Comparing the effect of buprenorphine and methadone in the reduction of methamphetamine craving: a randomized clinical trial.

abstract：BACKGROUND:Dentin hypersensitivity (DH) is a condition characterized by short and sharp episodes of pain which will arise in response to tactile, chemical, thermal, evaporative or osmotic stimuli. The painful symptoms cause discomfort in patients and reduce their quality of life. Recently, the novel zinc-containing des...

journal_title：Trials

authors： Matsuura T,Mae M,Ohira M,Yamashita Y,Nakazono A,Sugimoto K,Yanagiguchi K,Yamada S

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Upper limb dysfunction is common after stroke, posing an important challenge for post-stroke rehabilitation. The clinical efficacy of acupuncture for the recovery of post-stroke upper limb function has been previously demonstrated. Mirror therapy (MT) has also been found to be effective. However, the effects...

journal_title：Trials

authors： Xu Y,Lin S,Jiang C,Ye X,Tao J,Wilfried S,Wong AWK,Chen L,Yang S

更新日期：2018-05-31 00:00:00

abstract：BACKGROUND:In the United Kingdom (UK), there is an extensive market for the class 'A' drug heroin. Many heroin users spend time in prison. People addicted to heroin often require prescribed medication when attempting to cease their drug use. The most commonly used detoxification agents in UK prisons are buprenorphine, ...

journal_title：Trials

authors： Sheard L,Adams CE,Wright NM,El-Sayeh H,Dalton R,Tompkins CN

更新日期：2007-01-08 00:00:00

abstract：BACKGROUND:There is a large treatment gap with few community services for people with schizophrenia in low income countries largely due to the shortage of specialist mental healthcare human resources. Community based rehabilitation (CBR), involving lay health workers, has been shown to be feasible, acceptable and more ...

journal_title：Trials

authors： Chatterjee S,Leese M,Koschorke M,McCrone P,Naik S,John S,Dabholkar H,Goldsmith K,Balaji M,Varghese M,Thara R,Patel V,Thornicroft G,COmmunity care for People with Schizophrenia in India (COPSI) group.

更新日期：2011-01-13 00:00:00

abstract：BACKGROUND:The application of artificial intelligence (AI) in healthcare is an area of immense interest. The high profile of 'AI in health' means that there are unusually strong drivers to accelerate the introduction and implementation of innovative AI interventions, which may not be supported by the available evidence...

journal_title：Trials

authors： Ibrahim H,Liu X,Rivera SC,Moher D,Chan AW,Sydes MR,Calvert MJ,Denniston AK

更新日期：2021-01-06 00:00:00

abstract：OBJECTIVES:The GETAFIX trial will test the hypothesis that favipiravir is a more effective treatment for COVID-19 infection in patients who have early stage disease, compared to current standard of care. This study will also provide an important opportunity to investigate the safety and tolerability of favipiravir, the...

journal_title：Trials

authors： Hanna CR,Blyth KG,Burley G,Carmichael S,Evans C,Hinsley S,Khadra I,Khoo S,Lewsley LA,Jones RR,Sharma R,Taladriz-Sender A,Thomson EC,Scott JT

更新日期：2020-11-19 00:00:00

abstract：BACKGROUND:Hypothyroidism is a prevalent endocrine condition. Individuals with this disease are commonly managed through supplementation with synthetic thyroid hormone, with the aim of alleviating symptoms and restoring normal thyroid stimulating hormone levels. Generally this management strategy is effective and well ...

journal_title：Trials

authors： Brown BT,Bonello R,Pollard H,Graham P

更新日期：2010-11-15 00:00:00

abstract：BACKGROUND:In the presence of heterogeneous treatment effects, it is desirable to divide patients into subgroups based on their expected response to treatment. This is formalised via a personalised treatment recommendation: an algorithm that uses biomarker measurements to select treatments. It could be that multiple, r...

journal_title：Trials

authors： Pierce M,Emsley R

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:The incidence of cardiovascular disease (CVD) in rheumatoid arthritis (RA) is increased compared to the general population. Immune dysregulation and systemic inflammation are thought to be associated with this increased risk. Early diagnosis with immediate treatment and tight control of RA forms a central tr...

journal_title：Trials

authors： Erhayiem B,Pavitt S,Baxter P,Andrews J,Greenwood JP,Buch MH,Plein S

更新日期：2014-11-08 00:00:00

abstract：BACKGROUND:Allergic rhinitis is a chronic illness, affecting 10 to 40% of the worldwide population. Chinese herbal medicines, the treatment of allergic rhinitis, adopted thousands of years in ancient China, has recently raised much attention among researchers globally. This study evaluates the effects of two Chinese he...

