Discontinuing adalimumab in patients with controlled juvenile idiopathic arthritis-associated uveitis (ADJUST-Adalimumab in Juvenile Idiopathic Arthritis-associated Uveitis Stopping Trial): study protocol for a randomised controlled trial.

abstract：BACKGROUND:The cross-sectional area of the subclavian vein (csSCV) is an important factor determining the success rate of SCV catheterization. The head-down position increases the csSCV. However, the effects of lateral tilting on subclavian venous cross-sectional area have not yet been explored. In this trial, we test ...

journal_title：Trials

authors： Jung DE,Lee HC,Yoon HK,Park HP

更新日期：2018-05-24 00:00:00

abstract：BACKGROUND:In coronary artery bypass grafting surgery, arterial conduits are preferred because of more favourable long-term patency and outcome. Anyway the greater saphenous vein continues to be the most commonly used bypass conduit. Minimally invasive endoscopic saphenous vein harvesting is increasingly being investig...

journal_title：Trials

authors： Campanella A,Bergamasco L,Macri L,Asioli S,Devotini R,Scipioni S,Barbaro S,Rispoli P,Rinaldi M

更新日期：2011-11-18 00:00:00

abstract：BACKGROUND:Postoperative atrial fibrillation (POAF) is a common complication following cardiac surgery. POAF is associated with increased morbidity and hospital costs. We herein describe the protocol for a randomized controlled trial to determine if performing a posterior left pericardiotomy prevents POAF after cardiac...

journal_title：Trials

authors： Abouarab AA,Leonard JR,Ohmes LB,Lau C,Rong LQ,Ivascu NS,Pryor KO,Munjal M,Crea F,Massetti M,Sanna T,Girardi LN,Gaudino M

更新日期：2017-12-13 00:00:00

abstract：BACKGROUND:Noncompliance to treatment assignment is an inevitable occurrence in randomized clinical trials (RCTs). Intention to treat (ITT) is generally considered the best method for addressing noncompliance in RCTs. Alternatives to ITT exist, including per protocol (PP), as treated (AT), and instrumental variables (I...

journal_title：Trials

authors： Merrill PD,McClure LA

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Patients can struggle to make sense of trials in emergency situations. This study examines patient experience of participating in the United Kingdom, Wound management of Open Lower Limb Fractures (UK WOLLF) study, a trial of standard wound management versus Negative Pressure Wound Therapy (NPWT). METHODS:Th...

journal_title：Trials

authors： Tutton E,Achten J,Lamb SE,Willett K,Costa ML,UK WOLLF Research Collaborators.

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:Basal cell carcinoma is the most common skin cancer worldwide. Treatment options include both surgical and topical modalities. Although risk of metastasis is low, basal cell carcinoma can be invasive and infiltrate important underlying structures such as bone or cartilage. While many clinical trials examinin...

journal_title：Trials

authors： Schlessinger DI,Iyengar S,Yanes AF,Lazaroff JM,Godinez-Puig V,Chen BR,Kurta AO,Henley JK,Chiren SG,Furlan KC,Schmitt J,Deckert S,Poon E,Sobanko JF,Cartee TV,Alam M,Maher IA

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:In Germany, clinical trials and comparative effectiveness studies in primary care are still very rare, while their usefulness has been recognised in many other countries. A network of researchers from German academic general practice has explored the reasons for this discrepancy. METHODS:Based on a comprehe...

journal_title：Trials

authors： Hummers-Pradier E,Bleidorn J,Schmiemann G,Joos S,Becker A,Altiner A,Chenot JF,Scherer M,German ‘Clinical Trials in German General Practice Network’.

更新日期：2012-11-08 00:00:00

abstract：BACKGROUND:Registration of clinical trials is critical for promoting transparency and integrity in medical research; however, trials must be registered in a prospective fashion to deter unaccounted protocol modifications or selection of alternate outcomes that may enhance favorability of reported findings. We assessed ...

journal_title：Trials

authors： Gopal AD,Wallach JD,Aminawung JA,Gonsalves G,Dal-Ré R,Miller JE,Ross JS

更新日期：2018-08-23 00:00:00

abstract：BACKGROUND:Randomised controlled trials are being increasingly used to evaluate new surgical interventions. There are a number of problematic methodological issues specific to surgical trials, the most important being identifying whether patients are eligible for recruitment into the trial. This is in part due to the d...

journal_title：Trials

authors： Parsons NR,Kulikov Y,Girling A,Griffin D

更新日期：2011-12-13 00:00:00

abstract：:There is a critical need for objective data to guide effective health promotion and care for homeless populations. However, many investigators exclude homeless populations from clinical trials due to practical concerns about conducting research with this population. This report is based on our experience and lessons l...

