Efficacy, safety, and economic assessment of hominis placental pharmacopuncture for chronic temporomandibular disorder: a protocol for a multicentre randomised controlled trial.

abstract：BACKGROUND:Several drugs are being repurposed for the treatment of the coronavirus disease 2019 (COVID-19) pandemic based on in vitro or early clinical findings. As these drugs are being used in varied regimens and dosages, it is important to enable synthesis of existing safety data from clinical trials. However, avail...

journal_title：Trials

authors： Rodgers F,Pepperrell T,Keestra S,Pilkington V

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Verrucae are a common, infectious and sometimes painful problem. The optimal treatment for verrucae is unclear due to a lack of high quality randomised controlled trials. The primary objective of this study is to compare the clinical effectiveness of two common treatments for verrucae: cryotherapy using liqu...

journal_title：Trials

authors： Cockayne ES,EVERT Trial Team.

更新日期：2010-02-08 00:00:00

abstract：BACKGROUND:Asylum seekers and refugees are at great risk for developing mental disorders. Afghan refugees are a particularly vulnerable group with a low average education and mental health literacy level. Traumatic experiences and hardship before and during migration are predictive of mental health problems. However, p...

journal_title：Trials

authors： Knefel M,Kantor V,Nicholson AA,Schiess-Jokanovic J,Weindl D,Schäfer I,Lueger-Schuster B

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:Despite a burgeoning interest in using interprofessional approaches to promote effective collaboration in health care, systematic reviews find scant evidence of benefit. This protocol describes the first cluster randomized controlled trial (RCT) to design and evaluate an intervention intended to improve inte...

journal_title：Trials

authors： Zwarenstein M,Reeves S,Russell A,Kenaszchuk C,Conn LG,Miller KL,Lingard L,Thorpe KE

更新日期：2007-09-18 00:00:00

abstract：BACKGROUND:Many patients at high risk of cardiovascular disease do not achieve recommended low-density lipoprotein cholesterol (LDL-C) goals. This study compared the efficacy and safety of low doses of rosuvastatin (10 mg) and atorvastatin (20 mg) in high-risk patients with hypercholesterolemia. METHODS:A total of 996...

journal_title：Trials

authors： Clearfield MB,Amerena J,Bassand JP,Hernández García HR,Miller SS,Sosef FF,Palmer MK,Bryzinski BS

更新日期：2006-12-21 00:00:00

abstract：BACKGROUND:Depression is not a normal side effect of aging, however it is one of the most prevalent mental health issues in later life, imposing a tremendous burden on patients, their families, and the healthcare system. We describe the experimental implementation of a collaborative, stepped-care model for the treatmen...

journal_title：Trials

authors： Wernher I,Bjerregaard F,Tinsel I,Bleich C,Boczor S,Kloppe T,Scherer M,Härter M,Niebling W,König HH,Hüll M

更新日期：2014-09-06 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is a major contributor to the burden of disease and the number one cause of death worldwide. From 1990 until today, more people died from coronary heart disease than from any other cause. CVD is regularly treated with minimally or non-minimally invasive off- or on-pump cardiothor...

journal_title：Trials

authors： Moza A,Benstoem C,Autschbach R,Stoppe C,Goetzenich A

更新日期：2015-12-02 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Trials

authors： Eckhardt CM,Cummings MJ,Rajagopalan KN,Borden S,Bitan ZC,Wolf A,Kantor A,Briese T,Meyer BJ,Jacobson SD,Scotto D,Mishra N,Philip NM,Stotler BA,Schwartz J,Shaz B,Spitalnik SL,Eisenberger A,Hod EA,Justman J,Cheung K

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' understandings are inevitably influenced by the recruiting clinician's understanding of the trial, yet rel...

journal_title：Trials

authors： Ziebland S,Featherstone K,Snowdon C,Barker K,Frost H,Fairbank J

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Chronic musculoskeletal pain (MSP) affects more than 40% of adults aged 50 years and older and is the leading cause of disability in the USA. Older adults with chronic MSP are at risk for analgesic-related side effects, long-term opioid use, and functional decline. Recognizing the burden of chronic MSP, redu...

journal_title：Trials

authors： Platts-Mills TF,McLean SA,Weinberger M,Stearns SC,Bush M,Teresi BB,Hurka-Richardson K,Kroenke K,Kerns RD,Weaver MA,Keefe FJ

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Optimising the use of antibiotic agents is a pressing challenge to overcoming the rapid emergence and spread of multidrug-resistant pathogens in intensive care units (ICUs). Although Gram staining may possibly provide immediate information for predicting pathogenic bacteria, Gram stain-guided initial antibio...

