Abstract:
BACKGROUND:This paper presents the study protocol for a pragmatic randomised controlled trial to evaluate the impact of a school based program developed to prevent teenage pregnancy. The program includes students taking care of an Infant Simulator; despite growing popularity and an increasing global presence of such programs, there is no published evidence of their long-term impact. The aim of this trial is to evaluate the Virtual Infant Parenting (VIP) program by investigating pre-conceptual health and risk behaviours, teen pregnancy and the resultant birth outcomes, early child health and maternal health. METHODS AND DESIGN:Fifty-seven schools (86% of 66 eligible secondary schools) in Perth, Australia were recruited to the clustered (by school) randomised trial, with even randomisation to the intervention and control arms. Between 2003 and 2006, the VIP program was administered to 1,267 participants in the intervention schools, while 1,567 participants in the non-intervention schools received standard curriculum. Participants were all female and aged between 13-15 years upon recruitment. Pre and post-intervention questionnaires measured short-term impact and participants are now being followed through their teenage years via data linkage to hospital medical records, abortion clinics and education records. Participants who have a live birth are interviewed by face-to-face interview. Kaplan-Meier survival analysis and proportional hazards regression will test for differences in pregnancy, birth and abortion rates during the teenage years between the study arms. DISCUSSION:This protocol paper provides a detailed overview of the trial design as well as initial results in the form of participant flow. The authors describe the intervention and its delivery within the natural school setting and discuss the practical issues in the conduct of the trial, including recruitment. The trial is pragmatic and will directly inform those who provide Infant Simulator based programs in school settings. TRIAL REGISTRATION:ISRCTN24952438.
journal_name
Trialsjournal_title
Trialsauthors
Brinkman SA,Johnson SE,Lawrence D,Codde JP,Hart MB,Straton JA,Silburn Sdoi
10.1186/1745-6215-11-100subject
Has Abstractpub_date
2010-10-21 00:00:00pages
100issn
1745-6215pii
1745-6215-11-100journal_volume
11pub_type
杂志文章,随机对照试验相关文献
Trials文献大全abstract:BACKGROUND:Surgical site infections (SSI) remain one of the most common complications in conventional abdominal surgery with an incidence between 4% and 19% (Sandini et al., Medicine (Baltimore) 95:e4057, 2016) in the literature. It is unclear whether the use of coated suture material for skin closure reduces the risk ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3492-3
更新日期:2019-07-02 00:00:00
abstract:BACKGROUND:Most people who stop smoking successfully for a few weeks will return to smoking again in the medium term. There are few effective interventions to prevent this relapse and none used routinely in clinical practice. A previous exploratory meta-analysis suggested that self-help booklets may be effective but re...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-13-69
更新日期:2012-05-30 00:00:00
abstract:BACKGROUND:Sleep disturbance in older people is an important health issue that is associated with many other health problems. Effective interventions are required to address sleep problems in this group. Acupressure has been suggested as a potential therapeutic technique to improve sleep. The aim of this study is to ev...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04286-2
更新日期:2020-04-25 00:00:00
abstract:BACKGROUND:Tracheal intubation with the patient in the lateral position is difficult because the laryngeal view is compromised during direct laryngoscopy. Flexible video endoscopes may facilitate intubation even when laryngeal views are poor on direct laryngoscopy because the patients are positioned laterally. Thus, th...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3263-1
更新日期:2019-03-15 00:00:00
abstract:BACKGROUND:At least 40% of people with psychosis have persistent distressing symptoms despite optimal medication treatment. Cognitive behaviour therapy for psychosis (CBTp) is the only NICE-recommended individual therapy for psychosis, with effects on symptoms, distress and quality of life. Yet <10% of service-users re...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-3023-7
