Longitudinal multi-centre brain imaging studies: guidelines and practical tips for accurate and reproducible imaging endpoints and data sharing.

abstract：:In October 2015 we published the paper 'Measurement of HbA1c in multicentre diabetes trials - should blood samples be tested locally or sent to a central laboratory: an agreement analysis'. Chatterjee and Pradhan have submitted a letter to the editor asking critical questions regarding the methods we used. We offer th...

journal_title：Trials

authors： Arch BN,Blair J,McKay A,Gregory JW,Newland P,Gamble C

更新日期：2017-05-26 00:00:00

abstract：BACKGROUND:With high morbidity, mortality and disability rate, brain infarction brings a huge economic and health burden to the whole society in China. Although some previous studies suggested that telerehabilitation may facilitate rehabilitation for stroke survivors at home, the evidence is insufficient for clinical a...

journal_title：Trials

authors： Jin W,Chen J,Shi F,Yang W,Zhang Y,Liu Y,Dong W,Jin Y,Ma W,Ma Z,Min X,Jin Y,Gu Y,Ren C

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:It was reported that prolonging the injection time or diluting administration can reduce the incidence of opioid-induced cough. However, the incidence of sufentanil-induced cough (SIC) via a standardized infusion rate is unclear. A mechanical dropper is an infusion filtering device commonly used for intraven...

journal_title：Trials

authors： Liu M,Li Z,Wang S,Liu Y,Zhong X,He R,Li F

更新日期：2019-03-15 00:00:00

abstract：BACKGROUND:The Northwestern University Center for Education and Research on Therapeutics (CERT), funded by the Agency for Healthcare Research and Quality, is one of seven such centers in the USA. The thematic focus of the Northwestern CERT is 'Tools for Optimizing Medication Safety.' Ensuring drug safety is essential, ...

journal_title：Trials

authors： Przytula K,Bailey SC,Galanter WL,Lambert BL,Shrestha N,Dickens C,Falck S,Wolf MS

更新日期：2015-01-27 00:00:00

abstract：BACKGROUND:The prevalence of depressive disorder in adults with advanced cancer is around 20 %. Although cognitive behavioural therapy (CBT) is recommended for depression and may be beneficial in depressed people with cancer, its use for depression in those with advanced disease for whom cure is not likely has not been...

journal_title：Trials

authors： Serfaty M,King M,Nazareth I,Tookman A,Wood J,Gola A,Aspden T,Mannix K,Davis S,Moorey S,Jones L

更新日期：2016-02-29 00:00:00

abstract：BACKGROUND:Overt chronic metabolic acidosis in patients with chronic kidney disease develops after a drop of glomerular filtration rate to less than approximately 25 mL/min/1.73 m2. The pathogenic mechanism seems to be a lack of tubular bicarbonate production, which in healthy individuals neutralizes the acid net produ...

journal_title：Trials

authors： Gaggl M,Cejka D,Plischke M,Heinze G,Fraunschiel M,Schmidt A,Hörl WH,Sunder-Plassmann G

更新日期：2013-07-04 00:00:00

abstract：BACKGROUND:Asthma is a prevalent and costly disease resulting in reduced quality of life for a large proportion of individuals. Effective patient self-management is critical for improving health outcomes. However, key aspects of self-management such as self-monitoring of behaviours and symptoms, coupled with regular fe...

journal_title：Trials

authors： Ahmed S,Bartlett SJ,Ernst P,Paré G,Kanter M,Perreault R,Grad R,Taylor L,Tamblyn R

更新日期：2011-12-14 00:00:00

abstract：BACKGROUND:Eyes sustaining open globe trauma are at high risk of severe visual impairment. Ocular injuries which result in visual loss invariably affect the posterior segment of the eye, and prevention of visual loss involves posterior segment (vitreoretinal) surgery. Despite improvements in vitreoretinal surgical tech...

journal_title：Trials

authors： Banerjee PJ,Cornelius VR,Phillips R,Lo JW,Bunce C,Kelly J,Murphy C,Edwards RT,Robertson EL,Charteris DG

更新日期：2016-07-22 00:00:00

abstract：BACKGROUND:Diabetes mellitus is associated with risk of sudden sensorineural hearing loss (SSNHL). Systemic and intratympanic corticosteroids are the two primary treatments for SSNHL in patients with diabetes mellitus. The benefit of intratympanic compared to systemic treatment is the reduced systemic steroid exposure ...

journal_title：Trials

authors： Yang W,Li X,Zhong J,Mei X,Liu H,Yang L,Lu L,Hu H

更新日期：2020-02-03 00:00:00

abstract：BACKGROUND:Heart valve diseases are common with an estimated prevalence of 2.5% in the Western world. The number is rising due to an ageing population. Once symptomatic, heart valve diseases are potentially lethal, and heavily influence daily living and quality of life. Surgical treatment, either valve replacement or r...

