Implementation of observational pain management protocol to improve pain management for long-term institutionalized older care residents with dementia: study protocol for a cluster-randomized controlled trial.

abstract：BACKGROUND:Depression Care for People with Lung Cancer is a complex intervention delivered by specially trained cancer nurses, under the supervision of a psychiatrist. It is given as a supplement to the usual care for depression, which patients receive from their general practitioner and cancer service. The third Sympt...

journal_title：Trials

authors： Walker J,Cassidy J,Sharpe M,SMaRT Oncology-3 Trialists.

更新日期：2009-09-30 00:00:00

abstract：BACKGROUND:Depression accounts for the greatest burden of disease among all mental health problems, and is expected to become the second-highest amongst all general health problems by 2020. By the age of 75, 1 in 7 older people meet formal diagnostic criteria for depression. Efforts to ameliorate the burden of illness ...

journal_title：Trials

authors： Mitchell N,Hewitt C,Adamson J,Parrott S,Torgerson D,Ekers D,Holmes J,Lester H,McMillan D,Richards D,Spilsbury K,Godfrey C,Gilbody S

更新日期：2011-10-11 00:00:00

abstract：BACKGROUND:Individuals who sustain traumatic brain injuries (TBIs) often continue to experience significant impairment of cognitive functions mediated by the prefrontal cortex well into chronic stages of recovery. Traditional brain training programs that focus on improving specific skills fall short of addressing integ...

journal_title：Trials

authors： Krawczyk DC,Marquez de la Plata C,Schauer GF,Vas AK,Keebler M,Tuthill S,Gardner C,Jantz T,Yu W,Chapman SB

更新日期：2013-01-30 00:00:00

abstract：BACKGROUND:Cesarean delivery has already become a very common method of delivery around the world, especially in low-income countries. Hypertrophic scars and wound infections have affected younger mothers and frustrated obstetricians for a long time. Mesenchymal stem cells (MSCs) have strong potential for self-renewal ...

journal_title：Trials

authors： Fan D,Xia Q,Wu S,Ye S,Liu L,Wang W,Guo X,Liu Z

更新日期：2018-03-02 00:00:00

abstract：BACKGROUND:Hospitalized older persons with Alzheimer's disease and related dementias are at greater risk for functional decline and increased care dependency after discharge due to a combination of intrinsic factors, environmental, policy, and care practices that restrict physical and cognitive activity, lack of family...

journal_title：Trials

authors： Boltz M,Kuzmik A,Resnick B,Trotta R,Mogle J,BeLue R,Leslie D,Galvin JE

更新日期：2018-09-17 00:00:00

abstract：BACKGROUND:Children can find anaesthesia induction especially distressing and postoperative psychological and physical morbidity are common. Preparation programmes for general anaesthesia (GA) are highly effective in reducing this distress. A Phase II study has already verified the effectiveness of a prototype preopera...

journal_title：Trials

authors： Hosey MT,Donaldson AN,Huntington C,Liossi C,Reynolds PA,Alharatani R,Newton JT

更新日期：2014-06-11 00:00:00

abstract：BACKGROUND:This study was carried out as a prospective clinical field study with the aim of evaluating the clinical performance of Equia Fil® with a nanofilled resin coating and the conventional Fuji IX GP® fast with an LC coating according to the World Dental Federation (FDI) restoration material evaluation criteria. ...

journal_title：Trials

authors： Klinke T,Daboul A,Turek A,Frankenberger R,Hickel R,Biffar R

更新日期：2016-05-08 00:00:00

abstract：BACKGROUND:High-protein diets and total diet replacements are becoming increasingly popular for weight regulation; however, further research is needed to elucidate their impact on the physiology of body weight regulation. The aim of this inpatient metabolic balance study is to compare the impact of a high-protein total...

journal_title：Trials

authors： Oliveira CLP,Boulé NG,Sharma AM,Elliott S,Siervo M,Ghosh S,Berg A,Prado CM

更新日期：2019-12-27 00:00:00

abstract：:After publication of our article [1] we have been notified on a mistake in the sample size. ...

journal_title：Trials

authors： Zhu L,Shi X,Yin S,Yin J,Zhu Z,Gao X,Jiao Y,Yu W,Yang L

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Recommendations for good clinical practice have been reported to be difficult to apply in real life by primary care clinicians. This could be because the clinical trials at the origin of the guidelines are based on explanatory trials, conducted under ideal conditions not reflecting the reality of primary car...

journal_title：Trials

authors： Ettori-Ajasse I,Tatin E,Forbes G,Eldridge S,Dibao-Dina C

更新日期：2020-03-19 00:00:00

abstract：OBJECTIVES:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about COVID-19 hygiene practices-such as social ...