更新日期:2018-11-20 00:00:00
abstract:BACKGROUND:Spine surgery is associated with considerable postoperative pain and can be challenging to treat. A loco-regional technique suitable for spine surgery should cover the dorsal root of the spinal nerves at the levels where surgery is performed. The erector spinae block is a loco-regional technique with promisi...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3541-y
更新日期:2019-07-17 00:00:00
abstract:BACKGROUND:There is evidence to suggest that delivery of diabetes self-management support by diabetes educators in primary care may improve patient care processes and patient clinical outcomes; however, the evaluation of such a model in primary care is nonexistent in Canada. This article describes the design for the ev...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-13-165
更新日期:2012-09-13 00:00:00
abstract:BACKGROUND:With a prevalence of 3 to 8% among women of reproductive age, severe premenstrual symptoms are very common. Symptoms range from emotional and cognitive to physical changes. Severe symptoms (that is, premenstrual syndrome) can have a strong impact on everyday functioning and quality of life. Impairment can be...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-15-472
更新日期:2014-12-02 00:00:00
abstract:BACKGROUND:Intrathecally administered morphine is effective as part of a postoperative analgesia regimen following major hepatopancreaticobiliary surgery. However, the potential for postoperative respiratory depression at the doses required for effective analgesia currently limits its clinical use. The use of a low-dos...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-017-2370-0
更新日期:2017-12-29 00:00:00
abstract:BACKGROUND:There is no recommendation to screen ferritin level in blood donors, even though several studies have noted the high prevalence of iron deficiency after blood donation, particularly among menstruating females. Furthermore, some clinical trials have shown that non-anaemic women with unexplained fatigue may be...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-10-4
更新日期:2009-01-16 00:00:00
abstract::Mental health problems are highly prevalent in children and adolescents, but professional help-seeking behavior in this age group is extremely low. Therefore, the ProHEAD ("Promoting Help-seeking using E-technology for Adolescents") consortium focuses on three main objectives, i.e.: (1) improving young people's help-s...
journal_title:Trials
pub_type: 社论
doi:10.1186/s13063-018-3162-x
更新日期:2019-01-22 00:00:00
abstract:BACKGROUND:Classroom-based stuttering intervention addressing negative peer attitudes, perceptions, teasing and bullying of children who stutter (CWS) is required as part of holistic stuttering management because of its occurrence in primary school. This study was conducted in 2017, in 10 primary schools in the Western...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-018-3043-3
更新日期:2018-11-29 00:00:00
abstract:BACKGROUND:Socially disadvantaged men are at a substantially higher risk of developing alcohol-related problems. The frequency of heavy drinking in a single session is high among disadvantaged men. Brief alcohol interventions were developed for, and are usually delivered in, healthcare settings. The group who binge dri...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-15-494
更新日期:2014-12-19 00:00:00
abstract:BACKGROUND:Announcements of interim analyses of a clinical trial convey information about the results beyond the trial's Data Safety Monitoring Board (DSMB). The amount of information conveyed may be minimal, but the fact that none of the trial's stopping boundaries has been crossed implies that the experimental therap...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/1745-6215-15-73
更新日期:2014-03-07 00:00:00
abstract::After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled. ...
journal_title:Trials
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13063-020-4107-8
更新日期:2020-02-12 00:00:00
abstract:BACKGROUND:For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs results in an increase in the...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2542-6
更新日期:2018-03-05 00:00:00
abstract::Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...
