Feasibility of weekly participant-reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema).

abstract：BACKGROUND:Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not without side effects. It impedes early mobilization, could pose an infection risk, and may encourage the...

journal_title：Trials

authors： Roffe C,Nevatte T,Crome P,Gray R,Sim J,Pountain S,Handy L,Handy P

更新日期：2014-03-31 00:00:00

abstract：BACKGROUND:Patients with liver cirrhosis have a highly elevated risk of developing bacterial infections that significantly decrease survival rates. One of the most relevant infections is spontaneous bacterial peritonitis (SBP). Recently, NOD2 germline variants were found to be potential predictors of the development of...

journal_title：Trials

authors： Casper M,Mengel M,Fuhrmann C,Herrmann E,Appenrodt B,Schiedermaier P,Reichert M,Bruns T,Engelmann C,Grünhage F,Lammert F,INCA trial group.

更新日期：2015-03-08 00:00:00

abstract：BACKGROUND:It is generally accepted that an active lifestyle is beneficial for cognition in children, adults and the elderly. Recently, studies using the rat animal model found that the pups of mothers who exercised during pregnancy had increased hippocampal neurogenesis and better memory and learning abilities. The ai...

journal_title：Trials

authors： LeMoyne EL,Curnier D,St-Jacques S,Ellemberg D

更新日期：2012-05-29 00:00:00

abstract：BACKGROUND:Previous research has suggested an association between more liberal red blood cell (RBC) transfusion and greater risk of further bleeding and mortality following acute upper gastrointestinal bleeding (AUGIB). METHODS AND DESIGN:The Transfusion in Gastrointestinal Bleeding (TRIGGER) trial is a pragmatic clus...

journal_title：Trials

authors： Kahan BC,Jairath V,Murphy MF,Doré CJ

更新日期：2013-07-10 00:00:00

abstract：RATIONALE:In critically ill patients receiving invasive mechanical ventilation (MV), research supports the use of daily screening to identify patients who are ready to undergo a spontaneous breathing trial (SBT) followed by conduct of an SBT. However, once daily (OD) screening is poorly aligned with the continuous care...

journal_title：Trials

authors： Burns KEA,Rizvi L,Cook DJ,Seely AJE,Rochwerg B,Lamontagne F,Devlin JW,Dodek P,Mayette M,Tanios M,Gouskos A,Kay P,Mitchell S,Kiedrowski KC,Hill NS,Canadian Critical Care Trials Group.

更新日期：2019-10-11 00:00:00

abstract：BACKGROUND:Increasing numbers of patients are surviving critical illness, but survival may be associated with a constellation of physical and psychological sequelae that can cause ongoing disability and reduced health-related quality of life. Limited evidence currently exists to guide the optimum structure, timing, and...

journal_title：Trials

authors： Ramsay P,Salisbury LG,Merriweather JL,Huby G,Rattray JE,Hull AM,Brett SJ,Mackenzie SJ,Murray GD,Forbes JF,Walsh TS,RECOVER trial collaboration.

更新日期：2014-01-29 00:00:00

abstract：BACKGROUND:Generalized anxiety disorder (GAD) is a psychiatric disorder characterized by a constant and unspecific anxiety that interferes with daily-life activities. Its high prevalence in general population and the severe limitations it causes, point out the necessity to find new efficient strategies to treat it. Tog...

journal_title：Trials

authors： Gorini A,Riva G

更新日期：2008-05-05 00:00:00

abstract：BACKGROUND:Loss of upper limb function affects up to 85 % of acute stroke patients. Recovery of upper limb function requires regular intensive practise of specific upper limb tasks. To enhance intensity of practice interventions are being developed to encourage patients to undertake self-directed exercise practice. Mos...

journal_title：Trials

authors： Moore SA,Da Silva R,Balaam M,Brkic L,Jackson D,Jamieson D,Ploetz T,Rodgers H,Shaw L,van Wijck F,Price C

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Low back pain is a common, disabling musculoskeletal disorder in both developing and developed countries. Although often recommended, the potential efficacy of massage therapy in general, and Chinese massage (tuina) in particular, for relief of chronic low back pain (CLBP) has not been fully established due ...

journal_title：Trials

authors： Yang M,Feng Y,Pei H,Deng S,Wang M,Xiao X,Zheng H,Lai Z,Chen J,Li X,He X,Liang F

更新日期：2014-10-29 00:00:00

abstract：:Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for individual patients, we propose a new RCT adaptation termed the nested-pr...

journal_title：Trials

authors： Kappelmann N,Müller-Myhsok B,Kopf-Beck J

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:AirSeal is a novel class of valve-free insufflation system that enables a stable pneumoperitoneum with continuous smoke evacuation and carbon dioxide (CO₂) recirculation during laparoscopic surgery. Comparison data to standard CO₂ pressure pneumoperitoneum insufflators is scarce. The aim of this study is to ...

