Double blind randomized placebo-controlled trial on the effects of testosterone supplementation in elderly men with moderate to low testosterone levels: design and baseline characteristics [ISRCTN23688581].

abstract：BACKGROUND:In rural Ethiopia, 72% of women are exposed to lifetime intimate partner violence (IPV); IPV is most prevalent during pregnancy. As well as adversely affecting women's physical and mental health, IPV also increases the risk of child morbidity and mortality associated with maternal depression, thus making ant...

journal_title：Trials

authors： Keynejad RC,Bitew T,Sorsdahl K,Myers B,Honikman S,Medhin G,Deyessa N,Sevdalis N,Tol WA,Howard L,Hanlon C

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Trauma contributes to psychosis and in psychotic disorders post-traumatic stress disorder (PTSD) is often a comorbid disorder. A problem is that PTSD is underdiagnosed and undertreated in people with psychotic disorders. This study's primary goal is to examine the efficacy and safety of prolonged exposure an...

journal_title：Trials

authors： de Bont PA,van den Berg DP,van der Vleugel BM,de Roos C,Mulder CL,Becker ES,de Jongh A,van der Gaag M,van Minnen A

更新日期：2013-05-23 00:00:00

abstract：BACKGROUND:The Pneumatic CompREssion for Preventing VENous Thromboembolism (PREVENT) trial evaluates the effect of adjunctive intermittent pneumatic compression (IPC) with pharmacologic thromboprophylaxis compared to pharmacologic thromboprophylaxis alone on venous thromboembolism (VTE) in critically ill adults. METHO...

journal_title：Trials

authors： Arabi Y,Al-Hameed F,Burns KEA,Mehta S,Alsolamy S,Almaani M,Mandourah Y,Almekhlafi GA,Al Bshabshe A,Finfer S,Alshahrani M,Khalid I,Mehta Y,Gaur A,Hawa H,Buscher H,Arshad Z,Lababidi H,Al Aithan A,Jose J,Abdukahil SA

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Osteoarthritis (OA) is the most prevalent chronic joint disease, characterized by joint structural deterioration, pain and loss of function among the elders. It is also associated with several extra-articular symptoms (fatigue, sleep disorders, anxiety and depression) and a reduction of life quality. Studies...

journal_title：Trials

authors： Huang Z,Pan X,Deng W,Huang Z,Huang Y,Huang X,Zhu Z,Han W,Zheng S,Guo X,Ding C,Li T

更新日期：2018-04-17 00:00:00

abstract：BACKGROUND:Dietary interventions have limited success in promoting sustainable weight loss; new treatments allowing better compliance with hypocaloric diets should be developed. The aim of this trial is to describe the effects of a protocol combining repetitive active transcranial direct current stimulation (tDCS) with...

journal_title：Trials

authors： Araujo C,Fitz RC,Nogara DA,Schestatsky P,Gerchman F

更新日期：2018-07-16 00:00:00

abstract：BACKGROUND:Asylum seekers and refugees are at great risk for developing mental disorders. Afghan refugees are a particularly vulnerable group with a low average education and mental health literacy level. Traumatic experiences and hardship before and during migration are predictive of mental health problems. However, p...

journal_title：Trials

authors： Knefel M,Kantor V,Nicholson AA,Schiess-Jokanovic J,Weindl D,Schäfer I,Lueger-Schuster B

更新日期：2020-01-09 00:00:00

abstract：BACKGROUND:UK National Institute of Health and Clinical Excellence guidelines for obsessive compulsive disorder (OCD) specify recommendations for the treatment and management of OCD using a stepped care approach. Steps three to six of this model recommend treatment options for people with OCD that range from low-intens...

journal_title：Trials

authors： Gellatly J,Bower P,McMillan D,Roberts C,Byford S,Bee P,Gilbody S,Arundel C,Hardy G,Barkham M,Reynolds S,Gega L,Mottram P,Lidbetter N,Pedley R,Peckham E,Connell J,Molle J,O'Leary N,Lovell K

更新日期：2014-07-10 00:00:00

abstract：BACKGROUND:Non-cystic fibrosis bronchiectasis is characterized by the irreversible dilatation of the medium-sized bronchi as a result of airway injury from recurrent or chronic inflammation and lower respiratory tract infections. Bronchiectasis airways are commonly colonized with bacterial species. Infections of the ai...

journal_title：Trials

authors： Gao J,Gao X,Kong L

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:Three-dimensional (3D) stereoscopic vision is crucial to perform any kind of manual task. The reduction from real life 3D to virtual two-dimensional (2D) sight is a major challenge in minimally invasive surgery (MIS). A 3D display technique has been shown to reduce operation time and mistakes and to improve ...

journal_title：Trials

authors： Wahba R,Datta RR,Hedergott A,Bußhoff J,Bruns T,Kleinert R,Dieplinger G,Fuchs H,Gietzelt C,Möller D,Hellmich M,Bruns CJ,Stippel DL