journal_title：Trials

authors： Chan RY,Chien WT

更新日期：2014-07-02 00:00:00

abstract：BACKGROUND:Laparoscopic surgery has become the preferred approach for many procedures because of reduced post-operative pain, better recovery, shorter hospital stay and improved cosmesis. Single incision laparoscopic surgery is one of the many recent variants where either standard ports or a specially designed single m...

journal_title：Trials

authors： Malik M,McCormack K,Krukowski ZH,McDonald A,McPherson G,Cook JA,Ahmed I,SCARLESS Study Group.

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:During the last decade, the use of ministernotomy in cardiac surgery has increased. Quality of life and patient satisfaction after ministernotomy have never been compared to conventional full sternotomy in randomised trials. The aim of the study is to determine if this minimally invasive approach improves qu...

journal_title：Trials

authors： Rodríguez-Caulo EA,Guijarro-Contreras A,Otero-Forero J,Mataró MJ,Sánchez-Espín G,Guzón A,Porras C,Such M,Ordóñez A,Melero-Tejedor JM,Jiménez-Navarro M

更新日期：2018-02-17 00:00:00

abstract：:Adaptations to the gold standard randomised controlled trial (RCT) have been introduced to decrease trial costs and avoid high sample sizes. To facilitate development of precision medicine algorithms that aim to optimise treatment allocation for individual patients, we propose a new RCT adaptation termed the nested-pr...

journal_title：Trials

authors： Kappelmann N,Müller-Myhsok B,Kopf-Beck J

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:At an early stage, prostate cancer patients are often eligible for more than one treatment option, or may choose to defer curative treatment. Without a pre-existing superior option, a patient has to weigh his personal preferences against the risks and benefits of each alternative to select the most appropria...

journal_title：Trials

authors： Cuypers M,Lamers RE,Kil PJ,van de Poll-Franse LV,de Vries M

更新日期：2015-05-27 00:00:00

abstract：BACKGROUND:Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is noninferior to ventilation with high PEEP with regard to the number of ventilator-free days and bei...

journal_title：Trials

authors： Algera AG,Pisani L,Bergmans DCJ,den Boer S,de Borgie CAJ,Bosch FH,Bruin K,Cherpanath TG,Determann RM,Dondorp AM,Dongelmans DA,Endeman H,Haringman JJ,Horn J,Juffermans NP,van Meenen DM,van der Meer NJ,Merkus MP,Moenira

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:Intensive rehabilitation of patients with severe traumatic brain injury is generally applied in the subacute stages of the hospital stay. Few studies have assessed the association between early and intensive physical rehabilitation and functional outcomes. The aim of this trial is to assess the feasibility o...

journal_title：Trials

authors： Riberholt CG,Lindschou J,Gluud C,Mehlsen J,Møller K

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Severe thrombocytopenia should be corrected by prophylactic platelet transfusion prior to central venous catheter (CVC) insertion, according to national and international guidelines. Even though correction is thought to prevent bleeding complications, evidence supporting the routine administration of prophyl...

journal_title：Trials

authors： van de Weerdt EK,Biemond BJ,Zeerleder SS,van Lienden KP,Binnekade JM,Vlaar APJ,Study collaborative.

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:The application of neuroendoscopy in intraventricular hemorrhage (IVH) has attracted more and more attention in recent years. Studies have shown that the use of neuroendoscopy for IVH evacuation has advantages over external ventricular drainage (EVD) alone. However, the cases of most current research are sma...

journal_title：Trials

authors： Zhu J,Tang C,Cong Z,Yang J,Cai X,Liu Y,Ma C

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND:Mindfulness-based interventions, modified and shortened versions of meditation teachings, have proved to be effective in the improvement of quality of life in many clinical conditions, including chronic diseases. Preliminary results available in the literature and in clinical experience indicate a high poten...

journal_title：Trials

authors： Cavalera C,Pagnini F,Rovaris M,Mendozzi L,Pugnetti L,Garegnani M,Molinari E

更新日期：2016-01-04 00:00:00

abstract：BACKGROUND:Biomass fuel smoke is a leading risk factor for the burden of disease worldwide. International campaigns are promoting the widespread adoption of liquefied petroleum gas (LPG) in resource-limited settings. However, it is unclear if the introduction and use of LPG stoves, in settings where biomass fuels are u...