journal_title：Trials

authors： Luketina RR,Knauer M,Köhler G,Koch OO,Strasser K,Egger M,Emmanuel K

更新日期：2014-06-20 00:00:00

abstract：BACKGROUND:Postoperative delirium (POD) is a manifestation of acute postoperative brain dysfunction that is frequently observed after cardiac surgery. POD is associated with short-term complications such as an increase in mortality, morbidity, costs and length of stay, but can also have long-term sequelae, including pe...

journal_title：Trials

authors： Al Tmimi L,Van de Velde M,Herijgers P,Meyns B,Meyfroidt G,Milisen K,Fieuws S,Coburn M,Poesen K,Rex S

更新日期：2015-10-09 00:00:00

abstract：BACKGROUND:A wide range of prophylactic antibiotic regimens are used for patients undergoing open-heart cardiac surgery. This reflects clinical equipoise in choice and duration of antibiotic agents. Although individual-level randomized control trials (RCT) are considered the gold standard when evaluating the efficacy o...

journal_title：Trials

authors： van Oostveen RB,Romero-Palacios A,Whitlock R,Lee SF,Connolly S,Carignan A,Mazer CD,Loeb M,Mertz D

更新日期：2018-12-17 00:00:00

abstract：BACKGROUND:Tobacco smoking remains the leading preventable cause of death in the US. A hospital admission provides smokers with a unique opportunity to stop smoking because it requires temporary tobacco abstinence while illness may enhance motivation to quit. Hospital interventions must continue post-discharge to incre...

journal_title：Trials

authors： Rigotti NA,Schnitzer K,Davis EM,Regan S,Chang Y,Kelley JHK,Notier AE,Gilliam K,Douaihy A,Levy DE,Singer DE,Tindle HA

更新日期：2020-04-16 00:00:00

abstract：BACKGROUND:Surgical microvascular decompression (MVD) is the curative treatment for hemifacial spasm (HFS). Monitoring MVD by recording the lateral spread response (LSR) intraoperatively can predict a successful clinical outcome. However, the rate of the LSR varies between trials, and the reason for this variation is u...

journal_title：Trials

authors： Fang Y,Zhang H,Liu W,Li Y

更新日期：2012-09-08 00:00:00

abstract：BACKGROUND:Maintaining adequate oxygenation during rapid sequence intubation (RSI) is imperative to prevent peri-intubation adverse events that can lead to increased duration of hospital and intensive care unit stay, or a prolonged vegetative state requiring long-term institutionalisation. Despite employing current bes...

journal_title：Trials

authors： Chua MT,Khan FA,Ng WM,Lu Q,Low MJW,Yau YW,Punyadasa A,Kuan WS

更新日期：2019-04-04 00:00:00

abstract：BACKGROUND:We sought to test the effectiveness of methadone and buprenorphine in the treatment of methamphetamine withdrawal craving over a 17-day treatment period. METHODS:Patients were randomized into one of two groups. The study sample comprised 40 male subjects dependent on methamphetamine who met criteria of the ...

journal_title：Trials

authors： Ahmadi J,Razeghian Jahromi L

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Although various pancreaticojejunal duct-to-mucosa anastomosis methods have been developed to reduce the postoperative risks of pancreaticoduodenectomy, pancreatic fistula remains the most serious complication with a high incident rate. The aim of this study is to compare the safety and effectiveness of one-...

journal_title：Trials

authors： Pan SB,Geng W,Zhou DC,Chen JM,Zhao HC,Liu FB,Xie SX,Hou H,Zhao YJ,Xie K,Wang GB,Geng XP

更新日期：2016-08-17 00:00:00

abstract：BACKGROUND:Exercise-based cardiac rehabilitation is a beneficial therapy for patients with chronic heart failure. The delivery of exercise-based cardiac rehabilitation should adopt an evidence-based approach, as well as be culturally appropriate and sensitive to individual needs and preferences. The Baduanjin Eight-Sil...

journal_title：Trials

authors： Chen X,Jiang W,Lin X,Lundborg CS,Wen Z,Lu W,Marrone G

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:There are more than a quarter of a million individuals aged ≥ 65 years who are resident in care homes in England and Wales. Care home residents have high levels of cognitive impairment, physical disability, multimorbidity and polypharmacy. Research is needed to ensure there are robust, evidence-based interve...

journal_title：Trials

authors： Ellwood A,Airlie J,Cicero R,Cundill B,Ellard DR,Farrin A,Godfrey M,Graham L,Green J,McLellan V,Siddiqi N,Forster A,REACH Programme Team.

