Coronary Artery Disease Evaluation in Rheumatoid Arthritis (CADERA): study protocol for a randomized controlled trial.

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a rapid-onset sensorineural hearing impairment with unclear etiology and unsatisfying treatment effects. Vestibular dysfunction has been considered as a poor indicator in the clinical manifestations and prognosis of ISSNHL, which occurred in approximat...

journal_title：Trials

authors： Hao W,Zhao L,Yu H,Li H

更新日期：2020-07-22 00:00:00

abstract：BACKGROUND:Muscle glycogen has been well established as the primary metabolic energy substrate during physical exercise of moderate- to high-intensity and has accordingly been implicated as a limiting factor when such activity is sustained for a prolonged duration. However, the role of this substrate during repeated ex...

journal_title：Trials

authors： Alghannam AF,Tsintzas K,Thompson D,Bilzon J,Betts JA

更新日期：2014-03-26 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a health condition sensitive to patient's preferences and values regarding the benefits and risks of the different treatment options. In this sense, patient decision aids (PtDA) can play an important role in helping patients to incorporate their values, needs, and preferences into the ...

journal_title：Trials

authors： Perestelo-Pérez L,Álvarez-Pérez Y,Rivero-Santana A,Ramos-García V,Duarte-Díaz A,Torres-Castaño A,Toledo-Chávarri A,Herrera-Perez M,País-Brito JL,Del Castillo JC,Vázquez JR,Orrego C,Serrano-Aguilar P

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:Chest tube insertion is a standard intervention for management of various injuries of the thorax. Quick and accurate execution facilitates efficient therapy without further complications. Here, we propose a new training concept comprised of e-learning elements as well as continuous rating using an objective ...

journal_title：Trials

authors： Friedrich M,Bergdolt C,Haubruck P,Bruckner T,Kowalewski KF,Müller-Stich BP,Tanner MC,Nickel F

更新日期：2017-02-06 00:00:00

abstract：BACKGROUND:Youth depression is highly prevalent and is related to impairments in academic, social and behavioural functioning. Evidence-based treatments are available, but many young people do not respond or sufficiently recover with first-line options, and a significant proportion experience relapse. Consequently, the...

journal_title：Trials

authors： Hallford DJ,Carmichael AM,Austin DW,Takano K,Raes F,Fuller-Tyszkiewicz M

更新日期：2020-01-14 00:00:00

abstract：BACKGROUND:Cancer is one of the major health issues worldwide. An increasing number of cancer patients are offered treatment with surgery, chemotherapy and radiotherapy. Traditional Chinese medicine (TCM) is one of the most common complementary therapies offered to cancer patients in Taiwan. We designed a randomized, d...

journal_title：Trials

authors： Lo LC,Chen CY,Chen ST,Chen HC,Lee TC,Chang CS

更新日期：2012-12-03 00:00:00

abstract：BACKGROUND:Advance care planning (ACP) is a process whereby patients prepare for medical decision-making. The traditional objective of ACP has focused on the completion of advance directives. We have developed a new paradigm of ACP focused on preparing patients and their loved ones for communication and informed medica...

journal_title：Trials

authors： Sudore R,Le GM,McMahan R,Feuz M,Katen M,Barnes DE

更新日期：2015-12-12 00:00:00

abstract：BACKGROUND:Patients' treatment preferences are often cited as barriers to recruitment in randomized controlled trials (RCTs). We investigated how RCT recruiters reacted to patients' treatment preferences and identified key strategies to improve informed decision-making and trial recruitment. METHODS:Audio-recordings o...

journal_title：Trials

authors： Mills N,Blazeby JM,Hamdy FC,Neal DE,Campbell B,Wilson C,Paramasivan S,Donovan JL

更新日期：2014-08-13 00:00:00

abstract：BACKGROUND:Approximately 40% of the newly diagnosed patients with advanced ovarian cancer are aged 70 years or older. Standard treatment for advanced disease consists of cytoreductive surgery and combination chemotherapy. In older patients, standard treatment is often withheld or prematurely stopped due to suspected fr...

journal_title：Trials

authors： van Soolingen NJ,Smorenburg CH,Hamaker ME,Groen WG,Retèl VP,Lok CAR,van de Poll-Franse LV,Trum JW

更新日期：2020-02-22 00:00:00

abstract：:After publication of our article [1] we became aware that several sections of text in our Methods section were copied from a previously published article [2]. ...

journal_title：Trials

authors： Langella LG,Silva PFC,Costa-Santos L,Gonçalves MLL,Motta LJ,Deana AM,Fernandes KPS,Mesquita-Ferrari RA,Bussadori SK

