Effect of transcranial direct current stimulation associated with hypocaloric diet on weight loss and metabolic profile in overweight or obesity: study protocol for a double-blind, randomized controlled clinical trial.

abstract：BACKGROUND:This update outlines changes to the MObile Technology for Improved Family Planning study statistical analysis plan and plans for long-term follow-up. These changes result from obtaining additional funding and the decision to restrict the primary analysis to participants with available follow-up data. The cha...

journal_title：Trials

authors： Smith C,Ngo TD,Edwards P,Free C

更新日期：2014-11-12 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Systematic use of observational pain tools has been advocated as a means to improve pain management for care home residents with dementia. Pain experts suggest that any observational tool should be used as part of a comprehensive pain management protocol, which should include score interpretation and verific...

journal_title：Trials

authors： Liu JY,Lai C

更新日期：2014-03-13 00:00:00

abstract：BACKGROUND:Verrucae are a common, infectious and sometimes painful problem. The optimal treatment for verrucae is unclear due to a lack of high quality randomised controlled trials. The primary objective of this study is to compare the clinical effectiveness of two common treatments for verrucae: cryotherapy using liqu...

journal_title：Trials

authors： Cockayne ES,EVERT Trial Team.

更新日期：2010-02-08 00:00:00

abstract：BACKGROUND:Ascites is one of the most common complications of cirrhosis. Umbilical therapy with traditional Chinese medicines has been increasingly prescribed to treat cirrhotic ascites. However, high-quality evidence from clinical trials supporting such application of traditional Chinese medicines remains limited. The...

journal_title：Trials

authors： Yang X,Ru S,Luo L,Lv X,Bai W,Zhang F,Jiang F

更新日期：2019-02-13 00:00:00

abstract：BACKGROUND:In coronary artery bypass grafting surgery, arterial conduits are preferred because of more favourable long-term patency and outcome. Anyway the greater saphenous vein continues to be the most commonly used bypass conduit. Minimally invasive endoscopic saphenous vein harvesting is increasingly being investig...

journal_title：Trials

authors： Campanella A,Bergamasco L,Macri L,Asioli S,Devotini R,Scipioni S,Barbaro S,Rispoli P,Rinaldi M

更新日期：2011-11-18 00:00:00

abstract：BACKGROUND:Maintaining adequate oxygenation during rapid sequence intubation (RSI) is imperative to prevent peri-intubation adverse events that can lead to increased duration of hospital and intensive care unit stay, or a prolonged vegetative state requiring long-term institutionalisation. Despite employing current bes...

journal_title：Trials

authors： Chua MT,Khan FA,Ng WM,Lu Q,Low MJW,Yau YW,Punyadasa A,Kuan WS

更新日期：2019-04-04 00:00:00

abstract：BACKGROUND:Equine-assisted therapy is more often practiced with children and adolescents than with the elderly, although individuals in the second half of life could also profit from it. This group, from the age of 50, is characterised by increasing emotional, social, health-related and cognitive changes; a critical li...

journal_title：Trials

authors： Schmidt J,Wartenberg-Demand A,Forstmeier S

更新日期：2020-10-15 00:00:00

abstract：:Randomised controlled trials are the best research design for decisions about the effect of different interventions but randomisation does not, of itself, promote the applicability of a trial's results to situations other than the precise one in which the trial was done. While methodologists and trialists have rightly...

journal_title：Trials

authors： Treweek S,Zwarenstein M

更新日期：2009-06-03 00:00:00

abstract：BACKGROUND:Surgical site infections (SSI) remain one of the most common complications in conventional abdominal surgery with an incidence between 4% and 19% (Sandini et al., Medicine (Baltimore) 95:e4057, 2016) in the literature. It is unclear whether the use of coated suture material for skin closure reduces the risk ...

journal_title：Trials

authors： Matz D,Teuteberg S,Wiencierz A,Soysal SD,Heizmann O

更新日期：2019-07-02 00:00:00

abstract：BACKGROUND:Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortality. Exercise has potential to improve depression, and has been shown in existing trials to improve o...

journal_title：Trials

authors： Underwood M,Eldridge S,Lamb S,Potter R,Sheehan B,Slowther AM,Taylor S,Thorogood M,Weich S

