Evaluating the effectiveness of reasoning training in military and civilian chronic traumatic brain injury patients: study protocol.

abstract：BACKGROUND:Quitting smokers gain weight. This deters some from trying to stop smoking and may explain the increased incidence of type 2 diabetes after cessation. Dieting when stopping smoking may be counterproductive. Hunger increases cravings for smoking and tackling two behaviours together may undermine quitting succ...

journal_title：Trials

authors： Lycett D,Aveyard P,Farmer A,Lewis A,Munafò M

更新日期：2013-06-19 00:00:00

abstract：BACKGROUND:There is no existing report on the quality of randomized controlled trials (RCTs) of melasma treatment currently conducted in China. This study aims to assess the quality of RCT- reporting in the treatment of melasma conducted in China. METHODS:Several databases were searched from their inception through to...

journal_title：Trials

authors： Chen Z,Chen Y,Zeng J,Wang Y,Ye T,Zhou Q,Du X,Su W,Ding Z

更新日期：2015-04-12 00:00:00

abstract：BACKGROUND:Assistive technology and telecare (ATT) are relatively new ways of delivering care and support to people with social care needs. It is claimed that ATT reduces the need for community care, prevents unnecessary hospital admission, and delays or prevents admission into residential or nursing care. The current ...

journal_title：Trials

authors： Leroi I,Woolham J,Gathercole R,Howard R,Dunk B,Fox C,O'Brien J,Bateman A,Poland F,Bentham P,Burns A,Davies A,Forsyth K,Gray R,Knapp M,Newman S,McShane R,Ritchie C

更新日期：2013-10-23 00:00:00

abstract：BACKGROUND:The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effe...

journal_title：Trials

authors： Swanson SA,Holme Ø,Løberg M,Kalager M,Bretthauer M,Hoff G,Aas E,Hernán MA

更新日期：2015-11-30 00:00:00

abstract：BACKGROUND:In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS:Based on a comprehe...

journal_title：Trials

authors： Hummers-Pradier E,Bleidorn J,Schmiemann G,Joos S,Becker A,Altiner A,Chenot JF,Scherer M,German ‘Clinical Trials in German General Practice Network’.

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Stroke is a common cause of cognitive impairment and dementia. However, effective strategies for reducing the risk of post-stroke dementia remain undefined. Potential strategies include intensive lowering of blood pressure and/or lipids. METHODS/DESIGN: DESIGN:multi-centre prospective randomised open-label...

journal_title：Trials

authors： Blackburn DJ,Krishnan K,Fox L,Ballard C,Burns A,Ford GA,Mant J,Passmore P,Pocock S,Reckless J,Sprigg N,Stewart R,Wardlaw J,Bath PM

更新日期：2013-11-22 00:00:00

abstract：BACKGROUND:Childhood obesity is one of the most critical public health problems in the world. It is associated with low neuromuscular function and postural deformities. Whether weight loss can improve postural stability and neuromuscular control, benefit daily activities, or prevent injury is unknown. Therefore, this s...

journal_title：Trials

authors： Sun F,Wang LJ,Wang L

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:This descriptive study aimed to investigate adolescents' motivations for participating in a randomised controlled trial (RCT), to explore the understanding that the young people had regarding a number of aspects of the trial design, to examine whether or not they found participation in the trial to be accept...

journal_title：Trials

authors： Midgley N,Isaacs D,Weitkamp K,Target M

更新日期：2016-07-28 00:00:00

abstract：BACKGROUND:Carotid atherosclerosis disease (CAD) is generally associated with the occurrence of cardiovascular and cerebrovascular accidents. However, CAD has not been taken seriously enough in the clinic, which, coupled with the single treatment and prevention of CAD, has led to a generally low level of patient compli...

journal_title：Trials

authors： Zhou J,Zhao L,Meng L,Liang H,Zhou T,Ye S,Qi Z,Huang X,Zhou P,Fu W

更新日期：2020-09-07 00:00:00

abstract：BACKGROUND:For adults surviving stroke due to spontaneous (non-traumatic) intracerebral haemorrhage (ICH) who had taken an antithrombotic (i.e. anticoagulant or antiplatelet) drug for the prevention of vaso-occlusive disease before the ICH, it is unclear whether starting antiplatelet drugs results in an increase in the...

journal_title：Trials

authors： Al-Shahi Salman R,Dennis MS,Murray GD,Innes K,Drever J,Dinsmore L,Williams C,White PM,Whiteley WN,Sandercock PAG,Sudlow CLM,Newby DE,Sprigg N,Werring DJ,RESTART collaborators.