journal_title：Trials

authors： Fandiño-Del-Rio M,Goodman D,Kephart JL,Miele CH,Williams KN,Moazzami M,Fung EC,Koehler K,Davila-Roman VG,Lee KA,Nangia S,Harvey SA,Steenland K,Gonzales GF,Checkley W,Cardiopulmonary outcomes and Household Air Pollution tria

更新日期：2017-11-03 00:00:00

abstract：BACKGROUND:The gap between the level of care recommended by evidence-based clinical practice guidelines and the actual care delivered to patients in practice has been well established. The Canadian Diabetes Association (CDA) created an implementation strategy to improve the implementation of its 2008 guidelines. This s...

journal_title：Trials

authors： Shah BR,Bhattacharyya O,Yu C,Mamdani M,Parsons JA,Straus SE,Zwarenstein M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Glaucoma is a chronic eye disease associated with irreversible visual loss. In Africa, glaucoma patients often present late, with very advanced disease. One-off procedures, such as laser or surgery, are recommended in Africa because of lack of or poor adherence to medical treatment. However, acceptance of su...

journal_title：Trials

authors： Abdull MM,Gilbert C,McCambridge J,Evans J

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:The focus in recent years on physical inactivity and metabolic disturbances in individuals with schizophrenia raises the question of potential effects of physical activity. Physical activity has shown beneficial effects on cognition in healthy older individuals as well as on symptom severity in depression. H...

journal_title：Trials

authors： Engh JA,Andersen E,Holmen TL,Martinsen EW,Mordal J,Morken G,Egeland J

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:Muscle glycogen has been well established as the primary metabolic energy substrate during physical exercise of moderate- to high-intensity and has accordingly been implicated as a limiting factor when such activity is sustained for a prolonged duration. However, the role of this substrate during repeated ex...

journal_title：Trials

authors： Alghannam AF,Tsintzas K,Thompson D,Bilzon J,Betts JA

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:Burst stimulation is a novel form of neurostimulation for the treatment of chronic pain which has demonstrated promise in small uncontrolled studies, but has not yet gained approval for use in the U.S. We report the study methods for an ongoing multicenter, randomized, controlled, cross-over study designed t...

journal_title：Trials

authors： Slavin KV,North RB,Deer TR,Staats P,Davis K,Diaz R

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:People with severe mental illness (SMI) are two to three times more likely to be overweight and obese than the general population and this is associated with significant morbidity and premature mortality. Although lifestyle interventions can support people with SMI to lose weight, some are unable to make the...

journal_title：Trials

authors： Whicher CA,Price HC,Phiri P,Rathod S,Barnard-Kelly K,Reidy C,Thorne K,Asher C,Peveler R,McCarthy J,Holt RIG

更新日期：2019-11-20 00:00:00

abstract：BACKGROUND:The cross-sectional area of the subclavian vein (csSCV) is an important factor determining the success rate of SCV catheterization. The head-down position increases the csSCV. However, the effects of lateral tilting on subclavian venous cross-sectional area have not yet been explored. In this trial, we test ...

journal_title：Trials

authors： Jung DE,Lee HC,Yoon HK,Park HP

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:Oxygen is a life-saving, essential medicine that is important for the treatment of many common childhood conditions. Improved oxygen systems can reduce childhood pneumonia mortality substantially. However, providing oxygen to children is challenging, especially in small hospitals with weak infrastructure and...

journal_title：Trials

authors： Graham HR,Ayede AI,Bakare AA,Oyewole OB,Peel D,Gray A,McPake B,Neal E,Qazi S,Izadnegahdar R,Falade AG,Duke T

更新日期：2017-10-27 00:00:00

abstract：BACKGROUND:Tinnitus is the perception of a sound in the absence of an objective physical source. Up to now, there is no generally accepted view how these phantom sounds come about, and also no efficient treatment. Patients are turning to complementary or alternative medical therapies, such as acupuncture. Based on the ...

journal_title：Trials

authors： Shi GX,Han LL,Liu LY,Li QQ,Liu CZ,Wang LP

更新日期：2012-11-23 00:00:00

abstract：BACKGROUND:To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils-Listerine Zero (LZ)-and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo ...

journal_title：Trials

authors： Marchetti E,Tecco S,Caterini E,Casalena F,Quinzi V,Mattei A,Marzo G

更新日期：2017-03-31 00:00:00