更新日期：2018-10-03 00:00:00

abstract：BACKGROUND:With a prevalence of 3 to 8% among women of reproductive age, severe premenstrual symptoms are very common. Symptoms range from emotional and cognitive to physical changes. Severe symptoms (that is, premenstrual syndrome) can have a strong impact on everyday functioning and quality of life. Impairment can be...

journal_title：Trials

authors： Kues JN,Janda C,Kleinstäuber M,Weise C

更新日期：2014-12-02 00:00:00

abstract：BACKGROUND:ICU stay is often associated with negative experiences for the individual patient. Many patients are disabled and their communication is restricted during the ICU stay. Specific information on procedures, sensations and coping behavior are thought to reduce anxiety on the ICU. Until now information programs ...

journal_title：Trials

authors： Fleischer S,Berg A,Neubert TR,Koller M,Behrens J,Becker R,Horbach A,Radke J,Rothmund M,Kuss O

更新日期：2009-09-14 00:00:00

abstract：BACKGROUND:Chest tube insertion is a standard intervention for management of various injuries of the thorax. Quick and accurate execution facilitates efficient therapy without further complications. Here, we propose a new training concept comprised of e-learning elements as well as continuous rating using an objective ...

journal_title：Trials

authors： Friedrich M,Bergdolt C,Haubruck P,Bruckner T,Kowalewski KF,Müller-Stich BP,Tanner MC,Nickel F

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Transurethral resection of the prostate (TURP) has been the standard operation for benign prostatic obstruction (BPO) for 40 years, with approximately 25,000 procedures performed annually, and has remained largely unchanged. It is generally a successful operation, but has well-documented risks for the patien...

journal_title：Trials

authors： Worthington J,Taylor H,Abrams P,Brookes ST,Cotterill N,Noble SM,Page T,Swami KS,Lane JA,Hashim H

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Three-dimensional (3D) stereoscopic vision is crucial to perform any kind of manual task. The reduction from real life 3D to virtual two-dimensional (2D) sight is a major challenge in minimally invasive surgery (MIS). A 3D display technique has been shown to reduce operation time and mistakes and to improve ...

journal_title：Trials

authors： Wahba R,Datta RR,Hedergott A,Bußhoff J,Bruns T,Kleinert R,Dieplinger G,Fuchs H,Gietzelt C,Möller D,Hellmich M,Bruns CJ,Stippel DL

更新日期：2019-05-28 00:00:00

abstract：BACKGROUND:The United Nations Millennium Development Goals include targets for the health of children under five years old. Poor health is linked to poverty and microfinance initiatives are economic interventions that may improve health by breaking the cycle of poverty. However, there is a lack of reliable evidence to ...

journal_title：Trials

authors： Ojha S,Szatkowski L,Sinha R,Yaron G,Fogarty A,Allen S,Choudhary S,Smyth AR

更新日期：2014-07-23 00:00:00

abstract：BACKGROUND:In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS:Based on a comprehe...

journal_title：Trials

authors： Hummers-Pradier E,Bleidorn J,Schmiemann G,Joos S,Becker A,Altiner A,Chenot JF,Scherer M,German ‘Clinical Trials in German General Practice Network’.

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:The increasing prevalence of Alzheimer's disease and other forms of dementia raises new challenges to ensure that healthcare decisions are informed by research evidence and reflect what is important for seniors and their caregivers. Therefore, we aim to evaluate a tailored intervention to help healthcare pro...

journal_title：Trials

authors： Giguere AMC,Lawani MA,Fortier-Brochu É,Carmichael PH,Légaré F,Kröger E,Witteman HO,Voyer P,Caron D,Rodríguez C

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Patients admitted to intensive care units (ICU) with acute respiratory failure (ARF) face chronic complications that can impede return to normal daily function. A mobile, collaborative critical care model may enhance the recovery of ARF survivors. METHODS:The Mobile Critical Care Recovery Program (m-CCRP) s...

journal_title：Trials

authors： Khan S,Biju A,Wang S,Gao S,Irfan O,Harrawood A,Martinez S,Brewer E,Perkins A,Unverzagt FW,Lasiter S,Zarzaur B,Rahman O,Boustani M,Khan B

更新日期：2018-02-07 00:00:00

abstract：BACKGROUND:Individuals with chronic lung disease are more susceptible to present reduction in exercise tolerance and muscles strength not only due to pulmonary limitations but also due systemic repercussions of the pulmonary disease. The aim of this study is to assess the physical capacity, peripheral muscle function, ...

journal_title：Trials

authors： Reimberg MM,Castro RA,Selman JP,Meneses AS,Politti F,Mallozi MC,Wandalsen GF,Solé D,De Angelis K,Dal Corso S,Lanza FC

更新日期：2015-08-13 00:00:00