A randomized phase II study to assess the effect of adjuvant immunotherapy using α-GalCer-pulsed dendritic cells in the patients with completely resected stage II-IIIA non-small cell lung cancer: study protocol for a randomized controlled trial.

abstract：BACKGROUND:Feeding practices and child undernutrition can be improved when trained health workers provide proper nutrition counseling to caregivers. However, this important management component is difficult to achieve in countries where trained health workers are limited; Tanzania is no exception. In rural and semi-urb...

journal_title：Trials

authors： Sunguya BF,Poudel KC,Mlunde LB,Urassa DP,Jimba M,Yasuoka J

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Three decades of research suggests that prevention of iron deficiency anemia (IDA) in the primary care setting may be an unrealized and unique opportunity to prevent poor developmental outcomes in children. A longitudinal study of infants with IDA showed that the developmental disadvantage persists long term...

journal_title：Trials

authors： Abdullah K,Thorpe KE,Mamak E,Maguire JL,Birken CS,Fehlings D,Hanley AJ,Macarthur C,Zlotkin SH,Parkin PC

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two strategies for retention in a randomised prevention trial using a two-by-two factorial randomised s...

journal_title：Trials

authors： Bradshaw LE,Montgomery AA,Williams HC,Chalmers JR,Haines RH

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Adaptive servo-ventilation (ASV) therapy, which is a form of noninvasive positive pressure ventilation therapy and uses an innovative ventilator that has simple operability and provides good patient adherence, potentially has therapeutic benefits-suppression of the deterioration and progression of chronic he...

journal_title：Trials

authors： Seino Y,Momomura S,Kihara Y,Adachi H,Yasumura Y,Yokoyama H,SAVIOR-C investigators.

更新日期：2015-01-16 00:00:00

abstract：BACKGROUND:There is currently a lack of randomized, sham-controlled trials that are adequately powered, using validated outcomes, to allow for firm recommendations on the use of magnetic stimulation for stress urinary incontinence. We report a protocol of a multicenter, randomized, double-blind, sham-controlled paralle...

journal_title：Trials

authors： Lim R,Liong ML,Leong WS,Khan NA,Yuen KH

更新日期：2015-06-21 00:00:00

abstract：:Periconceptional supplementation could extend the period over which maternal and fetal nutrition is improved, but there are many challenges facing early-life intervention studies. Periconceptional trials differ from pregnancy supplementation trials, not only because of the very early or pre-gestational timing of nutri...

journal_title：Trials

authors： Brabin BJ,Gies S,Owens S,Claeys Y,D'Alessandro U,Tinto H,Brabin L

更新日期：2016-01-30 00:00:00

abstract：BACKGROUND:Drooling saliva is a common problem in children with neurodevelopmental disorders. The negative consequences of drooling include skin breakdown, dehydration, and damage to clothing and equipment. Children and families often suffer social embarrassment due to drooling. There is no evidence about the relative ...

journal_title：Trials

authors： Parr JR,Weldon E,Pennington L,Steen N,Williams J,Fairhurst C,O'Hare A,Lodh R,Colver A

更新日期：2014-02-17 00:00:00

abstract：BACKGROUND:The gap between the level of care recommended by evidence-based clinical practice guidelines and the actual care delivered to patients in practice has been well established. The Canadian Diabetes Association (CDA) created an implementation strategy to improve the implementation of its 2008 guidelines. This s...

journal_title：Trials

authors： Shah BR,Bhattacharyya O,Yu C,Mamdani M,Parsons JA,Straus SE,Zwarenstein M

更新日期：2010-04-23 00:00:00

abstract：BACKGROUND:Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' understandings are inevitably influenced by the recruiting clinician's understanding of the trial, yet rel...

journal_title：Trials

authors： Ziebland S,Featherstone K,Snowdon C,Barker K,Frost H,Fairbank J

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Neointimal hyperplasia plays a pivotal role in the pathogenesis of in-stent restenosis in patients undergoing percutaneous coronary interventions. Drug-eluting balloons are a promising tool to prevent restenosis after coronary angioplasty. Moreover, an increased knowledge of the pathophysiology of restenosis...

journal_title：Trials

authors： Burzotta F,Brancati MF,Trani C,Porto I,Tommasino A,De Maria G,Niccoli G,Leone AM,Coluccia V,Schiavoni G,Crea F

