The effectiveness of a web-based decision aid for patients with hip osteoarthritis: study protocol for a randomized controlled trial.

abstract：BACKGROUND:Acute kidney allograft rejection is a major cause for declining graft function and has a negative impact on the long-term graft survival. The majority (90%) of acute rejections are T-cell mediated and, therefore, the anti-rejection therapy targets T-cell-mediated mechanisms of the rejection process. However,...

journal_title：Trials

authors： Schiffer L,Schiffer M,Merkel S,Schwarz A,Mengel M,Jürgens C,Schroeder C,Zoerner AA,Püllmann K,Bröcker V,Becker JU,Dämmrich ME,Träder J,Grosshennig A,Biertz F,Haller H,Koch A,Gwinner W

更新日期：2012-10-26 00:00:00

abstract：BACKGROUND:Maori, the indigenous people of New Zealand, who present to hospital after intentionally harming themselves, do so at a higher rate than non-Maori. There have been no previous treatment trials in Maori who self harm and previous reviews of interventions in other populations have been inconclusive as existing...

journal_title：Trials

authors： Hatcher S,Coupe N,Durie M,Elder H,Tapsell R,Wikiriwhi K,Parag V

更新日期：2011-05-11 00:00:00

abstract：BACKGROUND:Non-inferiority trials are increasingly used to evaluate new treatments that are expected to have secondary advantages over standard of care, but similar efficacy on the primary outcome. When designing a non-inferiority trial with a binary primary outcome, the choice of effect measure for the non-inferiority...

journal_title：Trials

authors： Quartagno M,Walker AS,Babiker AG,Turner RM,Parmar MKB,Copas A,White IR

更新日期：2020-02-06 00:00:00

abstract：BACKGROUND:Previous research has suggested an association between more liberal red blood cell (RBC) transfusion and greater risk of further bleeding and mortality following acute upper gastrointestinal bleeding (AUGIB). METHODS AND DESIGN:The Transfusion in Gastrointestinal Bleeding (TRIGGER) trial is a pragmatic clus...

journal_title：Trials

authors： Kahan BC,Jairath V,Murphy MF,Doré CJ

更新日期：2013-07-10 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a major health problem in modern society, with 70-85% of the population experiencing LBP at some time in their lives. Each year, 5-10% of the workforce misses work due to LBP, most for less than 7 days. Almost 10% of all patients are at risk of developing chronic pain and disability. L...

journal_title：Trials

authors： Buselli P,Bosoni R,Busè G,Fasoli P,La Scala E,Mazzolari R,Zanetti F,Messina S

更新日期：2011-10-04 00:00:00

abstract：BACKGROUND:The prevalence of depressive disorder in adults with advanced cancer is around 20 %. Although cognitive behavioural therapy (CBT) is recommended for depression and may be beneficial in depressed people with cancer, its use for depression in those with advanced disease for whom cure is not likely has not been...

journal_title：Trials

authors： Serfaty M,King M,Nazareth I,Tookman A,Wood J,Gola A,Aspden T,Mannix K,Davis S,Moorey S,Jones L

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Obesity affects 25% of the UK adult population but modest weight loss can reduce the incidence of obesity-related chronic disease. Some effective weight loss treatments exist but there is no nationally available National Health Service (NHS) treatment service, and general practitioners (GPs) rarely discuss w...

journal_title：Trials

authors： Lewis A,Jolly K,Adab P,Daley A,Farley A,Jebb S,Lycett D,Clarke S,Christian A,Jin J,Thompson B,Aveyard P

更新日期：2013-11-19 00:00:00

abstract：BACKGROUND:Budesonide has a long history as intranasal drug, with many marketed products. Efforts should be made to demonstrate the therapeutic equivalence and safety comparability between them. Given that systemic availability significantly varies from formulations, the clinical comparability of diverse products comes...

journal_title：Trials

authors： Algorta J,Pena MA,Francisco S,Abajo Z,Sanz E

更新日期：2008-06-09 00:00:00

abstract：BACKGROUND:Amnestic mild cognitive impairment (aMCI) is a syndrome characterized by significant forgetfulness that does not meet the criteria of dementia. Individuals with aMCI are at greater risk of progressing to dementia. Current studies suggest that good sleep quality is linked with preserved cognition in the elder...

journal_title：Trials

authors： Yue S,He T,Li B,Qu Y,Peng H,Chen J,Lei M,Chen C,Wu W

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:In a sham-controlled double-blind trial, we aim to establish the efficacy and safety of the local application of laser therapy in patients with diabetes, onychomycosis and risk factors for diabetes-related foot complications. Onychomycosis leads to thickened and distorted nails, which in turn lead to increas...

journal_title：Trials

authors： Nijenhuis-Rosien L,Kleefstra N,Wolfhagen MJ,Groenier KH,Bilo HJ,Landman GW