journal_title：Trials

authors： Sibilitz KL,Berg SK,Hansen TB,Risom SS,Rasmussen TB,Hassager C,Køber L,Steinbrüchel D,Gluud C,Winkel P,Thygesen LC,Hansen JL,Schmid JP,Conraads V,Brocki BC,Zwisler AD

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:Amnestic mild cognitive impairment (aMCI) is a syndrome characterized by significant forgetfulness that does not meet the criteria of dementia. Individuals with aMCI are at greater risk of progressing to dementia. Current studies suggest that good sleep quality is linked with preserved cognition in the elder...

journal_title：Trials

authors： Yue S,He T,Li B,Qu Y,Peng H,Chen J,Lei M,Chen C,Wu W

更新日期：2019-08-20 00:00:00

abstract：BACKGROUND:Untreated advanced hepatocellular carcinoma (HCC) is linked to poor prognosis. While sorafenib is the current recommended treatment for advanced HCC, radioembolisation (RE; also called selective internal radiation therapy or SIRT) with yttrium-90 microspheres has shown efficacy in cohort studies. However, th...

journal_title：Trials

authors： Vilgrain V,Abdel-Rehim M,Sibert A,Ronot M,Lebtahi R,Castéra L,Chatellier G,SARAH Trial Group.

更新日期：2014-12-03 00:00:00

abstract：BACKGROUND:It is expected that in 2020 more than 17,000 cases of colorectal cancer will be diagnosed in The Netherlands. To date, patients are included in a surgeon-led follow-up programme whose main focus is recurrence detection. However, patients often experience multiple physical and psychosocial problems. Currently...

journal_title：Trials

authors： Duineveld LA,Wieldraaijer T,van Asselt KM,Nugteren IC,Donkervoort SC,van de Ven AW,Smits AB,van Geloven AA,Bemelman WA,Beverdam FH,van Tets WF,Govaert MJ,Bosmans JE,Verdonck-de Leeuw IM,van Uden-Kraan CF,van Weert HC,Wind

更新日期：2015-06-26 00:00:00

abstract：BACKGROUND:Quitting smokers gain weight. This deters some from trying to stop smoking and may explain the increased incidence of type 2 diabetes after cessation. Dieting when stopping smoking may be counterproductive. Hunger increases cravings for smoking and tackling two behaviours together may undermine quitting succ...

journal_title：Trials

authors： Lycett D,Aveyard P,Farmer A,Lewis A,Munafò M

更新日期：2013-06-19 00:00:00

abstract：BACKGROUND:Generalised anxiety disorder (GAD) is a chronic and disabling condition with considerable personal and economic impact. Cognitive behavioural therapy (CBT) is a recommended psychological therapy for GAD; however, there are substantial barriers to accessing treatment. Digital CBT, in particular smartphone-del...

journal_title：Trials

authors： Gu J,Miller CB,Henry AL,Espie CA,Davis ML,Stott R,Emsley R,Smits JAJ,Craske M,Saunders KEA,Goodwin G,Carl JR

更新日期：2020-04-23 00:00:00

abstract：BACKGROUND:The effect of pregabalin on acute herpes zoster pain has not been previously evaluated. METHODS:In a randomized, double-blind, placebo-controlled, two-session crossover study the effect of a single oral dose of pregabalin (150 mg) on pain and allodynia was evaluated in 8 subjects with herpes zoster. RESULT...

journal_title：Trials

authors： Jensen-Dahm C,Rowbotham MC,Reda H,Petersen KL

更新日期：2011-02-28 00:00:00

abstract：BACKGROUND:Recovery after a major stroke is usually limited, but cell therapy for patients with fixed neurologic deficits is emerging. Several recent clinical trials have investigated mesenchymal stem cell (MSC) therapy for patients with ischemic stroke. We previously reported the results of a controlled trial on the a...

journal_title：Trials

authors： Kim SJ,Moon GJ,Chang WH,Kim YH,Bang OY,STARTING-2 (STem cell Application Researches and Trials In NeuroloGy-2) collaborators.

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Contrast-induced nephropathy (CIN) is a serious clinical problem associated with increased morbidity and mortality, particularly in patients with chronic renal insufficiency. Although some agents including hydration with saline are being prescribed to prevent renal deterioration in these high risk patients, ...

journal_title：Trials

authors： Park K,Chung WY,Seo JB,Kim SH,Zo JH,Kim MA,Park YB

更新日期：2010-12-20 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated the benefit of early integration of palliative care (PC) in oncology. However, patients continue to receive late referrals to PC even in comprehensive cancer centers. Patients and health professionals may perceive PC as 'a place to die,' and this stigma is a barrier to time...

journal_title：Trials

authors： do Carmo TM,Paiva BS,de Siqueira MR,da Rosa Lde T,de Oliveira CZ,Nascimento MS,Paiva CE

更新日期：2015-04-12 00:00:00

abstract：BACKGROUND:There is a high prevalence of pain and post-traumatic symptoms among refugees and feasible interventions to manage these are needed. However, knowledge about the effect of physiotherapy and psychological group interventions among refugees is scarce. Our aim is to determine whether two different interventions...

