StudiCare mindfulness-study protocol of a randomized controlled trial evaluating an internet- and mobile-based intervention for college students with no and "on demand" guidance.

abstract：BACKGROUND:The oversight and conduct of a randomised controlled trial involves several stakeholders, including a Trial Steering Committee (TSC), Trial Management Group (TMG), Data Monitoring Committee (DMC), funder and sponsor. We aimed to examine how the relationships between these stakeholders affect the trial oversi...

journal_title：Trials

authors： Daykin A,Selman LE,Cramer H,McCann S,Shorter GW,Sydes MR,Gamble C,Macefield R,Lane JA,Shaw A

更新日期：2017-12-22 00:00:00

abstract：BACKGROUND:Diabetes mellitus is associated with risk of sudden sensorineural hearing loss (SSNHL). Systemic and intratympanic corticosteroids are the two primary treatments for SSNHL in patients with diabetes mellitus. The benefit of intratympanic compared to systemic treatment is the reduced systemic steroid exposure ...

journal_title：Trials

authors： Yang W,Li X,Zhong J,Mei X,Liu H,Yang L,Lu L,Hu H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are eligible for recruitment into the trial. This is in part due to the d...

journal_title：Trials

authors： Parsons NR,Kulikov Y,Girling A,Griffin D

更新日期：2011-12-13 00:00:00

abstract：BACKGROUND:Research involving brain imaging is important for understanding common brain diseases. Study endpoints can include features and measures derived from imaging modalities, providing a benchmark against which other phenotypical data can be assessed. In trials, imaging data provide objective evidence of benefici...

journal_title：Trials

authors： Wiseman SJ,Meijboom R,Valdés Hernández MDC,Pernet C,Sakka E,Job D,Waldman AD,Wardlaw JM

更新日期：2019-01-07 00:00:00

abstract：BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...

journal_title：Trials

authors： Leyenaar JK,McDaniel CE,Acquilano SC,Schaefer AP,Bruce ML,O'Malley AJ

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a major cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and is pop...

journal_title：Trials

authors： Fei YP,Zheng Y,Lai D,Zhong P,Lu JZ,Li G,Liu P

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Juvenile dermatomyositis (JDM) is a rare autoimmune inflammatory disorder associated with significant morbidity and mortality. International collaboration is necessary to better understand the pathogenesis of the disease, response to treatment and long-term outcome. To aid international collaboration, it is ...

journal_title：Trials

authors： McCann LJ,Kirkham JJ,Wedderburn LR,Pilkington C,Huber AM,Ravelli A,Appelbe D,Williamson PR,Beresford MW

更新日期：2015-06-12 00:00:00

abstract：BACKGROUND:Bariatric surgery is an effective approach to weight loss and long-term comorbidity resolution. Although recommended in several guidelines, supervised exercise has not been systematically prescribed after bariatric surgery. The aim of this study is to determine the effects of two types of exercise, moderate-...

journal_title：Trials

authors： Herrera-Santelices A,Tabach-Apraiz A,Andaur-Cáceres K,Zamunér AR

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Pharmacological therapies of proven efficacy in coronavirus disease 2019 (COVID-19) are still lacking. We have identified IFNβ-1a as the most promising drug to be repurposed for COVID-19. The rationale relies on the evidence of IFNβ anti-viral activity in vitro against SARS-CoV-2 and animal models resembling...

journal_title：Trials

authors： Bosi E,Bosi C,Rovere Querini P,Mancini N,Calori G,Ruggeri A,Canzonieri C,Callegaro L,Clementi M,De Cobelli F,Filippi M,Bregni M

更新日期：2020-11-23 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease lowers the quality of life and increases medical costs. Electroacupuncture has been used to ease symptoms and improve gastrointestinal motility in patients with gastroesophageal reflux disease. The main purposes of this study are to evaluate the efficacy and safety of this pro...

journal_title：Trials

authors： Han G,Leem J,Lee H,Lee J

更新日期：2016-05-17 00:00:00

abstract：BACKGROUND:To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils-Listerine Zero (LZ)-and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo ...