journal_title：Trials

authors： Yoshimura J,Yamakawa K,Kinoshita T,Ohta Y,Morimoto T

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Distal pancreatectomy for benign and malignant tumours is the second most common surgical procedure on the pancreas. Postoperative pancreatic fistulas (POPF) represent the most significant clinical complication, causing prolongation of hospital stay and the need for additional diagnostic and therapeutic proc...

journal_title：Trials

authors： Hassenpflug M,Bruckner T,Knebel P,Diener MK,Büchler MW,Werner J

更新日期：2013-12-14 00:00:00

abstract：BACKGROUND:Co-infection with malaria parasite and HIV is an emerging public health problem in tropical areas, particularly in pregnant women, and management of the concurrent effects of these two infections is challenging. Co-trimoxazole is a sulfamide preparation used to prevent opportunistic infections in HIV-infecte...

journal_title：Trials

authors： Manirakiza A,Sepou A,Serdouma E,Gondje S,Bata GG,Moussa S,Boulay A,Moyen JM,Sakanga O,Le-Fouler L,Kazanji M,Vray M

更新日期：2013-08-14 00:00:00

abstract：BACKGROUND:There has been a recent steep growth in platelet-rich plasma (PRP) use for musculoskeletal conditions, but findings from high quality clinical trial data are lacking in the literature. Here, we describe the statistical analysis plan (SAP) for the Platelet-rich plasma in Achilles Tendon Healing 2 (PATH-2) tri...

journal_title：Trials

authors： Schlüssel MM,Keene DJ,Wagland S,Alsousou J,Lamb SE,Willett K,Dutton SJ,PATH-2 Trial Study Group.

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Quality of residential care for people with severe dementia is in urgent need of improvement. One reason for this may be the assumption that people with severe dementia are unaware of what is happening to them. However, there is converging evidence to suggest that global assumptions of unawareness are inappr...

journal_title：Trials

authors： Clare L,Woods RT,Whitaker R,Wilson BA,Downs M

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:Women with highly penetrant BRCA mutations have a 55-60 % lifetime risk for breast cancer and a 16-59 % lifetime risk of developing ovarian cancer. However, penetrance differs interindividually, indicating that environmental and behavioral factors may modify this risk. It is well documented that the risk for...

journal_title：Trials

authors： Kiechle M,Engel C,Berling A,Hebestreit K,Bischoff SC,Dukatz R,Siniatchkin M,Pfeifer K,Grill S,Yahiaoui-Doktor M,Kirsch E,Niederberger U,Enders U,Löffler M,Meindl A,Rhiem K,Schmutzler R,Erickson N,Halle M

更新日期：2016-07-29 00:00:00

abstract：BACKGROUND:Patients' treatment preferences are often cited as barriers to recruitment in randomized controlled trials (RCTs). We investigated how RCT recruiters reacted to patients' treatment preferences and identified key strategies to improve informed decision-making and trial recruitment. METHODS:Audio-recordings o...

journal_title：Trials

authors： Mills N,Blazeby JM,Hamdy FC,Neal DE,Campbell B,Wilson C,Paramasivan S,Donovan JL

更新日期：2014-08-13 00:00:00

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a major cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and is pop...

journal_title：Trials

authors： Fei YP,Zheng Y,Lai D,Zhong P,Lu JZ,Li G,Liu P

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Angulated fractures of the distal forearm are very frequent lesions in childhood. Currently, there are no standard guidelines on whether these children should be treated conservatively with a cast; with reduction and a cast; or with reduction, pinning and a cast under anesthesia. Minor prospective and retros...

journal_title：Trials

authors： Adrian M,Wachtlin D,Kronfeld K,Sommerfeldt D,Wessel LM

更新日期：2015-09-30 00:00:00

abstract：BACKGROUND:To evaluate the antiplaque effects of an alcohol-free mouthrinse containing essential oils-Listerine Zero (LZ)-and an alcohol-based essential oils mouthrinse (EO+) compared with a positive control of 0.20% chlorhexidine mouthrinse (CHX) and a negative control of a placebo solution (saline), using an in vivo ...

journal_title：Trials

authors： Marchetti E,Tecco S,Caterini E,Casalena F,Quinzi V,Mattei A,Marzo G

更新日期：2017-03-31 00:00:00

abstract：BACKGROUND:College is an exciting but also challenging time with an increased risk for mental health issues. Only a minority of the college students concerned get professional help, a problem that might be improvable by internet- and mobile-based interventions (IMIs). However, adherence of IMIs is a concern. While guid...

journal_title：Trials

authors： Küchler AM,Schultchen D,Pollatos O,Moshagen M,Ebert DD,Baumeister H

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immunosuppression. Recurrent lesions of PG are common, but the relative rarity of this condition means th...

journal_title：Trials

authors： Craig FF,Thomas KS,Mitchell EJ,Williams HC,Norrie J,Mason JM,Ormerod AD,UK Dermatology Clinical Trials Network’s STOP GAP Trial Team.

