GERiatric Screening in the treatment of elderly patients with Ovarian Carcinoma (GERSOC): study protocol for a pragmatic, cluster randomised controlled trial.

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Drooling saliva is a common problem in children with neurodevelopmental disorders. The negative consequences of drooling include skin breakdown, dehydration, and damage to clothing and equipment. Children and families often suffer social embarrassment due to drooling. There is no evidence about the relative ...

journal_title：Trials

authors： Parr JR,Weldon E,Pennington L,Steen N,Williams J,Fairhurst C,O'Hare A,Lodh R,Colver A

更新日期：2014-02-17 00:00:00

abstract：BACKGROUND:We aimed to test whether a common set of key data items reported across high-impact neonatal clinical trials could be identified, and to quantify their completeness in routinely recorded United Kingdom neonatal data held in the National Neonatal Research Database (NNRD). METHODS:We systematically reviewed n...

journal_title：Trials

authors： Jawad S,Modi N,Prevost AT,Gale C

更新日期：2019-12-16 00:00:00

abstract：BACKGROUND:UK National Institute of Health and Clinical Excellence guidelines for obsessive compulsive disorder (OCD) specify recommendations for the treatment and management of OCD using a stepped care approach. Steps three to six of this model recommend treatment options for people with OCD that range from low-intens...

journal_title：Trials

authors： Gellatly J,Bower P,McMillan D,Roberts C,Byford S,Bee P,Gilbody S,Arundel C,Hardy G,Barkham M,Reynolds S,Gega L,Mottram P,Lidbetter N,Pedley R,Peckham E,Connell J,Molle J,O'Leary N,Lovell K

更新日期：2014-07-10 00:00:00

abstract：BACKGROUND:Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated with high rates of morbidity and mortality due to uncontrolled disease and treatment...

journal_title：Trials

authors： Walsh M,Merkel PA,Peh CA,Szpirt W,Guillevin L,Pusey CD,De Zoysa J,Ives N,Clark WF,Quillen K,Winters JL,Wheatley K,Jayne D,PEXIVAS Investigators.

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Endovenous thermal techniques, such as endovenous laser ablation (EVLA), are the recommended treatment for truncal varicose veins. However, a disadvantage of thermal techniques is that it requires the administration of tumescent anaesthesia, which can be uncomfortable. Non-thermal, non-tumescent techniques, ...

journal_title：Trials

authors： Leung CC,Carradice D,Wallace T,Chetter IC

更新日期：2016-08-24 00:00:00

abstract：BACKGROUND:There is an urgent need to protect children against dengue since this age group is particularly sensitive to the disease. Since dengue vectors are active mainly during the day, a potential target for control should be schools where children spend a considerable amount of their day. School uniforms are the cu...

journal_title：Trials

authors： Wilder-Smith A,Byass P,Olanratmanee P,Maskhao P,Sringernyuang L,Logan JG,Lindsay SW,Banks S,Gubler D,Louis VR,Tozan Y,Kittayapong P

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Patients with liver cirrhosis have a highly elevated risk of developing bacterial infections that significantly decrease survival rates. One of the most relevant infections is spontaneous bacterial peritonitis (SBP). Recently, NOD2 germline variants were found to be potential predictors of the development of...

journal_title：Trials

authors： Casper M,Mengel M,Fuhrmann C,Herrmann E,Appenrodt B,Schiedermaier P,Reichert M,Bruns T,Engelmann C,Grünhage F,Lammert F,INCA trial group.

更新日期：2015-03-08 00:00:00

abstract：:After publication of our article [1] we have been notified on a mistake in the sample size. ...

journal_title：Trials

authors： Zhu L,Shi X,Yin S,Yin J,Zhu Z,Gao X,Jiao Y,Yu W,Yang L

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a degenerative component, leading to irreversible disability. Mesenchymal stem cells (MSC) have been shown to prevent inflammation and neurodegeneration in animal models of MS, but no large phase II clinical trials have yet...

journal_title：Trials

authors： Uccelli A,Laroni A,Brundin L,Clanet M,Fernandez O,Nabavi SM,Muraro PA,Oliveri RS,Radue EW,Sellner J,Soelberg Sorensen P,Sormani MP,Wuerfel JT,Battaglia MA,Freedman MS,MESEMS study group.

