TReatIng Urinary symptoms in Men in Primary Healthcare using non-pharmacological and non-surgical interventions (TRIUMPH) compared with usual care: study protocol for a cluster randomised controlled trial.

abstract：BACKGROUND:Preterm birth accounts for 75% of perinatal deaths and more than 50% of long-term neurological disabilities. For a singleton pregnancy, progesterone treatment is effective in prevention of preterm birth in women with an asymptomatic short cervix or a history of preterm birth. However, a large proportion of p...

journal_title：Trials

authors： Cheung KW,Seto MTY,Ng EHY

更新日期：2020-01-30 00:00:00

abstract：BACKGROUND:Adolescent idiopathic scoliosis (AIS) is one of the most prevalent spinal deformities that may progress sharply during growth. The aim of this study will be to evaluate the efficacy of three-dimensionally integrated exercise on the Cobb angle, angle of trunk rotation, sagittal profile, and quality of life in...

journal_title：Trials

authors： Liang J,Zhou X,Chen N,Li X,Yu H,Yang Y,Song Y,Du Q

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Patients with type 2 diabetes (T2DM) are at increased risk for macrovascular events as well as for microvascular complications. There is evidence that in patients with coronary artery disease (CAD), about 35 % suffer from manifest T2DM. Early glucose-lowering intervention in subjects with T2DM has been demon...

journal_title：Trials

authors： Tripolt NJ,Aberer F,Riedl R,Hutz B,Url J,Dimsity G,Meinitzer A,Stojakovic T,Hödl R,Brodmann M,Hafner F,Sourij H

更新日期：2016-10-13 00:00:00

abstract：BACKGROUND:Feeding practices and child undernutrition can be improved when trained health workers provide proper nutrition counseling to caregivers. However, this important management component is difficult to achieve in countries where trained health workers are limited; Tanzania is no exception. In rural and semi-urb...

journal_title：Trials

authors： Sunguya BF,Poudel KC,Mlunde LB,Urassa DP,Jimba M,Yasuoka J

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Despite efforts to improve the accuracy and transparency of the design, conduct, and reporting of randomised controlled trials (RCTs), deficiencies remain. Such deficiencies contribute to significant, avoidable waste of health research investment and impede reproducibility. This study aimed to synthesise and...

journal_title：Trials

authors： Clyne B,Boland F,Murphy N,Murphy E,Moriarty F,Barry A,Wallace E,Devine T,Smith SM,Devane D,Murphy A,Fahey T

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:The Swiss health ministry launched a national quality program 'QualiCCare' in 2011 to improve health care for patients with COPD.The aim of this study is to determine whether participation in the COPD quality initiative ('QualiCCare') improves adherence to recommended clinical processes and shows impact on p...

journal_title：Trials

authors： Steurer-Stey C,Markun S,Lana KD,Frei A,Held U,Wensing M,Rosemann T

更新日期：2014-03-27 00:00:00

abstract：BACKGROUND:Spontaneous recovery from articular cartilage injury is difficult, and the ongoing progression of disease can eventually lead to osteoarthritis. Currently, there is no effective non-surgical treatment for articular cartilage injury. Arthroscopic debridement and microfracture surgery are performed for fibroca...

journal_title：Trials

authors： Ma N,Wang H,Xu X,Wan Y,Liu Y,Wang M,Yu W,Dai Y,Peng J,Guo Q,Yu C,Lu S

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:More than 60,000 people have health problems due to chemical weapons exposure during the Iran-Iraq war. Respiratory consequences of mustard gas exposure are common and disabling; medical interventions have limited effect. Patients complain of cough, sputum, breathlessness and exercise limitation. We hypothes...

journal_title：Trials

authors： Sedighi Moghadam MR,Ghanei M,Kenn K,Hopkinson NS

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:Extended brief interventions (EBIs) are effective in targeting alcohol misuse in the general population. However, little is known of the effects of EBI in adults with intellectual (also known as learning) disabilities. In this feasibility trial we compared EBI with usual care for alcohol misuse in adults wit...

journal_title：Trials

authors： Kouimtsidis C,Bosco A,Scior K,Baio G,Hunter R,Pezzoni V,Mcnamara E,Hassiotis A

更新日期：2017-05-12 00:00:00

abstract：BACKGROUND:Surgical interventions are complex, which complicates their rigorous assessment through randomised clinical trials. An important component of complexity relates to surgeon experience and the rate at which the required level of skill is achieved, known as the learning curve. There is considerable evidence tha...

journal_title：Trials

authors： Papachristofi O,Jenkins D,Sharples LD

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Smoking in pregnancy is a major international public health problem. Self-help support (SHS) increases the likelihood of women stopping smoking in pregnancy and delivering this kind of support by text message could be a cost-effective way to deliver SHS to pregnant women who smoke. SHS delivered by text mess...