更新日期：2019-05-28 00:00:00

abstract：BACKGROUND:Studies exploring parents' trial experiences generally relate to their understanding of the consent process and the development of researcher strategies to facilitate recruitment and retention. The aim was to better understand parents' experience of being part of a trial at the time and their perceptions of ...

journal_title：Trials

authors： Harvey M,Nongena P,Edwards D,Redshaw M

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Patients' treatment preferences are often cited as barriers to recruitment in randomized controlled trials (RCTs). We investigated how RCT recruiters reacted to patients' treatment preferences and identified key strategies to improve informed decision-making and trial recruitment. METHODS:Audio-recordings o...

journal_title：Trials

authors： Mills N,Blazeby JM,Hamdy FC,Neal DE,Campbell B,Wilson C,Paramasivan S,Donovan JL

更新日期：2014-08-13 00:00:00

abstract：BACKGROUND:Gestational diabetes (GDM) is associated with an increased lifetime risk for the development of glucose abnormalities, metabolic syndrome, cardiovascular disease, depression and tumours. Despite this high risk of additional comorbidities, there is no standardised approach to the long-term follow-up of women ...

journal_title：Trials

authors： Bogdanet D,Egan A,Fhelelboom N,Biesty L,Thangaratinam S,Dempsey E,Crowther C,Devane D,Dunne F

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:More than 60,000 people have health problems due to chemical weapons exposure during the Iran-Iraq war. Respiratory consequences of mustard gas exposure are common and disabling; medical interventions have limited effect. Patients complain of cough, sputum, breathlessness and exercise limitation. We hypothes...

journal_title：Trials

authors： Sedighi Moghadam MR,Ghanei M,Kenn K,Hopkinson NS

更新日期：2019-02-14 00:00:00

abstract：:International calls for registering all trials involving humans and for sharing the results, and sometimes also the raw data and the trial protocols, have increased in recent years. Such calls have come, for example, from the Organization for Economic Cooperation and Development (OECD), the World Health Organization (...

journal_title：Trials

authors： Gøtzsche PC

更新日期：2011-11-23 00:00:00

abstract：BACKGROUND:Research involving brain imaging is important for understanding common brain diseases. Study endpoints can include features and measures derived from imaging modalities, providing a benchmark against which other phenotypical data can be assessed. In trials, imaging data provide objective evidence of benefici...

journal_title：Trials

authors： Wiseman SJ,Meijboom R,Valdés Hernández MDC,Pernet C,Sakka E,Job D,Waldman AD,Wardlaw JM

更新日期：2019-01-07 00:00:00

abstract：BACKGROUND:Low back pain (LBP) is a common cause of disability among U.S. military personnel. Approximately 20% of all diagnoses resulting in disability discharges are linked to back-related conditions. Because LBP can negatively influence trunk muscle strength, balance, and endurance, the military readiness of active-...

journal_title：Trials

authors： Vining R,Minkalis A,Long CR,Corber L,Franklin C,Gudavalli MR,Xia T,Goertz CM

更新日期：2018-12-05 00:00:00

abstract：BACKGROUND:Photobiomodulation using low-level laser therapy (LLLT) has been tested as a new technique to optimize recovery of patients with traumatic brain injury (TBI). The aim of this study is to evaluate inhibitory attentional control after 18 sessions of active LLLT and compare with the placebo group (sham LLLT). O...

journal_title：Trials

authors： Poiani GDCR,Zaninotto AL,Carneiro AMC,Zangaro RA,Salgado ASI,Parreira RB,de Andrade AF,Teixeira MJ,Paiva WS

更新日期：2018-01-08 00:00:00

abstract：BACKGROUND:Graves' hyperthyroidism is an autoimmune disease causing hyperfunction of the thyroid gland. The concentration of selenium is high in the thyroid gland and two important groups of enzymes within the thyroid are selenoproteins, that is, they depend on selenium. Selenium may have beneficial effects on autoimmu...

journal_title：Trials

authors： Watt T,Cramon P,Bjorner JB,Bonnema SJ,Feldt-Rasmussen U,Gluud C,Gram J,Hansen JL,Hegedüs L,Knudsen N,Bach-Mortensen P,Nolsøe R,Nygaard B,Pociot F,Skoog M,Winkel P,Rasmussen AK

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:In 2007, the Chinese Science Division of the State Administration of Traditional Chinese Medicine(TCM) convened a special conference to discuss quality control for TCM clinical research. Control and assurance standards were established to guarantee the quality of clinical research. This paper provides practi...

journal_title：Trials

authors： Zhao L,Liang FR,Li Y,Zhang FW,Zheng H,Wu X

更新日期：2009-12-27 00:00:00

abstract：BACKGROUND:Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic rhinitis symptoms and to avoid the side effects of conventional medication. Acupuncture has been widely used to treat patients with allergic rhiniti...

