, in children and adolescents with attention deficit hyperactivity disorder (ADHD). The primar...

journal_title：Trials

authors： Tsang TW,Kohn MR,Hermens DF,Clarke SD,Clark CR,Efron D,Cranswick N,Lamb C,Williams LM

更新日期：2011-03-13 00:00:00

abstract：BACKGROUND:Compulsory submission of a checklist from the relevant reporting guideline is one of the most widespread journal requirements aiming to improve completeness of reporting. However, the current suboptimal levels of adherence to reporting guidelines observed in the literature may indicate that this journal poli...

journal_title：Trials

authors： Blanco D,Biggane AM,Cobo E,MiRoR network.

更新日期：2018-01-29 00:00:00

abstract：BACKGROUND:Traumatic brain injury (TBI) is often associated with life-long medical, cognitive, emotional, and behavioral changes. Although long-lasting disabilities are expected, research on effective treatment options in the chronic phase of TBI is scarce. METHODS/DESIGN:This study protocol describes a randomized con...

journal_title：Trials

authors： Borgen IMH,Løvstad M,Andelic N,Hauger S,Sigurdardottir S,Søberg HL,Sveen U,Forslund MV,Kleffelgård I,Lindstad MØ,Winter L,Røe C

更新日期：2020-03-27 00:00:00

abstract：BACKGROUND:Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dementia symptoms are needed because current treatment options (antidepressants and antipsychotics) can...

journal_title：Trials

authors： Timler A,Bulsara C,Bulsara M,Vickery A,Smith J,Codde J

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:There is a strong evidence base for the benefits of parenting interventions for parents without severe mental illness (SMI). As the impact of maternal SMI can be significant on child development, mothers need support to maximise outcomes for themselves and their children. Some mothers with SMI require admiss...

journal_title：Trials

authors： Wittkowski A,Cartwright K,Emsley R,Bee P,Calam R,Cross C,Abel KM,Reid H

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:The burden of chronic pain is a major challenge, impacting the quality of life of patients. Intensive programmes of mindfulness-based therapy can help patients to cope with chronic pain but can be time consuming and require a trained specialist to implement. The self-management model of care is now integral ...

journal_title：Trials

authors： Howarth A,Perkins-Porras L,Smith JG,Subramaniam J,Copland C,Hurley M,Beith I,Riaz M,Ussher M

更新日期：2016-06-02 00:00:00

abstract：BACKGROUND:Depression is one of the most common reasons for consulting in primary care. Acupuncture is a popular complementary therapy choice for depression but its evidence base is poor with more robust high quality trials being required. More than half of depressed patients experience painful symptoms, with severe pa...

journal_title：Trials

authors： Schroer S,Macpherson H

更新日期：2009-01-09 00:00:00

abstract：BACKGROUND:People with serious mental illness (SMI) (psychosis, bipolar disorder and major depressive disorder) experience a considerable risk of premature mortality because of cardiovascular disease. Recent research has demonstrated that this population spends almost 13 h per day being sedentary. Sedentary behaviour i...

journal_title：Trials

authors： Williams J,Stubbs B,Gaughran F,Craig T

更新日期：2016-12-12 00:00:00

abstract：BACKGROUND:Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as acupuncture. Based on the ...

journal_title：Trials

authors： Shi GX,Han LL,Liu LY,Li QQ,Liu CZ,Wang LP

更新日期：2012-11-23 00:00:00

abstract：BACKGROUND:Metabolic acidosis is more common with advancing chronic kidney disease, and has been associated with impaired physical function, impaired bone health, accelerated decline in kidney function and increased vascular risk. Although oral sodium bicarbonate is widely used to correct metabolic acidosis, there exis...

journal_title：Trials

authors： Witham MD,Band MM,Littleford RC,Avenell A,Soiza RL,McMurdo ME,Sumukadas D,Ogston SA,Lamb EJ,Hampson G,McNamee P,BiCARB Study Group.

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Chronic back pain continues to be a costly and prevalent condition. The latest NICE guidelines issued in 2009 state that for patients with persistent back pain (of between six weeks and twelve months duration), who are highly distressed and/or disabled and for whom exercise, manual therapy and acupuncture ha...

journal_title：Trials

authors： Pincus T,Anwar S,McCracken L,McGregor A,Graham L,Collinson M,Farrin AJ,OBI Trial Management Team.

更新日期：2013-06-13 00:00:00

abstract：BACKGROUND:Clavicle fractures account for around 4% of all fractures and up to 44% of fractures of the shoulder girdle. Fractures of the middle third (or mid-shaft) account for approximately 80% of all clavicle fractures. Management of this group of fractures is often challenging and the outcome can be unsatisfactory. ...

journal_title：Trials

authors： Longo UG,Banerjee S,Barber J,Chambler A,Cobiella C,Corbett S,Crowther M,Drew S,Francis A,Lee M,Garlick N,Packham I,Pearse Y,Richards A,Roberts C,Tennent D,Tims E,Ahrens PM

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:People with decompensated cirrhosis require complex medical care and are often prescribed an intricate and frequently changing medication and lifestyle regimen. However, many patients mismanage their medications or have poor comprehension of their disease and self-management tasks. This can lead to harm, hos...

journal_title：Trials

authors： Hayward KL,Martin JH,Cottrell WN,Karmakar A,Horsfall LU,Patel PJ,Smith DD,Irvine KM,Powell EE,Valery PC

更新日期：2017-07-20 00:00:00

abstract：BACKGROUND:There is no existing report on the quality of randomized controlled trials (RCTs) of melasma treatment currently conducted in China. This study aims to assess the quality of RCT- reporting in the treatment of melasma conducted in China. METHODS:Several databases were searched from their inception through to...

journal_title：Trials

authors： Chen Z,Chen Y,Zeng J,Wang Y,Ye T,Zhou Q,Du X,Su W,Ding Z

更新日期：2015-04-12 00:00:00

abstract：BACKGROUND:Diabetes Mellitus constitutes one of the most important public health problems due to its high prevalence and enormous social and economic consequences. Diabetic foot ulcers are one of the chronic complications of diabetes mellitus and constitute the most important cause of non-traumatic amputation of inferi...

journal_title：Trials

authors： Silva SY,Rueda LC,Márquez GA,López M,Smith DJ,Calderón CA,Castillo JC,Matute J,Rueda-Clausen CF,Orduz A,Silva FA,Kampeerapappun P,Bhide M,López-Jaramillo P

更新日期：2007-09-26 00:00:00