Synergistic effect of acupuncture and mirror therapy on post-stroke upper limb dysfunction: a study protocol for a randomized controlled trial.

abstract：BACKGROUND:Central sensitization is modulated by the endogenous opioid system and plays a major role in the development and maintenance of pain. Recent animal studies performed following resolution of inflammatory pain showed reinstatement of tactile hypersensitivity induced by administration of a mu-opioid-antagonist,...

journal_title：Trials

authors： Pereira MP,Werner MU,Dahl JB

更新日期：2015-11-10 00:00:00

abstract：BACKGROUND:Chronic thoracic pain after cardiac surgery is prevalent (11 to 56%) and may affect patients' physical and mental health status. Despite its favorable pharmacokinetic and pharmacodynamic properties, high doses of remifentanil administered during surgery are reported to cause acute postoperative pain and incr...

journal_title：Trials

authors： de Hoogd S,Ahlers SJ,van Dongen EP,Tibboel D,Dahan A,Knibbe CA

更新日期：2014-11-27 00:00:00

abstract：BACKGROUND:Patients affected by hepatic cirrhosis show reductions in muscle mass and function, with poor quality of life and functional performance. As such, resistance training with blood flow restriction (BFR-RT) could be a useful therapeutic tool for health promotion. Thus, we aim to verify the effects of this inter...

journal_title：Trials

authors： Nóbrega SR,Chachá SGF,Libardi CA

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Spontaneous recovery from articular cartilage injury is difficult, and the ongoing progression of disease can eventually lead to osteoarthritis. Currently, there is no effective non-surgical treatment for articular cartilage injury. Arthroscopic debridement and microfracture surgery are performed for fibroca...

journal_title：Trials

authors： Ma N,Wang H,Xu X,Wan Y,Liu Y,Wang M,Yu W,Dai Y,Peng J,Guo Q,Yu C,Lu S

更新日期：2017-11-06 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immunosuppression. Recurrent lesions of PG are common, but the relative rarity of this condition means th...

journal_title：Trials

authors： Craig FF,Thomas KS,Mitchell EJ,Williams HC,Norrie J,Mason JM,Ormerod AD,UK Dermatology Clinical Trials Network’s STOP GAP Trial Team.

更新日期：2012-04-28 00:00:00

abstract：BACKGROUND:Approximately 50% of heart failure patients are readmitted to hospital within 6 months, owing to deterioration of their condition. Thus, symptomatic treatment of heart failure requires significant improvement. The aim of this study is to compare the effects of torasemide and furosemide on biochemical paramet...

journal_title：Trials

authors： Balsam P,Ozierański K,Tymińska A,Główczyńska R,Peller M,Fojt A,Cacko A,Sieradzki B,Bakuła E,Markulis M,Kowalik R,Huczek Z,Filipiak KJ,Opolski G,Grabowski M

更新日期：2017-01-23 00:00:00

abstract：BACKGROUND:Bone graft substitutes are widely used for reconstruction of posttraumatic bone defects. However, their clinical significance in comparison to autologous bone grafting, the gold-standard in reconstruction of larger bone defects, still remains under debate. This prospective, randomized, controlled clinical st...

journal_title：Trials

authors： Nusselt T,Hofmann A,Wachtlin D,Gorbulev S,Rommens PM

更新日期：2014-03-08 00:00:00

abstract：BACKGROUND:In people with chronic obstructive pulmonary disease (COPD), limb-muscle dysfunction is one of the most troublesome systemic manifestations of the disease, which at the functional level is evidenced by reduced strength and endurance of limb muscles. Improving limb-muscle function is an important therapeutic ...

journal_title：Trials

authors： Frykholm E,Klijn P,Saey D,van Hees HWH,Stål P,Sandström T,Sörlin A,Maltais F,Nyberg A

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:Chronic lymphocytic leukaemia (CLL) is the most common adult leukaemia. Combination immunochemotherapy such as fludarabine, cyclophosphamide and rituximab is the standard first line therapy in fit patients, but there is limited evidence regarding the optimal treatment of patients after relapse. Ofatumumab as...

journal_title：Trials

authors： Howard DR,Munir T,Hockaday A,Rawstron AC,Collett L,Oughton JB,Allsup D,Bloor A,Phillips D,Hillmen P

更新日期：2016-09-20 00:00:00

abstract：BACKGROUND:Post-stroke depression (PSD) is the most common psychiatric complication after a stroke. The most frequently used antidepressants are selective serotonin receptor inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), however, these exhibit a series of side effects. Traditional Chin...