更新日期：2018-03-05 00:00:00

abstract：BACKGROUND:College is an exciting but also challenging time with an increased risk for mental health issues. Only a minority of the college students concerned get professional help, a problem that might be improvable by internet- and mobile-based interventions (IMIs). However, adherence of IMIs is a concern. While guid...

journal_title：Trials

authors： Küchler AM,Schultchen D,Pollatos O,Moshagen M,Ebert DD,Baumeister H

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:Low back pain is a common, disabling musculoskeletal disorder in both developing and developed countries. Although often recommended, the potential efficacy of massage therapy in general, and Chinese massage (tuina) in particular, for relief of chronic low back pain (CLBP) has not been fully established due ...

journal_title：Trials

authors： Yang M,Feng Y,Pei H,Deng S,Wang M,Xiao X,Zheng H,Lai Z,Chen J,Li X,He X,Liang F

更新日期：2014-10-29 00:00:00

abstract：BACKGROUND:An increasing number of clinical trials of traditional Chinese medicine are being conducted in the treatment of non-valvular atrial fibrillation (NVAF) in China. However, the heterogeneity of outcomes and outcome measurement instruments has produced little evidence for traditional Chinese medicine in treatin...

journal_title：Trials

authors： Qiu R,Li M,Zhang X,Chen S,Li C,Shang H

更新日期：2018-10-05 00:00:00

abstract：BACKGROUND:Randomised clinical trials are the 'gold standard' for evaluating the effectiveness of healthcare interventions. However, successful recruitment of participants remains a key challenge for many trialists. In this paper, we present a conceptual framework for creating a digital, population-based database for t...

journal_title：Trials

authors： Nwaru BI,Soyiri IN,Simpson CR,Griffiths C,Sheikh A

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:Surgical interventions are complex, which complicates their rigorous assessment through randomised clinical trials. An important component of complexity relates to surgeon experience and the rate at which the required level of skill is achieved, known as the learning curve. There is considerable evidence tha...

journal_title：Trials

authors： Papachristofi O,Jenkins D,Sharples LD

更新日期：2016-06-01 00:00:00

abstract：:Data sharing from clinical trials is one way of promoting fair and transparent conduct of clinical trials. It would maximise the use of data and permit the exploration of additional hypotheses. On the other hand, the quality of secondary analyses cannot always be ascertained, and it may be unfair to investigators who ...

journal_title：Trials

authors： Mbuagbaw L,Foster G,Cheng J,Thabane L

更新日期：2017-02-14 00:00:00

abstract：BACKGROUND:Current international guidelines recommend the use of a daily topical exit-site antimicrobial to prevent peritoneal dialysis (PD)-related infections. Although nonantibiotic-based therapies are appealing because they may limit antimicrobial resistance, no controlled trials have been conducted to compare topic...

journal_title：Trials

authors： Nochaiwong S,Ruengorn C,Noppakun K,Panyathong S,Dandecha P,Sood MM,Saenjum C,Awiphan R,Sirilun S,Mongkhon P,Chongruksut W,Thavorn K,Thai Renal Outcomes Research (THOR) Investigators.

更新日期：2019-12-19 00:00:00

abstract：BACKGROUND:In people with chronic obstructive pulmonary disease (COPD), limb-muscle dysfunction is one of the most troublesome systemic manifestations of the disease, which at the functional level is evidenced by reduced strength and endurance of limb muscles. Improving limb-muscle function is an important therapeutic ...

journal_title：Trials

authors： Frykholm E,Klijn P,Saey D,van Hees HWH,Stål P,Sandström T,Sörlin A,Maltais F,Nyberg A

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Quality and service improvement (QSI) research employs a broad range of methods to enhance the efficiency of healthcare delivery. QSI research differs from traditional healthcare research and poses unique ethical questions. Since QSI research aims to generate knowledge to enhance quality improvement efforts,...

journal_title：Trials

authors： Goldstein CE,Weijer C,Brehaut JC,Campbell M,Fergusson DA,Grimshaw JM,Hemming K,Horn AR,Taljaard M

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:The incidence of strokes in industrialized nations is on the rise, particularly in the older population. In Canada, a minority of individuals who have had a stroke actually receive intensive rehabilitation because most stroke patients do not have access to services or because their motor recovery was judged ...

journal_title：Trials

authors： Tousignant M,Corriveau H,Kairy D,Berg K,Dubois MF,Gosselin S,Swartz RH,Boulanger JM,Danells C