journal_title：Trials

authors： Marchetti E,Tecco S,Caterini E,Casalena F,Quinzi V,Mattei A,Marzo G

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:Burns and the associated wound care procedures can be extremely painful and anxiety-provoking for children. Burn injured children and adolescents are therefore at greater risk of experiencing a range of psychological reactions, in particular posttraumatic stress disorder, which can persist for months to year...

journal_title：Trials

authors： Chester SJ,Stockton K,De Young A,Kipping B,Tyack Z,Griffin B,Chester RL,Kimble RM

更新日期：2016-04-29 00:00:00

abstract：BACKGROUND:Classroom-based stuttering intervention addressing negative peer attitudes, perceptions, teasing and bullying of children who stutter (CWS) is required as part of holistic stuttering management because of its occurrence in primary school. This study was conducted in 2017, in 10 primary schools in the Western...

journal_title：Trials

authors： Mallick R,Kathard H,Borhan ASM,Pillay M,Thabane L

更新日期：2018-11-29 00:00:00

abstract：BACKGROUND:Immunologic derangement may be the critical pathophysiologic mechanism in sepsis, and immunotherapy might be a potential new treatment. Si-ni-tang (SNT), an ancient Chinese herbal formula documented in Shanghan Lun, has been used for treating severe sepsis for thousands of years. Research shows that it may h...

journal_title：Trials

authors： Zeng R,Zheng Y,Fan R,Zhou G,Zhang Y,Mai S,Xie D,Weng Y,Du J,Han Y,Lai F

更新日期：2019-08-28 00:00:00

abstract：BACKGROUND:The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults. METHO...

journal_title：Trials

authors： Arabi Y,Al-Hameed F,Burns KEA,Mehta S,Alsolamy S,Almaani M,Mandourah Y,Almekhlafi GA,Al Bshabshe A,Finfer S,Alshahrani M,Khalid I,Mehta Y,Gaur A,Hawa H,Buscher H,Arshad Z,Lababidi H,Al Aithan A,Jose J,Abdukahil SA

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:School-based comprehensive sexual health education can improve adolescent health outcomes, and web-based programs are a promising approach to overcoming challenges associated with teacher-led formats by ensuring that students receive content that is consistent, unbiased, and medically accurate. However, many...

journal_title：Trials

authors： Scull TM,Malik CV,Morrison A,Keefe EM

更新日期：2020-01-08 00:00:00

abstract：BACKGROUND:We sought to test the effectiveness of methadone and buprenorphine in the treatment of methamphetamine withdrawal craving over a 17-day treatment period. METHODS:Patients were randomized into one of two groups. The study sample comprised 40 male subjects dependent on methamphetamine who met criteria of the ...

journal_title：Trials

authors： Ahmadi J,Razeghian Jahromi L

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Less invasive surfactant administration (LISA) is a way of giving surfactant without endotracheal intubation and has shown to be promising in reducing the incidence of bronchopulmonary dysplasia (BPD) in preterm infants. However, the mechanism underlying its beneficial effect and variations in the technique ...

journal_title：Trials

authors： Zhu J,Bao Y,Du L,Huang H,Lv Q,Jiang Y,Dai Y,Chen Z,Shi J,Shi Y,Yang C,Mei H,Jiang H,Sun Y,Sun X

更新日期：2020-06-11 00:00:00

abstract：:International calls for registering all trials involving humans and for sharing the results, and sometimes also the raw data and the trial protocols, have increased in recent years. Such calls have come, for example, from the Organization for Economic Cooperation and Development (OECD), the World Health Organization (...

journal_title：Trials

authors： Gøtzsche PC

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Equine-assisted therapy is more often practiced with children and adolescents than with the elderly, although individuals in the second half of life could also profit from it. This group, from the age of 50, is characterised by increasing emotional, social, health-related and cognitive changes; a critical li...

journal_title：Trials

authors： Schmidt J,Wartenberg-Demand A,Forstmeier S

更新日期：2020-10-15 00:00:00

abstract：BACKGROUND:Hysterosalpingography (HSG) is an accepted radiologic diagnostic modality for initial infertility workup, and is generally considered uncomfortable and painful. However, the management of pain related to HSG remains inefficient. As an emerging nonpharmacologic and noninvasive pain control strategy, virtual r...