journal_title：Trials

authors： Zhao AM,Qiu WR,Mao LJ,Ren JG,Xu L,Yao MJ,Bilinksi K,Chang D,Liu JX

更新日期：2018-05-10 00:00:00

abstract：:In ageing men testosterone levels decline, while cognitive function, muscle and bone mass, sexual hair growth, libido and sexual activity decline and the risk of cardiovascular diseases increase. We set up a double-blind, randomized placebo-controlled trial to investigate the effects of testosterone supplementation on...

journal_title：Trials

authors： Nakhai Pour HR,Emmelot-Vonk MH,Sukel-Helleman M,Verhaar HJ,Grobbee DE,van der Schouw YT

更新日期：2006-08-03 00:00:00

abstract：BACKGROUND:Prospective meta-analysis (PMA) is a collaborative research design in which individual sites perform randomized controlled trials (RCTs) and pool the data for meta-analysis. Members of the PMA collaboration agree upon specific research interventions and outcome measures, ideally before initiation but at leas...

journal_title：Trials

authors： Turok DK,Espey E,Edelman AB,Lotke PS,Lathrop EH,Teal SB,Jacobson JC,Simonsen SE,Schulz KF

更新日期：2011-04-29 00:00:00

abstract：BACKGROUND:A wound that does not heal in the orderly stages of the healing process or does not heal within 3 months is considered a chronic wound. Wound healing is impaired when the wound remains in the inflammatory stage for too long. A range of factors can delay the healing process: imbalance between proteases and pr...

journal_title：Trials

authors： Comino-Sanz IM,López-Franco MD,Castro B,Pancorbo-Hidalgo PL

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Mild hypoxia is common in stroke patients and may have significant adverse effects on the ischemic brain after stroke. The use of oxygen treatment is rapidly increasing in European stroke units but is not without side effects. It impedes early mobilization, could pose an infection risk, and may encourage the...

journal_title：Trials

authors： Roffe C,Nevatte T,Crome P,Gray R,Sim J,Pountain S,Handy L,Handy P

更新日期：2014-03-31 00:00:00

abstract：BACKGROUND:The perimenopausal period refers to the interval when women's menstrual cycles become irregular and is characterized by an increased risk of depressive symptoms. Use of homeopathy to treat depression is widespread but there is a lack of clinical trials about its efficacy in depression in peri- and postmenopa...

journal_title：Trials

authors： Macías-Cortés Edel C,Aguilar-Faisal L,Asbun-Bojalil J

更新日期：2013-04-23 00:00:00

abstract：BACKGROUND:This study was carried out as a prospective clinical field study with the aim of evaluating the clinical performance of Equia Fil® with a nanofilled resin coating and the conventional Fuji IX GP® fast with an LC coating according to the World Dental Federation (FDI) restoration material evaluation criteria. ...

journal_title：Trials

authors： Klinke T,Daboul A,Turek A,Frankenberger R,Hickel R,Biffar R

更新日期：2016-05-08 00:00:00

abstract：BACKGROUND:People with severe mental illness (SMI) are two to three times more likely to be overweight and obese than the general population and this is associated with significant morbidity and premature mortality. Although lifestyle interventions can support people with SMI to lose weight, some are unable to make the...

journal_title：Trials

authors： Whicher CA,Price HC,Phiri P,Rathod S,Barnard-Kelly K,Reidy C,Thorne K,Asher C,Peveler R,McCarthy J,Holt RIG

更新日期：2019-11-20 00:00:00

abstract：BACKGROUND:Disinvestment from inefficient or ineffective health services is a growing priority for health care systems. Provision of allied health services over the weekend is now commonplace despite a relative paucity of evidence supporting their provision. The relatively high cost of providing this service combined w...

journal_title：Trials

authors： Haines TP,O'Brien L,Mitchell D,Bowles KA,Haas R,Markham D,Plumb S,Chiu T,May K,Philip K,Lescai D,McDermott F,Sarkies M,Ghaly M,Shaw L,Juj G,Skinner EH

更新日期：2015-04-02 00:00:00

abstract：BACKGROUND:The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effe...

journal_title：Trials

authors： Swanson SA,Holme Ø,Løberg M,Kalager M,Bretthauer M,Hoff G,Aas E,Hernán MA

更新日期：2015-11-30 00:00:00

abstract：BACKGROUND:Modern clinical-research practice favors placebo controls over usual-care controls whenever a credible placebo exists. An unrecognized consequence of this preference is that clinicians are more limited in their ability to provide the benefits of the non-specific healing effects of placebos in clinical practi...

