Non-concealed placebo treatment for menopausal hot flushes: Study protocol of a randomized-controlled trial.

abstract：BACKGROUND:Increasing numbers of patients are surviving critical illness, but survival may be associated with a constellation of physical and psychological sequelae that can cause ongoing disability and reduced health-related quality of life. Limited evidence currently exists to guide the optimum structure, timing, and...

journal_title：Trials

authors： Ramsay P,Salisbury LG,Merriweather JL,Huby G,Rattray JE,Hull AM,Brett SJ,Mackenzie SJ,Murray GD,Forbes JF,Walsh TS,RECOVER trial collaboration.

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Sleep disturbance in older people is an important health issue that is associated with many other health problems. Effective interventions are required to address sleep problems in this group. Acupressure has been suggested as a potential therapeutic technique to improve sleep. The aim of this study is to ev...

journal_title：Trials

authors： Hmwe NTT,Browne G,Mollart L,Allanson V,Chan SW

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:At least 40% of people with psychosis have persistent distressing symptoms despite optimal medication treatment. Cognitive behaviour therapy for psychosis (CBTp) is the only NICE-recommended individual therapy for psychosis, with effects on symptoms, distress and quality of life. Yet <10% of service-users re...

journal_title：Trials

authors： Greenwood K,Alford K,O'Leary I,Peters E,Hardy A,Cavanagh K,Field AP,de Visser R,Fowler D,Davies M,Papamichail A,Garety P

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immunosuppression. Recurrent lesions of PG are common, but the relative rarity of this condition means th...

journal_title：Trials

authors： Craig FF,Thomas KS,Mitchell EJ,Williams HC,Norrie J,Mason JM,Ormerod AD,UK Dermatology Clinical Trials Network’s STOP GAP Trial Team.

更新日期：2012-04-28 00:00:00

abstract：BACKGROUND:Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dementia symptoms are needed because current treatment options (antidepressants and antipsychotics) can...

journal_title：Trials

authors： Timler A,Bulsara C,Bulsara M,Vickery A,Smith J,Codde J

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:The Northwestern University Center for Education and Research on Therapeutics (CERT), funded by the Agency for Healthcare Research and Quality, is one of seven such centers in the USA. The thematic focus of the Northwestern CERT is 'Tools for Optimizing Medication Safety.' Ensuring drug safety is essential, ...

journal_title：Trials

authors： Przytula K,Bailey SC,Galanter WL,Lambert BL,Shrestha N,Dickens C,Falck S,Wolf MS

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:Microvascular obstruction (MVO) secondary to ischaemic-reperfusion injury is an important but underappreciated determinant of short- and longer-term outcome following percutaneous coronary intervention (PCI) treatment of ST-elevation myocardial infarction (STEMI). Several small studies have demonstrated a re...

journal_title：Trials

authors： Nazir SA,Khan JN,Mahmoud IZ,Greenwood JP,Blackman DJ,Kunadian V,Been M,Abrams KR,Wilcox R,Adgey AA,McCann GP,Gershlick AH

更新日期：2014-09-25 00:00:00

abstract：:After publication of our article [1] we have been notified on a mistake in the sample size. ...

journal_title：Trials

authors： Zhu L,Shi X,Yin S,Yin J,Zhu Z,Gao X,Jiao Y,Yu W,Yang L

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:This paper presents the study protocol for a pragmatic randomised controlled trial to evaluate the impact of a school based program developed to prevent teenage pregnancy. The program includes students taking care of an Infant Simulator; despite growing popularity and an increasing global presence of such pr...

journal_title：Trials

authors： Brinkman SA,Johnson SE,Lawrence D,Codde JP,Hart MB,Straton JA,Silburn S

更新日期：2010-10-21 00:00:00

abstract：BACKGROUND:The traditional Chinese theory of acupuncture emphasizes that the intensity of acupuncture must reach a threshold to generate de qi (a specific and compound sensation during the acupuncture), which is necessary to achieve the best therapeutic effect. However, the notion that de qi must be achieved for maximu...

journal_title：Trials

authors： Chen Q,Zhang Q,Jiang L,Li X,Liu Y,Xie Y,Mu S,Liu Y,Wang X,Yu Y,Li M

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:Despite a burgeoning interest in using interprofessional approaches to promote effective collaboration in health care, systematic reviews find scant evidence of benefit. This protocol describes the first cluster randomized controlled trial (RCT) to design and evaluate an intervention intended to improve inte...