journal_title：Trials

authors： Wang YL,Gao HX,Wang JS,Wang JH,Bo L,Zhang TT,Dai YL,Gao LL,Liu Q,Zhang JJ,Cai JM,Yu JQ,Li YX

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about preventive COVID-19 behaviors that can be ...

journal_title：Trials

authors： Vandormael A,Adam M,Greuel M,Bärnighausen T

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Intensive rehabilitation of patients with severe traumatic brain injury is generally applied in the subacute stages of the hospital stay. Few studies have assessed the association between early and intensive physical rehabilitation and functional outcomes. The aim of this trial is to assess the feasibility o...

journal_title：Trials

authors： Riberholt CG,Lindschou J,Gluud C,Mehlsen J,Møller K

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Cigarette smoking negatively impacts on maternal and fetal health. Smoking cessation is one of the few interventions capable of improving pregnancy outcomes. Despite the risks, the most effective antenatal model of care for smokers is still unclear, and specific recommendations for screening for fetal growth...

journal_title：Trials

authors： McDonnell BP,Dicker P,Keogan S,Clancy L,Regan C

更新日期：2019-09-03 00:00:00

abstract：BACKGROUND:Incomplete recovery from facial palsy results in social and physical disabilities, and the medical options for the sequelae of Bell's palsy are limited. Acupuncture is widely used for Bell's palsy patients in East Asia, but its efficacy is unclear. METHODS:We performed a randomized controlled trial includin...

journal_title：Trials

authors： Kwon HJ,Choi JY,Lee MS,Kim YS,Shin BC,Kim JI

更新日期：2015-06-03 00:00:00

abstract：BACKGROUND:Among patients with hepatocellular carcinoma (HCC), 85% of patients have an advanced disease stage at diagnosis and curative therapies cannot be performed. Prognosis has been quite poor as until recently there was no proven effective chemotherapy. Our group found that all-trans-retinoic acid (ATRA) could imp...

journal_title：Trials

authors： Shi J,Sun J,Liu C,Chai Z,Wang N,Zhang H,Cheng S

更新日期：2019-04-29 00:00:00

abstract：BACKGROUND:Burst stimulation is a novel form of neurostimulation for the treatment of chronic pain which has demonstrated promise in small uncontrolled studies, but has not yet gained approval for use in the U.S. We report the study methods for an ongoing multicenter, randomized, controlled, cross-over study designed t...

journal_title：Trials

authors： Slavin KV,North RB,Deer TR,Staats P,Davis K,Diaz R

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Recent clinical observations have reported the potential benefit of vagus nerve stimulation (VNS) as an adjunctive therapy for pediatric epilepsy. Preliminary evidence suggests that VNS treatment is effective for seizure reduction and mental development in young participants between 3 and 6 years of age who ...

journal_title：Trials

authors： Ji T,Yang Z,Liu Q,Liao J,Yin F,Chen Y,Zou L,Li B,Gao Y,Shu X,Huang S,Gao F,Liang J,Lin SF,Peng J,Song S,Wang J,Che C,Sun W,Tian M,Yang L,Hua Y,Hao Y,Cai L,Li L,Jiang Y

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:The increasing prevalence and associated cost of treating chronic obstructive pulmonary disease (COPD) is unsustainable, and focus is needed on self-management and prevention of hospital admissions. Telehealth monitoring of patients' vital signs allows clinicians to prioritise their workload and enables pati...

journal_title：Trials

authors： Bentley CL,Mountain GA,Thompson J,Fitzsimmons DA,Lowrie K,Parker SG,Hawley MS

更新日期：2014-08-06 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated the benefit of early integration of palliative care (PC) in oncology. However, patients continue to receive late referrals to PC even in comprehensive cancer centers. Patients and health professionals may perceive PC as 'a place to die,' and this stigma is a barrier to time...

journal_title：Trials

authors： do Carmo TM,Paiva BS,de Siqueira MR,da Rosa Lde T,de Oliveira CZ,Nascimento MS,Paiva CE

更新日期：2015-04-12 00:00:00