An international, Delphi consensus study to identify priorities for methodological research in behavioral trials in health research.

abstract：:Following the South African case, Treatment Action Campaign and Others v Minister of Health and Others, the use of 'pilot' studies to investigate interventions already proven efficacious, offered free of charge to government, but confined by the government to a small part of the population, may violate children's righ...

journal_title：Trials

authors： Oduwo E,Edwards SJ

更新日期：2014-07-16 00:00:00

abstract：BACKGROUND:Tracheal intubation with the patient in the lateral position is difficult because the laryngeal view is compromised during direct laryngoscopy. Flexible video endoscopes may facilitate intubation even when laryngeal views are poor on direct laryngoscopy because the patients are positioned laterally. Thus, th...

journal_title：Trials

authors： Gao Y,Lin B,Huang J,Lin X,Lin C

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Feeding practices and child undernutrition can be improved when trained health workers provide proper nutrition counseling to caregivers. However, this important management component is difficult to achieve in countries where trained health workers are limited; Tanzania is no exception. In rural and semi-urb...

journal_title：Trials

authors： Sunguya BF,Poudel KC,Mlunde LB,Urassa DP,Jimba M,Yasuoka J

更新日期：2013-10-25 00:00:00

abstract：BACKGROUND:Current management for men with lower urinary tract symptoms (LUTS) is a pathway that results in prostate surgery in a significant proportion. While helpful in relieving benign prostatic obstruction (BPO), surgery may be ineffective for men suffering from difficulties not relating to BPO. The UPSTREAM trial ...

journal_title：Trials

authors： Young GJ,Lewis AL,Lane JA,Winton HL,Drake MJ,Blair PS

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:A growing body of evidence shows the short-term benefits of breastfeeding, which include protection against infections, allergies, and lung diseases. However, evidence on the long-term benefits of breastfeeding is scarce and often conflicting. The BReastfeeding Attitude and Volume Optimization (BRAVO) trial ...

journal_title：Trials

authors： Savitri AI,Idris NS,Indawati W,Saldi SR,Amelia D,Baharuddin M,Sastroasmoro S,Grobbee DE,Uiterwaal CS

更新日期：2016-06-02 00:00:00

abstract：BACKGROUND:The cross-sectional area of the subclavian vein (csSCV) is an important factor determining the success rate of SCV catheterization. The head-down position increases the csSCV. However, the effects of lateral tilting on subclavian venous cross-sectional area have not yet been explored. In this trial, we test ...

journal_title：Trials

authors： Jung DE,Lee HC,Yoon HK,Park HP

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m2. The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutralizes the acid net produ...

journal_title：Trials

authors： Gaggl M,Cejka D,Plischke M,Heinze G,Fraunschiel M,Schmidt A,Hörl WH,Sunder-Plassmann G

更新日期：2013-07-04 00:00:00

abstract：RATIONALE:Aspiration, infections, and fever are common in the first days after stroke, especially in older patients. The occurrence of these complications has been associated with an increased risk of death or dependency. AIMS AND DESIGN:PREvention of Complications to Improve OUtcome in elderly patients with acute Str...

journal_title：Trials

authors： de Jonge JC,Woodhouse LJ,Reinink H,van der Worp HB,Bath PM,PRECIOUS investigators.

更新日期：2020-10-26 00:00:00

abstract：:There are many acknowledged benefits for the reuse of clinical trial data; from independent verification of published results to the evaluation of new hypotheses. However, the reuse of shared clinical trial data is not without obstacles. Here we present some of the issues and lessons learned from our own experiences i...

journal_title：Trials

authors： Wilkinson T,Sinha S,Peek N,Geifman N

更新日期：2019-08-19 00:00:00

abstract：BACKGROUND:Autism spectrum disorder (ASD) is found in approximately 1% of the population and includes core symptoms that affect general and social development. Beside these core symptoms, it is suggested that up to 60% of children with ASD suffer from comorbid anxiety disorders which may further affect educational, soc...