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Chronic non-specific low back pain is the most common medical problem for which patients seek complementary and alternative medical treatment, including bee venom acupuncture. However, the effectiveness and safety of such treatments have not been fully established by randomized clinical trials. The aim of th...

journal_title：Trials

authors： Seo BK,Lee JH,Sung WS,Song EM,Jo DJ

更新日期：2013-01-14 00:00:00

abstract：OBJECTIVES:Assessing the effect of surfactant on clinical outcome in patients with COVID-19 under mechanical ventilation TRIAL DESIGN: Single centre, two arm, parallel group (1:1 allocation ratio), randomised superiority trial with blinded care and outcome assessment. PARTICIPANTS:Inclusion criteria: Adult COVID-19 pa...

journal_title：Trials

authors： Dabbagh A,Rajaei S,Ghahremani M,Fathi M,Massoudi N,Tavana S,Fani K,Nooraee N,Malekpour Alamdari N,Besharat S,Najafi Abrandabadi A,Pirsalehi A,Khabiri Khatiri MA

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:Coronary artery disease is the leading cause of morbidity and mortality in patients with type 2 diabetes. Screening for asymptomatic coronary artery disease with treatment by means of revascularization seems to be an appealing option for prevention. The utility of such a strategy has never been challenged in...

journal_title：Trials

authors： Turrini F,Messora R,Giovanardi P,Tondi S,Magnavacchi P,Cavani R,Tosoni G,Cappelli C,Pellegrini E,Romano S,Baldini A,Zennaro RG,Bondi M

更新日期：2009-12-23 00:00:00

abstract：BACKGROUND:Cognitive behavioural therapy is an effective treatment for depression. However, one third of the patients do not respond satisfactorily, and relapse rates of around 30 % within the first post-treatment year were reported in a recent meta-analysis. In total, 30-50 % of remitted patients present with residual...

journal_title：Trials

authors： Hvenegaard M,Watkins ER,Poulsen S,Rosenberg NK,Gondan M,Grafton B,Austin SF,Howard H,Moeller SB

更新日期：2015-08-11 00:00:00

abstract：OBJECTIVES:To investigate the potential efficacy of Acacia Senegal extract Gum Arabic (GA) supplementation as immunomodulatory and anti-inflammatory dietary intervention among newly diagnosed COVID 19 Sudanese patients. To study the effect of GA on the level of cytokines, TNFα, IL8, IL6 IL10, CRP and the viral load. Se...

journal_title：Trials

authors： Kaddam L,Babiker R,Ali S,Satti S,Ali N,Elamin M,Mukhtar M,Elnimeiri M,Saeed A

更新日期：2020-09-05 00:00:00

abstract：BACKGROUND:There is a large treatment gap with few community services for people with schizophrenia in low income countries largely due to the shortage of specialist mental healthcare human resources. Community based rehabilitation (CBR), involving lay health workers, has been shown to be feasible, acceptable and more ...

journal_title：Trials

authors： Chatterjee S,Leese M,Koschorke M,McCrone P,Naik S,John S,Dabholkar H,Goldsmith K,Balaji M,Varghese M,Thara R,Patel V,Thornicroft G,COmmunity care for People with Schizophrenia in India (COPSI) group.

更新日期：2011-01-13 00:00:00

abstract：OBJECTIVES:Colchicine is a well-known drug, which has been used for years to treat a wide range of rheumatic and inflammatory disorders. It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress p...

journal_title：Trials

authors： Dalili N,Kashefizadeh A,Nafar M,Poorrezagholi F,Firouzan A,Samadian F,Samavat S,Ziaie S,Fatemizadeh S

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:Youth depression is highly prevalent and is related to impairments in academic, social and behavioural functioning. Evidence-based treatments are available, but many young people do not respond or sufficiently recover with first-line options, and a significant proportion experience relapse. Consequently, the...

journal_title：Trials

authors： Hallford DJ,Carmichael AM,Austin DW,Takano K,Raes F,Fuller-Tyszkiewicz M

更新日期：2020-01-14 00:00:00

abstract：BACKGROUND:Less invasive surfactant administration (LISA) is a way of giving surfactant without endotracheal intubation and has shown to be promising in reducing the incidence of bronchopulmonary dysplasia (BPD) in preterm infants. However, the mechanism underlying its beneficial effect and variations in the technique ...

journal_title：Trials

authors： Zhu J,Bao Y,Du L,Huang H,Lv Q,Jiang Y,Dai Y,Chen Z,Shi J,Shi Y,Yang C,Mei H,Jiang H,Sun Y,Sun X

更新日期：2020-06-11 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease lowers the quality of life and increases medical costs. Electroacupuncture has been used to ease symptoms and improve gastrointestinal motility in patients with gastroesophageal reflux disease. The main purposes of this study are to evaluate the efficacy and safety of this pro...

