Remifentanil versus fentanyl during cardiac surgery on the incidence of chronic thoracic pain (REFLECT): study protocol for a randomized controlled trial.

abstract：BACKGROUND:Acupuncture has been widely applied in the clinic to treat irritable bowel syndrome (IBS), but the underlying mechanism remains unknown. Diffuse noxious inhibitory control (DNIC) is deficient in patients with IBS, which attenuates the systemic analgesic effect elicited by noxious stimulation that is remote f...

journal_title：Trials

authors： Peng Y,You H,Chen X,Chen Y,Yang Y,Huang J,Xu N,Liu J

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:Current management for men with lower urinary tract symptoms (LUTS) is a pathway that results in prostate surgery in a significant proportion. While helpful in relieving benign prostatic obstruction (BPO), surgery may be ineffective for men suffering from difficulties not relating to BPO. The UPSTREAM trial ...

journal_title：Trials

authors： Young GJ,Lewis AL,Lane JA,Winton HL,Drake MJ,Blair PS

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:As the toxicity associated with the α-GalCer-pulsed dendritic cell (DC) therapy could be considered to be negligible, its addition to postoperative adjuvant chemotherapy would be expected to greatly improve the therapeutic effect, and could result in prolonged survival. The aim of the present study is to com...

journal_title：Trials

authors： Saka H,Kitagawa C,Ichinose Y,Takenoyama M,Ibata H,Kato T,Takami K,Yamashita M,Maeda T,Takeo S,Ueda H,Okabayashi K,Nagashima S,Oka T,Kouso H,Fukuyama S,Yoshimoto K,Shimokawa M,Saito AM,Ito S

更新日期：2017-09-15 00:00:00

abstract：BACKGROUND:Chronic subdural hematoma (cSDH) is one of the most common conditions encountered in neurosurgical practice. Recurrence, observed in 5-30% of patients, is a major clinical problem. The temperature of the irrigation fluid used during evacuation of the hematoma might theoretically influence recurrence rates si...

journal_title：Trials

authors： Bartley A,Jakola AS,Bartek J Jr,Sundblom J,Förander P,Marklund N,Tisell M

更新日期：2017-10-11 00:00:00

abstract：BACKGROUND:Depression has serious personal, family and economic consequences. It is estimated that it will cost £12.15 billion to the economy each year in England by 2026. Improving access to psychological therapies (IAPT) is the National Health Service talking therapies service in England for adults experiencing anxie...

journal_title：Trials

authors： Strauss C,Arbon A,Barkham M,Byford S,Crane R,de Visser R,Heslin M,Jones AM,Jones F,Lea L,Parry G,Rosten C,Cavanagh K

更新日期：2020-05-04 00:00:00

abstract：BACKGROUND:There is a high prevalence of pain and post-traumatic symptoms among refugees and feasible interventions to manage these are needed. However, knowledge about the effect of physiotherapy and psychological group interventions among refugees is scarce. Our aim is to determine whether two different interventions...

journal_title：Trials

authors： Hasha W,Fadnes LT,Igland J,Vårdal R,Giusti LM,Strømme EM,Haj-Younes J,Heltne U,Kumar BN,Diaz E

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:Recruiting and retaining participants in randomised controlled trials (RCTs) is challenging. Digital tools, such as social media, data mining, email or text-messaging, could improve recruitment or retention, but an overview of this research area is lacking. We aimed to systematically map the characteristics ...

journal_title：Trials

authors： Frampton GK,Shepherd J,Pickett K,Griffiths G,Wyatt JC

更新日期：2020-06-05 00:00:00

abstract：BACKGROUND:Acute kidney allograft rejection is a major cause for declining graft function and has a negative impact on the long-term graft survival. The majority (90%) of acute rejections are T-cell mediated and, therefore, the anti-rejection therapy targets T-cell-mediated mechanisms of the rejection process. However,...

journal_title：Trials

authors： Schiffer L,Schiffer M,Merkel S,Schwarz A,Mengel M,Jürgens C,Schroeder C,Zoerner AA,Püllmann K,Bröcker V,Becker JU,Dämmrich ME,Träder J,Grosshennig A,Biertz F,Haller H,Koch A,Gwinner W

更新日期：2012-10-26 00:00:00

abstract：BACKGROUND:Diabetic kidney disease (DKD) is one of the most common microvascular complications of diabetes mellitus and the main cause of end-stage renal disease. Present medications for DKD are not entirely satisfactory. Preliminary studies indicate that the Chinese herbal formula Tangshen Formula (TSF) appears to dec...

journal_title：Trials

authors： Yan M,Wen Y,Yang L,Wu X,Lu X,Zhang B,Huang W,Li P

更新日期：2016-05-23 00:00:00

abstract：BACKGROUND:Enrollment in interventional therapeutic clinical trials is a small fraction of all patients who might participate given reasonable access. METHODS:A hierarchical approach is utilized in measuring staged participation from trial availability to patient enrollment. Our framework suggests that concern for jus...