journal_title：Trials

authors： Kilburn TR,Sørensen MJ,Thastum M,Rapee RM,Rask CU,Arendt KB,Thomsen PH

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:Suffering linked to previous interpersonal trauma is common among patients in mental health care. Diagnostic labels may vary, but the clinical picture is often characterized by long-lasting and complex psychological and somatic symptoms, subjective distress and reduced quality of health and life. A substanti...

journal_title：Trials

authors： Holgersen KH,Brønstad I,Jensen M,Brattland H,Reitan SK,Hassel AM,Arentz M,Lara-Cabrera M,Skjervold AE

更新日期：2020-05-27 00:00:00

abstract：BACKGROUND:Around 35-45 % of people in contact with services for a first episode of psychosis are using cannabis. Cannabis use is associated with delays in remission, poorer clinical outcomes, significant increases in the risk of relapse, and lower engagement in work or education. While there is a clear need for effect...

journal_title：Trials

authors： Johnson S,Sheridan Rains L,Marwaha S,Strang J,Craig T,Weaver T,McCrone P,King M,Fowler D,Pilling S,Marston L,Omar RZ,Craig M,Hinton M

更新日期：2016-10-22 00:00:00

abstract：BACKGROUND:Depression is seriously affecting the physical and mental health of young people worldwide. Subthreshold depression, as an early stage of depression, is essential for early prevention and treatment of depression. Tai Chi, as a traditional Chinese mind-body therapy, may become an alternative intervention. How...

journal_title：Trials

authors： Xie X,Song J,Zhu J,Han M,He Y,Huang J,Tao J,Wu J

更新日期：2021-01-30 00:00:00

abstract：BACKGROUND:The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the ef...

journal_title：Trials

authors： Demant MN,Jensen RG,Jakobsen JC,Gluud C,Homøe P

更新日期：2017-01-19 00:00:00

abstract：BACKGROUND:People with serious mental illness (SMI) (psychosis, bipolar disorder and major depressive disorder) experience a considerable risk of premature mortality because of cardiovascular disease. Recent research has demonstrated that this population spends almost 13 h per day being sedentary. Sedentary behaviour i...

journal_title：Trials

authors： Williams J,Stubbs B,Gaughran F,Craig T

更新日期：2016-12-12 00:00:00

abstract：BACKGROUND:Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.The...

journal_title：Trials

authors： Rodrigo R,Hasson D,Prieto JC,Dussaillant G,Ramos C,León L,Gárate J,Valls N,Gormaz JG

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Dementia is a neurological condition that affects the cognitive and functional ability of the brain and is the leading cause of disability among those aged 65 years and above. More effective ways to manage dementia symptoms are needed because current treatment options (antidepressants and antipsychotics) can...

journal_title：Trials

authors： Timler A,Bulsara C,Bulsara M,Vickery A,Smith J,Codde J

更新日期：2020-02-14 00:00:00

abstract：BACKGROUND:Pragmatic randomised controlled trials (RCTs) are considered essential to determine effective interventions for routine clinical practice, but many fail to recruit participants efficiently, and some really important RCTs are not undertaken because recruitment is thought to be too difficult. The 'QuinteT Recr...

journal_title：Trials

authors： Donovan JL,Rooshenas L,Jepson M,Elliott D,Wade J,Avery K,Mills N,Wilson C,Paramasivan S,Blazeby JM

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:Laparoscopic surgery has become the preferred approach for many procedures because of reduced post-operative pain, better recovery, shorter hospital stay and improved cosmesis. Single incision laparoscopic surgery is one of the many recent variants where either standard ports or a specially designed single m...

journal_title：Trials

authors： Malik M,McCormack K,Krukowski ZH,McDonald A,McPherson G,Cook JA,Ahmed I,SCARLESS Study Group.