journal_title：Trials

authors： Vandormael A,Adam M,Greuel M,Bärnighausen T

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) increase the morbidity and mortality of surgery in obese patients. High levels of positive end-expiratory pressure (PEEP) with lung recruitment maneuvers may improve intraoperative respiratory function, but they can also compromise hemodynamics, and the effects on...

journal_title：Trials

authors： Bluth T,Teichmann R,Kiss T,Bobek I,Canet J,Cinnella G,De Baerdemaeker L,Gregoretti C,Hedenstierna G,Hemmes SN,Hiesmayr M,Hollmann MW,Jaber S,Laffey JG,Licker MJ,Markstaller K,Matot I,Müller G,Mills GH,Mulier JP,Pu

更新日期：2017-04-28 00:00:00

abstract：BACKGROUND:Approximately 2 million children are hospitalized each year in the United States, with more than three-quarters of non-elective hospitalizations admitted through emergency departments (EDs). Direct admission, defined as admission to hospital without first receiving care in the hospital's ED, may offer benefi...

journal_title：Trials

authors： Leyenaar JK,McDaniel CE,Acquilano SC,Schaefer AP,Bruce ML,O'Malley AJ

更新日期：2020-11-30 00:00:00

abstract：OBJECTIVES:The BCG vaccine, widely used in Brazil in new-borns, induces adjuvant protection for several diseases, including childhood virus infections. BCG activates monocytes and innate memory NK cells which are crucial for the antiviral immune response. Therefore, strategies to prevent COVID-19 in health workers (HW)...

journal_title：Trials

authors： Junqueira-Kipnis AP,Dos Anjos LRB,Barbosa LCS,da Costa AC,Borges KCM,Cardoso ADRO,Ribeiro KM,Rosa SBA,Souza CC,das Neves RC,Saraiva G,da Silva SM,Silveira EA,Rabahi MF,Conte MB,Kipnis A

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND:Respiratory support following postoperative extubation is of major importance to prevent hypoxemia and subsequent respiratory failure and reintubation. High-flow nasal cannula oxygen (HFNC) delivers a flow-dependent positive airway pressure and improves oxygenation by increasing end-expiratory lung volume. W...

journal_title：Trials

authors： Futier E,Paugam-Burtz C,Constantin JM,Pereira B,Jaber S

更新日期：2013-10-18 00:00:00

abstract：BACKGROUND:The physical and mental health of college students tends to continuously decline around the world. Since they are in a significant transition period which presents opportunities and challenges in health promotion, it is important to improve their health in this period. As a traditional Chinese exercise form ...

journal_title：Trials

authors： Zheng G,Li M,Lan X,Yan X,Lin Q,Chen L,Tao J,Zheng X,Li J,Chen B,Fang Q

更新日期：2013-12-05 00:00:00

abstract：OBJECTIVES:Patients with diabetes are - compared to people without diabetes - at increased risk of worse outcomes from COVID-19 related pneumonia during hospitalization. We aim to investigate whether telemetric continuous glucose monitoring (CGM) in quarantined hospitalized patients with diabetes and confirmed SARS-CoV...

journal_title：Trials

authors： Klarskov CK,Lindegaard B,Pedersen-Bjergaard U,Kristensen PL

更新日期：2020-11-25 00:00:00

abstract：BACKGROUND:Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.The...

journal_title：Trials

authors： Rodrigo R,Hasson D,Prieto JC,Dussaillant G,Ramos C,León L,Gárate J,Valls N,Gormaz JG

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Surgical interventions are complex, which complicates their rigorous assessment through randomised clinical trials. An important component of complexity relates to surgeon experience and the rate at which the required level of skill is achieved, known as the learning curve. There is considerable evidence tha...

journal_title：Trials

authors： Papachristofi O,Jenkins D,Sharples LD

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Increasingly, genomics is informing clinical practice, but challenges remain for medical professionals lacking genetics expertise, and in access to and clinical utility of genomic testing for minority and underrepresented populations. The latter is a particularly pernicious problem due to the historical lack...

journal_title：Trials

authors： Odgis JA,Gallagher KM,Suckiel SA,Donohue KE,Ramos MA,Kelly NR,Bertier G,Blackburn C,Brown K,Fielding L,Lopez J,Aguiniga KL,Maria E,Rodriguez JE,Sebastin M,Teitelman N,Watnick D,Yelton NM,Abhyankar A,Abul-Husn NS,B