更新日期：2014-01-30 00:00:00

abstract：BACKGROUND:Fibroblast growth factor 23 (FGF23) is associated with left ventricular hypertrophy (LVH) in patients with chronic kidney disease, and calcimimetic therapy reduces plasma concentrations of FGF23. It remains unknown whether treatment with the calcimimetic etelcalcetide (ETL) reduces LVH in patients on hemodia...

journal_title：Trials

authors： Dörr K,Kammer M,Reindl-Schwaighofer R,Lorenz M,Loewe C,Marculescu R,Erben R,Oberbauer R

更新日期：2019-10-24 00:00:00

abstract：BACKGROUND:Poverty undermines adherence to tuberculosis treatment. Economic support may both encourage and enable patients to complete treatment. In South Africa, which carries a high burden of tuberculosis, such support may improve the currently poor outcomes of patients on tuberculosis treatment. The aim of this stud...

journal_title：Trials

authors： Lutge E,Lewin S,Volmink J,Friedman I,Lombard C

更新日期：2013-05-28 00:00:00

abstract：BACKGROUND:Angulated fractures of the distal forearm are very frequent lesions in childhood. Currently, there are no standard guidelines on whether these children should be treated conservatively with a cast; with reduction and a cast; or with reduction, pinning and a cast under anesthesia. Minor prospective and retros...

journal_title：Trials

authors： Adrian M,Wachtlin D,Kronfeld K,Sommerfeldt D,Wessel LM

更新日期：2015-09-30 00:00:00

abstract：OBJECTIVE:The objective of the Dutch Sildenafil therapy in dismal prognosis early onset fetal growth restriction (STRIDER) randomised clinical trial is to assess the beneficial and harmful effects of sildenafil versus placebo on fetal and neonatal mortality in pregnant women with severe early-onset fetal growth restric...

journal_title：Trials

authors： Pels A,Jakobsen JC,Ganzevoort W,Naaktgeboren CA,Onland W,van Wassenaer-Leemhuis AG,Gluud C

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Periprosthetic joint infection (PJI) affects approximately 1% of patients following total hip replacement (THR) and often results in severe physical and emotional suffering. Current surgical treatment options are debridement, antibiotics and implant retention; revision THR; excision of the joint and amputati...

journal_title：Trials

authors： Strange S,Whitehouse MR,Beswick AD,Board T,Burston A,Burston B,Carroll FE,Dieppe P,Garfield K,Gooberman-Hill R,Jones S,Kunutsor S,Lane A,Lenguerrand E,MacGowan A,Moore A,Noble S,Simon J,Stockley I,Taylor AH,Toms A

更新日期：2016-02-17 00:00:00

abstract：BACKGROUND:Adolescent depression is a common mental health problem and there is an urgent need for effective and accessible treatments. Internet-based interventions solve many obstacles for seeking and receiving treatment, thus increasing access to effective treatments. Internet-based cognitive behavioural therapy (ICB...

journal_title：Trials

authors： Mechler J,Lindqvist K,Carlbring P,Lilliengren P,Falkenström F,Andersson G,Topooco N,Johansson R,Midgley N,Edbrooke-Childs J,J Dahl HS,Sandell R,Thorén A,Ulberg R,Lindert Bergsten K,Philips B

更新日期：2020-06-29 00:00:00

abstract：BACKGROUND:A growing body of evidence shows the short-term benefits of breastfeeding, which include protection against infections, allergies, and lung diseases. However, evidence on the long-term benefits of breastfeeding is scarce and often conflicting. The BReastfeeding Attitude and Volume Optimization (BRAVO) trial ...

journal_title：Trials

authors： Savitri AI,Idris NS,Indawati W,Saldi SR,Amelia D,Baharuddin M,Sastroasmoro S,Grobbee DE,Uiterwaal CS

更新日期：2016-06-02 00:00:00

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...

journal_title：Trials

authors： Smit-Fun VM,de Korte-de Boer D,Posthuma LM,Stolze A,Dirksen CD,Hollmann MW,Buhre WF,Boer C

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:Children in low and middle-income countries (LMICs) are at risk for problems in their cognitive, social and behavioural development. Factors such as a lack of cognitive stimulation, harsh parenting practices, and severe and persistent aggression in early childhood are central to the genesis of these problems...

journal_title：Trials

authors： Dowdall N,Cooper PJ,Tomlinson M,Skeen S,Gardner F,Murray L

更新日期：2017-03-09 00:00:00