更新日期：2012-05-06 00:00:00

abstract：BACKGROUND:Coronary artery disease (CAD) is one of the most common types of the cardiovascular disease. Previous pilot trials have suggested that Traditional Chinese Medicine (TCM) has brought clinical benefits for patients with CAD. We will conduct this trial to determine the efficacy and safety of Shenzhu Guanxin Rec...

journal_title：Trials

authors： Jin X,Pan B,Wu H,Wu B,Li Y,Wang X,Liu G,Dang X,Xu D

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Upper limb dysfunction is common after stroke, posing an important challenge for post-stroke rehabilitation. The clinical efficacy of acupuncture for the recovery of post-stroke upper limb function has been previously demonstrated. Mirror therapy (MT) has also been found to be effective. However, the effects...

journal_title：Trials

authors： Xu Y,Lin S,Jiang C,Ye X,Tao J,Wilfried S,Wong AWK,Chen L,Yang S

更新日期：2018-05-31 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is associated with reduced skin microbial diversity and overgrowth of Staphylococcus (S.) aureus. However, the importance of S. aureus colonisation in the complex pathogenesis remains unclear and studies on the effect of anti-staphylococcal therapy in non-infected AD show contradictory...

journal_title：Trials

authors： Totté J,de Wit J,Pardo L,Schuren F,van Doorn M,Pasmans S

更新日期：2017-08-31 00:00:00

abstract：BACKGROUND:Despite long-standing problems in decisions to stop clinical trials, stopping guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assist the data monitoring committees for effectiveness trials. MAIN TEXT:To specify better stopping gui...

journal_title：Trials

authors： Tyson JE,Pedroza C,Wallace D,D'Angio C,Bell EF,Das A

更新日期：2016-05-10 00:00:00

abstract：BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...

journal_title：Trials

authors： Oliveira CLP,Boulé NG,Sharma AM,Elliott S,Siervo M,Ghosh S,Berg A,Prado CM

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Oral mucositis (OM) is the most frequent and debilitating acute side effect associated with head and neck cancer (HNC) treatment. When present, severe OM negatively impacts the quality of life of patients undergoing HNC treatment. Photobiomodulation is a well-consolidated and effective therapy for the treatm...

journal_title：Trials

authors： Martins AFL,Nogueira TE,Morais MO,Oton-Leite AF,Valadares MC,Batista AC,Freitas NMA,Leles CR,Mendonça EF

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA)-associated uveitis is a chronic paediatric ocular inflammatory condition that can result in visual impairment. Adalimumab, a tumour necrosis factor (TNF)-alpha inhibitor, effectively controls joint and eye inflammation; however, its long-term use may increase the risk of a...

journal_title：Trials

authors： Acharya NR,Ebert CD,Kelly NK,Porco TC,Ramanan AV,Arnold BF,ADJUST Research Group.

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Pruritus (itch) is a frequent, burdensome and difficult-to-treat symptom in patients with cholestasis. Fibrates are currently under investigation for the treatment of primary biliary cholangitis in patients with a suboptimal response to ursodeoxycholic acid. Moreover, there is empirical evidence for a possib...

journal_title：Trials

authors： Bolier R,de Vries ES,Parés A,Helder J,Kemper EM,Zwinderman K,Elferink RPO,Beuers U,Netherlands Association for the Study of the Liver (NASL) Cholestatic Liver Diseases Study Group.

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Aortic valve replacement is one of the most common cardiac surgical procedures performed worldwide. Conventional aortic valve replacement surgery is performed via a median sternotomy; the sternum is divided completely from the sternal notch to the xiphisternum. Minimally invasive aortic valve replacement, us...

journal_title：Trials

authors： Akowuah E,Goodwin AT,Owens WA,Hancock HC,Maier R,Kasim A,Mellor A,Khan K,Murphy G,Mason J

更新日期：2017-01-28 00:00:00

abstract：BACKGROUND:Graves' hyperthyroidism is an autoimmune disease causing hyperfunction of the thyroid gland. The concentration of selenium is high in the thyroid gland and two important groups of enzymes within the thyroid are selenoproteins, that is, they depend on selenium. Selenium may have beneficial effects on autoimmu...

journal_title：Trials

authors： Watt T,Cramon P,Bjorner JB,Bonnema SJ,Feldt-Rasmussen U,Gluud C,Gram J,Hansen JL,Hegedüs L,Knudsen N,Bach-Mortensen P,Nolsøe R,Nygaard B,Pociot F,Skoog M,Winkel P,Rasmussen AK