更新日期：2018-12-24 00:00:00

abstract：BACKGROUND:Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will d...

journal_title：Trials

authors： Dennis RA,Ponnappan U,Kodell RL,Garner KK,Parkes CM,Bopp MM,Padala KP,Peterson CA,Padala PR,Sullivan DH

更新日期：2015-03-27 00:00:00

abstract：BACKGROUND:Hypertension is a risk factor for cardiovascular disease, and the prevalence of hypertension tends to increase with age. Current treatments for hypertension have side effects and poor adherence. Qigong has been studied as an alternative therapy for hypertension; however, the types of qigong used in those stu...

journal_title：Trials

authors： Park JE,Liu Y,Park T,Hong S,Kim JE,Kim TH,Kim AR,Jung SY,Park H,Choi SM

更新日期：2011-11-21 00:00:00

abstract：BACKGROUND:Central sensitization is modulated by the endogenous opioid system and plays a major role in the development and maintenance of pain. Recent animal studies performed following resolution of inflammatory pain showed reinstatement of tactile hypersensitivity induced by administration of a mu-opioid-antagonist,...

journal_title：Trials

authors： Pereira MP,Werner MU,Dahl JB

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Transurethral resection of the prostate (TURP) has been the standard operation for benign prostatic obstruction (BPO) for 40 years, with approximately 25,000 procedures performed annually, and has remained largely unchanged. It is generally a successful operation, but has well-documented risks for the patien...

journal_title：Trials

authors： Worthington J,Taylor H,Abrams P,Brookes ST,Cotterill N,Noble SM,Page T,Swami KS,Lane JA,Hashim H

更新日期：2017-04-17 00:00:00

abstract：BACKGROUND:Indigenous Australian youth (aged 15 to 34) have up to four times the risk of suicide compared with their non-Indigenous counterparts. Barriers to help-seeking include shame, feared loss of autonomy and negative attitudes towards healthcare providers. The use of mobile devices and apps continues to rise amon...

journal_title：Trials

authors： Shand FL,Ridani R,Tighe J,Christensen H

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Young men in South Africa face concurrent epidemics of HIV, drug and alcohol abuse, and unemployment. Standard HIV prevention programs, located in healthcare settings and/or using counseling models, fail to engage men. Soccer and vocational training are examined as contexts to deliver male-specific, HIV prev...

journal_title：Trials

authors： Rotheram-Borus MJ,Tomlinson M,Mayekiso A,Bantjes J,Harris DM,Stewart J,Weiss RE

更新日期：2018-08-03 00:00:00

abstract：BACKGROUND:It is generally accepted that an active lifestyle is beneficial for cognition in children, adults and the elderly. Recently, studies using the rat animal model found that the pups of mothers who exercised during pregnancy had increased hippocampal neurogenesis and better memory and learning abilities. The ai...

journal_title：Trials

authors： LeMoyne EL,Curnier D,St-Jacques S,Ellemberg D

更新日期：2012-05-29 00:00:00

abstract：BACKGROUND:Ascites is one of the most common complications of cirrhosis. Umbilical therapy with traditional Chinese medicines has been increasingly prescribed to treat cirrhotic ascites. However, high-quality evidence from clinical trials supporting such application of traditional Chinese medicines remains limited. The...

journal_title：Trials

authors： Yang X,Ru S,Luo L,Lv X,Bai W,Zhang F,Jiang F

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:Low back pain is highly prevalent and a major source of disability worldwide. Spa therapy is frequently used to treat low back pain, but the associated level of evidence for efficacy is insufficient. To fill this knowledge gap, this protocol proposes an appropriately powered, prospective, evaluator-blinded, ...

journal_title：Trials

authors： Forestier R,Suehs C,Françon A,Marty M,Genevay S,Sellam J,Chauveton C,Erol Forestier FB,Molinari N

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a common chronic disease in older adults. Currently, there are no effective therapies to reduce disease severity and progression of knee OA (KOA), particularly in mid- to late-stages. This study aims to examine the effect of methotrexate (MTX) on knee effusion-synovitis and pain in sym...

journal_title：Trials

authors： Zhu Z,Yu Q,Leng X,Han W,Li Z,Huang C,Gu J,Zhao Y,Wang K,Li T,Mei Y,Xu J,Zhang Z,Hunter D,Cicuttini F,Zeng X,Ding C