journal_title：Trials

authors： Avins AL,Cherkin DC,Sherman KJ,Goldberg H,Pressman A

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:Neck pain is a common symptom in most patients suffering from cervical radiculopathy. However, some conservative treatments are limited by their modest effectiveness. On the other hand, surgical intervention for cervical disc disorders is indicated when symptoms are refractory to conservative treatments and ...

journal_title：Trials

authors： Cui XJ,Sun YL,You SF,Mo W,Lu S,Shi Q,Wang YJ

更新日期：2013-10-07 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a common cause of disability among U.S. military personnel. Approximately 20% of all diagnoses resulting in disability discharges are linked to back-related conditions. Because LBP can negatively influence trunk muscle strength, balance, and endurance, the military readiness of active-...

journal_title：Trials

authors： Vining R,Minkalis A,Long CR,Corber L,Franklin C,Gudavalli MR,Xia T,Goertz CM

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:In rural Ethiopia, 72% of women are exposed to lifetime intimate partner violence (IPV); IPV is most prevalent during pregnancy. As well as adversely affecting women's physical and mental health, IPV also increases the risk of child morbidity and mortality associated with maternal depression, thus making ant...

journal_title：Trials

authors： Keynejad RC,Bitew T,Sorsdahl K,Myers B,Honikman S,Medhin G,Deyessa N,Sevdalis N,Tol WA,Howard L,Hanlon C

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Perioperative complications occur in 30-40% of non-cardiac surgical patients and are the leading cause of early postoperative morbidity and mortality. Regular visits by trained health professionals may decrease the incidence of complications and mortality through earlier detection and adequate treatment of c...

journal_title：Trials

authors： Smit-Fun VM,de Korte-de Boer D,Posthuma LM,Stolze A,Dirksen CD,Hollmann MW,Buhre WF,Boer C

更新日期：2018-10-26 00:00:00

abstract：BACKGROUND:In the last few years, excessive internet use and computer gaming have increased dramatically. Salience, mood modification, tolerance, withdrawal symptoms, conflict, and relapse have been defined as diagnostic criteria for internet addiction (IA) and computer addiction (CA) in the scientific community. Despi...

journal_title：Trials

authors： Jäger S,Müller KW,Ruckes C,Wittig T,Batra A,Musalek M,Mann K,Wölfling K,Beutel ME

更新日期：2012-04-27 00:00:00

abstract：BACKGROUND:The prevalence of depressive disorder in adults with advanced cancer is around 20 %. Although cognitive behavioural therapy (CBT) is recommended for depression and may be beneficial in depressed people with cancer, its use for depression in those with advanced disease for whom cure is not likely has not been...

journal_title：Trials

authors： Serfaty M,King M,Nazareth I,Tookman A,Wood J,Gola A,Aspden T,Mannix K,Davis S,Moorey S,Jones L

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:There is a strong evidence base for the benefits of parenting interventions for parents without severe mental illness (SMI). As the impact of maternal SMI can be significant on child development, mothers need support to maximise outcomes for themselves and their children. Some mothers with SMI require admiss...

journal_title：Trials

authors： Wittkowski A,Cartwright K,Emsley R,Bee P,Calam R,Cross C,Abel KM,Reid H

更新日期：2018-09-10 00:00:00

abstract：BACKGROUND:Atrial fibrillation is common in patients with structural heart disease who are undergoing cardiac surgery. Surgical CryoMaze has been shown to be an effective treatment in several trials, but success rates have varied considerably, between 47-95 %. The sequential hybrid approach, combining surgical CryoMaze...

journal_title：Trials

authors： Eisenberger M,Bulava A,Kautzner J,Neuzil P,Mokracek A,Hanis J,Dusek L

更新日期：2016-10-24 00:00:00

abstract：BACKGROUND:Asylum seekers and refugees are at great risk for developing mental disorders. Afghan refugees are a particularly vulnerable group with a low average education and mental health literacy level. Traumatic experiences and hardship before and during migration are predictive of mental health problems. However, p...

journal_title：Trials

authors： Knefel M,Kantor V,Nicholson AA,Schiess-Jokanovic J,Weindl D,Schäfer I,Lueger-Schuster B

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:Recognizing the value of promoting public access to clinical trial protocols, Trials pioneered the way for their publication over a decade ago. However, despite major advances in the public accessibility of information about trial methods and results, protocol sharing remains relatively rare. MAIN BODY:Prot...

journal_title：Trials

authors： Chan AW,Hróbjartsson A

更新日期：2018-02-17 00:00:00