journal_title：Trials

authors： Kanarek NF,Kanarek MS,Olatoye D,Carducci MA

更新日期：2012-12-10 00:00:00

abstract：BACKGROUND:Adverse effects such as fatigue, pain, erythema, nausea and vomiting are commonly known in patients undergoing irradiation (RT) alone or in combination with chemotherapy (RCHT). Patients suffering from these symptoms are limited in their daily life and their quality of life (QOL) is often reduced. As address...

journal_title：Trials

authors： Asadpour R,Kessel KA,Bruckner T,Sertel S,Combs SE

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:Many funding bodies require researchers to actively involve service users in research to improve relevance, accountability and quality. Current guidance to researchers mainly discusses general principles. Formal guidance about how to involve service users operationally in the conduct of trials is lacking. We...

journal_title：Trials

authors： Evans BA,Bedson E,Bell P,Hutchings H,Lowes L,Rea D,Seagrove A,Siebert S,Smith G,Snooks H,Thomas M,Thorne K,Russell I,West Wales Organisation for Rigorous Trials in Health (WWORTH).

更新日期：2013-07-17 00:00:00

abstract：BACKGROUND:Many people living with HIV suffer from depressive symptoms. In a previous pilot study, self-help cognitive behavioral therapy (in booklet format) was found to be effective in treating depressive symptoms in people with HIV. We developed an online self-help program in Dutch and English (based on the booklet)...

journal_title：Trials

authors： van Luenen S,Kraaij V,Spinhoven P,Garnefski N

更新日期：2016-03-31 00:00:00

abstract：BACKGROUND:The aim of this study is to demonstrate that capecitabine metronomic chemotherapy is non-inferior to capecitabine conventional chemotherapy as maintenance treatment, in patients who have responded to 16-18 weeks first-line chemotherapy in metastatic colorectal cancer (mCRC). METHODS:The study design is a pr...

journal_title：Trials

authors： Shi M,Ma T,Xi W,Jiang J,Wu J,Zhou C,Yang C,Zhu Z,Zhang J

更新日期：2020-03-06 00:00:00

abstract：BACKGROUND:Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive malignancies with marked resistance to chemo- and radiotherapy. PDA-cancer stem cells (CSCs) are not targeted by current therapies and may be a reason for poor prognosis. Studies indicate that diets rich in cabbage, broccoli, and cauliflowe...

journal_title：Trials

authors： Lozanovski VJ,Houben P,Hinz U,Hackert T,Herr I,Schemmer P

更新日期：2014-06-03 00:00:00

abstract：BACKGROUND:The ability to retrieve specific memories is a cognitive and emotional protective factor. Among the most effective techniques to generate autobiographical memories is the use of audio-visual stimuli, particularly images. Developing and improving techniques that facilitate the generation of such memories coul...

journal_title：Trials

authors： Fernández D,Ros L,Sánchez-Reolid R,Ricarte JJ,Latorre JM

更新日期：2020-07-20 00:00:00

abstract：BACKGROUND:Trials of complex interventions are associated with high costs and burdens in terms of paperwork, management, data collection, validation, and intervention fidelity assessment occurring across multiple sites. Traditional data collection methods rely on paper-based forms, where processing can be time-consumin...

journal_title：Trials

authors： Drew CJ,Poile V,Trubey R,Watson G,Kelson M,Townson J,Rosser A,Hood K,Quinn L,Busse M

更新日期：2016-11-17 00:00:00

abstract：BACKGROUND:Whiplash-associated disorders (WAD) are an enormous and costly burden to Australian society. Up to 50% of people who experience a whiplash injury will never fully recover. Whiplash is resistant to treatment and no early management approach has yet been shown to prevent chronic pain. The early presence of cen...

journal_title：Trials

authors： Nikles J,Keijzers G,Mitchell G,Schug S,Ware R,McLean SA,Connelly L,Gibson S,Farrell SF,Sterling M

更新日期：2018-01-17 00:00:00

abstract：BACKGROUND:More than 60,000 people have health problems due to chemical weapons exposure during the Iran-Iraq war. Respiratory consequences of mustard gas exposure are common and disabling; medical interventions have limited effect. Patients complain of cough, sputum, breathlessness and exercise limitation. We hypothes...

journal_title：Trials

authors： Sedighi Moghadam MR,Ghanei M,Kenn K,Hopkinson NS

更新日期：2019-02-14 00:00:00

abstract：BACKGROUND:PaVOS is a randomized controlled trial (RCT) which aims to address the use of whole-body vibration exercise (WBV) in combination with parathyroid hormone 1-34 fragment teriparatide (PTH 1-34) treatment in patients with osteoporosis. PTH 1-34 is an effective but expensive anabolic treatment for osteoporosis. ...

journal_title：Trials

authors： Jepsen DB,Ryg J,Jørgensen NR,Hansen S,Masud T

更新日期：2018-03-16 00:00:00

abstract：BACKGROUND:Acute respiratory failure (ARF) remains the leading reason for intensive care unit (ICU) admission of immunocompromised patients. In the most severe cases, high-flow oxygen therapy may fail to ensure adequate gas exchange, and mechanical ventilation (MV) must be used. This scenario is associated with high mo...

journal_title：Trials

authors： Lemiale V,Resche-Rigon M,Azoulay E,Study Group for Respiratory Intensive Care in Malignancies Groupe de Recherche en Réanimation Respiratoire du patient d’Onco-Hématologie.