journal_title：Trials

authors： Zwarenstein M,Reeves S,Russell A,Kenaszchuk C,Conn LG,Miller KL,Lingard L,Thorpe KE

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Sexual dysfunction can have a negative impact on women's quality of life and relationships. There is limited information about female sexual function and treatment, particularly during pregnancy and the postpartum period. The effect of pelvic floor muscle exercise (PFME) on sexual function (SF) has not been ...

journal_title：Trials

authors： Sobhgol SS,Priddis H,Smith CA,Dahlen HG

更新日期：2019-02-20 00:00:00

abstract：BACKGROUND:Previous studies have shown that acupuncture and electroacupuncture (EA) are effective in the treatment of patients with low back pain. However, there is little evidence to support the use of one intervention over the other. The aim of this study is to compare the effect of acupuncture and electroacupuncture...

journal_title：Trials

authors： Comachio J,Oliveira Magalhães M,Nogueira Burke T,Vidal Ramos LA,Peixoto Leão Almeida G,Silva AP,Ferreira de Meneses SR,Costa-Frutuoso JR,Santos Miotto Amorim C,Pasqual Marques A

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Patients' treatment preferences are often cited as barriers to recruitment in randomized controlled trials (RCTs). We investigated how RCT recruiters reacted to patients' treatment preferences and identified key strategies to improve informed decision-making and trial recruitment. METHODS:Audio-recordings o...

journal_title：Trials

authors： Mills N,Blazeby JM,Hamdy FC,Neal DE,Campbell B,Wilson C,Paramasivan S,Donovan JL

更新日期：2014-08-13 00:00:00

abstract：BACKGROUND:Low back pain is a common, disabling musculoskeletal disorder in both developing and developed countries. Although often recommended, the potential efficacy of massage therapy in general, and Chinese massage (tuina) in particular, for relief of chronic low back pain (CLBP) has not been fully established due ...

journal_title：Trials

authors： Yang M,Feng Y,Pei H,Deng S,Wang M,Xiao X,Zheng H,Lai Z,Chen J,Li X,He X,Liang F

更新日期：2014-10-29 00:00:00

abstract：BACKGROUND:The reported incidence of peripheral intravenous catheter (PIV) failure has been as high as 69%. This is in part due to inadequate stabilisation or securement to the skin, which allows micro-motion of the catheter within the vein. METHODS:A pilot open randomised controlled trial of 300 patients was conducte...

journal_title：Trials

authors： Marsh N,Larsen E,Genzel J,Mihala G,Ullman AJ,Kleidon T,Cadigan S,Rickard CM

更新日期：2018-10-30 00:00:00

abstract：BACKGROUND:The purpose of clinical trials of acupuncture is to help clinicians and patients make decisions about treatment. Yet this is not straightforward: some trials report acupuncture to be superior to sham (placebo) acupuncture while others show evidence that acupuncture is superior to usual care but not sham, and...

journal_title：Trials

authors： Vickers AJ,Cronin AM,Maschino AC,Lewith G,Macpherson H,Victor N,Sherman KJ,Witt C,Linde K,Acupuncture Trialists' Collaboration.

更新日期：2010-09-28 00:00:00

abstract：BACKGROUND:There are marked disparities between pre-school children in key skills affecting school readiness, disparities that commonly persist and influence children's later academic achievements, employment, and adjustment. Much of this disparity is linked to socio-economic disadvantage and its impact on the home lea...

journal_title：Trials

authors： Murray L,Jennings S,Mortimer A,Prout A,Melhuish E,Hughes C,Duncan J,Holmes J,Dishington C,Cooper PJ

更新日期：2018-08-22 00:00:00

abstract：BACKGROUND:A growing body of evidence shows the short-term benefits of breastfeeding, which include protection against infections, allergies, and lung diseases. However, evidence on the long-term benefits of breastfeeding is scarce and often conflicting. The BReastfeeding Attitude and Volume Optimization (BRAVO) trial ...

journal_title：Trials

authors： Savitri AI,Idris NS,Indawati W,Saldi SR,Amelia D,Baharuddin M,Sastroasmoro S,Grobbee DE,Uiterwaal CS

更新日期：2016-06-02 00:00:00

abstract：OBJECTIVES:The BCG vaccine, widely used in Brazil in new-borns, induces adjuvant protection for several diseases, including childhood virus infections. BCG activates monocytes and innate memory NK cells which are crucial for the antiviral immune response. Therefore, strategies to prevent COVID-19 in health workers (HW)...