更新日期：2015-03-22 00:00:00

abstract：BACKGROUND:Linezolid, an oxazolidinone, substantially improves treatment outcomes of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis. We started a trial to test whether the use of linezolid instead of ethambutol could increase the rate of sputum culture conversion as of 8 weeks of treatment...

journal_title：Trials

authors： Lee JY,Kim DK,Lee JK,Yoon HI,Jeong I,Heo E,Park YS,Lee JH,Park SS,Lee SM,Lee CH,Lee J,Choi SM,Park JS,Joh JS,Cho YJ,Lee YJ,Kim SJ,Hwang YR,Kim H,Ki J,Choi H,Han J,Ahn H,Hahn S,Yim JJ

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:The prevalence of central obesity is constantly increasing, and visceral fat is associated with increased production of inflammatory factors and metabolic risk factors. Lutein might retard the development of metabolic disease through its antioxidant and anti-inflammatory properties. Furthermore, epidemiologi...

journal_title：Trials

authors： Zhou J,Zhao D,Wang N,Zeng Z,Wang C,Hao L,Peng X

更新日期：2020-01-06 00:00:00

abstract：BACKGROUND:Haemorrhage remains a leading cause of morbidity and mortality in trauma patients. Fibrinogen is an essential endogenous component of haemostasis and the plasma level is associated with bleeding, transfusion and outcome. Fibrinogen concentrate is widely used to correct acquired hypofibrinogenaemia, recommend...

journal_title：Trials

authors： Steinmetz J,Sørensen AM,Henriksen HH,Lange T,Larsen CF,Johansson PI,Stensballe J

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Idiopathic sudden sensorineural hearing loss (ISSNHL) is a major cause of deafness. Despite the advances in systemic therapy, some cases of ISSNHL are untreated, because the exact ISSNHL aetiology is unclear. Traditional Chinese medicine (TCM) has been used to treat diseases for thousands of years and is pop...

journal_title：Trials

authors： Fei YP,Zheng Y,Lai D,Zhong P,Lu JZ,Li G,Liu P

更新日期：2019-12-02 00:00:00

abstract：BACKGROUND:Among clinical trials of interventions that aim to modify time spent on mechanical ventilation for critically ill patients there is considerable inconsistency in chosen outcomes and how they are measured. The Core Outcomes in Ventilation Trials (COVenT) study aims to develop a set of core outcomes for use in...

journal_title：Trials

authors： Blackwood B,Ringrow S,Clarke M,Marshall J,Rose L,Williamson P,McAuley D

更新日期：2015-08-20 00:00:00

abstract：BACKGROUND:The success of a clinical trial is often dependant on whether recruitment targets can be met in the required time frame. Despite an increase in research into the benefits of exercise in people with multiple sclerosis (PwMS), no trial has reported detailed data on effective recruitment strategies for large-sc...

journal_title：Trials

authors： Carter A,Humphreys L,Snowdon N,Sharrack B,Daley A,Petty J,Woodroofe N,Saxton J

更新日期：2015-10-15 00:00:00

abstract：BACKGROUND:Randomised clinical trials are the 'gold standard' for evaluating the effectiveness of healthcare interventions. However, successful recruitment of participants remains a key challenge for many trialists. In this paper, we present a conceptual framework for creating a digital, population-based database for t...

journal_title：Trials

authors： Nwaru BI,Soyiri IN,Simpson CR,Griffiths C,Sheikh A

更新日期：2016-05-26 00:00:00

abstract：BACKGROUND:Chronic back pain is a major public health problem and the primary reason patients seek massage treatment. Despite the growing use of massage for chronic low back pain, there have been few studies of its effectiveness. This trial will be the first evaluation of the effectiveness of relaxation massage for chr...

journal_title：Trials

authors： Cherkin DC,Sherman KJ,Kahn J,Erro JH,Deyo RA,Haneuse SJ,Cook AJ

更新日期：2009-10-20 00:00:00

abstract：BACKGROUND:Untreated advanced hepatocellular carcinoma (HCC) is linked to poor prognosis. While sorafenib is the current recommended treatment for advanced HCC, radioembolisation (RE; also called selective internal radiation therapy or SIRT) with yttrium-90 microspheres has shown efficacy in cohort studies. However, th...

journal_title：Trials

authors： Vilgrain V,Abdel-Rehim M,Sibert A,Ronot M,Lebtahi R,Castéra L,Chatellier G,SARAH Trial Group.