journal_title：Trials

authors： Han G,Leem J,Lee H,Lee J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:As the toxicity associated with the α-GalCer-pulsed dendritic cell (DC) therapy could be considered to be negligible, its addition to postoperative adjuvant chemotherapy would be expected to greatly improve the therapeutic effect, and could result in prolonged survival. The aim of the present study is to com...

journal_title：Trials

authors： Saka H,Kitagawa C,Ichinose Y,Takenoyama M,Ibata H,Kato T,Takami K,Yamashita M,Maeda T,Takeo S,Ueda H,Okabayashi K,Nagashima S,Oka T,Kouso H,Fukuyama S,Yoshimoto K,Shimokawa M,Saito AM,Ito S

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:An individualized treatment algorithm (Copenhagen Achilles Rupture Treatment Algorithm (CARTA)) based on the ultrasonographic appearance of an acute Achilles tendon rupture has been developed aiming to select the correct patients for operative and non-operative treatment. The objective of this study is to in...

journal_title：Trials

authors： Hansen MS,Vestermark MT,Hölmich P,Kristensen MT,Barfod KW

更新日期：2020-05-12 00:00:00

abstract：BACKGROUND:Delirium is a state of confusion characterized by an acute and fluctuating decline in cognitive functioning. Delirium is common and deadly in older adults with dementia, and is often referred to as delirium superimposed on dementia, or DSD. Interventions that treat DSD are not well-developed because the mech...

journal_title：Trials

authors： Kolanowski AM,Fick DM,Litaker MS,Clare L,Leslie D,Boustani M

更新日期：2011-05-11 00:00:00

abstract：BACKGROUND:Video-laryngoscopes are marketed for intubation in difficult airway management. They provide a better view of the larynx and may facilitate tracheal intubation, but there is no adequately powered study comparing different types of video-laryngoscopes in a difficult airway scenario or in a simulated difficult...

journal_title：Trials

authors： Theiler L,Hermann K,Schoettker P,Savoldelli G,Urwyler N,Kleine-Brueggeney M,Arheart KL,Greif R

更新日期：2013-04-04 00:00:00

abstract：INTRODUCTION:Psoriasis vulgaris is a common skin disease characterized by persistent localized erythematous scaly plaques, typically on the elbows, knees, and scalp. It is an immune-abnormal disease that progresses slowly over a long period with frequent symptom recurrence. Current studies have shown that acupuncture i...

journal_title：Trials

authors： Deng J,Lu C,Xiang Y,Deng H,Wen Z,Yao D,Xuan M,Yan Y

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:The practice of traditional Chinese medicine (TCM) has a profound history in many Asian countries. TCM syndrome is a set of characteristic physical signs and symptoms shared by a group of patients. Syndrome diagnosis and treatment assignment according to the identified TCM syndrome is a long-held practice of...

journal_title：Trials

authors： Cao H,Zhai J,Mu W,Lei X,Cao H,Liu C,Shang H

更新日期：2014-03-19 00:00:00

abstract：BACKGROUND:Premature ejaculation (PE) is the most common sexual dysfunction among men. According to patients, the general practitioner (GP) is the appropriate professional with whom to discuss this issue. However, few patients receive the medical help needed because GPs find it difficult to talk to their patients about...

journal_title：Trials

authors： Barais M,Vaillant Roussel H,Costa D,Derriennic J,Pereira B,Cadier S

更新日期：2018-11-12 00:00:00

abstract：BACKGROUND:Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' understandings are inevitably influenced by the recruiting clinician's understanding of the trial, yet rel...

journal_title：Trials

authors： Ziebland S,Featherstone K,Snowdon C,Barker K,Frost H,Fairbank J

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Among patients with hepatocellular carcinoma (HCC), 85% of patients have an advanced disease stage at diagnosis and curative therapies cannot be performed. Prognosis has been quite poor as until recently there was no proven effective chemotherapy. Our group found that all-trans-retinoic acid (ATRA) could imp...

journal_title：Trials

authors： Shi J,Sun J,Liu C,Chai Z,Wang N,Zhang H,Cheng S

更新日期：2019-04-29 00:00:00

abstract：RATIONALE:Aspiration, infections, and fever are common in the first days after stroke, especially in older patients. The occurrence of these complications has been associated with an increased risk of death or dependency. AIMS AND DESIGN:PREvention of Complications to Improve OUtcome in elderly patients with acute Str...

journal_title：Trials

authors： de Jonge JC,Woodhouse LJ,Reinink H,van der Worp HB,Bath PM,PRECIOUS investigators.

更新日期：2020-10-26 00:00:00