journal_title:Trials
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s13063-015-1050-1
更新日期:2015-11-14 00:00:00
abstract:BACKGROUND:Obesity represents a major public health problem and is the fifth leading risk factor for mortality. Morbid obesity is associated with chronic systemic inflammation which increases the risk of comorbidities. Bariatric surgery (BS) is considered an effective intervention for obese patients. However, BS is ass...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-018-2844-8
更新日期:2018-10-31 00:00:00
abstract:BACKGROUND:Patients' treatment preferences are often cited as barriers to recruitment in randomized controlled trials (RCTs). We investigated how RCT recruiters reacted to patients' treatment preferences and identified key strategies to improve informed decision-making and trial recruitment. METHODS:Audio-recordings o...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/1745-6215-15-323
更新日期:2014-08-13 00:00:00
abstract:BACKGROUND:Neointimal hyperplasia plays a pivotal role in the pathogenesis of in-stent restenosis in patients undergoing percutaneous coronary interventions. Drug-eluting balloons are a promising tool to prevent restenosis after coronary angioplasty. Moreover, an increased knowledge of the pathophysiology of restenosis...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/1745-6215-13-55
更新日期:2012-05-06 00:00:00
abstract:BACKGROUND:Home parenteral nutrition (HPN) is a life-preserving therapy for patients with chronic intestinal failure (CIF) indicated for patients who cannot achieve their nutritional requirements by enteral intake. Intravenously administered lipid emulsions (ILEs) are an essential component of HPN, providing energy and...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-019-3994-z
更新日期:2019-12-30 00:00:00
abstract:BACKGROUND:There is currently a lack of randomized, sham-controlled trials that are adequately powered, using validated outcomes, to allow for firm recommendations on the use of magnetic stimulation for stress urinary incontinence. We report a protocol of a multicenter, randomized, double-blind, sham-controlled paralle...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s13063-015-0803-1
更新日期:2015-06-21 00:00:00
abstract:BACKGROUND:Around 35-45 % of people in contact with services for a first episode of psychosis are using cannabis. Cannabis use is associated with delays in remission, poorer clinical outcomes, significant increases in the risk of relapse, and lower engagement in work or education. While there is a clear need for effect...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-016-1620-x
更新日期:2016-10-22 00:00:00
abstract:BACKGROUND:Research shows that more than half of the people taking medication for a chronic condition are non-adherent. Nonadherence hinders disease control with a burden on patient quality of life and healthcare systems. We developed a tool that provides insight into nonadherence risks and barriers for medication-adhe...
journal_title:Trials
pub_type: 杂志文章,随机对照试验
doi:10.1186/s13063-016-1393-2
更新日期:2016-06-03 00:00:00
abstract:BACKGROUND:Spinal manipulative therapy is commonly used in the treatment of adolescent idiopathic scoliosis. Some therapists also rely on physiotherapeutic scoliosis-specific exercise (PSSE). Combining these two modalities seems reasonable, but the effectiveness of this combination has never been rigorously tested. Her...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-05000-y
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Infections are common in nursing home (NH) residents with advanced dementia but are often managed inappropriately. Antimicrobials are extensively prescribed, but frequently with insufficient evidence to support a bacterial infection, promoting the emergence of multidrug-resistant organisms. Moreover, the ben...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-019-3675-y
更新日期:2019-10-15 00:00:00
abstract::An amendment to this paper has been published and can be accessed via the original article. ...
journal_title:Trials
pub_type: 杂志文章,已发布勘误
doi:10.1186/s13063-020-04504-x
更新日期:2020-06-16 00:00:00
abstract:BACKGROUND:Laminoplasty and laminectomy have been used for decades for the treatment of intraspinal space-occupying lesions, spinal stenosis, disc herniation, injuries, etc. After these procedures, patients often experience severe postoperative pain at the surgical site. Intense immediate postoperative pain after many ...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/s13063-020-04308-z
更新日期:2020-05-05 00:00:00
abstract:BACKGROUND:Symptoms in hypertrophic cardiomyopathy (HC) appear to be caused by diastolic dysfunction, myocardial ischemia, left ventricle (LV) outflow obstruction, and atrial fibrillation. However, clinical deterioration and severe heart failure symptoms can be observed in patients without any of these factors. Thus, t...
journal_title:Trials
pub_type: 杂志文章
doi:10.1186/1745-6215-9-11
更新日期:2008-02-29 00:00:00
abstract:BACKGROUND:Quadriplegia is a severe, catastrophic injury that predominantly affects people early in life, resulting in lifelong physical disability. Obstructive sleep apnoea is a direct consequence of quadriplegia and is associated with neurocognitive deficits, sleepiness and reduced quality of life. The usual treatmen...
journal_title:Trials
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1745-6215-14-181
更新日期:2013-06-19 00:00:00