journal_title：Trials

authors： Ojo-Fati O,Joseph AM,Ig-Izevbekhai J,Thomas JL,Everson-Rose SA,Pratt R,Raymond N,Cooney NL,Luo X,Okuyemi KS

更新日期：2017-07-05 00:00:00

abstract：BACKGROUND:Depression is not a normal side effect of aging, however it is one of the most prevalent mental health issues in later life, imposing a tremendous burden on patients, their families, and the healthcare system. We describe the experimental implementation of a collaborative, stepped-care model for the treatmen...

journal_title：Trials

authors： Wernher I,Bjerregaard F,Tinsel I,Bleich C,Boczor S,Kloppe T,Scherer M,Härter M,Niebling W,König HH,Hüll M

更新日期：2014-09-06 00:00:00

abstract：BACKGROUND:Chronic back pain continues to be a costly and prevalent condition. The latest NICE guidelines issued in 2009 state that for patients with persistent back pain (of between six weeks and twelve months duration), who are highly distressed and/or disabled and for whom exercise, manual therapy and acupuncture ha...

journal_title：Trials

authors： Pincus T,Anwar S,McCracken L,McGregor A,Graham L,Collinson M,Farrin AJ,OBI Trial Management Team.

更新日期：2013-06-13 00:00:00

abstract：:Randomised controlled trials are the best research design for decisions about the effect of different interventions but randomisation does not, of itself, promote the applicability of a trial's results to situations other than the precise one in which the trial was done. While methodologists and trialists have rightly...

journal_title：Trials

authors： Treweek S,Zwarenstein M

更新日期：2009-06-03 00:00:00

abstract：BACKGROUND:Renal transplantation represents the treatment of choice of end-stage kidney disease. Delayed graft function (DGF) remains the most frequent complication after this procedure, reaching more than 30%. Its prevention is essential as it impedes early- and long-term prognosis of transplantation. Numerous pharmac...

journal_title：Trials

authors： Orban JC,Fontaine E,Cassuto E,Baumstarck K,Leone M,Constantin JM,Ichai C,AzuRéa network.

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Acupuncture is a widely serviced complementary medicine. Although acupuncture is suggested for managing postoperative ileus and pain, supporting evidence is weak. The AcuLap trial is designed to provide high-level evidence regarding whether or not electroacupuncture is effective in promoting gastrointestinal...

journal_title：Trials

authors： Kim G

更新日期：2015-10-14 00:00:00

abstract：BACKGROUND:The key aim of the study is to establish an agreed standardised core outcome set (COS) for use when evaluating non-pharmacological health and social care interventions for people living at home with dementia. METHODS/DESIGN:Drawing on the guidance and approaches of the Core Outcome Measures in Effectiveness...

journal_title：Trials

authors： Harding AJE,Morbey H,Ahmed F,Opdebeeck C,Wang YY,Williamson P,Swarbrick C,Leroi I,Challis D,Davies L,Reeves D,Holland F,Hann M,Hellström I,Hydén LC,Burns A,Keady J,Reilly S

更新日期：2018-04-24 00:00:00

abstract：BACKGROUND:Obesity affects 25% of the UK adult population but modest weight loss can reduce the incidence of obesity-related chronic disease. Some effective weight loss treatments exist but there is no nationally available National Health Service (NHS) treatment service, and general practitioners (GPs) rarely discuss w...

journal_title：Trials

authors： Lewis A,Jolly K,Adab P,Daley A,Farley A,Jebb S,Lycett D,Clarke S,Christian A,Jin J,Thompson B,Aveyard P

更新日期：2013-11-19 00:00:00

abstract：BACKGROUND:Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining repetitive active transcranial direct current stimulation (tDCS) with...

journal_title：Trials

authors： Araujo C,Fitz RC,Nogara DA,Schestatsky P,Gerchman F

更新日期：2018-07-16 00:00:00

abstract：BACKGROUND:Quality and service improvement (QSI) research employs a broad range of methods to enhance the efficiency of healthcare delivery. QSI research differs from traditional healthcare research and poses unique ethical questions. Since QSI research aims to generate knowledge to enhance quality improvement efforts,...

journal_title：Trials

authors： Goldstein CE,Weijer C,Brehaut JC,Campbell M,Fergusson DA,Grimshaw JM,Hemming K,Horn AR,Taljaard M

