Core Outcomes in Ventilation Trials (COVenT): protocol for a core outcome set using a Delphi survey with a nested randomised trial and observational cohort study.

abstract：BACKGROUND:Central sensitization is modulated by the endogenous opioid system and plays a major role in the development and maintenance of pain. Recent animal studies performed following resolution of inflammatory pain showed reinstatement of tactile hypersensitivity induced by administration of a mu-opioid-antagonist,...

journal_title：Trials

authors： Pereira MP,Werner MU,Dahl JB

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:There is evidence to suggest that delivery of diabetes self-management support by diabetes educators in primary care may improve patient care processes and patient clinical outcomes; however, the evaluation of such a model in primary care is nonexistent in Canada. This article describes the design for the ev...

journal_title：Trials

authors： Gucciardi E,Fortugno M,Horodezny S,Lou W,Sidani S,Espin S,Webster F,Shah BR

更新日期：2012-09-13 00:00:00

abstract：BACKGROUND:The effect of pregabalin on acute herpes zoster pain has not been previously evaluated. METHODS:In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster. RESULT...

journal_title：Trials

authors： Jensen-Dahm C,Rowbotham MC,Reda H,Petersen KL

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:Sleep disturbance in older people is an important health issue that is associated with many other health problems. Effective interventions are required to address sleep problems in this group. Acupressure has been suggested as a potential therapeutic technique to improve sleep. The aim of this study is to ev...

journal_title：Trials

authors： Hmwe NTT,Browne G,Mollart L,Allanson V,Chan SW

更新日期：2020-04-25 00:00:00

abstract：BACKGROUND:Radiation therapy (RT) of bone metastases provides an important treatment approach in palliative care treatment concepts. As a consequence of treatment, the extent of radiation-induced toxicity is a crucial feature with consequences to a patient's quality of life. In this context this study aims at reducing ...

journal_title：Trials

authors： Meyerhof E,Sprave T,Welte SE,Nicolay NH,Förster R,Bostel T,Bruckner T,Schlampp I,Debus J,Rief H

更新日期：2017-03-03 00:00:00

abstract：BACKGROUND:Multi-centre randomised controlled trials (RCTs) in surgery are challenging. It is particularly difficult to establish standards of surgery and ensure that interventions are delivered as intended. This study developed and tested methods for identifying the key components of surgical interventions and standar...

journal_title：Trials

authors： Blencowe NS,Blazeby JM,Donovan JL,Mills N

更新日期：2015-12-28 00:00:00

abstract：BACKGROUND:It was reported that prolonging the injection time or diluting administration can reduce the incidence of opioid-induced cough. However, the incidence of sufentanil-induced cough (SIC) via a standardized infusion rate is unclear. A mechanical dropper is an infusion filtering device commonly used for intraven...

journal_title：Trials

authors： Liu M,Li Z,Wang S,Liu Y,Zhong X,He R,Li F

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:Medical training is very demanding and associated with a high prevalence of psychological distress. Compared to the general population, medical students are at a greater risk of developing a psychological disorder. Various attempts of stress management training in medical school have achieved positive result...

journal_title：Trials

authors： Kuhlmann SM,Bürger A,Esser G,Hammerle F

更新日期：2015-02-08 00:00:00

abstract：BACKGROUND:This paper presents the study protocol for a pragmatic randomised controlled trial to evaluate the impact of a school based program developed to prevent teenage pregnancy. The program includes students taking care of an Infant Simulator; despite growing popularity and an increasing global presence of such pr...

journal_title：Trials

authors： Brinkman SA,Johnson SE,Lawrence D,Codde JP,Hart MB,Straton JA,Silburn S

更新日期：2010-10-21 00:00:00

abstract：BACKGROUND:Depression occurs in up to 50% of patients after stroke and limits rehabilitation and recovery. Mood disorders are also highly prevalent in carers; their mental health intertwined with the physical and mental wellbeing of the person they are caring for. We argue that working with families, rather than patien...

journal_title：Trials

authors： Gray RJ,Myint PK,Elender F,Barton G,Pfeil M,Price G,Wyatt N,Ravenhill G,Thomas E,Jagger J,Hursey A,Waterfield K,Hardy S

更新日期：2011-04-30 00:00:00

abstract：BACKGROUND:The prevalence of otitis media in Greenlandic children is one of the highest in the world. International studies have shown that otitis-prone children may benefit from tubulation of the tympanic membrane. However, it is unknown whether these results can be applied to Greenlandic children and trials on the ef...