journal_title：Trials

authors： Whitemore R,Leonardi-Bee J,Naughton F,Sutton S,Cooper S,Parrott S,Hewitt C,Clark M,Ussher M,Jones M,Torgerson D,Coleman T

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:Nitrogen containing bisphosphonates such as zoledronic acid (ZA) are known to contain certain anti-cancer properties. These have been investigated in the past in various cancers such as breast, prostate and colon. ZA in particular has shown promising results in pre-clinical studies. We propose a multicentre ...

journal_title：Trials

authors： de Fonseka D,Morley A,Stadon L,Keenan E,Walker S,Smith S,Harvey JE,Cox RA,Dangoor A,Comins C,Rogers C,Edey A,Addeo A,Maskell NA

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Research has shown that recruitment to trials is a process that stretches from identifying potentially eligible patients, through eligibility assessment, to obtaining informed consent. The length and complexity of this pathway means that many patients do not have the opportunity to consider participation. Th...

journal_title：Trials

authors： Wilson C,Rooshenas L,Paramasivan S,Elliott D,Jepson M,Strong S,Birtle A,Beard DJ,Halliday A,Hamdy FC,Lewis R,Metcalfe C,Rogers CA,Stein RC,Blazeby JM,Donovan JL

更新日期：2018-01-19 00:00:00

abstract：BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...

journal_title：Trials

authors： Smit-Fun VM,de Korte-de Boer D,Posthuma LM,Stolze A,Dirksen CD,Hollmann MW,Buhre WF,Boer C

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:Many funding bodies require researchers to actively involve service users in research to improve relevance, accountability and quality. Current guidance to researchers mainly discusses general principles. Formal guidance about how to involve service users operationally in the conduct of trials is lacking. We...

journal_title：Trials

authors： Evans BA,Bedson E,Bell P,Hutchings H,Lowes L,Rea D,Seagrove A,Siebert S,Smith G,Snooks H,Thomas M,Thorne K,Russell I,West Wales Organisation for Rigorous Trials in Health (WWORTH).

更新日期：2013-07-17 00:00:00

abstract：BACKGROUND/AIMS:Prediabetes and diabetes disproportionately impact Latino youth, yet few diabetes prevention programs have prioritized inclusion of this underrepresented population. This report describes the recruitment process, yields, associated costs, and phenotypic characteristics of Latino youth with obesity and p...

journal_title：Trials

authors： Vander Wyst KB,Olson ML,Hooker E,Soltero EG,Konopken YP,Keller CS,Castro FG,Williams AN,Fernández ADR,Patrick DL,Ayers SL,Hu HH,Peña A,Pimentel J,Knowler WC,Shaibi GQ

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:Anaemia following hip fracture is common. Approximately 30 to 45% of patients have haemoglobin concentrations below population norms on admission, and around 10% are severely anaemic. Anaemia on admission, and in the postoperative period, is associated with poor outcomes with regard to mobility, postoperativ...

journal_title：Trials

authors： Rowlands M,Forward DP,Sahota O,Moppett IK

更新日期：2013-09-09 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a common cause of disability among U.S. military personnel. Approximately 20% of all diagnoses resulting in disability discharges are linked to back-related conditions. Because LBP can negatively influence trunk muscle strength, balance, and endurance, the military readiness of active-...

journal_title：Trials

authors： Vining R,Minkalis A,Long CR,Corber L,Franklin C,Gudavalli MR,Xia T,Goertz CM

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:Emergency department attendances with chest pain requiring assessment for acute coronary syndrome (ACS) are a major global health issue. Standard assessment includes history, examination, electrocardiogram (ECG) and serial troponin testing. Computerised tomography coronary angiography (CTCA) enables addition...

journal_title：Trials

authors： Gray AJ,Roobottom C,Smith JE,Goodacre S,Oatey K,O'Brien R,Storey RF,Na L,Lewis SC,Thokala P,Newby DE

更新日期：2016-12-07 00:00:00

abstract：BACKGROUND:Intra-operative electrocorticography, based on interictal spikes and spike patterns, is performed to optimize delineation of the epileptogenic tissue during epilepsy surgery. High frequency oscillations (HFOs, 80-500 Hz) have been identified as more precise biomarkers for epileptogenic tissue. The aim of the...

journal_title：Trials

authors： van 't Klooster MA,Leijten FS,Huiskamp G,Ronner HE,Baayen JC,van Rijen PC,Eijkemans MJ,Braun KP,Zijlmans M,HFO study group.