更新日期：2011-02-02 00:00:00

abstract：BACKGROUND:Loss of upper limb function affects up to 85 % of acute stroke patients. Recovery of upper limb function requires regular intensive practise of specific upper limb tasks. To enhance intensity of practice interventions are being developed to encourage patients to undertake self-directed exercise practice. Mos...

journal_title：Trials

authors： Moore SA,Da Silva R,Balaam M,Brkic L,Jackson D,Jamieson D,Ploetz T,Rodgers H,Shaw L,van Wijck F,Price C

更新日期：2016-10-21 00:00:00

abstract：BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mortality. The limitations of vancomycin, the current standard therapy for MRSA, make treatment difficult. The only other approved drug for treatment of MRSA bacteraemia, daptomycin, has not been...

journal_title：Trials

authors： Tong SY,Nelson J,Paterson DL,Fowler VG Jr,Howden BP,Cheng AC,Chatfield M,Lipman J,Van Hal S,O'Sullivan M,Robinson JO,Yahav D,Lye D,Davis JS,CAMERA2 study group and the Australasian Society for Infectious Diseases Clinical Res

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Most people who stop smoking successfully for a few weeks will return to smoking again in the medium term. There are few effective interventions to prevent this relapse and none used routinely in clinical practice. A previous exploratory meta-analysis suggested that self-help booklets may be effective but re...

journal_title：Trials

authors： Song F,Holland R,Barton GR,Bachmann M,Blyth A,Maskrey V,Aveyard P,Sutton S,Leonardi-Bee J,Brandon TH

更新日期：2012-05-30 00:00:00

abstract：BACKGROUND:Beneficial effects of placebos are high in double-blind hot flush trials. Studies in various conditions suggest that honestly prescribed placebos may elicit symptom improvement. OBJECTIVE:To determine whether open label placebo (OLP) treatment is efficacious in alleviating hot flushes among peri- and postme...

journal_title：Trials

authors： Pan Y,Meister R,Löwe B,Winkelmann A,Kaptchuk TJ,Buhling KJ,Nestoriuc Y

更新日期：2019-08-16 00:00:00

abstract：BACKGROUND:Chronic musculoskeletal pain (MSP) affects more than 40% of adults aged 50 years and older and is the leading cause of disability in the USA. Older adults with chronic MSP are at risk for analgesic-related side effects, long-term opioid use, and functional decline. Recognizing the burden of chronic MSP, redu...

journal_title：Trials

authors： Platts-Mills TF,McLean SA,Weinberger M,Stearns SC,Bush M,Teresi BB,Hurka-Richardson K,Kroenke K,Kerns RD,Weaver MA,Keefe FJ

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:Trials of complex interventions are associated with high costs and burdens in terms of paperwork, management, data collection, validation, and intervention fidelity assessment occurring across multiple sites. Traditional data collection methods rely on paper-based forms, where processing can be time-consumin...

journal_title：Trials

authors： Drew CJ,Poile V,Trubey R,Watson G,Kelson M,Townson J,Rosser A,Hood K,Quinn L,Busse M

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is a common chronic disease in older adults. Currently, there are no effective therapies to reduce disease severity and progression of knee OA (KOA), particularly in mid- to late-stages. This study aims to examine the effect of methotrexate (MTX) on knee effusion-synovitis and pain in sym...

journal_title：Trials

authors： Zhu Z,Yu Q,Leng X,Han W,Li Z,Huang C,Gu J,Zhao Y,Wang K,Li T,Mei Y,Xu J,Zhang Z,Hunter D,Cicuttini F,Zeng X,Ding C

更新日期：2020-09-16 00:00:00

abstract：BACKGROUND:Tracheal intubation with the patient in the lateral position is difficult because the laryngeal view is compromised during direct laryngoscopy. Flexible video endoscopes may facilitate intubation even when laryngeal views are poor on direct laryngoscopy because the patients are positioned laterally. Thus, th...

journal_title：Trials

authors： Gao Y,Lin B,Huang J,Lin X,Lin C

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:There is considerable evidence showing that injured people who are involved in a compensation process show poorer physical and mental recovery than those with similar injuries who are not involved in a compensation process. One explanation for this reduced recovery is that the legal process and the associate...