journal_title：Trials

authors： Demant MN,Jensen RG,Jakobsen JC,Gluud C,Homøe P

更新日期：2017-01-19 00:00:00

abstract：:Tuberculosis (TB) remains a major killer amongst the infectious diseases. Current treatment involves a four-drug regimen for at least 6 months. New drugs and regimens are required to shorten treatment duration, reduce toxicity and combat drug resistance, but the optimal methodology to define the critical path for nove...

journal_title：Trials

authors： Bonnett LJ,Davies GR

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Hypnotic drugs tend to be the dominant form of treatment of insomnia, but these come with a number of reported side effects. Acupuncture has been studied as an alternative, resulting in a rising need for methodological research towards verifying its efficacy as insomnia treatment. METHODS/DESIGN:We describe...

journal_title：Trials

authors： Han KH,Kim SY,Chung SY

更新日期：2014-10-23 00:00:00

abstract：BACKGROUND:Chronic musculoskeletal pain (MSP) affects more than 40% of adults aged 50 years and older and is the leading cause of disability in the USA. Older adults with chronic MSP are at risk for analgesic-related side effects, long-term opioid use, and functional decline. Recognizing the burden of chronic MSP, redu...

journal_title：Trials

authors： Platts-Mills TF,McLean SA,Weinberger M,Stearns SC,Bush M,Teresi BB,Hurka-Richardson K,Kroenke K,Kerns RD,Weaver MA,Keefe FJ

更新日期：2020-07-06 00:00:00

abstract：BACKGROUND:PaVOS is a randomized controlled trial (RCT) which aims to address the use of whole-body vibration exercise (WBV) in combination with parathyroid hormone 1-34 fragment teriparatide (PTH 1-34) treatment in patients with osteoporosis. PTH 1-34 is an effective but expensive anabolic treatment for osteoporosis. ...

journal_title：Trials

authors： Jepsen DB,Ryg J,Jørgensen NR,Hansen S,Masud T

更新日期：2018-03-16 00:00:00

abstract：BACKGROUND:Acute myocardial infarction (AMI) is the leading cause of mortality worldwide. Oxidative stress has been involved in the ischemia-reperfusion injury in AMI. It has been suggested that reperfusion accounts for up to 50% of the final size of a myocardial infarct, a part of the damage likely to be prevented.The...

journal_title：Trials

authors： Rodrigo R,Hasson D,Prieto JC,Dussaillant G,Ramos C,León L,Gárate J,Valls N,Gormaz JG

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:For the last decade continuous efforts have been made to translate regenerative cell therapy protocols in the cardiovascular field from 'bench to bedside'. Successful clinical introduction, supporting safety, and feasibility of this new therapeutic approach, led to the initiation of the German, Phase III, mu...

journal_title：Trials

authors： Donndorf P,Kaminski A,Tiedemann G,Kundt G,Steinhoff G

更新日期：2012-07-02 00:00:00

abstract：:Evidence-based treatment for pregnant women will ultimately require research conducted in the population of pregnant women. Currently, few scholars have addressed the issue of responsible inclusion of pregnant women in drug research. Because of additional risks associated with including pregnant women in drug research...

journal_title：Trials

authors： Roes KCB,van der Zande ISE,van Smeden M,van der Graaf R

更新日期：2018-02-20 00:00:00

abstract：BACKGROUND:Immune function may influence the ability of older adults to maintain or improve muscle mass, strength, and function during aging. Thus, nutritional supplementation that supports the immune system could complement resistance exercise as an intervention for age-associated muscle loss. The current study will d...

journal_title：Trials

authors： Dennis RA,Ponnappan U,Kodell RL,Garner KK,Parkes CM,Bopp MM,Padala KP,Peterson CA,Padala PR,Sullivan DH

更新日期：2015-03-27 00:00:00

abstract：BACKGROUND:Childhood obesity is one of the most critical public health problems in the world. It is associated with low neuromuscular function and postural deformities. Whether weight loss can improve postural stability and neuromuscular control, benefit daily activities, or prevent injury is unknown. Therefore, this s...

journal_title：Trials

authors： Sun F,Wang LJ,Wang L

更新日期：2015-04-10 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via the original article. ...

journal_title：Trials

authors： Eckhardt CM,Cummings MJ,Rajagopalan KN,Borden S,Bitan ZC,Wolf A,Kantor A,Briese T,Meyer BJ,Jacobson SD,Scotto D,Mishra N,Philip NM,Stotler BA,Schwartz J,Shaz B,Spitalnik SL,Eisenberger A,Hod EA,Justman J,Cheung K

更新日期：2020-06-16 00:00:00

abstract：BACKGROUND:Juvenile idiopathic arthritis (JIA)-associated uveitis is a chronic paediatric ocular inflammatory condition that can result in visual impairment. Adalimumab, a tumour necrosis factor (TNF)-alpha inhibitor, effectively controls joint and eye inflammation; however, its long-term use may increase the risk of a...

journal_title：Trials

authors： Acharya NR,Ebert CD,Kelly NK,Porco TC,Ramanan AV,Arnold BF,ADJUST Research Group.