更新日期：2015-09-23 00:00:00

abstract：BACKGROUND:Hypothyroidism is a prevalent endocrine condition. Individuals with this disease are commonly managed through supplementation with synthetic thyroid hormone, with the aim of alleviating symptoms and restoring normal thyroid stimulating hormone levels. Generally this management strategy is effective and well ...

journal_title：Trials

authors： Brown BT,Bonello R,Pollard H,Graham P

更新日期：2010-11-15 00:00:00

abstract：BACKGROUND:Spleen qi deficiency (SQD), a syndrome based on traditional Chinese medicine (TCM) theory, is common in patients after radical gastrectomy. SQD manifests with chronic gastrointestinal disorders and systemic symptoms and is challenging to manage. Hou Gu Mi Xi (HGMX) is a dietary TCM formula for SQD. This stud...

journal_title：Trials

authors： Zhou X,Yan DM,Zhu WF,Liu WJ,Nie HY,Xu S,Jiang YP,Zhang KH,Fu Y,Wan YY,Yu XY,Li H,Sun X,Chen XF

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:At least 40% of people with psychosis have persistent distressing symptoms despite optimal medication treatment. Cognitive behaviour therapy for psychosis (CBTp) is the only NICE-recommended individual therapy for psychosis, with effects on symptoms, distress and quality of life. Yet <10% of service-users re...

journal_title：Trials

authors： Greenwood K,Alford K,O'Leary I,Peters E,Hardy A,Cavanagh K,Field AP,de Visser R,Fowler D,Davies M,Papamichail A,Garety P

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Current international guidelines recommend the use of a daily topical exit-site antimicrobial to prevent peritoneal dialysis (PD)-related infections. Although nonantibiotic-based therapies are appealing because they may limit antimicrobial resistance, no controlled trials have been conducted to compare topic...

journal_title：Trials

authors： Nochaiwong S,Ruengorn C,Noppakun K,Panyathong S,Dandecha P,Sood MM,Saenjum C,Awiphan R,Sirilun S,Mongkhon P,Chongruksut W,Thavorn K,Thai Renal Outcomes Research (THOR) Investigators.

更新日期：2019-12-19 00:00:00

abstract：BACKGROUND:Diabetic foot ulcers (DFUs) represent a significant source of morbidity and an enormous financial burden. Standard care for DFUs involves systemic glucose control, ensuring adequate perfusion, debridement of nonviable tissue, off-loading, control of infection, local wound care and patient education, all admi...

journal_title：Trials

authors： Lev-Tov H,Li CS,Dahle S,Isseroff RR

更新日期：2013-01-09 00:00:00

abstract：BACKGROUND:Cigarette smoking negatively impacts on maternal and fetal health. Smoking cessation is one of the few interventions capable of improving pregnancy outcomes. Despite the risks, the most effective antenatal model of care for smokers is still unclear, and specific recommendations for screening for fetal growth...

journal_title：Trials

authors： McDonnell BP,Dicker P,Keogan S,Clancy L,Regan C

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Patient-reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing-remitting conditions, such as eczema, repeated measurements may allow a more accurate reflection of disease burden and treatment effect than less frequ...

journal_title：Trials

authors： Stuart B,Rumsby K,Santer M,Ridd MJ,Francis NA,Chorozoglou M,Spreadbury C,Steele M,Nollett C,Liddiard L,Prude M,Hooper J,Thomas-Jones E,Roberts A,Thomas KS,Williams HC,Little P

更新日期：2018-10-24 00:00:00

abstract：BACKGROUND:Earlier vascular healing after drug-eluting stent (DES) implantation may reduce the incidence of late stent thrombosis and provide theoretical evidence to shorten dual antiplatelet therapy duration in patients with high bleeding risks. The BuMA supreme stent is a newly developed DES-coated with the sirolimus...

journal_title：Trials

authors： Li B,Jin QH,Chen YD,Wang CQ,Shi B,Su X,Fu GS,Wu YQ,Zhou XC,Yuan ZY

更新日期：2019-06-07 00:00:00

abstract：BACKGROUND:People with severe mental illness (SMI) are two to three times more likely to be overweight and obese than the general population and this is associated with significant morbidity and premature mortality. Although lifestyle interventions can support people with SMI to lose weight, some are unable to make the...

journal_title：Trials

authors： Whicher CA,Price HC,Phiri P,Rathod S,Barnard-Kelly K,Reidy C,Thorne K,Asher C,Peveler R,McCarthy J,Holt RIG

更新日期：2019-11-20 00:00:00

abstract：BACKGROUND:Radical lymph node dissection (LND) along the left recurrent laryngeal nerve (RLN) is surgically demanding and can be associated with substantial postoperative morbidity. The question of whether robot-assisted esophagectomy (RE) might be superior to video-assisted thoracoscopic esophagectomy (VATE) for perfo...

journal_title：Trials

authors： Chao YK,Li ZG,Wen YW,Kim DJ,Park SY,Chang YL,van der Sluis PC,Ruurda JP,van Hillegersberg R

更新日期：2019-06-10 00:00:00