journal_title：Trials

authors： Hasha W,Fadnes LT,Igland J,Vårdal R,Giusti LM,Strømme EM,Haj-Younes J,Heltne U,Kumar BN,Diaz E

更新日期：2019-12-27 00:00:00

abstract：BACKGROUND:It is generally accepted that an active lifestyle is beneficial for cognition in children, adults and the elderly. Recently, studies using the rat animal model found that the pups of mothers who exercised during pregnancy had increased hippocampal neurogenesis and better memory and learning abilities. The ai...

journal_title：Trials

authors： LeMoyne EL,Curnier D,St-Jacques S,Ellemberg D

更新日期：2012-05-29 00:00:00

abstract：BACKGROUND:A wound that does not heal in the orderly stages of the healing process or does not heal within 3 months is considered a chronic wound. Wound healing is impaired when the wound remains in the inflammatory stage for too long. A range of factors can delay the healing process: imbalance between proteases and pr...

journal_title：Trials

authors： Comino-Sanz IM,López-Franco MD,Castro B,Pancorbo-Hidalgo PL

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Intensive rehabilitation of patients with severe traumatic brain injury is generally applied in the subacute stages of the hospital stay. Few studies have assessed the association between early and intensive physical rehabilitation and functional outcomes. The aim of this trial is to assess the feasibility o...

journal_title：Trials

authors： Riberholt CG,Lindschou J,Gluud C,Mehlsen J,Møller K

更新日期：2018-11-08 00:00:00

abstract：BACKGROUND:Granulomatosis with polyangiitis (GPA, Wegener's) and microscopic polyangiitis (MPA) are small vessel vasculitides collectively referred to as anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). AAV is associated with high rates of morbidity and mortality due to uncontrolled disease and treatment...

journal_title：Trials

authors： Walsh M,Merkel PA,Peh CA,Szpirt W,Guillevin L,Pusey CD,De Zoysa J,Ives N,Clark WF,Quillen K,Winters JL,Wheatley K,Jayne D,PEXIVAS Investigators.

更新日期：2013-03-14 00:00:00

abstract：BACKGROUND:Atopic dermatitis (AD) is a common pruritic inflammatory skin disease with increasing prevalence. It can manifest with many different clinical phenotypes; however, in its chronic stage, hyperpigmentation, excoriation, lichenification, and dryness are the main symptoms. Jaungo comprises two herbs, Lithospermi...

journal_title：Trials

authors： Yun Y,Ko Y,Ahn JH,Jang BH,Kim K,Ko SG,Choi I

更新日期：2017-04-12 00:00:00

abstract：BACKGROUND:Postpartum haemorrhage (PPH) is a major cause of maternal morbidity. Bleeding is caused by a combination of physical causes, such as failure of the uterus to contract or operations, and is made worse by impairment of the blood clotting system. A number of studies have shown that low levels of the blood clott...

journal_title：Trials

authors： Aawar N,Alikhan R,Bruynseels D,Cannings-John R,Collis R,Dick J,Elton C,Fernando R,Hall J,Hood K,Lack N,Mallaiah S,Maybury H,Nuttall J,Paranjothy S,Rayment R,Rees A,Sanders J,Townson J,Weeks A,Collins P

更新日期：2015-04-17 00:00:00

abstract：BACKGROUND:The incidence of cardiovascular disease (CVD) in rheumatoid arthritis (RA) is increased compared to the general population. Immune dysregulation and systemic inflammation are thought to be associated with this increased risk. Early diagnosis with immediate treatment and tight control of RA forms a central tr...

journal_title：Trials

authors： Erhayiem B,Pavitt S,Baxter P,Andrews J,Greenwood JP,Buch MH,Plein S

更新日期：2014-11-08 00:00:00

abstract：BACKGROUND:Entertainment-education (E-E) media can improve behavioral intent toward health-related practices. In the era of COVID-19, millions of people can be reached by E-E media without requiring any physical contact. We have designed a short, wordless, animated video about preventive COVID-19 behaviors that can be ...

journal_title：Trials

authors： Vandormael A,Adam M,Greuel M,Bärnighausen T

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Haemorrhage remains a leading cause of morbidity and mortality in trauma patients. Fibrinogen is an essential endogenous component of haemostasis and the plasma level is associated with bleeding, transfusion and outcome. Fibrinogen concentrate is widely used to correct acquired hypofibrinogenaemia, recommend...

journal_title：Trials

authors： Steinmetz J,Sørensen AM,Henriksen HH,Lange T,Larsen CF,Johansson PI,Stensballe J

更新日期：2016-07-19 00:00:00

abstract：BACKGROUND:Gastroesophageal reflux disease lowers the quality of life and increases medical costs. Electroacupuncture has been used to ease symptoms and improve gastrointestinal motility in patients with gastroesophageal reflux disease. The main purposes of this study are to evaluate the efficacy and safety of this pro...

journal_title：Trials

authors： Han G,Leem J,Lee H,Lee J

更新日期：2016-05-17 00:00:00