更新日期：2012-04-28 00:00:00

abstract：BACKGROUND:Acupressure therapy may be potentially beneficial in improving postoperative symptoms like postoperative nausea and vomiting (PONV), pain and sleep disorder and improving postoperative quality of recovery. The primary aim of this study is to investigate the efficacy of acupressure therapy on postoperative pa...

journal_title：Trials

authors： Noll E,Shodhan S,Madariaga MC,Page CR,Santangelo D,Guo X,Al Bizri E,Pryor AD,Romeiser J,Bennett-Guerrero E

更新日期：2017-03-07 00:00:00

abstract：OBJECTIVES:The GETAFIX trial will test the hypothesis that favipiravir is a more effective treatment for COVID-19 infection in patients who have early stage disease, compared to current standard of care. This study will also provide an important opportunity to investigate the safety and tolerability of favipiravir, the...

journal_title：Trials

authors： Hanna CR,Blyth KG,Burley G,Carmichael S,Evans C,Hinsley S,Khadra I,Khoo S,Lewsley LA,Jones RR,Sharma R,Taladriz-Sender A,Thomson EC,Scott JT

更新日期：2020-11-19 00:00:00

abstract：BACKGROUND:It is expected that in 2020 more than 17,000 cases of colorectal cancer will be diagnosed in The Netherlands. To date, patients are included in a surgeon-led follow-up programme whose main focus is recurrence detection. However, patients often experience multiple physical and psychosocial problems. Currently...

journal_title：Trials

authors： Duineveld LA,Wieldraaijer T,van Asselt KM,Nugteren IC,Donkervoort SC,van de Ven AW,Smits AB,van Geloven AA,Bemelman WA,Beverdam FH,van Tets WF,Govaert MJ,Bosmans JE,Verdonck-de Leeuw IM,van Uden-Kraan CF,van Weert HC,Wind

更新日期：2015-06-26 00:00:00

abstract：:After publication of our article [1] we have been notified on a mistake in the sample size. ...

journal_title：Trials

authors： Zhu L,Shi X,Yin S,Yin J,Zhu Z,Gao X,Jiao Y,Yu W,Yang L

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Recommendations for good clinical practice have been reported to be difficult to apply in real life by primary care clinicians. This could be because the clinical trials at the origin of the guidelines are based on explanatory trials, conducted under ideal conditions not reflecting the reality of primary car...

journal_title：Trials

authors： Ettori-Ajasse I,Tatin E,Forbes G,Eldridge S,Dibao-Dina C

更新日期：2020-03-19 00:00:00

abstract：BACKGROUND:Bariatric surgery is an effective approach to weight loss and long-term comorbidity resolution. Although recommended in several guidelines, supervised exercise has not been systematically prescribed after bariatric surgery. The aim of this study is to determine the effects of two types of exercise, moderate-...

journal_title：Trials

authors： Herrera-Santelices A,Tabach-Apraiz A,Andaur-Cáceres K,Zamunér AR

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:ST-elevation myocardial infarction (STEMI) accounts for nearly one third of acute coronary syndromes. Despite improved STEMI patient care, mortality remains high, contributing significantly to the ischemic heart disease burden. This may partly be related to ischemia-reperfusion injury (IRI). Remote ischemic ...

journal_title：Trials

authors： Gaspar A,Pereira MÁ,Azevedo P,Lourenço A,Marques J,Leite-Moreira A

更新日期：2015-09-08 00:00:00

abstract：BACKGROUND:Staphylococcus aureus bacteremia (SAB) is frequently encountered in the hospital setting, and current guidelines recommend at least 14 days of antibiotic treatment for SAB in order to minimize risks of secondary deep infections and relapse. However, evidence to support these treatment recommendations remains...

journal_title：Trials

authors： Thorlacius-Ussing L,Andersen CØ,Frimodt-Møller N,Knudsen IJD,Lundgren J,Benfield TL

更新日期：2019-05-02 00:00:00