更新日期：2020-10-27 00:00:00

abstract：BACKGROUND:Frozen shoulder (FS) is a musculoskeletal condition of poorly understood etiology that results in shoulder pain and large mobility deficits. Despite some physical therapy interventions, such as joint mobilization and exercise, having shown therapeutic benefit, a definitive treatment does not currently exist....

journal_title：Trials

authors： Lluch-Girbés E,Dueñas L,Mena-Del Horno S,Luque-Suarez A,Navarro-Ledesma S,Louw A

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Delirium prevalence in the intensive care unit (ICU) is high. Numerous psychotropic agents are used to manage delirium in the ICU with limited data regarding their efficacy or harms. METHODS/DESIGN:This is a randomized controlled trial of 428 patients aged 18 and older suffering from delirium and admitted t...

journal_title：Trials

authors： Campbell NL,Khan BA,Farber M,Campbell T,Perkins AJ,Hui SL,Abernathy G,Buckley J,Sing R,Tricker J,Zawahiri M,Boustani MA

更新日期：2011-06-06 00:00:00

abstract：BACKGROUND:Many people living with HIV suffer from depressive symptoms. In a previous pilot study, self-help cognitive behavioral therapy (in booklet format) was found to be effective in treating depressive symptoms in people with HIV. We developed an online self-help program in Dutch and English (based on the booklet)...

journal_title：Trials

authors： van Luenen S,Kraaij V,Spinhoven P,Garnefski N

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated the benefit of early integration of palliative care (PC) in oncology. However, patients continue to receive late referrals to PC even in comprehensive cancer centers. Patients and health professionals may perceive PC as 'a place to die,' and this stigma is a barrier to time...

journal_title：Trials

authors： do Carmo TM,Paiva BS,de Siqueira MR,da Rosa Lde T,de Oliveira CZ,Nascimento MS,Paiva CE

更新日期：2015-04-12 00:00:00

abstract：BACKGROUND:Perineal pain due to episiotomy is commonly reported and can be severe enough to disturb the mother-infant dyad during the postpartum period. Its incidence at day 7 postpartum varies from 63% to 74%. Recent studies have investigated the analgesic efficacy of perineal infiltration of ropivacaine after episiot...

journal_title：Trials

authors： Cardaillac C,Ploteau S,Le Thuaut A,Dochez V,Winer N,Ducarme G

更新日期：2020-06-12 00:00:00

abstract：BACKGROUND:Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortality. Exercise has potential to improve depression, and has been shown in existing trials to improve o...

journal_title：Trials

authors： Underwood M,Eldridge S,Lamb S,Potter R,Sheehan B,Slowther AM,Taylor S,Thorogood M,Weich S

更新日期：2011-02-02 00:00:00

abstract：BACKGROUND:Trigeminal neuralgia (TN) is a rare severe unilateral facial pain condition. Current guidelines in trigeminal neuralgia management recommend sodium channel blockers--carbamazepine or oxcarbazepine--as the first-line treatment. However, the currently available drugs are often associated with poor tolerability...

journal_title：Trials

authors： Zakrzewska JM,Palmer J,Ettlin DA,Obermann M,Giblin GM,Morisset V,Tate S,Gunn K

更新日期：2013-11-23 00:00:00

abstract：BACKGROUND:This study aims to evaluate the feasibility and efficacy of a complex health intervention, based on the combination of conventional Western medicine and traditional Chinese medicine (TCM), in an outpatient department of a university hospital for patients with frequent episodic or chronic tension-type headach...

journal_title：Trials

authors： Schiller J,Kellner T,Briest J,Hoepner K,Woyciechowski A,Ostermann A,Korallus C,Sturm C,Weiberlenn T,Jiang L,Egen C,Beissner F,Stiesch M,Karst M,Gutenbrunner C,Fink MG

更新日期：2019-11-08 00:00:00