journal_title：Trials

authors： Junqueira-Kipnis AP,Dos Anjos LRB,Barbosa LCS,da Costa AC,Borges KCM,Cardoso ADRO,Ribeiro KM,Rosa SBA,Souza CC,das Neves RC,Saraiva G,da Silva SM,Silveira EA,Rabahi MF,Conte MB,Kipnis A

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND:Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim of this study is to evaluate inhibitory attentional control after 18 sessions of active LLLT and compare with the placebo group (sham LLLT). O...

journal_title：Trials

authors： Poiani GDCR,Zaninotto AL,Carneiro AMC,Zangaro RA,Salgado ASI,Parreira RB,de Andrade AF,Teixeira MJ,Paiva WS

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:The Swiss health ministry launched a national quality program 'QualiCCare' in 2011 to improve health care for patients with COPD.The aim of this study is to determine whether participation in the COPD quality initiative ('QualiCCare') improves adherence to recommended clinical processes and shows impact on p...

journal_title：Trials

authors： Steurer-Stey C,Markun S,Lana KD,Frei A,Held U,Wensing M,Rosemann T

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Care management interventions in the German health-care system have been evaluated with promising results, but further research is necessary to explore their full potential in the context of multi-morbidity. Our aim in this trial is to assess the efficacy of a primary care practice network-based care managem...

journal_title：Trials

authors： Bozorgmehr K,Szecsenyi J,Ose D,Besier W,Mayer M,Krisam J,Jacke CO,Salize HJ,Brandner R,Schmitt S,Kiel M,Kamradt M,Freund T

更新日期：2014-06-21 00:00:00

abstract：BACKGROUND:The risk of falling is significantly higher in people with chronic stroke and it is, therefore, important to design interventions to improve mobility and decrease falls risk. Minimum toe clearance (MTC) is the key gait cycle event for predicting tripping-falls because it occurs mid-swing during the walking c...

journal_title：Trials

authors： Begg R,Galea MP,James L,Sparrow WAT,Levinger P,Khan F,Said CM

更新日期：2019-05-31 00:00:00

abstract：BACKGROUND:At an early stage, prostate cancer patients are often eligible for more than one treatment option, or may choose to defer curative treatment. Without a pre-existing superior option, a patient has to weigh his personal preferences against the risks and benefits of each alternative to select the most appropria...

journal_title：Trials

authors： Cuypers M,Lamers RE,Kil PJ,van de Poll-Franse LV,de Vries M

更新日期：2015-05-27 00:00:00

abstract：:Mental health problems are highly prevalent in children and adolescents, but professional help-seeking behavior in this age group is extremely low. Therefore, the ProHEAD ("Promoting Help-seeking using E-technology for Adolescents") consortium focuses on three main objectives, i.e.: (1) improving young people's help-s...

journal_title：Trials

authors： Kaess M,Bauer S

更新日期：2019-01-22 00:00:00

abstract：BACKGROUND:Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clinical use. The use of a low-dos...

journal_title：Trials

authors： Cosgrave D,Galligan M,Soukhin E,McMullan V,McGuinness S,Puttappa A,Conlon N,Boylan J,Hussain R,Doran P,Nichol A

更新日期：2017-12-29 00:00:00

abstract：BACKGROUND:Chronic central serous chorioretinopathy (cCSC) is an eye disease characterized by an accumulation of serous fluid under the retina. It is postulated that this fluid accumulation results from hyperpermeability and swelling of the choroid, the underlying vascular tissue of the eye, causing a dysfunction of th...

journal_title：Trials

authors： Breukink MB,Downes SM,Querques G,van Dijk EHC,den Hollander AI,Blanco-Garavito R,Keunen JEE,Souied EH,MacLaren RE,Hoyng CB,Fauser S,Boon CJF

更新日期：2015-09-21 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy (CIN) is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal insufficiency. Although some agents including hydration with saline are being prescribed to prevent renal deterioration in these high risk patients, ...

journal_title：Trials

authors： Park K,Chung WY,Seo JB,Kim SH,Zo JH,Kim MA,Park YB

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and debilitating condition characterised by high co-morbidity. Alongside pharmacological treatment, cognitive behavioural therapy (CBT) is an established psychological therapy for GAD. Its effectiveness is limited, however, with only an estimated 50% of clients...

journal_title：Trials

authors： Timulak L,Keogh D,Chigwedere C,Wilson C,Ward F,Hevey D,Griffin P,Jacobs L,Irwin B

更新日期：2018-09-19 00:00:00