更新日期：2012-10-30 00:00:00

abstract：BACKGROUND:Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining repetitive active transcranial direct current stimulation (tDCS) with...

journal_title：Trials

authors： Araujo C,Fitz RC,Nogara DA,Schestatsky P,Gerchman F

更新日期：2018-07-16 00:00:00

abstract：BACKGROUND:Clavicle fractures account for around 4% of all fractures and up to 44% of fractures of the shoulder girdle. Fractures of the middle third (or mid-shaft) account for approximately 80% of all clavicle fractures. Management of this group of fractures is often challenging and the outcome can be unsatisfactory. ...

journal_title：Trials

authors： Longo UG,Banerjee S,Barber J,Chambler A,Cobiella C,Corbett S,Crowther M,Drew S,Francis A,Lee M,Garlick N,Packham I,Pearse Y,Richards A,Roberts C,Tennent D,Tims E,Ahrens PM

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:Temporomandibular disorder (TMD) is a condition encompassing clinical symptoms of the temporomandibular joint, masseter muscle, and surrounding structures. Hominis placental pharmacopuncture (HPP), consisting of human placental extract, has been reported as effective for treating chronic musculoskeletal diso...

journal_title：Trials

authors： Kim J,Park KS,Lee YJ,Kim KW,Cho JH,Ha IH

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:Chronic back pain is a major public health problem and the primary reason patients seek massage treatment. Despite the growing use of massage for chronic low back pain, there have been few studies of its effectiveness. This trial will be the first evaluation of the effectiveness of relaxation massage for chr...

journal_title：Trials

authors： Cherkin DC,Sherman KJ,Kahn J,Erro JH,Deyo RA,Haneuse SJ,Cook AJ

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:Written participant information materials are important for ensuring that potential trial participants receive necessary information so that they can provide informed consent. However, such materials are frequently long and complex, which may negatively impact patient understanding and willingness to partici...

journal_title：Trials

authors： Parker A,Knapp P,Treweek S,Madhurasinghe V,Littleford R,Gallant S,Sullivan F,Schembri S,Rick J,Graffy J,Collier DJ,Eldridge S,Kennedy A,Bower P

更新日期：2018-09-18 00:00:00

abstract：BACKGROUND:Surgical site infections (SSI) remain one of the most common complications in conventional abdominal surgery with an incidence between 4% and 19% (Sandini et al., Medicine (Baltimore) 95:e4057, 2016) in the literature. It is unclear whether the use of coated suture material for skin closure reduces the risk ...

journal_title：Trials

authors： Matz D,Teuteberg S,Wiencierz A,Soysal SD,Heizmann O

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...

journal_title：Trials

authors： Smit-Fun VM,de Korte-de Boer D,Posthuma LM,Stolze A,Dirksen CD,Hollmann MW,Buhre WF,Boer C

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:Real-time functional magnetic resonance imaging (rtfMRI) is used for neurofeedback training (NFT). Preliminary results suggest that it can help patients to control their symptoms. This study uses rtfMRI NFT for relapse prevention in alcohol dependence. METHODS/DESIGN:Participants are alcohol-dependent patie...

journal_title：Trials

authors： Cox WM,Subramanian L,Linden DE,Lührs M,McNamara R,Playle R,Hood K,Watson G,Whittaker JR,Sakhuja R,Ihssen N

更新日期：2016-10-03 00:00:00

abstract：BACKGROUND:The focus in recent years on physical inactivity and metabolic disturbances in individuals with schizophrenia raises the question of potential effects of physical activity. Physical activity has shown beneficial effects on cognition in healthy older individuals as well as on symptom severity in depression. H...

journal_title：Trials

authors： Engh JA,Andersen E,Holmen TL,Martinsen EW,Mordal J,Morken G,Egeland J

更新日期：2015-12-08 00:00:00

abstract：BACKGROUND:With high morbidity, mortality and disability rate, brain infarction brings a huge economic and health burden to the whole society in China. Although some previous studies suggested that telerehabilitation may facilitate rehabilitation for stroke survivors at home, the evidence is insufficient for clinical a...

journal_title：Trials

authors： Jin W,Chen J,Shi F,Yang W,Zhang Y,Liu Y,Dong W,Jin Y,Ma W,Ma Z,Min X,Jin Y,Gu Y,Ren C

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:There is evidence to suggest that delivery of diabetes self-management support by diabetes educators in primary care may improve patient care processes and patient clinical outcomes; however, the evaluation of such a model in primary care is nonexistent in Canada. This article describes the design for the ev...

journal_title：Trials

authors： Gucciardi E,Fortugno M,Horodezny S,Lou W,Sidani S,Espin S,Webster F,Shah BR

更新日期：2012-09-13 00:00:00