更新日期：2014-12-03 00:00:00

abstract：BACKGROUND:Isovolemic anemia (decrease in hemoglobin concentration with normal or even increased blood volume) after gastric cancer surgery may negatively influence short- and long-term outcomes. Therefore correction of isovolemic postoperative anemia is supposed to be beneficial. This prospective randomized placebo-co...

journal_title：Trials

authors： Reim D,Kim YW,Nam BH,Kim MJ,Yook JH,Park YK,Roh SH,Yu WS,Bae JM

更新日期：2014-04-05 00:00:00

abstract：BACKGROUND:Small incision lenticule extraction or SMILE is a novel form of 'flapless' corneal refractive surgery that was adapted from refractive lenticule extraction (ReLEx). SMILE uses only one femtosecond laser to complete the refractive surgery, potentially reducing surgical time, side effects, and cost. If success...

journal_title：Trials

authors： Ang M,Tan D,Mehta JS

更新日期：2012-05-31 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and debilitating condition characterised by high co-morbidity. Alongside pharmacological treatment, cognitive behavioural therapy (CBT) is an established psychological therapy for GAD. Its effectiveness is limited, however, with only an estimated 50% of clients...

journal_title：Trials

authors： Timulak L,Keogh D,Chigwedere C,Wilson C,Ward F,Hevey D,Griffin P,Jacobs L,Irwin B

更新日期：2018-09-19 00:00:00

abstract：BACKGROUND:Postoperative pulmonary complications (PPCs) are frequent after on-pump cardiac surgery. Cardiac surgery results in a complex pulmonary insult leading to high susceptibility to perioperative pulmonary atelectasis. For technical reasons, ventilator settings interact with the surgical procedure and traditional...

journal_title：Trials

authors： Lagier D,Fischer F,Fornier W,Fellahi JL,Colson P,Cholley B,Jaber S,Baumstarck K,Guidon C,PROVECS investigators and the ARCOTHOVA group.

更新日期：2018-11-13 00:00:00

abstract：OBJECTIVES:The BCG vaccine, widely used in Brazil in new-borns, induces adjuvant protection for several diseases, including childhood virus infections. BCG activates monocytes and innate memory NK cells which are crucial for the antiviral immune response. Therefore, strategies to prevent COVID-19 in health workers (HW)...

journal_title：Trials

authors： Junqueira-Kipnis AP,Dos Anjos LRB,Barbosa LCS,da Costa AC,Borges KCM,Cardoso ADRO,Ribeiro KM,Rosa SBA,Souza CC,das Neves RC,Saraiva G,da Silva SM,Silveira EA,Rabahi MF,Conte MB,Kipnis A

更新日期：2020-10-26 00:00:00

abstract：BACKGROUND:Mobile health (mHealth) presents one of the potential solutions to maximize health worker impact and efficiency in an effort to reach the Sustainable Development Goals 3.1 and 3.2, particularly in sub-Saharan African countries. Poor-quality clinical decision-making is known to be associated with poor pregnan...

journal_title：Trials

authors： Amoakoh HB,Klipstein-Grobusch K,Amoakoh-Coleman M,Agyepong IA,Kayode GA,Sarpong C,Grobbee DE,Ansah EK

更新日期：2017-04-04 00:00:00

abstract：BACKGROUND:Multi-centre randomised controlled trials (RCTs) in surgery are challenging. It is particularly difficult to establish standards of surgery and ensure that interventions are delivered as intended. This study developed and tested methods for identifying the key components of surgical interventions and standar...

journal_title：Trials

authors： Blencowe NS,Blazeby JM,Donovan JL,Mills N

更新日期：2015-12-28 00:00:00

abstract：BACKGROUND:Non-retention of participants seriously affects the credibility of clinical trial results and significantly reduces the potential of a trial to influence clinical practice. Non-retention can be defined as instances where participants leave the study prematurely. Examples include withdrawal of consent and los...

journal_title：Trials

authors： Gillies K,Bower P,Elliott J,MacLennan G,Newlands RSN,Ogden M,Treweek SP,Wells M,Witham MD,Young B,Francis JJ

更新日期：2018-03-27 00:00:00

abstract：OBJECTIVE:The objective of the Dutch Sildenafil therapy in dismal prognosis early onset fetal growth restriction (STRIDER) randomised clinical trial is to assess the beneficial and harmful effects of sildenafil versus placebo on fetal and neonatal mortality in pregnant women with severe early-onset fetal growth restric...

journal_title：Trials

authors： Pels A,Jakobsen JC,Ganzevoort W,Naaktgeboren CA,Onland W,van Wassenaer-Leemhuis AG,Gluud C

更新日期：2019-01-11 00:00:00

abstract：BACKGROUND:Distal pancreatectomy for benign and malignant tumours is the second most common surgical procedure on the pancreas. Postoperative pancreatic fistulas (POPF) represent the most significant clinical complication, causing prolongation of hospital stay and the need for additional diagnostic and therapeutic proc...

journal_title：Trials

authors： Hassenpflug M,Bruckner T,Knebel P,Diener MK,Büchler MW,Werner J

更新日期：2013-12-14 00:00:00

abstract：BACKGROUND:The logrank test is routinely applied to design and analyse randomized controlled trials (RCTs) with time-to-event outcomes. Sample size and power calculations assume the treatment effect follows proportional hazards (PH). If the PH assumption is false, power is reduced and interpretation of the hazard ratio...

journal_title：Trials

authors： Royston P,B Parmar MK

更新日期：2020-04-06 00:00:00