更新日期：2020-09-16 00:00:00

abstract：BACKGROUND:Hypnotic drugs tend to be the dominant form of treatment of insomnia, but these come with a number of reported side effects. Acupuncture has been studied as an alternative, resulting in a rising need for methodological research towards verifying its efficacy as insomnia treatment. METHODS/DESIGN:We describe...

journal_title：Trials

authors： Han KH,Kim SY,Chung SY

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:Around 35-45 % of people in contact with services for a first episode of psychosis are using cannabis. Cannabis use is associated with delays in remission, poorer clinical outcomes, significant increases in the risk of relapse, and lower engagement in work or education. While there is a clear need for effect...

journal_title：Trials

authors： Johnson S,Sheridan Rains L,Marwaha S,Strang J,Craig T,Weaver T,McCrone P,King M,Fowler D,Pilling S,Marston L,Omar RZ,Craig M,Hinton M

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:The oversight and conduct of a randomised controlled trial involves several stakeholders, including a Trial Steering Committee (TSC), Trial Management Group (TMG), Data Monitoring Committee (DMC), funder and sponsor. We aimed to examine how the relationships between these stakeholders affect the trial oversi...

journal_title：Trials

authors： Daykin A,Selman LE,Cramer H,McCann S,Shorter GW,Sydes MR,Gamble C,Macefield R,Lane JA,Shaw A

更新日期：2017-12-22 00:00:00

abstract：BACKGROUND:Colonoscopy is one of the most effective methods of cancer prevention and detection, particularly for individuals with familial risk. Recruitment of family members to behavioral intervention trials remains uniquely challenging, owing to the intensive process required to identify and contact them. Recruiting ...

journal_title：Trials

authors： Simmons RG,Lee YC,Stroup AM,Edwards SL,Rogers A,Johnson C,Wiggins CL,Hill DA,Cress RD,Lowery J,Walters ST,Jasperson K,Higginbotham JC,Williams MS,Burt RW,Schwartz MD,Kinney AY

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Trials in rare diseases have many challenges, among which are the need to set up multiple sites in different countries to achieve recruitment targets and the divergent landscape of clinical trial regulations in those countries. Over the past years, there have been initiatives to facilitate the process of int...

journal_title：Trials

authors： Crow RA,Hart KA,McDermott MP,Tawil R,Martens WB,Herr BE,McColl E,Wilkinson J,Kirschner J,King WM,Eagle M,Brown MW,Hirtz D,Lochmuller H,Straub V,Ciafaloni E,Shieh PB,Spinty S,Childs AM,Manzur AY,Morandi L,Butterf

更新日期：2018-05-10 00:00:00

abstract：OBJECTIVES:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about COVID-19 hygiene practices-such as social ...

journal_title：Trials

authors： Vandormael A,Adam M,Greuel M,Bärnighausen T

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND/AIMS:Prediabetes and diabetes disproportionately impact Latino youth, yet few diabetes prevention programs have prioritized inclusion of this underrepresented population. This report describes the recruitment process, yields, associated costs, and phenotypic characteristics of Latino youth with obesity and p...

journal_title：Trials

authors： Vander Wyst KB,Olson ML,Hooker E,Soltero EG,Konopken YP,Keller CS,Castro FG,Williams AN,Fernández ADR,Patrick DL,Ayers SL,Hu HH,Peña A,Pimentel J,Knowler WC,Shaibi GQ

更新日期：2020-08-14 00:00:00

abstract：BACKGROUND:Randomised clinical trials are the 'gold standard' for evaluating the effectiveness of healthcare interventions. However, successful recruitment of participants remains a key challenge for many trialists. In this paper, we present a conceptual framework for creating a digital, population-based database for t...

journal_title：Trials

authors： Nwaru BI,Soyiri IN,Simpson CR,Griffiths C,Sheikh A

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:Maintaining adequate oxygenation during rapid sequence intubation (RSI) is imperative to prevent peri-intubation adverse events that can lead to increased duration of hospital and intensive care unit stay, or a prolonged vegetative state requiring long-term institutionalisation. Despite employing current bes...

journal_title：Trials

authors： Chua MT,Khan FA,Ng WM,Lu Q,Low MJW,Yau YW,Punyadasa A,Kuan WS

更新日期：2019-04-04 00:00:00

abstract：BACKGROUND:Non-communicable chronic diseases are linked to behavioral risk factors (including smoking, poor diet and physical inactivity), so effective behavior change interventions are needed to improve population health. However, uptake and impact of these interventions is limited by methodological challenges. We aim...

journal_title：Trials

authors： Byrne M,McSharry J,Meade O,Lavoie KL,Bacon SL

更新日期：2020-03-23 00:00:00