更新日期：2018-06-25 00:00:00

abstract：BACKGROUND:The oversight and conduct of a randomised controlled trial involves several stakeholders, including a Trial Steering Committee (TSC), Trial Management Group (TMG), Data Monitoring Committee (DMC), funder and sponsor. We aimed to examine how the relationships between these stakeholders affect the trial oversi...

journal_title：Trials

authors： Daykin A,Selman LE,Cramer H,McCann S,Shorter GW,Sydes MR,Gamble C,Macefield R,Lane JA,Shaw A

更新日期：2017-12-22 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the elders. It is also associated with several extra-articular symptoms (fatigue, sleep disorders, anxiety and depression) and a reduction of life quality. Studies...

journal_title：Trials

authors： Huang Z,Pan X,Deng W,Huang Z,Huang Y,Huang X,Zhu Z,Han W,Zheng S,Guo X,Ding C,Li T

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Intellectual disability (ID) is characterized by limitations in intellectual functioning and adaptive behavior. Adults with ID exhibit higher rates of obesity and poorer health status compared to the general population. Continuity of care and barriers to health-related activities may contribute to the poorer...

journal_title：Trials

authors： Neumeier WH,Guerra N,Thirumalai M,Geer B,Ervin D,Rimmer JH

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:Many people living with HIV suffer from depressive symptoms. In a previous pilot study, self-help cognitive behavioral therapy (in booklet format) was found to be effective in treating depressive symptoms in people with HIV. We developed an online self-help program in Dutch and English (based on the booklet)...

journal_title：Trials

authors： van Luenen S,Kraaij V,Spinhoven P,Garnefski N

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:Research shows that more than half of the people taking medication for a chronic condition are non-adherent. Nonadherence hinders disease control with a burden on patient quality of life and healthcare systems. We developed a tool that provides insight into nonadherence risks and barriers for medication-adhe...

journal_title：Trials

authors： Hilbink M,Lacroix J,Bremer-van der Heiden L,van Halteren A,Teichert M,van Lieshout J

更新日期：2016-06-03 00:00:00

abstract：BACKGROUND:Neck pain caused by cervical spondylosis (CS) has become one of the most common health problems around the world. Electroacupuncture (EA) has been employed to relieve CS neck pain, but there is limited clinical evidence for its effectiveness. METHODS/DESIGN:This study consists of a randomized controlled tri...

journal_title：Trials

authors： Sun ZR,Yue JH,Zhang QH

更新日期：2013-10-29 00:00:00

abstract：BACKGROUND:Maori, the indigenous people of New Zealand, who present to hospital after intentionally harming themselves, do so at a higher rate than non-Maori. There have been no previous treatment trials in Maori who self harm and previous reviews of interventions in other populations have been inconclusive as existing...

journal_title：Trials

authors： Hatcher S,Coupe N,Durie M,Elder H,Tapsell R,Wikiriwhi K,Parag V

更新日期：2011-05-11 00:00:00

abstract：BACKGROUND:Qualitative methods are increasingly used to study the process of clinical trials and patients understanding of the rationale for trials, randomisation and reasons for taking part or refusing. Patients' understandings are inevitably influenced by the recruiting clinician's understanding of the trial, yet rel...

journal_title：Trials

authors： Ziebland S,Featherstone K,Snowdon C,Barker K,Frost H,Fairbank J

更新日期：2007-01-27 00:00:00

abstract：BACKGROUND:Current guidelines recommend treatment of significant coronary artery disease by concomitant coronary artery bypass grafting (CABG) in patients undergoing surgical aortic valve replacement. However there is no consensus as to how best to treat coronary disease in high-risk patients requiring transcatheter ao...

journal_title：Trials

authors： Khawaja MZ,Wang D,Pocock S,Redwood SR,Thomas MR

更新日期：2014-07-24 00:00:00

abstract：BACKGROUND:Trigeminal neuralgia (TN) is a rare severe unilateral facial pain condition. Current guidelines in trigeminal neuralgia management recommend sodium channel blockers--carbamazepine or oxcarbazepine--as the first-line treatment. However, the currently available drugs are often associated with poor tolerability...

journal_title：Trials

authors： Zakrzewska JM,Palmer J,Ettlin DA,Obermann M,Giblin GM,Morisset V,Tate S,Gunn K

更新日期：2013-11-23 00:00:00

abstract：BACKGROUND:Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two strategies for retention in a randomised prevention trial using a two-by-two factorial randomised s...

journal_title：Trials

authors： Bradshaw LE,Montgomery AA,Williams HC,Chalmers JR,Haines RH

更新日期：2020-06-08 00:00:00