journal_title：Trials

authors： Kim JI,Lee MS,Jung SY,Choi JY,Lee S,Ko JM,Zhao H,Zhao J,Kim AR,Shin MS,Kang KW,Jung HJ,Kim TH,Liu B,Choi SM

更新日期：2009-07-14 00:00:00

abstract：BACKGROUND:Socially disadvantaged men are at a substantially higher risk of developing alcohol-related problems. The frequency of heavy drinking in a single session is high among disadvantaged men. Brief alcohol interventions were developed for, and are usually delivered in, healthcare settings. The group who binge dri...

journal_title：Trials

authors： Crombie IK,Irvine L,Williams B,Sniehotta FF,Petrie D,Evans JM,Emslie C,Jones C,Ricketts IW,Humphris G,Norrie J,Rice P,Slane PW

更新日期：2014-12-19 00:00:00

abstract：BACKGROUND:A high intake of salt is a major risk factor for cardiovascular diseases. Despite decades of effort to reduce salt consumption, the salt intake in China is still considerably above the recommended level. Thus, this study aims to design and implement an intelligent household added salt monitoring system (SALT...

journal_title：Trials

authors： Xian J,Zeng M,Zhu R,Cai Z,Shi Z,Abdullah AS,Zhao Y

更新日期：2020-04-21 00:00:00

abstract：BACKGROUND:Bariatric surgery is an effective approach to weight loss and long-term comorbidity resolution. Although recommended in several guidelines, supervised exercise has not been systematically prescribed after bariatric surgery. The aim of this study is to determine the effects of two types of exercise, moderate-...

journal_title：Trials

authors： Herrera-Santelices A,Tabach-Apraiz A,Andaur-Cáceres K,Zamunér AR

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Psychosis is a serious mental illness that typically emerges during early adulthood. The disorder is characterized by inactivity, cognitive deficits and the need for ongoing support. Regular exercise has mood enhancing and anxiolytic effects that could benefit this patient group. To date, few studies have ex...

journal_title：Trials

authors： Forsell Y,Hallgren M,Mattson M,Ekblom O,Lavebratt C

更新日期：2015-12-04 00:00:00

abstract：BACKGROUND:In the paediatric population, pain and distress associated with burn injuries during wound care procedures remain a constant challenge. Although silver dressings are the gold standard for burn care in Australasia, very few high-level trials have been conducted that compare silver dressings to determine which...

journal_title：Trials

authors： Gee Kee E,Kimble RM,Cuttle L,Stockton K

更新日期：2013-11-25 00:00:00

abstract：BACKGROUND:This randomized controlled clinical trial aims to evaluate the efficacy and safety of opposing needling in patients undergoing unilateral total knee arthroplasty (TKA). Opposing needling is one of the special needling methods used in acupuncture and moxibustion therapy. It involves needling acupoints on the ...

journal_title：Trials

authors： Huang H,Song X,Zhao L,Zheng L,Xiao L,Chen Y

更新日期：2020-05-07 00:00:00

abstract：BACKGROUND:Evidence for benefit of high positive end-expiratory pressure (PEEP) is largely lacking for invasively ventilated, critically ill patients with uninjured lungs. We hypothesize that ventilation with low PEEP is noninferior to ventilation with high PEEP with regard to the number of ventilator-free days and bei...

journal_title：Trials

authors： Algera AG,Pisani L,Bergmans DCJ,den Boer S,de Borgie CAJ,Bosch FH,Bruin K,Cherpanath TG,Determann RM,Dondorp AM,Dongelmans DA,Endeman H,Haringman JJ,Horn J,Juffermans NP,van Meenen DM,van der Meer NJ,Merkus MP,Moenira

更新日期：2018-05-09 00:00:00

abstract：BACKGROUND:Carpal tunnel syndrome (CTS) is the most common form of peripheral nerve injury, affecting approximately 3 % of the population. While surgery is effective in mild and moderate cases, nerve and functional recovery are often not complete in severe cases. Therefore, there is a need for adjuvant methods to impro...

journal_title：Trials

authors： Curran MW,Olson J,Morhart M,Sample D,Chan KM

更新日期：2016-04-14 00:00:00

abstract：BACKGROUND:For the last decade continuous efforts have been made to translate regenerative cell therapy protocols in the cardiovascular field from 'bench to bedside'. Successful clinical introduction, supporting safety, and feasibility of this new therapeutic approach, led to the initiation of the German, Phase III, mu...

journal_title：Trials

authors： Donndorf P,Kaminski A,Tiedemann G,Kundt G,Steinhoff G

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:The per-protocol effect is the effect that would have been observed in a randomized trial had everybody followed the protocol. Though obtaining a valid point estimate for the per-protocol effect requires assumptions that are unverifiable and often implausible, lower and upper bounds for the per-protocol effe...

journal_title：Trials

authors： Swanson SA,Holme Ø,Løberg M,Kalager M,Bretthauer M,Hoff G,Aas E,Hernán MA

更新日期：2015-11-30 00:00:00