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...

journal_title：Trials

authors： Leyenaar JK,McDaniel CE,Acquilano SC,Schaefer AP,Bruce ML,O'Malley AJ

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:In recent years, cold hypersensitivity in the hands (CHH) has become a common ailment of women in Korea. It can lead to gynecological problems such as irregular menstruation, miscarriage, and infertility. Traditionally, Korean herbal medicine has been the primary treatment method used to balance thermoregula...

journal_title：Trials

authors： Ko Y,Go HY,Cho YY,Shin JH,Kim TH,Choi DJ,Lee JM,Jang JB,Song YK,Ko SG,Sun SH,Jeon CY

更新日期：2017-06-08 00:00:00

abstract：BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...

journal_title：Trials

authors： Smit-Fun VM,de Korte-de Boer D,Posthuma LM,Stolze A,Dirksen CD,Hollmann MW,Buhre WF,Boer C

更新日期：2018-10-26 00:00:00

abstract：:There are many acknowledged benefits for the reuse of clinical trial data; from independent verification of published results to the evaluation of new hypotheses. However, the reuse of shared clinical trial data is not without obstacles. Here we present some of the issues and lessons learned from our own experiences i...

journal_title：Trials

authors： Wilkinson T,Sinha S,Peek N,Geifman N

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Verrucae are a common, infectious and sometimes painful problem. The optimal treatment for verrucae is unclear due to a lack of high quality randomised controlled trials. The primary objective of this study is to compare the clinical effectiveness of two common treatments for verrucae: cryotherapy using liqu...

journal_title：Trials

authors： Cockayne ES,EVERT Trial Team.

更新日期：2010-02-08 00:00:00

abstract：BACKGROUND:Juvenile dermatomyositis (JDM) is a rare autoimmune inflammatory disorder associated with significant morbidity and mortality. International collaboration is necessary to better understand the pathogenesis of the disease, response to treatment and long-term outcome. To aid international collaboration, it is ...

journal_title：Trials

authors： McCann LJ,Kirkham JJ,Wedderburn LR,Pilkington C,Huber AM,Ravelli A,Appelbe D,Williamson PR,Beresford MW

更新日期：2015-06-12 00:00:00

abstract：BACKGROUND:Plaque psoriasis is a refractory inflammatory skin disease. The common therapies used to treat plaque psoriasis in traditional Chinese medicine (TCM) and western medicine (WM) have distinct characteristics and advantages. Although a combination of TCM and WM therapies, adjusted to the clinical situation, is ...

journal_title：Trials

authors： Sun X,Zhou X,Wei Y,Yang W,Huang N,Ding Y,Hu R,Guo S,Yang C,Weng H,Zhang Y,Chen X,Ding X,Liu L,Yin Q,Wang R,Li X,Li B

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Lower urinary tract symptoms (LUTS) can relate to urinary storage or voiding. In men, the prevalence and severity of LUTS increases with age, with a significant impact on quality of life. The majority of men presenting with LUTS are managed by their general practitioner (GP) in the first instance, with conse...

journal_title：Trials

authors： Frost J,Lane JA,Cotterill N,Fader M,Hackshaw-McGeagh L,Hashim H,Macaulay M,MacNeill SJ,Noble S,Rees J,Ridd MJ,Robles L,Taylor G,Taylor J,Drake MJ,Worthington J

更新日期：2019-09-02 00:00:00

abstract：BACKGROUND:Diabetes Mellitus constitutes one of the most important public health problems due to its high prevalence and enormous social and economic consequences. Diabetic foot ulcers are one of the chronic complications of diabetes mellitus and constitute the most important cause of non-traumatic amputation of inferi...

journal_title：Trials

authors： Silva SY,Rueda LC,Márquez GA,López M,Smith DJ,Calderón CA,Castillo JC,Matute J,Rueda-Clausen CF,Orduz A,Silva FA,Kampeerapappun P,Bhide M,López-Jaramillo P

更新日期：2007-09-26 00:00:00

abstract：BACKGROUND:Depression is seriously affecting the physical and mental health of young people worldwide. Subthreshold depression, as an early stage of depression, is essential for early prevention and treatment of depression. Tai Chi, as a traditional Chinese mind-body therapy, may become an alternative intervention. How...

journal_title：Trials

authors： Xie X,Song J,Zhu J,Han M,He Y,Huang J,Tao J,Wu J

更新日期：2021-01-30 00:00:00