更新日期：2021-01-14 00:00:00

abstract：OBJECTIVES:To evaluate the safety of therapeutic plasma exchange (TPE) in adult patients with serious/life-threatening COVID-19 requiring intensive care unit (ICU) admission, and associated 28-day mortality. Serious and life threatening COVID-19 are defined as per published literature (please, refer to the full protoco...

journal_title：Trials

authors： Faqihi F,Alharthy A,Alodat M,Asad D,Aletreby W,Kutsogiannis DJ,Brindley PG,Karakitsos D

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Sleep disturbance in older people is an important health issue that is associated with many other health problems. Effective interventions are required to address sleep problems in this group. Acupressure has been suggested as a potential therapeutic technique to improve sleep. The aim of this study is to ev...

journal_title：Trials

authors： Hmwe NTT,Browne G,Mollart L,Allanson V,Chan SW

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:Current international guidelines recommend the use of a daily topical exit-site antimicrobial to prevent peritoneal dialysis (PD)-related infections. Although nonantibiotic-based therapies are appealing because they may limit antimicrobial resistance, no controlled trials have been conducted to compare topic...

journal_title：Trials

authors： Nochaiwong S,Ruengorn C,Noppakun K,Panyathong S,Dandecha P,Sood MM,Saenjum C,Awiphan R,Sirilun S,Mongkhon P,Chongruksut W,Thavorn K,Thai Renal Outcomes Research (THOR) Investigators.

更新日期：2019-12-19 00:00:00

abstract：BACKGROUND:Depression is a debilitating and costly disease for our society, especially in the case of treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is an effective adjuvant therapy in treatment-resistant unipolar and non-psychotic depression. It can be applied according to tw...

journal_title：Trials

authors： Bulteau S,Laurin A,Volteau C,Dert C,Lagalice L,Schirr-Bonnans S,Bukowski N,Guitteny M,Simons L,Cabelguen C,Pichot A,Tessier F,Bonnin A,Lepage A,ACOUSTIM Investigators Group.,HUGOPSY Network.,Vanelle JM,Sauvaget A,Rich

更新日期：2020-04-05 00:00:00

abstract：BACKGROUND:Diabetes mellitus is associated with risk of sudden sensorineural hearing loss (SSNHL). Systemic and intratympanic corticosteroids are the two primary treatments for SSNHL in patients with diabetes mellitus. The benefit of intratympanic compared to systemic treatment is the reduced systemic steroid exposure ...

journal_title：Trials

authors： Yang W,Li X,Zhong J,Mei X,Liu H,Yang L,Lu L,Hu H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Palmoplantar pustulosis is a rare but painful and debilitating disease. It consistently ranks the highest of all psoriasis phenotypic variants in terms of symptoms and functional impairment. Management of plaque-type psoriasis has been revolutionised in the last 10 years with the advent of biologic therapies...

journal_title：Trials

authors： Cornelius V,Wilson R,Cro S,Barker J,Burden D,Griffiths CEM,Lachmann H,McAteer H,Reynolds N,Pink A,Warren RB,Capon F,Smith C

更新日期：2018-08-29 00:00:00

abstract：BACKGROUND:Small incision lenticule extraction or SMILE is a novel form of 'flapless' corneal refractive surgery that was adapted from refractive lenticule extraction (ReLEx). SMILE uses only one femtosecond laser to complete the refractive surgery, potentially reducing surgical time, side effects, and cost. If success...

journal_title：Trials

authors： Ang M,Tan D,Mehta JS

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Randomized controlled trials (RCTs) often have more than one primary outcome and frequently have secondary and harm outcomes. Comparison of outcomes between study arms is the primary focus of RCTs, but there are times when the relation between outcomes is important, such as determining whether an intermediat...

journal_title：Trials

authors： Schriger DL,Cooper RJ,Lopez-O'Sullivan A,Wystrach C,Altman DG

更新日期：2015-02-22 00:00:00

abstract：BACKGROUND:This is a phase II randomised, double-blind, sham-controlled trial to evaluate the effectiveness and tolerability of repetitive transcranial magnetic stimulation for preventive treatment of episodic migraine amongst migraine subjects. METHODS:Subjects age 18 to 60 years will undergo a baseline evaluation to...

journal_title：Trials

authors： Mohamad Safiai NI,Amir NA,Basri H,Inche Mat LN,Hoo FK,Yusof Khan AHK,Loh WC,Chia PK,Ramachandran V,Mat Din H,Samsudin IN,Fernandez A,Mohamed MH,Ching SM,Hashim HZ,Wan Sulaiman WA

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist....

journal_title：Trials

authors： Lluch-Girbés E,Dueñas L,Mena-Del Horno S,Luque-Suarez A,Navarro-Ledesma S,Louw A

更新日期：2019-08-13 00:00:00