更新日期：2014-09-25 00:00:00

abstract：BACKGROUND:The prevalence of depression in young people is increasing. The predominant co-morbidities of juvenile depression include sleep disturbances and persistent problems with the sleep-wake rhythm, which have shown to influence treatment outcomes negatively. Severe mood dysregulation is another condition that inc...

journal_title：Trials

authors： Bogen S,Legenbauer T,Bogen T,Gest S,Jensch T,Schneider S,Holtmann M

更新日期：2013-06-17 00:00:00

abstract：BACKGROUND:Recently, clinical observations reported the potential benefit of vagus nerve stimulation (VNS) for pediatric epilepsy. Transcutaneous auricular vagus nerve stimulation (ta-VNS) is a newer non-invasive VNS, making it more accessible for treating pediatric epilepsy, yet there is limited clinical evidence for ...

journal_title：Trials

authors： He W,Wang XY,Zhou L,Li ZM,Jing XH,Lv ZL,Zhao YF,Shi H,Hu L,Su YS,Zhu B

更新日期：2015-08-21 00:00:00

abstract：BACKGROUND:The Northwestern University Center for Education and Research on Therapeutics (CERT), funded by the Agency for Healthcare Research and Quality, is one of seven such centers in the USA. The thematic focus of the Northwestern CERT is 'Tools for Optimizing Medication Safety.' Ensuring drug safety is essential, ...

journal_title：Trials

authors： Przytula K,Bailey SC,Galanter WL,Lambert BL,Shrestha N,Dickens C,Falck S,Wolf MS

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:Cardiovascular diseases (CVDs) remain the leading causes of morbidity and mortality in the world. Hypertension is an important and prevalent cardiovascular risk factor. The present study will be conducted to investigate the effect of barberry as a cardio-protective fruit on the blood pressure in patients wit...

journal_title：Trials

authors： Emamat H,Zahedmehr A,Asadian S,Tangestani H,Nasrollahzadeh J

更新日期：2020-11-27 00:00:00

abstract：BACKGROUND:Eyes sustaining open globe trauma are at high risk of severe visual impairment. Ocular injuries which result in visual loss invariably affect the posterior segment of the eye, and prevention of visual loss involves posterior segment (vitreoretinal) surgery. Despite improvements in vitreoretinal surgical tech...

journal_title：Trials

authors： Banerjee PJ,Cornelius VR,Phillips R,Lo JW,Bunce C,Kelly J,Murphy C,Edwards RT,Robertson EL,Charteris DG

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:Quality of residential care for people with severe dementia is in urgent need of improvement. One reason for this may be the assumption that people with severe dementia are unaware of what is happening to them. However, there is converging evidence to suggest that global assumptions of unawareness are inappr...

journal_title：Trials

authors： Clare L,Woods RT,Whitaker R,Wilson BA,Downs M

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:Lower urinary tract symptoms (LUTS) can relate to urinary storage or voiding. In men, the prevalence and severity of LUTS increases with age, with a significant impact on quality of life. The majority of men presenting with LUTS are managed by their general practitioner (GP) in the first instance, with conse...

journal_title：Trials

authors： Frost J,Lane JA,Cotterill N,Fader M,Hackshaw-McGeagh L,Hashim H,Macaulay M,MacNeill SJ,Noble S,Rees J,Ridd MJ,Robles L,Taylor G,Taylor J,Drake MJ,Worthington J

更新日期：2019-09-02 00:00:00

abstract：BACKGROUND:Carpal tunnel syndrome (CTS) is the most common form of peripheral nerve injury, affecting approximately 3 % of the population. While surgery is effective in mild and moderate cases, nerve and functional recovery are often not complete in severe cases. Therefore, there is a need for adjuvant methods to impro...

journal_title：Trials

authors： Curran MW,Olson J,Morhart M,Sample D,Chan KM

更新日期：2016-04-14 00:00:00

abstract：INTRODUCTION:Psoriasis vulgaris is a common skin disease characterized by persistent localized erythematous scaly plaques, typically on the elbows, knees, and scalp. It is an immune-abnormal disease that progresses slowly over a long period with frequent symptom recurrence. Current studies have shown that acupuncture i...

journal_title：Trials

authors： Deng J,Lu C,Xiang Y,Deng H,Wen Z,Yao D,Xuan M,Yan Y

更新日期：2019-06-17 00:00:00