journal_title：Trials

authors： Elbers NA,Akkermans AJ,Cuijpers P,Bruinvels DJ

更新日期：2013-07-20 00:00:00

abstract：BACKGROUND:The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults. METHO...

journal_title：Trials

authors： Arabi Y,Al-Hameed F,Burns KEA,Mehta S,Alsolamy S,Almaani M,Mandourah Y,Almekhlafi GA,Al Bshabshe A,Finfer S,Alshahrani M,Khalid I,Mehta Y,Gaur A,Hawa H,Buscher H,Arshad Z,Lababidi H,Al Aithan A,Jose J,Abdukahil SA

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Sub-threshold depression is common, impairs functioning, and increases the risk of developing major depression. Although psychological treatments have been investigated for sub-threshold depression, they are costly. A less costly alternative could be an educational health promotion campaign about effective s...

journal_title：Trials

authors： Morgan AJ,Jorm AF,Mackinnon AJ

更新日期：2011-01-13 00:00:00

abstract：BACKGROUND:Registration of clinical trials is critical for promoting transparency and integrity in medical research; however, trials must be registered in a prospective fashion to deter unaccounted protocol modifications or selection of alternate outcomes that may enhance favorability of reported findings. We assessed ...

journal_title：Trials

authors： Gopal AD,Wallach JD,Aminawung JA,Gonsalves G,Dal-Ré R,Miller JE,Ross JS

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the ef...

journal_title：Trials

authors： Demant MN,Jensen RG,Jakobsen JC,Gluud C,Homøe P

更新日期：2017-01-19 00:00:00

abstract：RATIONALE:Aspiration, infections, and fever are common in the first days after stroke, especially in older patients. The occurrence of these complications has been associated with an increased risk of death or dependency. AIMS AND DESIGN:PREvention of Complications to Improve OUtcome in elderly patients with acute Str...

journal_title：Trials

authors： de Jonge JC,Woodhouse LJ,Reinink H,van der Worp HB,Bath PM,PRECIOUS investigators.

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND:Low back pain is highly prevalent and a major source of disability worldwide. Spa therapy is frequently used to treat low back pain, but the associated level of evidence for efficacy is insufficient. To fill this knowledge gap, this protocol proposes an appropriately powered, prospective, evaluator-blinded, ...

journal_title：Trials

authors： Forestier R,Suehs C,Françon A,Marty M,Genevay S,Sellam J,Chauveton C,Erol Forestier FB,Molinari N

更新日期：2020-05-11 00:00:00

abstract：BACKGROUND:Effective recruitment is an essential element of successful research but notoriously difficult to achieve. This article examines health care professionals' views on the factors influencing decision-making regarding referral to a stroke rehabilitation trial. METHODS:Semi-structured interviews and a card-sort...

journal_title：Trials

authors： Thomas N,Plant S,Woodward-Nutt K,Prior Y,Tyson S

更新日期：2015-12-18 00:00:00

abstract：BACKGROUND:College is an exciting but also challenging time with an increased risk for mental health issues. Only a minority of the college students concerned get professional help, a problem that might be improvable by internet- and mobile-based interventions (IMIs). However, adherence of IMIs is a concern. While guid...

journal_title：Trials

authors： Küchler AM,Schultchen D,Pollatos O,Moshagen M,Ebert DD,Baumeister H

更新日期：2020-11-26 00:00:00

abstract：BACKGROUND:Low therapeutic adherence to medication is very common. Clinical effectiveness is related to dose rate and route of administration and so poor therapeutic adherence can reduce the clinical benefit of treatment. The therapeutic adherence of patients with chronic obstructive pulmonary disease (COPD) is extreme...

journal_title：Trials

authors： Barnestein-Fonseca P,Leiva-Fernández J,Vidal-España F,García-Ruiz A,Prados-Torres D,Leiva-Fernández F

更新日期：2011-02-14 00:00:00

abstract：BACKGROUND:Cleft palate (CP) has an incidence of approximately 1 in 700. Children with CP are also susceptible to otitis media with effusion (OME), with approximately 90% experiencing nontrivial OME. There are several approaches to the management of OME in children with CP. The Management of Otitis Media with Effusion ...

journal_title：Trials

authors： Harman NL,Bruce IA,Callery P,Tierney S,Sharif MO,O'Brien K,Williamson PR

更新日期：2013-03-12 00:00:00